{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:36:54Z","timestamp":1772609814669,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NRF","award":["2021M3H4A4079264"],"award-info":[{"award-number":["2021M3H4A4079264"]}]},{"name":"NRF","award":["2021M3H4A4079271"],"award-info":[{"award-number":["2021M3H4A4079271"]}]},{"name":"NRF","award":["2018-0-00219"],"award-info":[{"award-number":["2018-0-00219"]}]},{"name":"ICT R&amp;D program of MSIT\/IITP","award":["2021M3H4A4079264"],"award-info":[{"award-number":["2021M3H4A4079264"]}]},{"name":"ICT R&amp;D program of MSIT\/IITP","award":["2021M3H4A4079271"],"award-info":[{"award-number":["2021M3H4A4079271"]}]},{"name":"ICT R&amp;D program of MSIT\/IITP","award":["2018-0-00219"],"award-info":[{"award-number":["2018-0-00219"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Phosphorus is not only an import nutrient to aquatic habitats, but it also acts as a growth inhibitor in aquatic ecosystems; however, it also aggravates environmental issues, such as eutrophication. There is a growing interest in rapid phosphorus detection to manage and protect water resources. Due to the large molecular structure and high hydration energy of phosphate ions, ion-selective electrodes (ISEs) remain in their infancy for real-time measurements in terms of practical application. In this study, a newly developed ionophore based on a biomimetic nicotinamide functional group was used to detect phosphate selectively, displaying efficient binding through charge interactions and hydrogen bonds. The ISE membrane containing silicone rubber demonstrated an effective detection performance over a long period of time. With a dynamic range between 10\u22126 and 10\u22122 M and a limit of detection of 0.85 \u00d7 10\u22126 M (26 \u03bcg\/L), the newly synthesized ISE membranes demonstrated selectivity for phosphate ions over other ions, including acetate, sulfate, and chloride.<\/jats:p>","DOI":"10.3390\/polym14163392","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:56:40Z","timestamp":1661133400000},"page":"3392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ion-Selective Electrode Based on a Novel Biomimetic Nicotinamide Compound for Phosphate Ion Sensor"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-7215","authenticated-orcid":false,"given":"Bongjin","family":"Jeong","sequence":"first","affiliation":[{"name":"ICT Creative Research Laboratory, Electronics & Telecommunications Research Institute, Daejeon 34129, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-6272","authenticated-orcid":false,"given":"Jin Seong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-2906","authenticated-orcid":false,"given":"Do Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"ICT Creative Research Laboratory, Electronics & Telecommunications Research Institute, Daejeon 34129, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungseok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-8063","authenticated-orcid":false,"given":"Hyung-Kun","family":"Lee","sequence":"additional","affiliation":[{"name":"ICT Creative Research Laboratory, Electronics & Telecommunications Research Institute, Daejeon 34129, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1038\/s41598-019-38481-2","article-title":"Nitrogen\u2013Phosphorus-Associated Metabolic Activities during the Development of a Cyanobacterial Bloom Revealed by Metatranscriptomics","volume":"9","author":"Lu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.1073\/pnas.0605027103","article-title":"Bacterial Stalks Are Nutrient-Scavenging Antennas","volume":"103","author":"McAdams","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","unstructured":"Litke, D.W. (1999). Review of Phosphorus Control Measures in the United States and Their Effects on Water Quality."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2166\/wst.1999.0558","article-title":"Nutrient Management for Water Quality Protection: Integrating Research into Environmental Policy","volume":"39","author":"Sims","year":"1999","journal-title":"Water Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A304","DOI":"10.1289\/ehp.122-A304","article-title":"Nutrient Pollution: A Persistent Threat to Waterways","volume":"122","author":"Manuel","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.aca.2006.11.078","article-title":"Potentiometric Evaluation of Calix[4]Arene Anion Receptors in Membrane Electrodes: Phosphate Detection","volume":"585","author":"Kivlehan","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_7","unstructured":"Chambers, P. (2019). Standard Methods for the Examination of Water and Wastewater, Scientific e-Resources."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.electacta.2017.05.159","article-title":"Recent Advances in Ion-Selective Membrane Electrodes for in Situ Environmental Water Analysis","volume":"245","author":"Crespo","year":"2017","journal-title":"Electrochim. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0003-2670(01)80244-0","article-title":"Selectrode\u2014The Universal Ion-Selective Electrode","volume":"67","author":"Fiedler","year":"1973","journal-title":"Anal. Chim. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/S0045-6535(99)00136-8","article-title":"Monitoring the Houston Ship Channel for Inorganic Pollutants by Ion Selective Electrodes, Ion Chromatography, and Inductively Coupled Plasma Spectroscopy","volume":"39","author":"Saleh","year":"1999","journal-title":"Chemosphere"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/elan.200703916","article-title":"Ion-Selective Electrode Potentiometry in Environmental Analysis","volume":"19","author":"Clarke","year":"2007","journal-title":"Electroanalysis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100424","DOI":"10.1016\/j.eti.2019.100424","article-title":"Application of Ion Selective Electrode Array to Simultaneously Determinate Multi-Free Ions in Solution","volume":"15","author":"Wang","year":"2019","journal-title":"Environ. Technol. Innov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2012.07.012","article-title":"Sensing and Analysis of Soluble Phosphates in Environmental Samples: A Review","volume":"41","author":"Warwick","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/BF00323479","article-title":"Artificial Electron Donors for Nitrate and Nitrite Reductases Usable as Mediators in Amperometric Biosensors","volume":"349","author":"Strehlitz","year":"1994","journal-title":"Fresenius J. Anal. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cbpa.2006.09.020","article-title":"Interactions between Macromolecules and Ions: The Hofmeister Series","volume":"10","author":"Zhang","year":"2006","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cis.2008.09.010","article-title":"Hofmeister Series and Specific Interactions of Charged Headgroups with Aqueous Ions","volume":"146","author":"Vlachy","year":"2009","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"128546","DOI":"10.1016\/j.snb.2020.128546","article-title":"High-Performance Dual-Channel Ratiometric Colorimetric Sensing of Phosphate Ion Based on Target-Induced Differential Oxidase-like Activity Changes of Ce-Zr Bimetal-Organic Frameworks","volume":"321","author":"Li","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.snb.2019.03.059","article-title":"Colorimetric Sensor for Determination of Phosphate Ions Using Anti-Aggregation of 2-Mercaptoethanesulfonate-Modified Silver Nanoplates and Europium Ions","volume":"290","author":"Pinyorospathum","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"130789","DOI":"10.1016\/j.snb.2021.130789","article-title":"Enhancing the Sensitivity of Cobalt Based Solid-State Phosphate Sensor Using Electrical Pretreatment","volume":"349","author":"Patel","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.electacta.2018.06.021","article-title":"Phosphate Ion Sensor Using a Cobalt Phosphate Coated Cobalt Electrode","volume":"282","author":"Xu","year":"2018","journal-title":"Electrochim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.20964\/2017.06.18","article-title":"An All-Solid-State Phosphate Electrode with H3PO4 Doped Polyaniline as the Sensitive Layer","volume":"12","author":"Huang","year":"2017","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114883","DOI":"10.1016\/j.watres.2019.114883","article-title":"Highly Sensitive and Selective Fluorescent Detection of Phosphate in Water Environment by a Functionalized Coordination Polymer","volume":"163","author":"Zhang","year":"2019","journal-title":"Water Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kim, D.Y., Kim, D.G., Jeong, B., Kim, Y.I., Heo, J., and Lee, H.-K. (2022). Reusable and PH-Stable Luminescent Sensors for Highly Selective Detection of Phosphate. Polymers, 14.","DOI":"10.3390\/polym14010190"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1039\/C7EN01160A","article-title":"Rapid Detection of Nutrients with Electronic Sensors: A Review","volume":"5","author":"Chen","year":"2018","journal-title":"Environ. Sci. Nano"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.talanta.2011.08.042","article-title":"Novel Monohydrogenphosphate Ion-Selective Polymeric Membrane Sensor Based on Phenyl Urea Substituted Calix[4]Arene","volume":"86","author":"Modi","year":"2011","journal-title":"Talanta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1039\/B301141K","article-title":"Hydrogen-Bond Forming Ionophore for Highly Efficient Transport of Phosphate Anions across the Nitrobenzene\u2013Water Interface","volume":"128","author":"Nishizawa","year":"2003","journal-title":"Analyst"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.bbamem.2009.10.007","article-title":"Interaction of Nicotinamide and Picolinamide with Phosphatidylcholine and Phosphatidylethanolamine Membranes: A Combined Approach Using Dipole Potential Measurements and Quantum Chemical Calculations","volume":"1788","author":"Borba","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Nikas, I.P., Paschou, S.A., and Ryu, H.S. (2020). The Role of Nicotinamide in Cancer Chemoprevention and Therapy. Biomolecules, 10.","DOI":"10.3390\/biom10030477"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00304940409355392","article-title":"Synthesis of phenylene 1,3- and 1,44 bis (methylene)-3-carbamoyl pyridinium bromides","volume":"36","author":"Zhou","year":"2004","journal-title":"Org. Prep. Proced. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1021\/ed051p541","article-title":"PVC Matrix Membrane Ion-Selective Electrodes. Construction and Laboratory Experiments","volume":"51","author":"Craggs","year":"1974","journal-title":"J. Chem. Educ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10524","DOI":"10.1021\/acs.analchem.9b01490","article-title":"PVC-Based Ion-Selective Electrodes with a Silicone Rubber Outer Coating with Improved Analytical Performance","volume":"91","author":"Joon","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_32","unstructured":"Zoski, C.G. (2007). 7\u2014Ion-Selective Electrodes. Handbook of Electrochemistry, Elsevier."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1021\/ac960891m","article-title":"Determination of Unbiased Selectivity Coefficients of Neutral Carrier-Based Cation-Selective Electrodes","volume":"69","author":"Bakker","year":"1997","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1351\/pac200072101851","article-title":"Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part I. Inorganic Cations (Technical Report)","volume":"72","author":"Umezawa","year":"2000","journal-title":"Pure Appl. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"01005","DOI":"10.1051\/bioconf\/20202201005","article-title":"Development of an Effective Way to Increase the Biological Activity of Nicotinamide\u2014A New Strategy to Protect against Photoageing and Skin Neoplasia","volume":"22","author":"Uspenskaya","year":"2020","journal-title":"BIO Web Conf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.saa.2006.06.012","article-title":"FTIR Studies of PVC\/PMMA Blend Based Polymer Electrolytes","volume":"66","author":"Ramesh","year":"2007","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1039\/C6RA27219C","article-title":"Preparation of Magnetic Porous NiFe2O4\/SiO2 Composite Xerogels for Potential Application in Adsorption of Ce(Iv) Ions from Aqueous Solution","volume":"7","author":"Fu","year":"2017","journal-title":"RSC Adv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9753","DOI":"10.1002\/chem.201402916","article-title":"Phosphate-Triggered Self-Assembly of N-[(Uracil-5-Yl)Methyl]Urea: A Minimalistic Urea-Derived Hydrogelator","volume":"20","author":"Kleinsmann","year":"2014","journal-title":"Chem. Eur. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11956","DOI":"10.1021\/acsami.5b01946","article-title":"Rapid and Specific Aqueous-Phase Detection of Nitroaromatic Explosives with Inherent Porphyrin Recognition Sites in Metal\u2013Organic Frameworks","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.snb.2015.04.122","article-title":"Polymer\u2013Multiwall Carbon Nantubes Composites for Durable All Solid-Contact H2PO4\u2212-Selective Electrodes","volume":"219","author":"Liu","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Jiang, H., Ali, M.A., Jiao, Y., Yang, B., and Dong, L. (2017, January 18\u201322). In-Situ, Real-Time Monitoring of Nutrient Uptake on Plant Chip Integrated with Nutrient Sensor. Proceedings of the 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Kaohsiung, Taiwan.","DOI":"10.1109\/TRANSDUCERS.2017.7994045"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.13031\/2013.22633","article-title":"Evaluation of Phosphate Ion-Selective Membranes and Cobalt-Based Electrodes for Soil Nutrient Sensing","volume":"50","author":"Kim","year":"2007","journal-title":"Trans. ASABE"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.talanta.2003.12.034","article-title":"Organic Tin Compounds Combined with Anionic Additives\u2014An Ionophore System Leading to a Phosphate Ion-Selective Electrode?","volume":"63","author":"Sasaki","year":"2004","journal-title":"Talanta"}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/14\/16\/3392\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:14Z","timestamp":1760141534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/14\/16\/3392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":43,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["polym14163392"],"URL":"https:\/\/doi.org\/10.3390\/polym14163392","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]}}}