{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:01:51Z","timestamp":1792098111845,"version":"4.4.0"},"reference-count":96,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by Program for Research and Technological Innovation Projects (PAPIIT) UNAM","award":["IA207420"],"award-info":[{"award-number":["IA207420"]}]},{"name":"PhD Reyna-Urrutia thanks to UNAM for the postdoctoral fellowship.","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Cleft palate (CP) is one of the most common birth defects, presenting a multitude of negative impacts on the health of the patient. It also leads to increased mortality at all stages of life, economic costs and psychosocial effects. The embryological development of CP has been outlined thanks to the advances made in recent years due to biomolecular successions. The etiology is broad and combines certain environmental and genetic factors. Currently, all surgical interventions work off the principle of restoring the area of the fissure and aesthetics of the patient, making use of bone substitutes. These can involve biological products, such as a demineralized bone matrix, as well as natural\u2013synthetic polymers, and can be supplemented with nutrients or growth factors. For this reason, the following review analyzes different biomaterials in which nutrients or biomolecules have been added to improve the bioactive properties of the tissue construct to regenerate new bone, taking into account the greatest limitations of this approach, which are its use for bone substitutes for large areas exclusively and the lack of vascularity. Bone tissue engineering is a promising field, since it favors the development of porous synthetic substitutes with the ability to promote rapid and extensive vascularization within their structures for the regeneration of the CP area.<\/jats:p>","DOI":"10.3390\/polym14030547","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-392X","authenticated-orcid":false,"given":"V\u00edctor A.","family":"Reyna-Urrutia","sequence":"first","affiliation":[{"name":"Laboratorio de Ingenier\u00eda Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tenayuca-Chalmita S\/N, Cuautepec Barrio Bajo, Alcald\u00eda Gustavo A. Madero, Ciudad de M\u00e9xico CP 07239, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arely M.","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ingenier\u00eda Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tenayuca-Chalmita S\/N, Cuautepec Barrio Bajo, Alcald\u00eda Gustavo A. Madero, Ciudad de M\u00e9xico CP 07239, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-4421","authenticated-orcid":false,"given":"Ra\u00fal","family":"Rosales-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ingenier\u00eda Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tenayuca-Chalmita S\/N, Cuautepec Barrio Bajo, Alcald\u00eda Gustavo A. Madero, Ciudad de M\u00e9xico CP 07239, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/PRS.0b013e3181881f54","article-title":"Functional neuroanatomy of lexical processing in children with cleft lip and palate","volume":"122","author":"Becker","year":"2008","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_2","first-page":"18","article-title":"Revista odontol\u00f3gica mexicana nasoalveolar bone graft integration range in patients with cleft lip and palate sequels","volume":"16","year":"2012","journal-title":"Medigraphic"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chigurupati, R. (2012). Cleft Lip and Palate: Timing and approaches to reconstruction. 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