{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:19:47Z","timestamp":1787159987795,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RPO WSL 2014-2020 program","award":["WND-RPSL.01.01.00-24-05B3\/17-00"],"award-info":[{"award-number":["WND-RPSL.01.01.00-24-05B3\/17-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Gel dressings, composed of polymers both natural and synthetic, are successfully used in the treatment of burn wounds. They protect the burn wound site against adverse external factors, ensure an adequate level of tissue hydration, have soothing and pain-relieving properties, and also support the healing process and reduce the risk of pathological scars. Another promising material that can be used in the wound-healing process is an amnion membrane. Due to its valuable properties such as protecting the body against bacterial infections and permeability to nutrition, it has found usage in different brands of medicine. In this work, we have combined the beneficial properties of hydrogels and amnion in order to make the laminar dressing that may serve for wound healing. For that purpose, the physically crosslinked cryogel of poly(vinyl alcohol) (PVA) was covered with an amnion membrane. Subsequently, gamma irradiation was performed, leading to the simultaneous internal crosslinking of the hydrogel, its permanent bonding with the amnion, and dressing sterilization. The physicochemical properties of the dressing including gel fraction, swelling, and hardness were studied. Biological tests such as the MTT assay, antimicrobial activity, and histopathological examination confirmed that the obtained material constituted a promising candidate for further, more in-depth studies aiming at wound dressing application.<\/jats:p>","DOI":"10.3390\/polym15132955","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:41:27Z","timestamp":1688604087000},"page":"2955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laminar Biomaterial Composite of PVA Cryogel with Amnion as Potential Wound Dressing"],"prefix":"10.3390","volume":"15","author":[{"given":"\u0141ukasz","family":"Otulakowski","sequence":"first","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Klama-Bary\u0142a","sequence":"additional","affiliation":[{"name":"Dr. Stanislaw Sakiel Center for Burn Treatment, 2 Jana Pawla II St., 41-100 Siemianowice \u015al\u0105skie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-0439","authenticated-orcid":false,"given":"Anna","family":"Celny","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kaspr\u00f3w","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hercog","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-7452","authenticated-orcid":false,"given":"Marcin","family":"Godzierz","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sitkowska","sequence":"additional","affiliation":[{"name":"Dr. Stanislaw Sakiel Center for Burn Treatment, 2 Jana Pawla II St., 41-100 Siemianowice \u015al\u0105skie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Kad\u0142ubowski","sequence":"additional","affiliation":[{"name":"Institute of Applied Radiation Chemistry, Chemistry Faculty, Lodz University of Technology, Wr\u00f3blewskiego 15, 90-924 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Jaworska","sequence":"additional","affiliation":[{"name":"Tumor Pathology Department, Maria Sk\u0142odowska-Curie National Research Institute of Oncology Gliwice Branch, Wybrze\u017ce Armii Krajowej 15, 44-102 Gliwice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Chmielik","sequence":"additional","affiliation":[{"name":"Tumor Pathology Department, Maria Sk\u0142odowska-Curie National Research Institute of Oncology Gliwice Branch, Wybrze\u017ce Armii Krajowej 15, 44-102 Gliwice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Trzebicka","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-0137","authenticated-orcid":false,"given":"Alicja","family":"Utrata-Weso\u0142ek","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowskiej 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","first-page":"541","article-title":"Modern wound care\u2014Practical aspects of non-interventional topical treatment of patients with chronic wounds","volume":"12","author":"Dissemond","year":"2014","journal-title":"JDDG J. Dtsch. Dermatol. 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