{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:20:56Z","timestamp":1791832856244,"version":"4.3.4"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia de Pernambuco","doi-asserted-by":"publisher","award":["IBPG-1712-2.08\/16"],"award-info":[{"award-number":["IBPG-1712-2.08\/16"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0108-2.08\/14"],"award-info":[{"award-number":["APQ-0108-2.08\/14"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia de Pernambuco","doi-asserted-by":"publisher","award":["APQ-0661-2.08\/15"],"award-info":[{"award-number":["APQ-0661-2.08\/15"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["407192\/2018-2"],"award-info":[{"award-number":["407192\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Most anti-inflammatory drugs used nowadays have an excessive cost and their prolonged use has been connected with several injurious effects. Thus, the search for new anti-inflammatory agents is increasing. Lectins are carbohydrate-interacting proteins that can modulate immune response and the release of inflammation mediators. The Microgramma vacciniifolia frond lectin (MvFL) was previously reported to be an immunomodulatory agent in vitro. This work aimed to evaluate the effects of MvFL on the in vivo inflammatory status in the carrageenan-induced peritonitis and paw edema, using female Swiss mice. The animals were pretreated intraperitoneally with MvFL (5 and 10 mg\/kg). In the peritonitis assay, the total and differential migration of white blood cells was evaluated, as well as the levels of cytokines, nitric oxide (NO), and total proteins in the peritoneal fluid. In the paw edema evaluation, the paw volume was measured in the early (from 30 min\u20132 h) and late (3\u20134 h) phases of edema formation. MvFL (5 and 10 mg\/kg) was efficient in reducing neutrophil infiltration, pro-inflammatory cytokines (IL-6, IL-17, and TNF-\u03b1), NO, and protein content in the peritoneal fluid. It also repressed the edema formation in the late phase of the assay. In conclusion, MvFL showed inhibitory effects in in vivo acute inflammation, which encouraged future studies exploiting its immunomodulatory ability.<\/jats:p>","DOI":"10.3390\/polym14081609","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T02:39:31Z","timestamp":1650335971000},"page":"1609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Inhibition of Carrageenan-Induced Acute Inflammation in Mice by the Microgramma vacciniifolia Frond Lectin (MvFL)"],"prefix":"10.3390","volume":"14","author":[{"given":"Leydianne Leite","family":"de Siqueira Patriota","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-8773","authenticated-orcid":false,"given":"Dalila","family":"de Brito Marques Ramos","sequence":"additional","affiliation":[{"name":"Campus Amilcar Ferreira Sobral, Universidade Federal do Piau\u00ed, Floriano 64808-605, Piau\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Gama","family":"e Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Oncologia Experimental, Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56306-385, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Caroline Lima Amorim","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Oncologia Experimental, Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56306-385, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmym Ara\u00fajo","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Oncologia Experimental, Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56306-385, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Maria Guedes","family":"Paiva","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-3650","authenticated-orcid":false,"given":"Emmanuel Viana","family":"Pontual","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife 52171-900, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiane Pereira","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Farmacologia, Universidade Federal do Piau\u00ed, Teresina 64049-550, Piau\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6197-5475","authenticated-orcid":false,"given":"Rosemairy Luciane","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Oncologia Experimental, Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56306-385, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2602","authenticated-orcid":false,"given":"Thiago Henrique","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev-immunol-061020-053734","article-title":"Tissue Homeostasis and Inflammation","volume":"39","author":"Meizlish","year":"2021","journal-title":"Annu. 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