{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:27:54Z","timestamp":1779082074317,"version":"3.51.4"},"reference-count":179,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RUDN University Strategic Academic Leadership Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>A DNA structure, known as triple-stranded DNA, is made up of three oligonucleotide chains that wind around one another to form a triple helix (TFO). Hoogsteen base pairing describes how triple-stranded DNA may be built at certain conditions by the attachment of the third strand to an RNA, PNA, or DNA, which might all be employed as oligonucleotide chains. In each of these situations, the oligonucleotides can be employed as an anchor, in conjunction with a specific bioactive chemical, or as a messenger that enables switching between transcription and replication through the triplex-forming zone. These data are also considered since various illnesses have been linked to the expansion of triplex-prone sequences. In light of metabolic acidosis and associated symptoms, some consideration is given to the impact of several low-molecular-weight compounds, including pH on triplex production in vivo. The review is focused on the development of biomedical oligonucleotides with triplexes.<\/jats:p>","DOI":"10.3390\/polym15040858","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:18:35Z","timestamp":1676006315000},"page":"858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recent Development in Biomedical Applications of Oligonucleotides with Triplex-Forming Ability"],"prefix":"10.3390","volume":"15","author":[{"given":"Incherah","family":"Bekkouche","sequence":"first","affiliation":[{"name":"Nanotechnology Scientific and Educational Center, Institute of Biochemical Technology and Nanotechnology, Peoples\u2019 Friendship University of Russia (RUDN), Miklukho-Maklaya Str. 6, Moscow 117198, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Shishonin","sequence":"additional","affiliation":[{"name":"Complementary and Integrative Health Clinic of Dr. Shishonin, 5, Yasnogorskaya Str., Moscow 117588, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-8571","authenticated-orcid":false,"given":"Alexandre A.","family":"Vetcher","sequence":"additional","affiliation":[{"name":"Nanotechnology Scientific and Educational Center, Institute of Biochemical Technology and Nanotechnology, Peoples\u2019 Friendship University of Russia (RUDN), Miklukho-Maklaya Str. 6, Moscow 117198, Russia"},{"name":"Complementary and Integrative Health Clinic of Dr. Shishonin, 5, Yasnogorskaya Str., Moscow 117588, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15210","DOI":"10.1002\/anie.201701868","article-title":"Triplex DNA nanostructures: From basic properties to applications","volume":"56","author":"Hu","year":"2017","journal-title":"Angew. 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