{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:57:37Z","timestamp":1785297457310,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51861165203"],"award-info":[{"award-number":["51861165203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2020YJ0261 and 2019YJ0125"],"award-info":[{"award-number":["2020YJ0261 and 2019YJ0125"]}]},{"name":"Program for Featured Directions of Engineering Multidisciplines of Sichuan University","award":["2020SCUNG203"],"award-info":[{"award-number":["2020SCUNG203"]}]},{"DOI":"10.13039\/501100011263","name":"State Key Laboratory of Polymer Materials Engineering","doi-asserted-by":"publisher","award":["sklpme2019-2-19"],"award-info":[{"award-number":["sklpme2019-2-19"]}],"id":[{"id":"10.13039\/501100011263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization","award":["HZXYKFKT201902"],"award-info":[{"award-number":["HZXYKFKT201902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Electrospun cellulose nanofiber nonwovens have shown promise in wound dressing owing to the highly interconnected pore structure, high hydrophilicity coupled with other coveted characteristics of biodegradability, biocompatibility and renewability. However, electrospun cellulose wound dressings with loaded drugs for better wound healing have been rarely reported. In this study, a novel wound dressing with a high drug loading capacity and sustained drug release properties was successfully fabricated via electropinning of cellulose followed by polyethylenimine (PEI)-functionalization. Remarkably, the grafted PEI chains on the surface of electrospun cellulose nanofibers provided numerous active amino groups, while the highly porous structure of nonwovens could be well retained after modification, which resulted in enhanced adsorption performance against the anionic drug of sodium salicylate (NaSA). More specifically, when immersed in 100 mg\/L NaSA solution for 24 h, the as-prepared cellulose-PEI nonwoven displayed a multilayer adsorption behavior. And at the optimal pH of 3, a high drug loading capacity of 78 mg\/g could be achieved, which was 20 times higher than that of pristine electrospun cellulose nonwoven. Furthermore, it was discovered that the NaSA-loaded cellulose-PEI could continuously release the drug for 12 h in simulated body fluid (SBF), indicating the versatility of cellulose-PEI as an advanced wound dressing with drug carrier functionalities.<\/jats:p>","DOI":"10.3390\/polym14091748","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T21:37:53Z","timestamp":1651009073000},"page":"1748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polyethylenimine-Functionalized Nanofiber Nonwovens Electrospun from Cotton Cellulose for Wound Dressing with High Drug Loading and Sustained Release Properties"],"prefix":"10.3390","volume":"14","author":[{"given":"Qunhao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Ao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"},{"name":"Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5778-9936","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"},{"name":"Advanced Polymer Materials Research Center, Sichuan University, Shishi 362700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhui","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China"},{"name":"Advanced Polymer Materials Research Center, Sichuan University, Shishi 362700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.carbpol.2017.07.085","article-title":"Superhydrophilic Graphene Oxide @ electrospun Cellulose Nanofiber Hybrid Membrane for High-Efficiency Oil\/Water Separation","volume":"175","author":"Ao","year":"2017","journal-title":"Carbohydr. 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