{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:40:10Z","timestamp":1783478410657,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["NSTC 111-2314-B-035-002-MY3"],"award-info":[{"award-number":["NSTC 111-2314-B-035-002-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["110-2221-E-035-013"],"award-info":[{"award-number":["110-2221-E-035-013"]}]},{"name":"National Science and Technology Council, Taiwan","award":["109-2314-B-037-043"],"award-info":[{"award-number":["109-2314-B-037-043"]}]},{"name":"National Science and Technology Council, Taiwan","award":["109-2622-E-035-014-CC2"],"award-info":[{"award-number":["109-2622-E-035-014-CC2"]}]},{"name":"National Science and Technology Council, Taiwan","award":["KMUH109-9R56"],"award-info":[{"award-number":["KMUH109-9R56"]}]},{"name":"KMU research project","award":["NSTC 111-2314-B-035-002-MY3"],"award-info":[{"award-number":["NSTC 111-2314-B-035-002-MY3"]}]},{"name":"KMU research project","award":["110-2221-E-035-013"],"award-info":[{"award-number":["110-2221-E-035-013"]}]},{"name":"KMU research project","award":["109-2314-B-037-043"],"award-info":[{"award-number":["109-2314-B-037-043"]}]},{"name":"KMU research project","award":["109-2622-E-035-014-CC2"],"award-info":[{"award-number":["109-2622-E-035-014-CC2"]}]},{"name":"KMU research project","award":["KMUH109-9R56"],"award-info":[{"award-number":["KMUH109-9R56"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The cornea lacks the ability to repair itself and must rely on transplantation to repair damaged tissue. Therefore, creating alternative therapies using dressing membranes based on tissue engineering concepts to repair corneal damage before failure has become a major research goal. Themost outstanding features that are important in reconstructing a damaged cornea are the mechanical strength and transparency of the membrane, which are the most important standard considerations. In addition, preventing infection is an important issue, especially in corneal endothelial healing processes. The purpose of this study was to produce aligned fibers via electrospinning technology using gelatin (Gel) composite polycaprolactone (PCL) as an optimal transport and antibiotic release membrane. The aim of the composite membrane is to achieve good tenacity, transparency, antibacterial properties, and in vitro biocompatibility. Results showed that the Gel and PCL composite membranes with the same electrospinning flow rate had the best transparency. The Gel impregnated with gentamicin antibiotic in composite membranes subsequently exhibited transparency and enhanced mechanical properties provided by PCL and could sustainably release the antibiotic for 48 h, achieving good antibacterial effects without causing cytotoxicity. This newly developed membrane has the advantage of preventing epidermal tissue infection during clinical operations and is expected to be used in the reconstruction of damaged cornea in the future.<\/jats:p>","DOI":"10.3390\/polym16040448","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T05:36:43Z","timestamp":1707197803000},"page":"448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hybrid-Aligned Fibers of Electrospun Gelatin with Antibiotic and Polycaprolactone Composite Membranes as an In Vitro Drug Delivery System to Assess the Potential Repair Capacity of Damaged Cornea"],"prefix":"10.3390","volume":"16","author":[{"given":"Yi-Hsin","family":"Shao","sequence":"first","affiliation":[{"name":"Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ssu-Meng","family":"Huang","sequence":"additional","affiliation":[{"name":"Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-6029","authenticated-orcid":false,"given":"Jian-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan"},{"name":"Department of Orthopedics, Faculty of Medical School, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-9991","authenticated-orcid":false,"given":"Wen-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan"},{"name":"Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Dental Medical Devices and Materials Research Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"121228","DOI":"10.1016\/j.ijpharm.2021.121228","article-title":"Transformation of electrospun Keratin\/PVA nanofiber membranes into multilayered 3D Scaffolds: Physiochemical studies and corneal implant applications","volume":"610","author":"Jung","year":"2021","journal-title":"Int. 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