{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:49:14Z","timestamp":1762868954652,"version":"build-2065373602"},"reference-count":80,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Ministry of Health","award":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"],"award-info":[{"award-number":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"]}]},{"name":"CAPES","award":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"],"award-info":[{"award-number":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"]}]},{"name":"FINEP","award":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"],"award-info":[{"award-number":["405967\/2018-7","307695\/2020-4","88887.286821\/2018-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>In this study, we developed a bioadhesive emulsion-filled gel containing a high amount of Copaifera reticulata Ducke oil-resin as a veterinary or human clinical proposal. The phytotherapeutic system had easy preparation, low cost, satisfactory healing ability, and fly repellency, making it a cost-effective clinical strategy for wound care and myiasis prevention. Mechanical, rheological, morphological, and physical stability assessments were performed. The results highlight the crosslinked nature of the gelling agent, with three-dimensional channel networks stabilizing the Copaifera reticulata Ducke oil-resin (CrD-Ore). The emulgel presented antimicrobial activity, satisfactory adhesion, hardness, cohesiveness, and viscosity profiles, ensuring the easy spreading of the formulation. Considering dermatological application, the oscillatory responses showed a viscoelastic performance that ensures emulgel retention at the action site, reducing the dosage frequencies. In Vivo evaluations were performed using a case report to treat ulcerative skin wounds aggravated by myiasis in calves and heifers, which demonstrated healing, anti-inflammatory, and repellent performance for the emulsion-filled gel. The emulgel preparation, which is low in cost, shows promise as a drug for wound therapy.<\/jats:p>","DOI":"10.3390\/polym14214483","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"4483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Design and Optimization of a Natural Medicine from Copaifera reticulata Ducke for Skin Wound Care"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-8542","authenticated-orcid":false,"given":"Katieli da Silva Souza","family":"Campanholi","sequence":"first","affiliation":[{"name":"Chemistry Department, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranulfo Combuca da","family":"Silva Junior","sequence":"additional","affiliation":[{"name":"Chemistry Department, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-6101","authenticated-orcid":false,"given":"Renato Sonchini","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Products, Department of Chemistry, Center for Exact Sciences and Technology, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Bassi da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-6752","authenticated-orcid":false,"given":"Fl\u00e1via Amanda","family":"Pedroso de Morais","sequence":"additional","affiliation":[{"name":"Chemistry Department, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"},{"name":"Technological Innovation Laboratory in the Pharmaceuticals and Cosmetics Development, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela","family":"Said dos Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5760","authenticated-orcid":false,"given":"Bruno Henrique","family":"Vilsinski","sequence":"additional","affiliation":[{"name":"Chemistry Department, Institute of Exact Sciences, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielly Lorraynny Martins de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Chemistry Department, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali Soares dos Santos","family":"Pozza","sequence":"additional","affiliation":[{"name":"Department of Animal Science, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-5742","authenticated-orcid":false,"given":"Marcos Luciano","family":"Bruschi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Barnei","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Department of Animal Science, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Vataru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Technological Innovation Laboratory in the Pharmaceuticals and Cosmetics Development, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilker","family":"Caetano","sequence":"additional","affiliation":[{"name":"Chemistry Department, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cvsm.2017.06.001","article-title":"Initial Management of Traumatic Wounds","volume":"47","author":"Devriendt","year":"2017","journal-title":"Vet. 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