{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:32:20Z","timestamp":1785364340227,"version":"3.55.0"},"reference-count":189,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Knowledge Innovation Project of Wuhan","award":["230171408"],"award-info":[{"award-number":["230171408"]}]},{"name":"Knowledge Innovation Project of Wuhan","award":["82170932"],"award-info":[{"award-number":["82170932"]}]},{"name":"Knowledge Innovation Project of Wuhan","award":["LBQ20H140001"],"award-info":[{"award-number":["LBQ20H140001"]}]},{"name":"National Natural Science Foundation of China","award":["230171408"],"award-info":[{"award-number":["230171408"]}]},{"name":"National Natural Science Foundation of China","award":["82170932"],"award-info":[{"award-number":["82170932"]}]},{"name":"National Natural Science Foundation of China","award":["LBQ20H140001"],"award-info":[{"award-number":["LBQ20H140001"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["230171408"],"award-info":[{"award-number":["230171408"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["82170932"],"award-info":[{"award-number":["82170932"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LBQ20H140001"],"award-info":[{"award-number":["LBQ20H140001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The complex or compromised bone defects caused by osteomyelitis, malignant tumors, metastatic tumors, skeletal abnormalities, and systemic diseases are difficult to be self-repaired, leading to a non-union fracture. With the increasing demands of bone transplantation, more and more attention has been paid to artificial bone substitutes. As biopolymer-based aerogel materials, nanocellulose aerogels have been widely utilized in bone tissue engineering. More importantly, nanocellulose aerogels not only mimic the structure of the extracellular matrix but could also deliver drugs and bioactive molecules to promote tissue healing and growth. Here, we reviewed the most recent literature about nanocellulose-based aerogels, summarized the preparation, modification, composite fabrication, and applications of nanocellulose-based aerogels in bone tissue engineering, as well as giving special focus to the current limitations and future opportunities of nanocellulose aerogels for bone tissue engineering.<\/jats:p>","DOI":"10.3390\/polym15102323","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:52:41Z","timestamp":1684288361000},"page":"2323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Application of Nanocellulose-Based Aerogels in Bone Tissue Engineering: Current Trends and Outlooks"],"prefix":"10.3390","volume":"15","author":[{"given":"Yaoguang","family":"Zhang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China"},{"name":"Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Xu","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubing","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-9294","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-3096","authenticated-orcid":false,"given":"Gu","family":"Cheng","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","first-page":"1981","article-title":"Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering","volume":"368","author":"Ko","year":"2010","journal-title":"Philos. 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