{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:22:32Z","timestamp":1791339752807,"version":"4.3.1"},"reference-count":140,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["2020\/37\/B\/ST5\/01938"],"award-info":[{"award-number":["2020\/37\/B\/ST5\/01938"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Poly(2-oxazoline)s are the synthetic polymers that are the products of the cationic ring-opening polymerization (CROP) of 2-oxazoline monomers. Due to their beneficial properties, from which biocompatibility, stealth behavior, high functionalization possibilities, low dispersity, stability, nonionic character, and solubility in water and organic solvents should be noted, they have found many applications and gained enormous interest from scientists. Additionally, with high versatility attainable through copolymerization or through post-polymerization modifications, this class of polymeric systems has been widely used as a polymeric platform for novel biomedical applications. The chemistry of polymers significant expanded into biomedical applications, in which polymeric networks can be successfully used in pharmaceutical development for tissue engineering, gene therapies, and also drug delivery systems. On the other hand, there is also a need to create \u2018smart\u2019 polymer biomaterials, responsive to the specified factor, that will be sensitive to various environmental stimuli. The commonly used stimuli-responsive biomedical materials are based mostly on temperature-, light-, magnetic-, electric-, and pH-responsive systems. Thus, creating selective and responsive materials that allow personalized treatment is in the interest of the scientific world. This review article focuses on recent discoveries by Polish scientists working in the field of stimuli-responsive poly(2-oxazoline)s, and their work is compared and contrasted with results reported by other world-renowned specialists.<\/jats:p>","DOI":"10.3390\/polym14194176","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T03:07:28Z","timestamp":1665371248000},"page":"4176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Poly(2-oxazoline)s as Stimuli-Responsive Materials for Biomedical Applications: Recent Developments of Polish Scientists"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-7133","authenticated-orcid":false,"given":"Aleksandra","family":"Lusina","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-9352","authenticated-orcid":false,"given":"Tomasz","family":"Nazim","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-642X","authenticated-orcid":false,"given":"Micha\u0142","family":"Ceg\u0142owski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10856-013-5034-y","article-title":"Poly(2-Oxazoline)s as Materials for Biomedical Applications","volume":"25","author":"Rosa","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/anie.200502113","article-title":"Polymer Therapeutics: Concepts and Applications","volume":"45","author":"Haag","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/bc200049d","article-title":"Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery","volume":"22","author":"Viegas","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/cr60273a003","article-title":"Oxazolines. Their preparation, reactions, and applications","volume":"71","author":"Frump","year":"1971","journal-title":"Chem. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0079-6700(95)00020-8","article-title":"Polymerization of oxazolines","volume":"21","author":"Keigo","year":"1996","journal-title":"Pergamon Prog. Polym. Sci."},{"key":"ref_6","first-page":"153","article-title":"Polymerisation of Cyclic Imino Ethers","volume":"v","author":"Saegusa","year":"1975","journal-title":"Int. Rev. Sci. Phys. Chem. Ser."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1002\/pol.1966.150040919","article-title":"Homopolymerization of 2-Alkyl-and 2-Aryl-2-Oxazolines","volume":"4","author":"Tomalia","year":"1966","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/anie.196608751","article-title":"Recent Syntheses and Reactions of Cyclic Imidic Esters","volume":"5","author":"Seeliger","year":"1966","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/pol.1966.110040701","article-title":"RING-OPENING POLYMERIZATION OF 2-SUBSTITUTED 2-OXAZOLINES","volume":"4","author":"Kagyia","year":"1966","journal-title":"J. Polym. Sci. B"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/pol.1967.110050927","article-title":"Polymerization of cyclic imino ethers. I. Oxazolines","volume":"5","author":"Bassiri","year":"1967","journal-title":"J. Polym. Sci. B"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/1781168a0","article-title":"Polymerization Initiated by Electron Transfer to Monomer. A New Method of Formation of Block Polymers","volume":"178","author":"Szwarc","year":"1956","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.eurpolymj.2016.11.016","article-title":"The Chemistry of Poly(2-Oxazoline)s","volume":"88","author":"Verbraeken","year":"2017","journal-title":"Eur. Polym. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1021\/la702917z","article-title":"Poly-2-Methyl-2-Oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces","volume":"24","author":"Konradi","year":"2008","journal-title":"Langmuir"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.eurpolymj.2016.11.008","article-title":"Solution Behavior of Thermoresponsive Random and Gradient Copolymers of 2-n-Propyl-2-Oxazoline","volume":"88","author":"Dworak","year":"2017","journal-title":"Eur. Polym. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biomaterials.2018.05.022","article-title":"Poly(2-Oxazoline)s Based Biomaterials: A Comprehensive and Critical Update","volume":"178","author":"Lorson","year":"2018","journal-title":"Biomaterials"},{"key":"ref_16","first-page":"1","article-title":"Poly(2-Oxazoline)s","volume":"v","author":"Hoogenboom","year":"2022","journal-title":"Macromol. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.addr.2007.08.018","article-title":"Poly(2-Oxazolines) in Biological and Biomedical Application Contexts","volume":"59","author":"Adams","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/polym3010467","article-title":"Bioinspired Poly(2-Oxazoline)s","volume":"3","author":"Hoogenboom","year":"2011","journal-title":"Polymers"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/pi.5457","article-title":"Poly(2-Oxazoline)s: A Comprehensive Overview of Polymer Structures and Their Physical Properties","volume":"67","author":"Glassner","year":"2018","journal-title":"Polym. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/cber.188902201248","article-title":"Zur Kenntniss Des Brom\u00e4thylamins","volume":"22","author":"Gabriel","year":"1889","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/pol.1968.150060107","article-title":"Polymerization of Cyclic Iminoethers. IV. Oxazoline Polymerization in Solvents Containing Different Functional Groups","volume":"6","author":"Levy","year":"1968","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/ja0119696","article-title":"Unprecedented Chiral Molecular Recognition in a C3-Symmetric Environment","volume":"124","author":"Kim","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/pol.1967.110050928","article-title":"Polymerization of Cyclic Imino Ethers. II. Oxazines","volume":"5","author":"Levy","year":"1967","journal-title":"J. Polym. Sci. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1021\/ma00034a002","article-title":"Reaction of 2-Methyl-2-Oxazoline with Trimethylsilyl Initiators. An Unusual Mode of Ring Opening","volume":"25","author":"Hrkach","year":"1992","journal-title":"Macromolecules"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/marc.201200266","article-title":"How to Modulate the Chemical Structure of Polyoxazolines by Appropriate Functionalization","volume":"33","author":"Guillerm","year":"2012","journal-title":"Macromol. Rapid Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.eurpolymj.2015.01.014","article-title":"Poly(2-Oxazoline)s and Click Chemistry: A Versatile Toolbox toward Multi-Functional Polymers","volume":"65","author":"Lava","year":"2015","journal-title":"Eur. Polym. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/macp.1991.021920223","article-title":"Star Polymers and Block Copolymers of 2-Oxazolines Using Chloroformates as Initiators","volume":"192","author":"Dworak","year":"1991","journal-title":"Die Makromol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/mabi.201100126","article-title":"Oxazoline-Based Antimicrobial Oligomers: Synthesis by CROP Using Supercritical CO2","volume":"11","author":"Correia","year":"2011","journal-title":"Macromol. Biosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.eurpolymj.2015.01.019","article-title":"Systematic Investigation of Alkyl Sulfonate Initiators for the Cationic Ring-Opening Polymerization of 2-Oxazolines Revealing Optimal Combinations of Monomers and Initiators","volume":"65","author":"Glassner","year":"2015","journal-title":"Eur. Polym. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1002\/pola.24188","article-title":"Synthesis of Polyoxazolines Using Glycerol Carbonate Derivative and End Chains Functionalization via Carbonate and Isocyanate Routes","volume":"48","author":"Giardi","year":"2010","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/macp.200800226","article-title":"Clickable Poly(2-Oxazoline)s as Versatile Building Blocks","volume":"209","author":"Fijten","year":"2008","journal-title":"Macromol. Chem. Phys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/(SICI)1521-3935(19980901)199:9<1843::AID-MACP1843>3.0.CO;2-I","article-title":"The Role of Cationic and Covalent Active Centers in the Polymerization of 2-Methyl-2-Oxazoline Initiated with Benzyl Bromide","volume":"199","author":"Dworak","year":"1998","journal-title":"Macromol. Chem. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/ma60036a004","article-title":"Isomerization Polymerization of 2-Oxazoline. VI. Kinetic Study on the Polymerization of 2-Methyl-2-Oxazoline Initiated by Methyl Iodide","volume":"4","author":"Saegusa","year":"1973","journal-title":"Macromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/mabi.200400169","article-title":"Influence of Satellite Groups on Telechelic Antimicrobial Functions of Polyoxazolines","volume":"5","author":"Waschinski","year":"2005","journal-title":"Macromol. Biosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8858","DOI":"10.1021\/ma011573e","article-title":"Lipopolymers for Surface Functionalizations. 1. Synthesis and Characterization of Terminal Functionalized Poly(N-Propionylethylenimine)s","volume":"34","author":"Jordan","year":"2001","journal-title":"Macromolecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1021\/ma050407u","article-title":"Synthesis of Monoalkyl End-Capped Poly(2-Methyl-2-Oxazoline) and Its Micelle Formation in Aqueous Solution","volume":"38","author":"Volet","year":"2005","journal-title":"Macromolecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/(SICI)1521-3935(19990401)200:4<863::AID-MACP863>3.0.CO;2-N","article-title":"Synthesis of New Amphiphilic Star Polymers Derived from a Hyperbranched Macroinitiator by the Cationic \u201cgrafting from\u201d Method","volume":"200","author":"Weberskirch","year":"1999","journal-title":"Macromol. Chem. Phys."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/pi.3103","article-title":"Star Poly(2-Ethyl-2-Oxazoline)s-Synthesis and Thermosensitivity","volume":"60","author":"Kowalczuk","year":"2011","journal-title":"Polym. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1021\/ma802627y","article-title":"Cylindrical Molecular Brushes of Poly(2-Oxazoline)s from 2-Isopropenyl-2-Oxazoline","volume":"42","author":"Zhang","year":"2009","journal-title":"Macromolecules"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/pola.20603","article-title":"Concentration Effects in the Cationic Ring-Opening Polymerization of 2-Ethyl-2-Oxazoline in N,N-Dimethylacetamide","volume":"43","author":"Hoogenboom","year":"2005","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1002\/pola.22814","article-title":"Initiator Effect on the Cationic Ring-Opening Copolymerization of 2-Ethyl-2-Oxazoline and 2-Phenyl-2-Oxazoline","volume":"46","author":"Fijten","year":"2008","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/macp.1976.021770805","article-title":"Kinetics and Mechanism of the Isomerization Polymerization of 2-Methyl-2-Oxazoline by Benzyl Chloride and Bromide Initiators. Effect of Halogen Counteranions","volume":"177","author":"Saegusa","year":"1976","journal-title":"Makromol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/12_2015_340","article-title":"Microwave-Assisted Cationic Ring-Opening Polymerization of 2-Oxazolines","volume":"Volume 274","author":"Luef","year":"2016","journal-title":"Advances in Polymer Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1039\/C5CC04319K","article-title":"Continuous Poly(2-Oxazoline) Triblock Copolymer Synthesis in a Microfluidic Reactor Cascade","volume":"51","author":"Baeten","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/00222337508065890","article-title":"Polymerization of Cyclic Imino Ethers. X. Kinetics, Chain Transfer, and Repolymerization","volume":"9","author":"Litt","year":"1975","journal-title":"J. Macromol. Sci. Part A Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/mz400293y","article-title":"Cationic Ring-Opening Polymerization of 2-Propyl-2-Oxazolines: Understanding Structural Effects on Polymerization Behavior Based on Molecular Modeling","volume":"2","author":"Goossens","year":"2013","journal-title":"ACS Macro Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1021\/ma00197a002","article-title":"Synthesis of acryl- and methacryl-type macromonomers and telechelics by utilizing living polymerization of 2-oxazolines","volume":"22","author":"Kobayashi","year":"1989","journal-title":"Macromolecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1039\/C5PY01913C","article-title":"Poly(2-Ethyl-2-Oxazoline)-Block-Polycarbonate Block Copolymers: From Improved End-Group Control in Poly(2-Oxazoline)s to Chain Extension with Aliphatic Polycarbonate through a Fully Metal-Free Ring-Opening Polymerisation Process","volume":"7","author":"Rosa","year":"2016","journal-title":"Polym. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109273","DOI":"10.1016\/j.eurpolymj.2019.109273","article-title":"End-Group Functionalization of Poly(2-Oxazoline)s Using Methyl Bromoacetate as Initiator Followed by Direct Amidation","volume":"120","author":"Podevyn","year":"2019","journal-title":"Eur. Polym. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.eurpolymj.2016.11.029","article-title":"A Facile Amino-Functionalization of Poly(2-Oxazoline)s\u2019 Distal End through Sequential Azido End-Capping and Staudinger Reactions","volume":"88","author":"Osawa","year":"2017","journal-title":"Eur. Polym. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109281","DOI":"10.1016\/j.eurpolymj.2019.109281","article-title":"Telechelic Poly(2-Oxazoline)s","volume":"121","author":"Delaittre","year":"2019","journal-title":"Eur. Polym. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1002\/macp.1996.021970919","article-title":"Synthesis and Copolymerization of Macromonomers Based on 2-Nonyl-and 2-Phenyl-2-Oxazoline","volume":"197","author":"Maiel","year":"1996","journal-title":"Macromol. Chem. Phys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1039\/c2py20479g","article-title":"Unexpected Radical Polymerization Behavior of Oligo(2-Ethyl-2-Oxazoline) Macromonomers","volume":"3","author":"Weber","year":"2012","journal-title":"Polym. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/marc.201200354","article-title":"Poly(2-Oxazoline)s as Polymer Therapeutics","volume":"33","author":"Luxenhofer","year":"2012","journal-title":"Macromol. Rapid Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.progpolymsci.2005.09.004","article-title":"Polymer-Drug Conjugates: Progress in Polymeric Prodrugs","volume":"31","author":"Khandare","year":"2006","journal-title":"Prog. Polym. Sci. (Oxf.)"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0168-3659(89)90013-8","article-title":"Soluble Polymeric Carriers for Drug Delivery. Part 2. Preparation and in Vivo Behaviour of N-Acylethylenimine Copolymers","volume":"10","author":"Goddard","year":"1989","journal-title":"J. Control. Release"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s10856-007-3334-9","article-title":"Gelatin Hydrogels: Enhanced Biocompatibility, Drug Release and Cell Viability","volume":"19","author":"Rathna","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00396-008-1942-7","article-title":"Effect of End Group Polarity upon the Lower Critical Solution Temperature of Poly(2-Isopropyl-2-Oxazoline)","volume":"286","author":"Huber","year":"2008","journal-title":"Colloid Polym. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0168-3659(01)00310-8","article-title":"DNA Transfection Using Linear Poly(Ethylenimine) Prepared by Controlled Acid Hydrolysis of Poly(2-Ethyl-2-Oxazoline)","volume":"73","author":"Jeong","year":"2001","journal-title":"J. Control. Release"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.biomaterials.2004.07.064","article-title":"Enzymatic Degradation of PLLA-PEOz-PLLA Triblock Copolymers","volume":"26","author":"Wang","year":"2005","journal-title":"Biomaterials"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"111484","DOI":"10.1016\/j.eurpolymj.2022.111484","article-title":"Polyoxazoline: A Review Article from Polymerization to Smart Behaviors and Biomedical Applications","volume":"178","author":"Aliakbarzadeh","year":"2022","journal-title":"Eur. Polym. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.progpolymsci.2004.08.003","article-title":"Stimuli-Reponsive Polymers and Their Bioconjugates","volume":"29","author":"Gil","year":"2004","journal-title":"Prog. Polym. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-Responsive Nanocarriers for Drug Delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.progpolymsci.2009.10.008","article-title":"Future Perspectives and Recent Advances in Stimuli-Responsive Materials","volume":"35","author":"Roy","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nmat2614","article-title":"Emerging Applications of Stimuli-Responsive Polymer Materials","volume":"9","author":"Stuart","year":"2010","journal-title":"Nat. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1039\/c2cs35091b","article-title":"Stimuli-Responsive Supramolecular Polymeric Materials","volume":"41","author":"Yan","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C3PY00880K","article-title":"Multi-Stimuli Responsive Polymers-the All-in-One Talents","volume":"5","author":"Schattling","year":"2014","journal-title":"Polym. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1039\/C9MH00490D","article-title":"Stimuli-Responsive Polymers for Sensing and Actuation","volume":"6","author":"Hu","year":"2019","journal-title":"Mater. Horiz."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1039\/D0TB00570C","article-title":"Stimuli-responsive polymer-based systems for diagnostic applications","volume":"8","author":"Shu","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.progpolymsci.2009.10.002","article-title":"Recent Advances and Challenges in Designing Stimuli-Responsive Polymers","volume":"35","author":"Liu","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"101164","DOI":"10.1016\/j.progpolymsci.2019.101164","article-title":"Recent Advances in Stimuli-Responsive Polymer Systems for Remotely Controlled Drug Release","volume":"99","author":"Zhang","year":"2019","journal-title":"Prog. Polym. Sci."},{"key":"ref_72","first-page":"92","article-title":"Review of Stimuli-Responsive Polymers Application as Stabilization Agents in Solid-Liquid Dispersion Systems","volume":"61","author":"Lemanowicz","year":"2021","journal-title":"Polymer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1039\/D0AN00686F","article-title":"Stimuli-Responsive Polymer\/Nanomaterial Hybrids for Sensing Applications","volume":"145","author":"Shu","year":"2020","journal-title":"Analyst"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s13233-017-5088-7","article-title":"Stimuli-Responsive Polymers: Fundamental Considerations and Applications","volume":"25","author":"Gao","year":"2017","journal-title":"Macromol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"101252","DOI":"10.1016\/j.progpolymsci.2020.101252","article-title":"Poly(2-Oxazoline)-Based Stimulus-Responsive (Co)Polymers: An Overview of Their Design, Solution Properties, Surface-Chemistries and Applications","volume":"106","author":"Jana","year":"2020","journal-title":"Prog. Polym. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/mabi.201200017","article-title":"Poly(2-Ethyl-2-Oxazoline) as Alternative for the Stealth Polymer Poly(Ethylene Glycol): Comparison of in Vitro Cytotoxicity and Hemocompatibility","volume":"12","author":"Bauer","year":"2012","journal-title":"Macromol. Biosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejpb.2018.10.003","article-title":"Rethinking the Impact of the Protonable Amine Density on Cationic Polymers for Gene Delivery: A Comparative Study of Partially Hydrolyzed Poly(2-Ethyl-2-Oxazoline)s and Linear Poly(Ethylene Imine)s","volume":"133","author":"Bauer","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102345","DOI":"10.1016\/j.nano.2020.102345","article-title":"Poly(2-Oxazoline) Nanoparticle Delivery Enhances the Therapeutic Potential of Vismodegib for Medulloblastoma by Improving CNS Pharmacokinetics and Reducing Systemic Toxicity","volume":"32","author":"Hwang","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3390\/polym3031215","article-title":"Thermoresponsive Polymers for Biomedical Applications","volume":"3","author":"Ward","year":"2011","journal-title":"Polymers"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.addr.2006.09.020","article-title":"Thermo- and PH-Responsive Polymers in Drug Delivery","volume":"58","author":"Schmaljohann","year":"2006","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C7MH00016B","article-title":"Thermoresponsive Polymers with Lower Critical Solution Temperature: From Fundamental Aspects and Measuring Techniques to Recommended Turbidimetry Conditions","volume":"4","author":"Zhang","year":"2017","journal-title":"Mater. Horiz."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1600470","DOI":"10.1002\/macp.201600470","article-title":"The Dependence of the Cloud Point, Clearing Point, and Hysteresis of Poly(N-Isopropylacrylamide) on Experimental Conditions: The Need for Standardization of Thermoresponsive Transition Determinations","volume":"218","year":"2017","journal-title":"Macromol. Chem. Phys."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1039\/c3cs35499g","article-title":"New Directions in Thermoresponsive Polymers","volume":"42","author":"Roy","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Taylor, M.J., Tomlins, P., and Sahota, T.S. (2017). Thermoresponsive Gels. Gels, 3.","DOI":"10.3390\/gels3010004"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajps.2014.08.010","article-title":"Studies on Thermoresponsive Polymers: Phase Behaviour, Drug Delivery and Biomedical Applications","volume":"10","author":"Gandhi","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"van Guyse, J.F.R., Bera, D., and Hoogenboom, R. (2021). Adamantane Functionalized Poly(2-Oxazoline)s with Broadly Tunable Lcst-Behavior by Molecular Recognition. Polymers, 13.","DOI":"10.3390\/polym13030374"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13233-016-4052-2","article-title":"Snapshot of Phase Transition in Thermoresponsive Hydrogel PNIPAM: Role in Drug Delivery and Tissue Engineering","volume":"24","author":"Ashraf","year":"2016","journal-title":"Macromol. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijpharm.2017.03.031","article-title":"Nanohydrogel with N,N\u2032-Bis(Acryloyl)Cystine Crosslinker for High Drug Loading","volume":"523","author":"Mackiewicz","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/ma2020577","article-title":"Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering","volume":"2","author":"Schwall","year":"2009","journal-title":"Materials"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.desal.2019.02.002","article-title":"Multi-Layer Temperature-Responsive Hydrogel for Forward-Osmosis Desalination with High Permeable Flux and Fast Water Release","volume":"459","author":"Zeng","year":"2019","journal-title":"Desalination"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1248\/cpb.51.1348","article-title":"Controlled Release of Vitamin E from Thermo-Responsive Polymeric Physico-Gel","volume":"51","author":"Ishida","year":"2003","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1166\/mex.2018.1406","article-title":"Poly(N-Vinyl Caprolactam) Thermoresponsive Polymer in Novel Drug Delivery Systems: A Review","volume":"8","author":"Mohammed","year":"2018","journal-title":"Mater. Express"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/ja001542j","article-title":"Thermosensitive Cyclotriphosphazenes","volume":"122","author":"Lee","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1039\/C6PY01320A","article-title":"Thermoresponsive Poly(2-Oxazoline)s, Polypeptoids, and Polypeptides","volume":"8","author":"Hoogenboom","year":"2017","journal-title":"Polym. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Hoogenboom, R., Thijs, H.M.L., Jochems, M.J.H.C., van Lankvelt, B.M., Fijten, M.W.M., and Schubert, U.S. (2008). Tuning the LCST of Poly(2-Oxazoline)s by Varying Composition and Molecular Weight: Alternatives to Poly(N-Isopropylacrylamide)?. Chem. Commun., 5758\u20135760.","DOI":"10.1039\/b813140f"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1002\/pola.27364","article-title":"Tuning the LCST of Poly(2-Cyclopropyl-2-Oxazoline) via Gradient Copolymerization with 2-Ethyl-2-Oxazoline","volume":"52","author":"Glassner","year":"2014","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1246\/cl.1992.1643","article-title":"A Novel Thermo-Sensitive Polymer. Poly(2- Iso -Propyl-2-Oxazoline)","volume":"21","author":"Uyama","year":"1992","journal-title":"Chem. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/ma200514n","article-title":"Poly(2-Cyclopropyl-2-Oxazoline): From Rate Acceleration by Cyclopropyl to Thermoresponsive Properties","volume":"44","author":"Bloksma","year":"2011","journal-title":"Macromolecules"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.3390\/polym7101494","article-title":"Thermal Properties of Methyl Ester-Containing Poly(2-Oxazoline)s","volume":"7","author":"Bouten","year":"2015","journal-title":"Polymers"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/polb.1988.090260312","article-title":"Solubility and Miscibility of Poly( Ethyl Oxazoline)","volume":"26","author":"Lin","year":"2010","journal-title":"Polym. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1021\/ma0358733","article-title":"Microcalorimetric Study of the Temperature-Induced Phase Separation in Aqueous Solutions of Poly(2-Isopropyl-2-Oxazolines)","volume":"37","author":"Diab","year":"2004","journal-title":"Macromolecules"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1021\/ma049677n","article-title":"Versatile Synthesis of End-Functionalized Thermosensitive Poly(2-Isopropyl-2-Oxazolines)","volume":"37","author":"Park","year":"2004","journal-title":"Macromolecules"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1021\/ma1012368","article-title":"Demixing and Remixing Kinetics of Poly(2-Isopropyl-2-Oxazoline) (PIPOZ) Aqueous Solutions Studied by Modulated Temperature Differential Scanning Calorimetry","volume":"43","author":"Zhao","year":"2010","journal-title":"Macromolecules"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Oleszko-Torbus, N., Bochenek, M., Utrata-Weso\u0142ek, A., Kowalczuk, A., Marcinkowski, A., Dworak, A., Fus-Kujawa, A., Siero\u0144, A.L., and Wa\u0142ach, W. (2020). Poly(2-Oxazoline) Matrices with Temperature-Dependent Solubility-Interactions with Water and Use for Cell Culture. Materials, 13.","DOI":"10.3390\/ma13122702"},{"key":"ref_105","first-page":"15","article-title":"Thermal and Crystalline Properties of Poly(2-Oxazoline)s","volume":"11","author":"Bochenek","year":"2019","journal-title":"Polym. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10856-013-5135-7","article-title":"Poly(2-Substituted-2-Oxazoline) Surfaces for Dermal Fibroblasts Adhesion and Detachment","volume":"25","author":"Dworak","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1021\/acs.biomac.5b00745","article-title":"Controlling the Crystallinity of Thermoresponsive Poly(2-Oxazoline)-Based Nanolayers to Cell Adhesion and Detachment","volume":"16","author":"Oleszko","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref_108","first-page":"327","article-title":"Thermoresponsive Polymer Surfaces and Their Application in Tissue Engineering","volume":"63","author":"Bochenek","year":"2018","journal-title":"Polymers"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Wa\u0142ach, W., Klama-bary\u0142a, A., Sitkowska, A., Kowalczuk, A., and Oleszko-torbus, N. (2021). Alternative to Poly(2-isopropyl-2-oxazoline) with a Reduced Ability to Crystallize and Physiological Lcst. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042221"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1039\/C7TB02748F","article-title":"Stable S tar Polymer Nanolayers and Their Thermoresponsiveness as a Tool for Controlled Culture and Detachment of Fibroblast Sheets","volume":"6","author":"Mendrek","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1039\/D1SM01066B","article-title":"A Simple Strategy for Efficient Preparation of Networks Based on Poly(2-Isopropenyl-2-Oxazoline), Poly(Ethylene Oxide), and Selected Biologically Active Compounds: Novel Hydrogels with Antibacterial Properties","volume":"17","author":"Kopka","year":"2021","journal-title":"Soft Matter"},{"key":"ref_112","first-page":"1200","article-title":"Ex Vivo and In Vitro Studies on the Cytotoxicity and Immunomodulative Properties of Poly(2-Isopropenyl-2-Oxazoline) as a New Type of Biomedical Polymer","volume":"v","author":"Mikulec","year":"2016","journal-title":"Macromol. Biosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/pola.29188","article-title":"Well-Defined Thermoresponsive Polymethacrylamide Copolymers with Ester Pendent Groups through One-Pot Statistical Postpolymerization Modification of Poly(2-Isopropenyl-2-Oxazoline) with Multiple Carboxylic Acids","volume":"57","author":"Jerca","year":"2019","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1039\/C8PY00612A","article-title":"Poly(2-Isopropenyl-2-Oxazoline) as a Versatile Platform towards Thermoresponsive Copolymers","volume":"9","author":"Jerca","year":"2018","journal-title":"Polym. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2008\/846453","article-title":"Bacterial Skin and Soft Tissue Infections in Adults: A Review of Their Epidemiology, Pathogenesis, Diagnosis, Treatment and Site Of Care. Canadian","volume":"19","author":"Ki","year":"2008","journal-title":"J. Infect. Dis. Med. Microbiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/656431","article-title":"Skin and Soft-Tissue Infections Requiring Hospitalization at an Academic Medical Center: Opportunities for Antimicrobial Stewardship","volume":"51","author":"Jenkins","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/pola.28011","article-title":"Synthesis of PH- and Thermoresponsive Poly(2-n-Propyl-2-Oxazoline) Based Copolymers","volume":"54","author":"Boerman","year":"2016","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1039\/C5PY00392J","article-title":"Versatile Side Chain Modification via Isocyanide-Based Multicomponent Reactions: Tuning the LCST of Poly(2-Oxazoline)s","volume":"6","author":"Sehlinger","year":"2015","journal-title":"Polym. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1021\/acs.macromol.5b00290","article-title":"Functional Poly(2-Oxazoline)s by Direct Amidation of Methyl Ester Side Chains","volume":"48","author":"Mees","year":"2015","journal-title":"Macromolecules"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.09.003","article-title":"Poly(2-Ethyl-2-Oxazoline) Conjugates with Doxorubicin for Cancer Therapy: In Vitro and in Vivo Evaluation and Direct Comparison to Poly[N-(2-Hydroxypropyl)Methacrylamide] Analogues","volume":"146","author":"Sedlacek","year":"2017","journal-title":"Biomaterials"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/pola.29542","article-title":"Acyl Guanidine Functional Poly(2-Oxazoline)s as Reactive Intermediates and Stimuli-Responsive Materials","volume":"57","author":"Xu","year":"2019","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.actbio.2015.01.010","article-title":"PH-Responsive Polymeric Micelles Based on Poly(2-Ethyl-2-Oxazoline)-Poly(d,l-Lactide) for Tumor-Targeting and Controlled Delivery of Doxorubicin and P-Glycoprotein Inhibitor","volume":"17","author":"Zhao","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"22316","DOI":"10.18632\/oncotarget.24806","article-title":"Tumor Targeting with PH-Responsive Poly(2-Oxazoline)-Based Nanogels for Metronomic Doxorubicin Treatment","volume":"9","author":"Hoelzer","year":"2018","journal-title":"Oncotarget"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fphar.2019.00270","article-title":"PH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo\/Photothermal Therapy","volume":"10","author":"Gao","year":"2019","journal-title":"Front Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1021\/ja203077x","article-title":"Catechol Polymers for PH-Responsive, Targeted Drug Delivery to Cancer Cells","volume":"133","author":"Su","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.colsurfb.2017.10.031","article-title":"Stable PH Responsive Layer-by-Layer Assemblies of Partially Hydrolysed Poly(2-Ethyl-2-Oxazoline) and Poly(Acrylic Acid) for Effective Prevention of Protein, Cell and Bacteria Surface Attachment","volume":"161","author":"He","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-409X(01)00203-4","article-title":"Environment-Sensitive Hydrogels for Drug Delivery","volume":"53","author":"Qiu","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1039\/C6PY01455K","article-title":"Field Responsive Materials: Photo-, Electro-, Magnetic- and Ultrasound-Sensitive Polymers","volume":"8","author":"Manouras","year":"2017","journal-title":"Polym. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1021\/acs.macromol.5b01046","article-title":"Multimodal Stimuli-Responsive Poly(2-Isopropyl-2-Oxazoline) with Dual Molecular Logic Gate Operations","volume":"48","author":"Kim","year":"2015","journal-title":"Macromolecules"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/pola.28537","article-title":"Photocleavable and Tunable Thermoresponsive Amphiphilic Random Copolymer: Self-Assembly into Micelles, Dye Encapsulation, and Triggered Release","volume":"55","author":"Jana","year":"2017","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10717544.2014.887157","article-title":"Classification of Stimuli\u2013Responsive Polymers as Anticancer Drug Delivery Systems","volume":"22","author":"Taghizadeh","year":"2015","journal-title":"Drug Deliv."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"110912","DOI":"10.1016\/j.colsurfb.2020.110912","article-title":"Poly(2-Oxazoline)-Based Magnetic Hydrogels: Synthesis, Performance and Cytotoxicity","volume":"190","author":"Cvek","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"117229","DOI":"10.1016\/j.carbpol.2020.117229","article-title":"A Novel Bioreducible and PH-Responsive Magnetic Nanohydrogel Based on \u03b2-Cyclodextrin for Chemo\/Hyperthermia Therapy of Cancer","volume":"252","author":"Soleimani","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/wnan.1678","article-title":"Reduction-Responsive Polymers for Drug Delivery in Cancer Therapy\u2014Is There Anything New to Discover?","volume":"13","author":"Monteiro","year":"2021","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1163\/156856208784522065","article-title":"Smart Polymers for Responsive Drug-Delivery Systems","volume":"19","author":"Traitel","year":"2008","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/acsnano.6b06040","article-title":"Diverse Applications of Nanomedicine","volume":"11","author":"Pelaz","year":"2017","journal-title":"ACS Nano"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/mp200108q","article-title":"Multicomponent Synthetic Polymers with Viral-Mimetic Chemistry for Nucleic Acid Delivery","volume":"9","author":"Soliman","year":"2012","journal-title":"Mol. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/adhm.201500344","article-title":"Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs","volume":"4","author":"Riber","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1039\/C6PY01365A","article-title":"Glutathione Responsive Polymers and Their Application in Drug Delivery Systems","volume":"8","author":"Quinn","year":"2017","journal-title":"Polym. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Ceg\u0142owski, M., Jerca, V.V., Jerca, F.A., and Hoogenboom, R. (2020). Reduction-Responsive Molecularly Imprinted Poly(2-Isopropenyl-2-Oxazoline) for Controlled Release of Anticancer Agents. 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