{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:45:17Z","timestamp":1790858717132,"version":"4.1.0"},"reference-count":101,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Fibrin, derived from proteins involved in blood clotting (fibrinogen and thrombin), is a biopolymer with different applications in the health area since it has hemostasis, biocompatible and three-dimensional physical structure properties, and can be used as scaffolds in tissue regeneration or drug delivery system for cells and\/or growth factors. Fibrin alone or together with other biomaterials, has been indicated for use as a biological support to promote the regeneration of stem cells, bone, peripheral nerves, and other injured tissues. In its diversity of forms of application and constitution, there are platelet-rich fibrin (PRF), Leukocyte- and platelet-rich fibrin (L-PRF), fibrin glue or fibrin sealant, and hydrogels. In order to increase fibrin properties, adjuvant therapies can be combined to favor tissue repair, such as photobiomodulation (PBM), by low-level laser therapy (LLLT) or LEDs (Light Emitting Diode). Therefore, this systematic review aimed to evaluate the relationship between PBM and the use of fibrin compounds, referring to the results of previous studies published in PubMed\/MEDLINE, Scopus and Web of Science databases. The descriptors \u201cfibrin AND low-level laser therapy\u201d and \u201cfibrin AND photobiomodulation\u201d were used, without restriction on publication time. The bibliographic search found 44 articles in PubMed\/MEDLINE, of which 26 were excluded due to duplicity or being outside the eligibility criteria. We also found 40 articles in Web of Science and selected 1 article, 152 articles in Scopus and no article selected, totaling 19 articles for qualitative analysis. The fibrin type most used in combination with PBM was fibrin sealant, mainly heterologous, followed by PRF or L-PRF. In PBM, the gallium-aluminum-arsenide (GaAlAs) laser prevailed, with a wavelength of 830 nm, followed by 810 nm. Among the preclinical studies, the most researched association of fibrin and PBM was the use of fibrin sealants in bone or nerve injuries; in clinical studies, the association of PBM with medication-related treatments osteonecrosis of the jaw (MRONJ). Therefore, there is scientific evidence of the contribution of PBM on fibrin composites, constituting a supporting therapy that acts by stimulating cell activity, angiogenesis, osteoblast activation, axonal growth, anti-inflammatory and anti-edema action, increased collagen synthesis and its maturation, as well as biomolecules.<\/jats:p>","DOI":"10.3390\/polym14153150","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:15:26Z","timestamp":1659485726000},"page":"3150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Application of Fibrin Associated with Photobiomodulation as a Promising Strategy to Improve Regeneration in Tissue Engineering: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Carlos Henrique Bertoni","family":"Reis","sequence":"first","affiliation":[{"name":"UNIMAR Beneficent Hospital (HBU), University of Marilia (UNIMAR), Marilia 17525-160, Brazil"},{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB\/USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1262","authenticated-orcid":false,"given":"Daniela Vieira","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"},{"name":"Teaching and Research Coordination of the Medical School, University Center of Adamantina (UniFAI), Adamantina 17800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-3246","authenticated-orcid":false,"given":"Adriana de C\u00e1ssia","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB\/USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9123-3560","authenticated-orcid":false,"given":"Simone Ortiz Moura","family":"Fideles","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB\/USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-1621","authenticated-orcid":false,"given":"Jefferson Aparecido","family":"Dias","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"},{"name":"Postgraduate Program in Law, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angelica","family":"Miglino","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ\/USP), S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-7911","authenticated-orcid":false,"given":"Daniel de Bortoli","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"},{"name":"Postgraduate Program in Animal Health, Production and Environment, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana de Souza Bastos Mazuqueli","family":"Pereira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Rodrigues","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Department of Morphology and Pathology, Jundia\u00ed Medical School, Jundia\u00ed 13202-550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-2218","authenticated-orcid":false,"given":"Rogerio Leone","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB\/USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"},{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ\/USP), S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3324\/haematol.2019.236901","article-title":"Fibrin(ogen) in human disease: Both friend and foe","volume":"105","author":"Vilar","year":"2020","journal-title":"Haematologica"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.34172\/jlms.2020.S4","article-title":"The Effectiveness of Photobiomudulation Therapy (Pbmt) in COVID-19 Infection","volume":"11","author":"Mokmeli","year":"2020","journal-title":"J. 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