{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:11:20Z","timestamp":1789096280436,"version":"build-2803163510"},"reference-count":24,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Philadelphia University, Amman, Jordan","award":["No. 511\/34\/100 PU."],"award-info":[{"award-number":["No. 511\/34\/100 PU."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site. This paved the way for the development of a smart colonic drug delivery system, thereby improving the therapeutic efficacy, reducing the dosing frequency and potential side effects, as well as improving patient acceptance, especially in cases where enemas or other topical preparations may not be effective alone in treating the inflammation. In healthy individuals, it takes an oral medication delivery system about 5 to 6 h to reach the colon. A colonic drug delivery system should delay or prohibit the medication release during these five to six hours while permitting its release afterward. The main aim of this study was to develop a smart drug delivery system based on pH-sensitive polymeric formulations, synthesized by a free-radical bulk polymerization method, using different monomer and crosslinker concentrations. The formulations were loaded with 5-amino salicylic acid as a model drug and Capmul MCM C8 as a bioavailability enhancer. The glass transition temperature (Tg), tensile strength, Young\u2019s modulus, and tensile elongation at break were all measured as a part of the dried films\u2019 characterization. In vitro swelling and release studies were performed to assess the behavior of the produced formulations. The in vitro swelling and release evaluation demonstrated the potential ability of the developed system to retard the drug release at conditions mimicking the stomach and small intestine while triggering its release at conditions mimicking the colon, which indicates its promising applicability as a potential smart colonic drug delivery system.<\/jats:p>","DOI":"10.3390\/polym14173697","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T01:40:13Z","timestamp":1662601213000},"page":"3697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-1799","authenticated-orcid":false,"given":"Mohammad F.","family":"Bayan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed M.","family":"Marji","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz S.","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan"},{"name":"Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-8585","authenticated-orcid":false,"given":"M. Yasmin","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-4562","authenticated-orcid":false,"given":"Kumarappan","family":"Chidambaram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakumar","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan"},{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy, ITM University, Gwalior 474001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jconrel.2020.04.006","article-title":"Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems","volume":"322","author":"Xu","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43094-020-00057-7","article-title":"Recent advances in mesalamine colonic delivery systems","volume":"6","author":"Bayan","year":"2020","journal-title":"Futur. J. Pharm. 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