{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:01:00Z","timestamp":1790535660310,"version":"4.1.0"},"reference-count":71,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Polymeric membranes are frequently used for bone regeneration in oral and periodontal surgery. Polymers provide adequate mechanical properties (i.e., Young\u2019s modulus) to support oral function and also pose some porosity with interconnectivity to permit for cell proliferation and migration. Bacterial contamination of the membrane is an event that may lead to infection at the bone site, hindering the clinical outcomes of the regeneration procedure. Therefore, polymeric membranes have been proposed as carriers for local antibiotic therapy. A literature search was performed for papers, including peer-reviewed publications. Among the different membranes, collagen is the most employed biomaterial. Collagen membranes and expanded polytetrafluoroethylene loaded with tetracyclines, and polycaprolactone with metronidazole are the combinations that have been assayed the most. Antibiotic liberation is produced in two phases. A first burst release is sometimes followed by a sustained liberation lasting from 7 to 28 days. All tested combinations of membranes and antibiotics provoke an antibacterial effect, but most of the time, they were measured against single bacteria cultures and usually non-specific pathogenic bacteria were employed, limiting the clinical relevance of the attained results. The majority of the studies on animal models state a beneficial effect of these antibiotic functionalized membranes, but human clinical assays are scarce and controversial.<\/jats:p>","DOI":"10.3390\/polym14040840","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:48:41Z","timestamp":1645476521000},"page":"840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone\/Tissue Regeneration: A Mini-Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Manuel","family":"Toledano-Osorio","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Colegio Ma\u0301ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-2811","authenticated-orcid":false,"given":"Cristina","family":"Vallecillo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio Ma\u0301ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vallecillo-Rivas","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio Ma\u0301ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco-Javier","family":"Manzano-Moreno","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio Ma\u0301ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"},{"name":"Biomedical Group (BIO277), Department of Stomatology, Facultad de Odontolog\u00eda, University of Granada, 18071 Granada, Spain"},{"name":"Instituto Investigaci\u00f3n Biosanitaria ibs.GRANADA, University of Granada, C\/Doctor Azpitarte 4, Planta, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Osorio","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio Ma\u0301ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-051X.1982.tb02095.x","article-title":"New Attachment Following Surgical Treatment of Human Periodontal Disease","volume":"9","author":"Nyman","year":"1982","journal-title":"J. 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