{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:02:28Z","timestamp":1787792548614,"version":"build-2784847793"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PAPIIT","award":["IG 200423"],"award-info":[{"award-number":["IG 200423"]}]},{"name":"PAPIIT","award":["2206"],"award-info":[{"award-number":["2206"]}]},{"name":"PAPIIT","award":["CF 140617"],"award-info":[{"award-number":["CF 140617"]}]},{"name":"C\u00e1tedra de Investigaci\u00f3n","award":["IG 200423"],"award-info":[{"award-number":["IG 200423"]}]},{"name":"C\u00e1tedra de Investigaci\u00f3n","award":["2206"],"award-info":[{"award-number":["2206"]}]},{"name":"C\u00e1tedra de Investigaci\u00f3n","award":["CF 140617"],"award-info":[{"award-number":["CF 140617"]}]},{"name":"CONACyT","award":["IG 200423"],"award-info":[{"award-number":["IG 200423"]}]},{"name":"CONACyT","award":["2206"],"award-info":[{"award-number":["2206"]}]},{"name":"CONACyT","award":["CF 140617"],"award-info":[{"award-number":["CF 140617"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The objective of this study was to create polymeric dressings, microfibers, and microneedles (MN) loaded with ceftriaxone, using PMVA (Poly (Methyl vinyl ether-alt-maleic acid), Kollicoat\u00ae 100P, and Kollicoat\u00ae Protect as polymers to treat diabetic wounds and accelerate their recovery. These formulations were optimized through a series of experiments and were subsequently subjected to physicochemical tests. The results of the characterization of the dressings, microfibers, and microneedles (PMVA and 100P) were, respectively, a bioadhesion of 281.34, 720, 720, 2487, and 510.5 gf; a post-humectation bioadhesion of 186.34, 831.5, 2380, and 630.5 gf, tear strength of 2200, 1233, 1562, and 385 gf, erythema of 358, 8.4, 227, and 188; transepidermal water loss (TEWL) of 2.6, 4.7, 1.9, and 5.2 g\/h\u00b7m2; hydration of 76.1, 89.9, 73.5, and 83.5%; pH of 4.85, 5.40, 5.85, and 4.85; and drug release (Peppas kinetics release) of n: 0.53, n: 0.62, n: 0.62, and n: 0.66). In vitro studies were performed on Franz-type diffusion cells and indicated flux of 57.1, 145.4, 718.7, and 2.7 \u00b5g\/cm2; permeation coefficient (Kp) of 13.2, 19.56, 42, and 0.00015 cm2\/h; and time lag (tL) of 6.29, 17.61, 27. 49, and 22.3 h, respectively, in wounded skin. There was no passage of ceftriaxone from dressings and microfibers to healthy skin, but that was not the case for PMVA\/100P and Kollicoat\u00ae 100P microneedles, which exhibited flux of 194 and 0.4 \u00b5g\/cm2, Kp of 11.3 and 0.00002 cm2\/h, and tL of 5.2 and 9.7 h, respectively. The healing time of the formulations in vivo (tests carried out using diabetic Wistar rats) was under 14 days. In summary, polymeric dressings, microfibers, and microneedles loaded with ceftriaxone were developed. These formulations have the potential to address the challenges associated with chronic wounds, such as diabetic foot, improving the outcomes.<\/jats:p>","DOI":"10.3390\/polym15122610","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:59:56Z","timestamp":1686196796000},"page":"2610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ceftriaxone-Loaded Polymeric Microneedles, Dressings, and Microfibers for Wound Treatment"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-2175","authenticated-orcid":false,"given":"Pablo","family":"Serrano-Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Alejandro","family":"Ochoa Loyo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Ezequiel","family":"Tinoco Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Miguel","family":"Anaya-Ortega","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Rodrigo","family":"Guadarrama-Escobar","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Anguiano-Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Multidisciplinaria-Lab 12, Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan, km 2.5 San Sebasti\u00e1n Xhala, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsab\u00e9","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Servicio de An\u00e1lisis de Prop\u00f3leos (LASAP), Unidad de Investigaci\u00f3n Multidisciplinaria (UIM), Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. 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