{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:03Z","timestamp":1793317443122,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technological Plan of Traditional Chinese Medicine Administration of Jiangxi Province of China","award":["2022A329"],"award-info":[{"award-number":["2022A329"]}]},{"name":"Technological Plan of Traditional Chinese Medicine Administration of Jiangxi Province of China","award":["202130519"],"award-info":[{"award-number":["202130519"]}]},{"name":"Technological Plan of Traditional Chinese Medicine Administration of Jiangxi Province of China","award":["20212BAB206072"],"award-info":[{"award-number":["20212BAB206072"]}]},{"name":"Technological Plan of Traditional Chinese Medicine Administration of Jiangxi Province of China","award":["20224BAB216078"],"award-info":[{"award-number":["20224BAB216078"]}]},{"name":"Technological Plan of Traditional Chinese Medicine Administration of Jiangxi Province of China","award":["2023CX193"],"award-info":[{"award-number":["2023CX193"]}]},{"name":"Technological Plan of Health Commission of Jiangxi Province of China","award":["2022A329"],"award-info":[{"award-number":["2022A329"]}]},{"name":"Technological Plan of Health Commission of Jiangxi Province of China","award":["202130519"],"award-info":[{"award-number":["202130519"]}]},{"name":"Technological Plan of Health Commission of Jiangxi Province of China","award":["20212BAB206072"],"award-info":[{"award-number":["20212BAB206072"]}]},{"name":"Technological Plan of Health Commission of Jiangxi Province of China","award":["20224BAB216078"],"award-info":[{"award-number":["20224BAB216078"]}]},{"name":"Technological Plan of Health Commission of Jiangxi Province of China","award":["2023CX193"],"award-info":[{"award-number":["2023CX193"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["2022A329"],"award-info":[{"award-number":["2022A329"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["202130519"],"award-info":[{"award-number":["202130519"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["20212BAB206072"],"award-info":[{"award-number":["20212BAB206072"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["20224BAB216078"],"award-info":[{"award-number":["20224BAB216078"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["2023CX193"],"award-info":[{"award-number":["2023CX193"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program of Nanchang University","award":["2022A329"],"award-info":[{"award-number":["2022A329"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program of Nanchang University","award":["202130519"],"award-info":[{"award-number":["202130519"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program of Nanchang University","award":["20212BAB206072"],"award-info":[{"award-number":["20212BAB206072"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program of Nanchang University","award":["20224BAB216078"],"award-info":[{"award-number":["20224BAB216078"]}]},{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program of Nanchang University","award":["2023CX193"],"award-info":[{"award-number":["2023CX193"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) are versatile drug nanocarriers with a wide spectrum of applications owing to their extensive advantages, including biodegradability, non-toxic side effects, and low immunogenicity. Among the numerous nanoparticle preparation methods available for PLGA NPs (the hydrophobic polymer), one of the most extensively utilized preparations is the sonicated-emulsified solvent evaporation method, owing to its simplicity, speed, convenience, and cost-effectiveness. Nevertheless, several factors can influence the outcomes, such as the types of concentration of the surfactants and organic solvents, as well as the volume of the aqueous phase. The objective of this article is to explore the influence of these factors on the properties of PLGA NPs and their drug release behavior following encapsulation. Herein, PLGA NPs were fabricated using bovine serum albumin (BSA) as a surfactant to investigate the impact of influencing factors, including different water-soluble organic solvents such as propylene carbonate (PC), ethyl acetate (PA), and dichloromethane (DCM). Notably, the size of PLGA NPs was smaller in the EA group compared to that in the DCM group. Moreover, PLGA NPs showed excellent stability, ascribed to the presence of the BSA surfactant. Furthermore, PLGA NPs were co-loaded with varying concentrations of hydrophilic drugs (doxorubicin hydrochloride) and hydrophobic drugs (celecoxib), and exhibited pH-sensitive drug release behavior in PBS with pH 7.4 and pH 5.5.<\/jats:p>","DOI":"10.3390\/polym16070865","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:58:02Z","timestamp":1711105082000},"page":"865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Effect of Different Factors on Poly(lactic-co-glycolic acid) Nanoparticle Properties and Drug Release Behaviors When Co-Loaded with Hydrophilic and Hydrophobic Drugs"],"prefix":"10.3390","volume":"16","author":[{"given":"Lianguo","family":"Wang","sequence":"first","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Atae","family":"Mustafa Mahayyudin","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang 330006, China"},{"name":"Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3389\/fphar.2018.01260","article-title":"PLGA-Based Nanoparticles in Cancer Treatment","volume":"9","author":"Rezvantalab","year":"2018","journal-title":"Front. 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