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A polysiloxane delivery vehicle was synthesized to deliver cyclic imide N-halamine onto cellulose via a benign and universal procedure that does not require a harmful solvent or chemical bonding. In brief, Knoevenagel condensation between barbituric acid and 4-hydroxybenzaldehyde furnished 5-(4-hydroxybenzylidene)pyrimidine-2,4,6-trione, whose phenolic O\u2212H was subsequently reacted with the Si\u2212H of poly(methylhydrosiloxane) (PMHS) via silane alcoholysis. The product of silane alcoholysis was interpenetrated into cellulose in supercritical CO2 (scCO2) at 50 \u00b0C, to form a continuous modification layer. The thickness of the modification layer positively correlated with interpenetration pressure in the experimental range of 10 to 28 MPa and reached a maximum value of 76.5 nm, which demonstrates the ability for tunable delivery, to control the loading of the imide N\u2212H bond originating from barbituric acid unit. The imide N\u2212H bonds on cellulose with the thickest modifier were then chlorinated into N\u2212Cl counterparts using tert-butyl hypochlorite, to exert a powerful biocidability, providing ~7 log reductions of both S. aureus and E. coli in 20 min. The stability and rechargeability of the biocidability were both very promising, suggesting that the polysiloxane modifier has a satisfactory chemical structure and interlocks firmly with cellulose via scCO2 interpenetration.<\/jats:p>","DOI":"10.3390\/polym14235080","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:54:05Z","timestamp":1669258445000},"page":"5080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Polysiloxane Delivery Vehicle of Cyclic N-Halamine for Biocidal Coating of Cellulose in Supercritical CO2"],"prefix":"10.3390","volume":"14","author":[{"given":"Leixuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengze","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Analytical and Testing Center, School of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Shan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Liaoning Normal University, 850 Huanghe Road, Dalian 116029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jhin.2015.02.017","article-title":"Role of healthcare apparel and other healthcare textiles in the transmission of pathogens: A review of the literature","volume":"90","author":"Mitchell","year":"2015","journal-title":"J. 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