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hemorrhage, brain tumor, and craniocerebral trauma, which may involve the injury of the dura mater, elicit the need to repair this membrane by dural grafts. However, common dural grafts tend to result in dural adhesions and scar tissue and have no further neuroprotective effects. In order to reduce or avoid the complications of dural repair, we used PLGA, tetramethylpyrazine, and chitosan as raw materials to prepare a nanofibrous dura mater (NDM) with excellent biocompatibility and adequate mechanical characteristics, which can play a neuroprotective role and have an antifibrotic effect. We fabricated PLGA NDM by electrospinning, and then chitosan was grafted on the nanofibrous dura mater by the EDC-NHS cross-linking method to obtain PLGA\/CS NDM. Then, we also prepared PLGA\/TMP\/CS NDM by coaxial electrospinning. Our study shows that the PLGA\/TMP\/CS NDM can inhibit the excessive proliferation of fibroblasts, as well as provide a sustained protective effect on the SH-SY5Y cells treated with oxygen\u2013glucose deprivation\/reperfusion (OGD\/R). In conclusion, our study may provide a new alternative to dural grafts in undesirable cases of dural injuries.<\/jats:p>","DOI":"10.3390\/polym14091882","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T02:46:39Z","timestamp":1651805199000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells"],"prefix":"10.3390","volume":"14","author":[{"given":"Zhiyuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao 266000, China"},{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-1868","authenticated-orcid":false,"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao 266000, China"},{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-2872","authenticated-orcid":false,"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao 266000, China"},{"name":"Qingdao Medical College, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10856-016-5736-z","article-title":"Bilayer oxidized regenerated cellulose\/poly \u03b5-caprolactone knitted fabric-reinforced composite for use as an artificial dural substitute","volume":"27","author":"Suwanprateeb","year":"2016","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.3390\/ijms150610855","article-title":"Bacterial Cellulose Membranes Used as Artificial Substitutes for Dural Defection in Rabbits","volume":"15","author":"Xu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1177\/0192623320947075","article-title":"Local Tolerance and Biodegradability of a Novel Artificial Dura Mater Graft Following Implantation Onto a Dural Defect in Rabbits","volume":"48","author":"Ramot","year":"2020","journal-title":"Toxicol. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3171\/jns.1997.86.6.1012","article-title":"Development of a dural substitute from synthetic bioabsorbable polymers","volume":"86","author":"Yamada","year":"1997","journal-title":"J. Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00701-010-0718-2","article-title":"Use of a collagen biomatrix (TissuDura\u00ae) for dura repair: A long-term neuroradiological and neuropathological evaluation","volume":"153","author":"Parlato","year":"2010","journal-title":"Acta Neurochir."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/jbm.b.32953","article-title":"Multilayer scaffold of electrospun PLA-PCL-collagen nanofibers as a dural substitute","volume":"101","author":"Wang","year":"2013","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10856-017-5845-3","article-title":"Experimental evaluation of new chitin\u2013chitosan graft for duraplasty","volume":"28","author":"Pogorielov","year":"2017","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118733","DOI":"10.1016\/j.ijpharm.2019.118733","article-title":"Doxorubicin-loaded PLGA nanoparticles for the chemotherapy of glioblastoma: Towards the pharmaceutical development","volume":"572","author":"Maksimenko","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0142-9612(96)85756-5","article-title":"Stabilized polyglycolic acid fibre-based tubes for tissue engineering","volume":"17","author":"Mooney","year":"1996","journal-title":"Biomaterials"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejpb.2009.09.003","article-title":"Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters","volume":"74","author":"Gelperina","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wohlfart, S., Khalansky, A.S., Gelperina, S., Maksimenko, O., Bernreuther, C., Glatzel, M., and Kreuter, J. (2011). Efficient Chemotherapy of Rat Glioblastoma Using Doxorubicin-Loaded PLGA Nanoparticles with Different Stabilizers. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019121"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1208\/s12249-013-9943-3","article-title":"Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery","volume":"14","author":"Wang","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biotechadv.2017.05.006","article-title":"Biocompatibility of hydrogel-based scaffolds for tissue engineering applications","volume":"35","author":"Naahidi","year":"2017","journal-title":"Biotechnol. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/nano.2006.1.4.541","article-title":"Less harmful acidic degradation of poly(lactic-co-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition","volume":"1","author":"Liu","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.carbpol.2016.07.002","article-title":"Epineurium-mimicking chitosan conduits for peripheral nervous tissue engineering","volume":"152","author":"Nawrotek","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1902\/jop.2005.76.10.1778","article-title":"Biological Evaluation of Chitosan Nanofiber Membrane for Guided Bone Regeneration","volume":"76","author":"Shin","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/0378-6323.98098","article-title":"The systematic effects of chitosan on fibroblasts derived from hypertrophic scars and keloids","volume":"78","author":"Zhang","year":"2012","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.surg.2003.07.005","article-title":"Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N, O-carboxymethyl chitosan","volume":"135","author":"Zhou","year":"2004","journal-title":"Surgery"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.21873\/invivo.11624","article-title":"Oral Administration of Chitosan Attenuates Bleomycin-induced Pulmonary Fibrosis in Rats","volume":"33","author":"Kim","year":"2019","journal-title":"In Vivo"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12588","DOI":"10.1111\/cpr.12588","article-title":"Fabrication of Chitosan\/Polypyrrole-coated poly(L-lactic acid)\/Polycaprolactone aligned fibre films for enhancement of neural cell compatibility and neurite growth","volume":"52","author":"Xu","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2017.02.026","article-title":"Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments","volume":"134","author":"Zhao","year":"2017","journal-title":"Biomaterials"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.msec.2016.03.107","article-title":"Fabrication and biocompatibility of poly(l-lactic acid) and chitosan composite scaffolds with hierarchical microstructures","volume":"64","author":"Lou","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s12033-021-00346-3","article-title":"Fabrication and Characterization of Nanofibrous Poly (L-Lactic Acid)\/Chitosan-Based Scaffold by Liquid\u2013Liquid Phase Separation Technique for Nerve Tissue Engineering","volume":"63","author":"Ehterami","year":"2021","journal-title":"Mol. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1055\/s-2006-957933","article-title":"Tetramethylpyrazine, a Calcium Antagonist","volume":"62","author":"Pang","year":"1996","journal-title":"Planta Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroscience.2014.08.010","article-title":"Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase II\u03b2","volume":"278","author":"Yan","year":"2014","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.neuint.2007.12.008","article-title":"Protective effects of tetramethylpyrazine on rat retinal cell cultures","volume":"52","author":"Yang","year":"2008","journal-title":"Neurochem. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.canlet.2013.03.015","article-title":"Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression","volume":"336","author":"Chen","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1215\/15228517-2007-051","article-title":"Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: Potential therapeutic application for treatment of gliomas","volume":"10","author":"Fu","year":"2008","journal-title":"Neuro-Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.freeradbiomed.2009.12.004","article-title":"Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus","volume":"48","author":"Li","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sc.2010.113","article-title":"Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats","volume":"49","author":"Liang","year":"2010","journal-title":"Spinal Cord"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1179\/174313209X414533","article-title":"Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia","volume":"32","author":"Xiao","year":"2010","journal-title":"Neurol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2010.02.066","article-title":"Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen-activated protein kinases pathway in vitro","volume":"474","author":"Tian","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijpharm.2009.03.034","article-title":"Brain pharmacokinetics of tetramethylpyrazine after intranasal and intravenous administration in awake rats","volume":"375","author":"Feng","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.msec.2016.08.001","article-title":"Investigating the passage of tetramethylpyrazine-loaded liposomes across blood-brain barrier models in vitro and ex vivo","volume":"69","author":"Xia","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11095-019-2580-0","article-title":"The Controlled Release and Anti-Inflammatory Activity of a Tetramethylpyrazine-Loaded Thermosensitive Poloxamer Hydrogel","volume":"36","author":"Xia","year":"2019","journal-title":"Pharm. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.colsurfb.2015.05.048","article-title":"A multi-layered vascular scaffold with symmetrical structure by bi-directional gradient electrospinning","volume":"133","author":"Wu","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e8993","DOI":"10.1590\/1414-431x20208993","article-title":"VPA\/PLGA microfibers produced by coaxial electrospinning for the treatment of central nervous system injury","volume":"53","author":"Reis","year":"2020","journal-title":"Braz. J. Med Biol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"50246","DOI":"10.1021\/acsami.1c15067","article-title":"Super-Assembled Periodic Mesoporous Organosilica Frameworks for Real-Time Hypoxia-Triggered Drug Release and Monitoring","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yang, S., Han, X., Jia, Y., Zhang, H., and Tang, T. (2017). Hydroxypropyltrimethyl Ammonium Chloride Chitosan Functionalized-PLGA Electrospun Fibrous Membranes as Antibacterial Wound Dressing: In Vitro and In Vivo Evaluation. Polymers, 9.","DOI":"10.3390\/polym9120697"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijpharm.2012.01.025","article-title":"Nanoporous multilayer poly(l-glutamic acid)\/chitosan microcapsules for drug delivery","volume":"427","author":"Yan","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.colsurfb.2017.10.037","article-title":"Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide","volume":"161","author":"Shi","year":"2018","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16655","DOI":"10.1038\/s41598-019-52836-9","article-title":"Mechanical Properties of Human Dura Mater in Tension\u2014An Analysis at an Age Range of 2 to 94 Years","volume":"9","author":"Zwirner","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eabc2036","DOI":"10.1126\/sciadv.abc2036","article-title":"ECM-inspired micro\/nanofibers for modulating cell function and tissue generation","volume":"6","author":"Xu","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1097\/BSD.0000000000000221","article-title":"Efficacy of Poly(d,l-Lactic Acid-co-Glycolic acid)-Poly(Ethylene Glycol)-Poly(d,l-Lactic Acid-co-Glycolic Acid) Thermogel As a Barrier to Prevent Spinal Epidural Fibrosis in a Postlaminectomy Rat Model","volume":"30","author":"Li","year":"2017","journal-title":"Clin. Spine Surg. A Spine Publ."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s00586-014-3438-0","article-title":"The prevention effect of poly (l-glutamic acid)\/chitosan on spinal epidural fibrosis and peridural adhesion in the post-laminectomy rabbit model","volume":"23","author":"Li","year":"2014","journal-title":"Eur. Spine J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1016\/S0142-9612(02)00207-7","article-title":"The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts","volume":"23","author":"Chen","year":"2002","journal-title":"Biomaterials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-014-8968-2","article-title":"Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a\/FOXO1 Axis","volume":"53","author":"Wang","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.12659\/MSM.904554","article-title":"Tetramethylpyrazine Protects Neurons from Oxygen-Glucose Deprivation-Induced Death","volume":"23","author":"Shao","year":"2017","journal-title":"Med Sci. Monit."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/iub.1704","article-title":"Ligustrazine suppresses neuron apoptosis via the Bax\/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia","volume":"70","author":"Zhao","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12017-018-8478-x","article-title":"Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy","volume":"20","author":"Zhang","year":"2018","journal-title":"Neuromol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1167\/iovs.16-19529","article-title":"Tetramethylpyrazine Attenuates Transdifferentiation of TGF-\u03b22\u2013Treated Human Tenon\u2019s Fibroblasts","volume":"57","author":"Cai","year":"2016","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_53","first-page":"9990166","article-title":"Growth Hormone (GH) Enhances Endogenous Mechanisms of Neuroprotection and Neuroplasticity after Oxygen and Glucose Deprivation Injury (OGD) and Reoxygenation (OGD\/R) in Chicken Hippocampal Cell Cultures","volume":"2021","author":"Carranza","year":"2021","journal-title":"Neural Plast."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/14\/9\/1882\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:06:11Z","timestamp":1760137571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/14\/9\/1882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["polym14091882"],"URL":"https:\/\/doi.org\/10.3390\/polym14091882","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]}}}