{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:14:42Z","timestamp":1790363682920,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Master of Oral Surgery and Implant Dentistry, University of Granada, Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Both guided bone and guided tissue regeneration are techniques that require the use of barrier membranes. Contamination and infection of the surgical area is one of the most feared complications. Some current lines of research focus on functionalizing these membranes with different antimicrobial agents. The objective of this study was to carry out a review of the use and antibacterial properties of regeneration membranes doped with antimicrobials such as zinc, silver, chlorhexidine, and lauric acid. The protocol was based on PRISMA recommendations, addressing the PICO question: \u201cDo membranes doped with non-antibiotic antimicrobials have antibacterial activity that can reduce or improve infection compared to membranes not impregnated with said antimicrobial?\u201d Methodological quality was evaluated using the RoBDEMAT tool. A total of 329 articles were found, of which 25 met the eligibility criteria and were included in this review. Most studies agree that zinc inhibits bacterial growth as it decreases colony-forming units, depending on the concentration used and the bacterial species studied. Silver compounds also decreased the secretion of proinflammatory cytokines and presented less bacterial adhesion to the membrane. Some concentrations of chlorhexidine that possess antimicrobial activity have shown high toxicity. Finally, lauric acid shows inhibition of bacterial growth measured by the disk diffusion test, the inhibition zone being larger with higher concentrations. Antimicrobial agents such as zinc, silver, chlorhexidine, and lauric acid have effective antibacterial activity and can be used to dope regenerative membranes in order to reduce the risk of bacterial colonization.<\/jats:p>","DOI":"10.3390\/polym16010095","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T09:56:27Z","timestamp":1703757387000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regeneration Membranes Loaded with Non-Antibiotic Anti-2 Microbials: A Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana","family":"Adamuz-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3176-7613","authenticated-orcid":false,"given":"Francisco-Javier","family":"Manzano-Moreno","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"},{"name":"Biomedical Group (BIO277), Department of Stomatology, University of Granada, 18071 Granada, Spain"},{"name":"Instituto Investigaci\u00f3n Biosanitaria, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-2811","authenticated-orcid":false,"given":"Cristina","family":"Vallecillo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1600-0501.2010.01922.x","article-title":"Guided Bone Regeneration: Biological principle and therapeutic applications","volume":"21","author":"Retzepi","year":"2010","journal-title":"Clin. 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