{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:33:59Z","timestamp":1768440839376,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Agency for Research and Development of Chile (ANID)","award":["11191065"],"award-info":[{"award-number":["11191065"]}]},{"name":"National Agency for Research and Development of Chile (ANID)","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}]},{"name":"MICINN, Spain","award":["11191065"],"award-info":[{"award-number":["11191065"]}]},{"name":"MICINN, Spain","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>In order to improve the water solubility and, therefore, bioavailability and therapeutic activity of anticancer hydrophobic drug \u03b1-tocopherol succinate (\u03b1-TOS), in this work, copolymers were synthesized via free radicals from QMES (1-[4,7-dichloroquinolin-2-ylmethyl]-4-methacryloyloxyethyl succinate) and VP (N-vinyl-2-pirrolidone) using different molar ratios, and were used to nanoencapsulate and deliver \u03b1-TOS into cancer cells MCF-7. QMES monomer was chosen because the QMES pendant group in the polymer tends to hydrolyze to form free 4,7-dichloro-2-quinolinemethanol (QOH), which also, like \u03b1-TOS, exhibit anti-proliferative effects on cancerous cells. From the QMES-VP 30:70 (QMES-30) and 40:60 (QMES-40) copolymers obtained, it was possible to prepare aqueous suspensions of empty nanoparticles (NPs) loaded with \u03b1-TOS by nanoprecipitation. The diameter and encapsulation efficiency (%EE) of the QMES-30 NPs loaded with \u03b1-TOS were 128.6 nm and 52%; while for the QMES-40 NPs loaded with \u03b1-TOS, they were 148.8 nm and 65%. The results of the AlamarBlue assay at 72 h of treatment show that empty QMES-30 NPs (without \u03b1-TOS) produced a marked cytotoxic effect on MCF-7 breast cancer cells, corresponding to an IC50 value of 0.043 mg mL\u22121, and importantly, they did not exhibit cytotoxicity against healthy HUVEC cells. Furthermore, NP-QMES-40 loaded with \u03b1-TOS were cytotoxic with an IC50 value of 0.076 mg mL\u22121, demonstrating a progressive release of \u03b1-TOS; however, the latter nanoparticles were also cytotoxic to healthy cells in the range of the assayed concentrations. These results contribute to the search for a new polymeric nanocarrier of QOH, \u03b1-TOS or other hydrophobic drugs for the treatment of cancer or others diseases treatable with these drugs.<\/jats:p>","DOI":"10.3390\/polym15224342","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:25:31Z","timestamp":1699356331000},"page":"4342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nanocarrier of \u03b1-Tocopheryl Succinate Based on a Copolymer Derivative of (4,7-dichloroquinolin-2-yl)methanol and Its Cytotoxicity against a Breast Cancer Cell Line"],"prefix":"10.3390","volume":"15","author":[{"given":"Hern\u00e1n","family":"Valle","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Basic Sciences, University of C\u00f3rdoba, Monter\u00eda 230002, Colombia"},{"name":"Laboratory of Chemistry of Natural Products, Department of Botany, Faculty of Natural and Oceanographic Sciences, University of Concepci\u00f3n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Palao-Suay","sequence":"additional","affiliation":[{"name":"Group of Biomaterials, Department of Polymeric Nanomaterials and Biomaterials, Institute of Polymer Science and Technology, Spanish National Research Council (ICTP-CSIC), 28006 Madrid, Spain"},{"name":"Networking Biomedical Research Centre in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-5754","authenticated-orcid":false,"given":"Mar\u00eda Rosa","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Group of Biomaterials, Department of Polymeric Nanomaterials and Biomaterials, Institute of Polymer Science and Technology, Spanish National Research Council (ICTP-CSIC), 28006 Madrid, Spain"},{"name":"Networking Biomedical Research Centre in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulio A.","family":"Lerma","sequence":"additional","affiliation":[{"name":"Research Group in Science with Technological Applications (GI-CAT), Department of Chemistry, Faculty of Natural and Exact Science, University of Valle, Cali 760042, Colombia"},{"name":"Mindtech Research Group (Mindtech-RG), Mindtech s.a.s., Barranquilla 080006, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-9040","authenticated-orcid":false,"given":"Manuel","family":"Palencia","sequence":"additional","affiliation":[{"name":"Research Group in Science with Technological Applications (GI-CAT), Department of Chemistry, Faculty of Natural and Exact Science, University of Valle, Cali 760042, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-9830","authenticated-orcid":false,"given":"Ramalinga Viswanathan","family":"Mangalaraja","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Sciences, Adolfo Ib\u00e1\u00f1ez University, Diagonal Las Torres 2640, Pe\u00f1alol\u00e9n, Santiago 7941169, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurobiology, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dairo","family":"P\u00e9rez Sotelo","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Basic Sciences, University of C\u00f3rdoba, Monter\u00eda 230002, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Becerra","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Products, Department of Botany, Faculty of Natural and Oceanographic Sciences, University of Concepci\u00f3n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","unstructured":"Pan American Health Organization PAHO\/WHO (2023, July 15). 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