{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:46:30Z","timestamp":1787499990459,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["CFH2020-2-2142"],"award-info":[{"award-number":["CFH2020-2-2142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Smart dental materials are designed to intelligently respond to physiological changes and local environmental stimuli to protect the teeth and promote oral health. Dental plaque, or biofilms, can substantially reduce the local pH, causing demineralization that can then progress to tooth caries. Progress has been made recently in developing smart dental materials that possess antibacterial and remineralizing capabilities in response to local oral pH in order to suppress caries, promote mineralization, and protect tooth structures. This article reviews cutting-edge research on smart dental materials, their novel microstructural and chemical designs, physical and biological properties, antibiofilm and remineralizing capabilities, and mechanisms of being smart to respond to pH. In addition, this article discusses exciting and new developments, methods to further improve the smart materials, and potential clinical applications.<\/jats:p>","DOI":"10.3390\/polym15122611","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:59:56Z","timestamp":1686196796000},"page":"2611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Smart Dental Materials Intelligently Responding to Oral pH to Combat Caries: A Literature Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Kan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinrou","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Chongqing Medical University, Chongqing 401147, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-0891","authenticated-orcid":false,"given":"Yuxing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7982-5758","authenticated-orcid":false,"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1038\/nrdp.2017.30","article-title":"Dental Caries","volume":"3","author":"Pitts","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41589-021-00745-2","article-title":"Mutanofactin Promotes Adhesion and Biofilm Formation of Cariogenic Streptococcus Mutans","volume":"17","author":"Li","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tim.2014.10.010","article-title":"Solving the Etiology of Dental Caries","volume":"23","author":"Mira","year":"2015","journal-title":"Trends Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2341\/07-147","article-title":"Effect of PH on the Wettability and Fluoride Release of an Ion-Releasing Resin Composite","volume":"33","author":"Namen","year":"2008","journal-title":"Oper. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioactmat.2022.12.002","article-title":"Smart Dental Materials for Antimicrobial Applications","volume":"24","author":"Montoya","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110454","DOI":"10.1016\/j.colsurfb.2019.110454","article-title":"An Enzyme-Responsive Membrane for Antibiotic Drug Release and Local Periodontal Treatment","volume":"183","author":"Li","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bioactmat.2022.02.008","article-title":"PH and Lipase-Responsive Nanocarrier-Mediated Dual Drug Delivery System to Treat Periodontitis in Diabetic Rats","volume":"18","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41413-018-0032-9","article-title":"Advanced Smart Biomaterials and Constructs for Hard Tissue Engineering and Regeneration","volume":"6","author":"Zhang","year":"2018","journal-title":"Bone Res."},{"key":"ref_9","first-page":"e30789","article-title":"Smart Materials Leading to Restorative Dentistry: An Overview","volume":"14","author":"Maloo","year":"2022","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1834-7819.2010.01291.x","article-title":"Smart Materials in Dentistry","volume":"56","author":"McCabe","year":"2011","journal-title":"Aust. Dent. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Francois, P., Fouquet, V., Attal, J.-P., and Dursun, E. (2020). Commercially Available Fluoride-Releasing Restorative Materials: A Review and a Proposal for Classification. Materials, 13.","DOI":"10.3390\/ma13102313"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lemos, J.A., Palmer, S.R., Zeng, L., Wen, Z.T., Kajfasz, J.K., Freires, I.A., Abranches, J., and Brady, L.J. (2019). The Biology of Streptococcus Mutans. Microbiol. Spectr., 7.","DOI":"10.1128\/microbiolspec.GPP3-0051-2018"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/00220345000790021101","article-title":"The PH of Dental Plaque in Its Relation to Early Enamel Caries and Dental Plaque Flora in Humans","volume":"79","author":"Kent","year":"2000","journal-title":"J. Dent. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cis.2019.04.011","article-title":"The Importance of Being Amorphous: Calcium and Magnesium Phosphates in the Human Body","volume":"269","author":"Gelli","year":"2019","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10856-007-3178-3","article-title":"Amorphous Calcium Phosphate\/Urethane Methacrylate Resin Composites. I. Physicochemical Characterization","volume":"19","author":"Regnault","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.dental.2017.03.002","article-title":"Novel Dental Adhesive with Triple Benefits of Calcium Phosphate Recharge, Protein-Repellent and Antibacterial Functions","volume":"33","author":"Xie","year":"2017","journal-title":"Dent. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.dental.2011.03.016","article-title":"Nanocomposite Containing Amorphous Calcium Phosphate Nanoparticles for Caries Inhibition","volume":"27","author":"Xu","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1016\/j.actbio.2010.05.013","article-title":"Apatite-Formation Ability\u2014Predictor of \u201cBioactivity\u201d?","volume":"6","author":"Pan","year":"2010","journal-title":"Acta Biomater"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0109-5641(02)00105-7","article-title":"Mechanical Properties and Biochemical Activity of Remineralizing Resin-Based Ca-PO4 Cements","volume":"19","author":"Dickens","year":"2003","journal-title":"Dent. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jbm.b.31834","article-title":"Mechanical and Acid Neutralizing Properties and Bacteria Inhibition of Amorphous Calcium Phosphate Dental Nanocomposite","volume":"98","author":"Moreau","year":"2011","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jdent.2015.06.009","article-title":"Rechargeable Dental Adhesive with Calcium Phosphate Nanoparticles for Long-Term Ion Release","volume":"43","author":"Zhang","year":"2015","journal-title":"J. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41368-019-0048-z","article-title":"Dental Remineralization via Poly(Amido Amine) and Restorative Materials Containing Calcium Phosphate Nanoparticles","volume":"11","author":"Liang","year":"2019","journal-title":"Int. J. Oral. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Torres, L., and Bienek, D.R. (2020). Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials. J. Funct. Biomater., 11.","DOI":"10.3390\/jfb11030054"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.dental.2018.09.005","article-title":"Protein-Repellent Nanocomposite with Rechargeable Calcium and Phosphate for Long-Term Ion Release","volume":"34","author":"Weir","year":"2018","journal-title":"Dent. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jdent.2018.08.011","article-title":"Protein-Repelling Adhesive Resin Containing Calcium Phosphate Nanoparticles with Repeated Ion-Recharge and Re-Releases","volume":"78","author":"Tay","year":"2018","journal-title":"J. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.dental.2018.03.014","article-title":"Antibacterial Quaternary Ammonium Compounds in Dental Materials: A Systematic Review","volume":"34","author":"Makvandi","year":"2018","journal-title":"Dent. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ijos.2015.33","article-title":"Effects of Quaternary Ammonium Chain Length on the Antibacterial and Remineralizing Effects of a Calcium Phosphate Nanocomposite","volume":"8","author":"Zhang","year":"2016","journal-title":"Int. J. Oral. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/jbm.b.32691","article-title":"Long-Term Mechanical Durability of Dental Nanocomposites Containing Amorphous Calcium Phosphate Nanoparticles","volume":"100","author":"Moreau","year":"2012","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.dental.2012.02.007","article-title":"Nanocomposite Containing CaF2 Nanoparticles: Thermal Cycling, Wear and Long-Term Water-Aging","volume":"28","author":"Weir","year":"2012","journal-title":"Dent. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.dental.2008.10.009","article-title":"Calcium and Phosphate Ion Releasing Composite: Effect of PH on Release and Mechanical Properties","volume":"25","author":"Xu","year":"2009","journal-title":"Dent. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jdent.2017.05.024","article-title":"A New Arginine-Based Dental Adhesive System: Formulation, Mechanical and Anti-Caries Properties","volume":"63","author":"Geraldeli","year":"2017","journal-title":"J. Dent."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhou, W., Peng, X., Zhou, X., Bonavente, A., Weir, M.D., Melo, M.A.S., Imazato, S., Oates, T.W., Cheng, L., and Xu, H.H.K. (2020). Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model. IJMS, 21.","DOI":"10.3390\/ijms21176369"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103344","DOI":"10.1016\/j.jdent.2020.103344","article-title":"Antibacterial and Remineralizing Nanocomposite Inhibit Root Caries Biofilms and Protect Root Dentin Hardness at the Margins","volume":"97","author":"Zhou","year":"2020","journal-title":"J. Dent."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.dental.2020.07.007","article-title":"In Vitro Evaluation of Composite Containing DMAHDM and Calcium Phosphate Nanoparticles on Recurrent Caries Inhibition at Bovine Enamel-Restoration Margins","volume":"36","author":"Zhou","year":"2020","journal-title":"Dent. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.actbio.2020.07.057","article-title":"Bioactive Low-Shrinkage-Stress Nanocomposite Suppresses S. Mutans Biofilm and Preserves Tooth Dentin Hardness","volume":"114","author":"Bhadila","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/jbm.b.34775","article-title":"Low-Shrinkage-Stress Nanocomposite: An Insight into Shrinkage Stress, Antibacterial, and Ion Release Properties","volume":"109","author":"Bhadila","year":"2021","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"103406","DOI":"10.1016\/j.jdent.2020.103406","article-title":"Novel Low-Shrinkage-Stress Nanocomposite with Remineralization and Antibacterial Abilities to Protect Marginal Enamel under Biofilm","volume":"99","author":"Bhadila","year":"2020","journal-title":"J. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"AlSahafi, R., Balhaddad, A.A., Mitwalli, H., Ibrahim, M.S., Melo, M.A.S., Oates, T.W., Xu, H.H.K., and Weir, M.D. (2020). Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles. Nanomaterials, 10.","DOI":"10.3390\/nano10102001"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.dental.2018.06.001","article-title":"Novel Magnetic Nanoparticle-Containing Adhesive with Greater Dentin Bond Strength and Antibacterial and Remineralizing Capabilities","volume":"34","author":"Li","year":"2018","journal-title":"Dent. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nchem.2635","article-title":"Targeted Drug Delivery through the Traceless Release of Tertiary and Heteroaryl Amines from Antibody-Drug Conjugates","volume":"8","author":"Staben","year":"2016","journal-title":"Nat. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1021\/nn507170s","article-title":"PH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol to Disrupt Oral Biofilm Virulence","volume":"9","author":"Horev","year":"2015","journal-title":"ACS Nano"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1177\/0022034520936639","article-title":"PH-Responsive Antibacterial Resin Adhesives for Secondary Caries Inhibition","volume":"99","author":"Liang","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Shi, Y., Liang, J., Zhou, X., Ren, B., Wang, H., Han, Q., Li, H., and Cheng, L. (2022). Effects of a Novel, Intelligent, PH-Responsive Resin Adhesive on Cariogenic Biofilms In Vitro. Pathogens, 11.","DOI":"10.3390\/pathogens11091014"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.dental.2021.08.002","article-title":"Intelligent PH-Responsive Dental Sealants to Prevent Long-Term Microleakage","volume":"37","author":"Li","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1063143","DOI":"10.3389\/fcimb.2022.1063143","article-title":"Novel Dental Resin Infiltrant Containing Smart Monomer Dodecylmethylaminoethyl Methacrylate","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ijos.2016.40","article-title":"Novel Rechargeable Calcium Phosphate Nanoparticle-Containing Orthodontic Cement","volume":"9","author":"Xie","year":"2017","journal-title":"Int. J. Oral. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1039\/D0MH01498B","article-title":"Porous Bioactive Glass Micro- and Nanospheres with Controlled Morphology: Developments, Properties and Emerging Biomedical Applications","volume":"8","author":"Zheng","year":"2021","journal-title":"Mater. Horiz."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.dental.2014.05.029","article-title":"Functionalizing a Dentin Bonding Resin to Become Bioactive","volume":"30","author":"Zehnder","year":"2014","journal-title":"Dent. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Deng, F., Sakai, H., Kitagawa, H., Kohno, T., Thongthai, P., Liu, Y., Kitagawa, R., Abe, G.L., Sasaki, J.-I., and Imazato, S. (2022). Fabrication of PH-Responsive Zn2+-Releasing Glass Particles for Smart Antibacterial Restoratives. Molecules, 27.","DOI":"10.3390\/molecules27217202"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40824-022-00274-6","article-title":"Application of Bioactive Glasses in Various Dental Fields","volume":"26","author":"Jafari","year":"2022","journal-title":"Biomater. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"103950","DOI":"10.1016\/j.jdent.2022.103950","article-title":"Ion Release and Hydroxyapatite Precipitation of Resin Composites Functionalized with Two Types of Bioactive Glass","volume":"118","author":"Par","year":"2022","journal-title":"J. Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"30120","DOI":"10.1021\/acsami.0c06865","article-title":"Zinc-Calcium-Fluoride Bioglass-Based Innovative Multifunctional Dental Adhesive with Thick Adhesive Resin Film Thickness","volume":"12","author":"Yao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12951-021-00788-6","article-title":"PH-Dependent Delivery of Chlorhexidine from PGA Grafted Mesoporous Silica Nanoparticles at Resin-Dentin Interface","volume":"19","author":"Akram","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1021\/mp500836w","article-title":"PH-Triggered Controllable Release of Silver-Indole-3 Acetic Acid Complexes from Mesoporous Silica Nanoparticles (IBN-4) for Effectively Killing Malignant Bacteria","volume":"12","author":"Kuthati","year":"2015","journal-title":"Mol. Pharm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"761583","DOI":"10.3389\/fmicb.2021.761583","article-title":"A New PH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic Bactericidal Agent on Mature Streptococcus Mutans Biofilm","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1124411","DOI":"10.3389\/fcimb.2023.1124411","article-title":"The Application of Mesoporous Silica Nanoparticles as a Drug Delivery Vehicle in Oral Disease Treatment","volume":"13","author":"Fang","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/10717544.2022.2037788","article-title":"Effect of PH-Sensitive Nanoparticles on Inhibiting Oral Biofilms","volume":"29","author":"Peng","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1039\/C8BM01640B","article-title":"PH-Responsive Polymeric Nanocarriers for Efficient Killing of Cariogenic Bacteria in Biofilms","volume":"7","author":"Zhao","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12951-020-00633-2","article-title":"Farnesal-Loaded PH-Sensitive Polymeric Micelles Provided Effective Prevention and Treatment on Dental Caries","volume":"18","author":"Yi","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1039\/C5TB02054A","article-title":"Characterization and Optimization of PH-Responsive Polymer Nanoparticles for Drug Delivery to Oral Biofilms","volume":"4","author":"Zhou","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Marin, L.M., Xiao, Y., Gillies, E.R., and Siqueira, W.L. (2021). PH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery. Nanomaterials, 11.","DOI":"10.3390\/nano11041028"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1039\/C7TB02682J","article-title":"PH-Activated Nanoparticles with Targeting for the Treatment of Oral Plaque Biofilm","volume":"6","author":"Zhou","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bioactmat.2022.06.010","article-title":"Dental Plaque-Inspired Versatile Nanosystem for Caries Prevention and Tooth Restoration","volume":"20","author":"Xu","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.2147\/IJN.S181168","article-title":"Redox\/PH Dual-Controlled Release of Chlorhexidine and Silver Ions from Biodegradable Mesoporous Silica Nanoparticles against Oral Biofilms","volume":"13","author":"Lu","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.7150\/thno.73181","article-title":"Dual-Sensitive Antibacterial Peptide Nanoparticles Prevent Dental Caries","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.actbio.2018.06.032","article-title":"Responsive Antimicrobial Dental Adhesive Based on Drug-Silica Co-Assembled Particles","volume":"76","author":"Stewart","year":"2018","journal-title":"Acta Biomater."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/15\/12\/2611\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:50:41Z","timestamp":1760125841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/15\/12\/2611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":66,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["polym15122611"],"URL":"https:\/\/doi.org\/10.3390\/polym15122611","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]}}}