{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:38:26Z","timestamp":1786462706929,"version":"build-2736575974"},"reference-count":117,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Economy and Competitiveness and the European Regional Development Fund","award":["Project PID2020-114694RB-100 MINECO\/AEI\/FEDER\/UE"],"award-info":[{"award-number":["Project PID2020-114694RB-100 MINECO\/AEI\/FEDER\/UE"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI and Web of Science. Through our search, we found literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules\u2019 occlusion by crystals\u2019 precipitation contributing to improved sealing efficacy of restorations. Loading dentin adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrix-metalloproteinases (MMPs), contributing to dentin matrix stabilization. Zinc may not only act as a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin.<\/jats:p>","DOI":"10.3390\/polym14030642","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:42:20Z","timestamp":1644363740000},"page":"642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Manuel","family":"Toledano","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18017 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledano-Osorio","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18017 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hannig","sequence":"additional","affiliation":[{"name":"Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, Building 73, 66421 Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Carrasco-Carmona","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18017 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Independent Researcher, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-3306","authenticated-orcid":false,"given":"Franklin","family":"Garc\u00eda-Godoy","sequence":"additional","affiliation":[{"name":"Health Science Center, College of Dentistry, University of Tennessee, 875 Union Avenue, Memphis, TN 381632110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-3929","authenticated-orcid":false,"given":"Inmaculada","family":"Cabello","sequence":"additional","affiliation":[{"name":"Integral Pediatric Dentistry Teaching Unit, Faculty of Medicine, University of Murcia, 30008 Murcia, Spain"},{"name":"Murcian Institute of Biosanitary Research (IMIB), 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Osorio","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18017 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dental.2010.10.016","article-title":"State of the Art Etch-and-Rinse Adhesives","volume":"27","author":"Pashley","year":"2011","journal-title":"Dent. 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