{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:18:17Z","timestamp":1785806297589,"version":"3.56.0"},"reference-count":86,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State Assignment of the Russian Federation","award":["075-00224-24-01"],"award-info":[{"award-number":["075-00224-24-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Polyelectrolyte microcapsules (PMC) based on polyallylamine and polystyrene sulfonate are utilized in various fields of human activity, including medicine, textiles, and the food industry, among others. However, characteristics such as microcapsule size, shell thickness, and pore size are not sufficiently studied and systematized, even though they determine the possibility of using microcapsules in applied tasks. The aim of this review is to identify general patterns and gaps in the study of the morphology of polyelectrolyte microcapsules obtained by the alternate adsorption of polystyrene sulfonate and polyallylamine on different solid cores. First and foremost, it was found that the morphological change in polyelectrolyte microcapsules formed on different cores exhibits a significant difference in response to varying stimuli. Factors such as ionic strength, the acidity of the medium, and temperature have different effects on the size of the microcapsules, the thickness of their shells, and the number and size of their pores. At present, the morphology of the microcapsules formed on the melamine formaldehyde core has been most studied, while the morphology of microcapsules formed on other types of cores is scarcely studied. In addition, modern methods of nanoscale system analysis will allow for an objective assessment of PMC characteristics and provide a fresh perspective on the subject of research.<\/jats:p>","DOI":"10.3390\/polym16111521","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T07:38:39Z","timestamp":1716881919000},"page":"1521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of Polyallylamine\/Polystyrene Sulfonate Polyelectrolyte Microcapsules Formed on Solid Cores: Morphology"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-9635","authenticated-orcid":false,"given":"Aleksandr L.","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-2042","authenticated-orcid":false,"given":"Egor V.","family":"Musin","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri S.","family":"Chebykin","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-9537","authenticated-orcid":false,"given":"Sergey A.","family":"Tikhonenko","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya St., 3, 142290 Puschino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/(SICI)1099-1581(1998100)9:10\/11<759::AID-PAT846>3.0.CO;2-Q","article-title":"Stepwise polyelectrolyte assembly on particle surfaces: A novel approach to colloid design","volume":"9","author":"Sukhorukov","year":"1998","journal-title":"Polym. Adv. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0927-7757(98)00213-1","article-title":"Layer-by-layer self assembly of polyelectrolytes on colloidal particles","volume":"137","author":"Sukhorukov","year":"1998","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1021\/ma048474w","article-title":"Drastic Morphological Modification of Polyelectrolyte Microcapsules Induced by High Temperature","volume":"37","author":"Shchukin","year":"2004","journal-title":"Macromolecules"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1002\/1521-3773(20021018)41:20<3789::AID-ANIE3789>3.0.CO;2-D","article-title":"Spontaneous Deposition of Water-Soluble Substances into Microcapsules: Phenomenon, Mechanism, and Application","volume":"41","author":"Gao","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1140\/epje\/i2003-10056-0","article-title":"Elastic properties of polyelectrolyte capsules studied by atomic-force microscopy and RICM","volume":"12","author":"Dubreuil","year":"2003","journal-title":"Eur. Phys. J. E"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/macp.200300004","article-title":"Comparative Analysis of Hollow and Filled Polyelectrolyte Microcapsules Templated on Melamine Formaldehyde and Carbonate Cores","volume":"205","author":"Sukhorukov","year":"2004","journal-title":"Macromol. Chem. Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"18250","DOI":"10.1021\/jp052208i","article-title":"Thermal Behavior of Polyelectrolyte Multilayer Microcapsules. 1. The Effect of Odd and Even Layer Number","volume":"109","author":"Shchukin","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12736","DOI":"10.1039\/c1cc13453a","article-title":"Encapsulation, release and applications of LbL polyelectrolyte multilayer capsules","volume":"47","author":"Skirtach","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/smll.200600441","article-title":"Ultrasound-Triggered Release from Multilayered Capsules","volume":"3","author":"Skirtach","year":"2007","journal-title":"Small"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1134\/S1027451010010155","article-title":"Formation and destruction of polyelectrolyte microcapsules modified by rhodamine 6G","volume":"4","author":"Marchenko","year":"2010","journal-title":"J. Surf. Investig. X-ray Synchrotron Neutron Tech."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Amin, M.K., and Boateng, J.S. (2022). Enhancing Stability and Mucoadhesive Properties of Chitosan Nanoparticles by Surface Modification with Sodium Alginate and Polyethylene Glycol for Potential Oral Mucosa Vaccine Delivery. Mar. Drugs, 20.","DOI":"10.3390\/md20030156"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1134\/S1063774511050051","article-title":"A New Approach to Modification of Polyelectrolyte Capsule Shells by Magnetite Nanoparticles","volume":"56","author":"Bukreeva","year":"2011","journal-title":"Crystallogr. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Reshetilov, A., Plekhanova, Y., Tarasov, S., Tikhonenko, S., Dubrovsky, A., Kim, A., Kashin, V., Machulin, A., Wang, G.J., and Kolesov, V. (2019). Bioelectrochemical properties of enzyme-containing multilayer polyelectrolyte microcapsules modified with multiwalled carbon nanotubes. Membranes, 9.","DOI":"10.3390\/membranes9040053"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1021\/nn3010476","article-title":"Targeting cancer cells: Controlling the binding and internalization of antibody-functionalized capsules","volume":"6","author":"Johnston","year":"2012","journal-title":"ACS Nano"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cis.2004.07.006","article-title":"Polyelectrolyte multilayer capsules as vehicles with tunable permeability","volume":"111","author":"Antipov","year":"2004","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00216-012-6381-0","article-title":"Chemosensors and biosensors based on polyelectrolyte microcapsules containing fluorescent dyes and enzymes","volume":"405","author":"Kazakova","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14011","DOI":"10.1021\/la900971h","article-title":"Encapsulation of Bacterial Spores in Nanoorganized Polyelectrolyte Shells","volume":"25","author":"Balkundi","year":"2009","journal-title":"Langmuir"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Musin, E.V., Kim, A.L., Dubrovskii, A.V., Kudryashova, E.B., and Tikhonenko, S.A. (2020). Decapsulation of dextran by destruction of polyelectrolyte microcapsule nanoscale shell by bacillus subtilis bacteria. Nanomaterials, 10.","DOI":"10.3390\/nano10010012"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/1439-2054(20011001)286:10<591::AID-MAME591>3.0.CO;2-I","article-title":"Permeability of Ibuprofen in Various Polyelectrolyte Multilayers","volume":"286","author":"Qiu","year":"2001","journal-title":"Macromol. Mater. Eng."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1021\/nl0100015","article-title":"Urease Encapsulation in Nanoorganized Microshells","volume":"1","author":"Lvov","year":"2001","journal-title":"Nano Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/bit.1184","article-title":"Encapsulation of proteins by layer-by-layer adsorption of polyelectrolytes onto protein aggregates: Factors regulating the protein release","volume":"76","author":"Balabushevitch","year":"2001","journal-title":"Biotechnol. Bioeng."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/jp026927y","article-title":"Deformation Properties of Nonadhesive Polyelectrolyte Microcapsules Studied with the Atomic Force Microscope","volume":"107","author":"Lulevich","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/1439-2054(20010601)286:6<355::AID-MAME355>3.0.CO;2-9","article-title":"The Decomposition Process of Melamine Formaldehyde Cores: The Key Step in the Fabrication of Ultrathin Polyelectrolyte Multilayer Capsules","volume":"286","author":"Gao","year":"2001","journal-title":"Macromol. Mater. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kim, A.L., Musin, E.V., Oripova, M.J., Oshchepkova, Y.I., Salikhov, S.I., and Tikhonenko, S.A. (2023). Polyelectrolyte Microcapsules\u2014A Promising Target Delivery System of Amiodarone with the Possibility of Prolonged Release. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043348"},{"key":"ref_25","first-page":"88","article-title":"Polyelectrolyte microcapsules as the systems for delivery of biologically active substances","volume":"2","author":"Borodina","year":"2008","journal-title":"Biochem. Suppl. Ser. B Biomed. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/smll.200900809","article-title":"Controlled Intracellular Release of Peptides from Microcapsules Enhances Antigen Presentation on MHC Class I Molecules","volume":"5","author":"Palankar","year":"2009","journal-title":"Small"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1166\/jnn.2010.2571","article-title":"Encapsulation and Release of Corrosion Inhibitors into Titania Nanocontainers","volume":"10","author":"Kartsonakis","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2116\/analsci.19P131","article-title":"Comparative study of electrochemical sensors based on enzyme immobilized into polyelectrolyte microcapsules and into chitosan gel","volume":"35","author":"Plekhanova","year":"2019","journal-title":"Anal. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pastorino, L., Dellacasa, E., Noor, M.R., Soulimane, T., Bianchini, P., D\u2019Autilia, F., Antipov, A., Diaspro, A., Tofail, S.A.M., and Ruggiero, C. (2014). Multilayered Polyelectrolyte Microcapsules: Interaction with the Enzyme Cytochrome C Oxidase. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112192"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70780B","DOI":"10.1117\/12.794157","article-title":"High-resolution tomographic imaging of microvessels","volume":"Volume 7078","author":"Stock","year":"2008","journal-title":"Developments in X-ray Tomography VI"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.matsci.36.011205.123733","article-title":"Mechanical Behavior and Characterization of Microcapsules","volume":"36","author":"Vinogradova","year":"2006","journal-title":"Annu. Rev. Mater. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"12905","DOI":"10.1021\/jp055258w","article-title":"Equilibrium Distribution of Permeants in Polyelectrolyte Microcapsules Filled with Negatively Charged Polyelectrolyte: The Influence of Ionic Strength and Solvent Polarity","volume":"110","author":"Tong","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1021\/ma034516p","article-title":"Base\u2013Acid Equilibria in Polyelectrolyte Systems: From Weak Polyelectrolytes to Interpolyelectrolyte Complexes and Multilayered Polyelectrolyte Shells","volume":"36","author":"Petrov","year":"2003","journal-title":"Macromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0927-7757(03)00195-X","article-title":"Carbonate microparticles for hollow polyelectrolyte capsules fabrication","volume":"224","author":"Antipov","year":"2003","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.colsurfb.2008.12.022","article-title":"Polyelectrolyte microcapsule interactions with cells in two- and three-dimensional culture","volume":"70","author":"An","year":"2009","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1002\/adfm.200700416","article-title":"In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules","volume":"17","author":"Cuvelier","year":"2007","journal-title":"Adv. Funct. Mater."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Verkhovskii, R., Ermakov, A., Sindeeva, O., Prikhozhdenko, E., Kozlova, A., Grishin, O., Makarkin, M., Gorin, D., and Bratashov, D. (2021). Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13122147"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/nn3046117","article-title":"Shape-Dependent Cellular Processing of Polyelectrolyte Capsules","volume":"7","author":"Shimoni","year":"2013","journal-title":"ACS Nano"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.porgcoat.2012.08.006","article-title":"Self-healing ability and adhesion strength of capsule embedded coatings\u2014Micro and nano sized capsules containing linseed oil","volume":"75","author":"Peikari","year":"2012","journal-title":"Prog. Org. Coat."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kalenichenko, D., Nifontova, G., Karaulov, A., Sukhanova, A., and Nabiev, I. (2021). Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment. Nanomaterials, 11.","DOI":"10.3390\/nano11113055"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/la702873f","article-title":"New Method for Fabrication of Loaded Micro- and Nanocontainers: Emulsion Encapsulation by Polyelectrolyte Layer-by-Layer Deposition on the Liquid Core","volume":"24","author":"Grigoriev","year":"2008","journal-title":"Langmuir"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1021\/la036177z","article-title":"Matrix Polyelectrolyte Microcapsules: New System for Macromolecule Encapsulation","volume":"20","author":"Volodkin","year":"2004","journal-title":"Langmuir"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"012156","DOI":"10.1088\/1742-6596\/946\/1\/012156","article-title":"Changes in the surface structure of melamine-formaldehyde particles in complex plasma","volume":"946","author":"Karasev","year":"2018","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s11671-016-1261-8","article-title":"Dispersion Polymerization of Polystyrene Particles Using Alcohol as Reaction Medium","volume":"11","author":"Cho","year":"2016","journal-title":"Nanoscale Res. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1002\/anie.200300568","article-title":"Tailor-Made Polyelectrolyte Microcapsules: From Multilayers to Smart Containers","volume":"43","author":"Peyratout","year":"2004","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1021\/la047388m","article-title":"Salt Softening of Polyelectrolyte Multilayer Capsules","volume":"21","author":"Heuvingh","year":"2005","journal-title":"Langmuir"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cis.2014.01.022","article-title":"Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules","volume":"207","author":"Parakhonskiy","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1021\/la049706n","article-title":"pH-Responsive Properties of Hollow Polyelectrolyte Microcapsules Templated on Various Cores","volume":"20","author":"Sukhorukov","year":"2004","journal-title":"Langmuir"},{"key":"ref_49","first-page":"850","article-title":"An electron microscopy study of the structure of polyelectrolyte microcapsules containing protein and containing no protein","volume":"52","author":"Kazakova","year":"2007","journal-title":"Biofizika"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1039\/B402617A","article-title":"Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds","volume":"14","author":"Sukhorukov","year":"2004","journal-title":"J. Mater. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.colsurfa.2005.05.017","article-title":"(PAH\/PSS)5 microcapsules templated on silica core: Encapsulation of anticancer drug DOX and controlled release study","volume":"264","author":"Yang","year":"2005","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1021\/jp002184+","article-title":"Sustained release properties of polyelectrolyte multilayer capsules","volume":"105","author":"Antipov","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1021\/ma0350213","article-title":"Young\u2019s Modulus of Polyelectrolyte Multilayers from Microcapsule Swelling","volume":"37","author":"Vinogradova","year":"2004","journal-title":"Macromolecules"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/1521-3927(20010101)22:1<44::AID-MARC44>3.0.CO;2-U","article-title":"pH-controlled macromolecule encapsulation in and release from polyelectrolyte multilayer nanocapsules","volume":"22","author":"Sukhorukov","year":"2001","journal-title":"Macromol. Rapid Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13159","DOI":"10.1021\/jp0511092","article-title":"Charge-Controlled Permeability of Polyelectrolyte Microcapsules","volume":"109","author":"Tong","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.colsurfa.2009.04.024","article-title":"Polyelectrolyte microcapsules and coated CaCO3 particles as fluorescence activated sensors in flowmetry","volume":"342","author":"Riebentanz","year":"2009","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1039\/c2sm25971k","article-title":"pH- and salt-mediated response of layer-by-layer assembled PSS\/PAH microcapsules: Fusion and polymer exchange","volume":"8","author":"Pechenkin","year":"2012","journal-title":"Soft Matter"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1039\/b507848b","article-title":"Influence of different salts on micro-sized polyelectrolyte hollow capsules","volume":"15","author":"Georgieva","year":"2005","journal-title":"J. Mater. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jcis.2004.10.040","article-title":"Salt softening of polyelectrolyte multilayer microcapsules","volume":"284","author":"Lebedeva","year":"2005","journal-title":"J. Colloid Interface Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1021\/cm050103m","article-title":"Influence of Shell Structure on Stability, Integrity, and Mesh Size of Polyelectrolyte Capsules: Mechanism and Strategy for Improved Preparation","volume":"17","author":"Dong","year":"2005","journal-title":"Chem. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8066","DOI":"10.1021\/ma051059z","article-title":"Superswollen Ultrasoft Polyelectrolyte Microcapsules","volume":"38","author":"Kim","year":"2005","journal-title":"Macromolecules"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s101890170082","article-title":"Shrinking of ultrathin polyelectrolyte multilayer capsules upon annealing: A confocal laser scanning microscopy and scanning force microscopy study","volume":"5","author":"Leporatti","year":"2001","journal-title":"Eur. Phys. J. E"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/cphc.200600167","article-title":"Behavior of Temperature-Sensitive PNIPAM Confined in Polyelectrolyte Capsules","volume":"7","author":"Prevot","year":"2006","journal-title":"ChemPhysChem"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1021\/la047008x","article-title":"Sustained Release Control via Photo-Cross-Linking of Polyelectrolyte Layer-by-Layer Hollow Capsules","volume":"21","author":"Park","year":"2005","journal-title":"Langmuir"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1134\/S0036024406100281","article-title":"Influence of the temperature on polyelectrolyte microcapsules: Light scattering and confocal microscopy data","volume":"80","author":"Dubrovskii","year":"2006","journal-title":"Russ. J. Phys. Chem. A"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s101890170083","article-title":"Elasticity of hollow polyelectrolyte capsules prepared by the layer-by-layer technique","volume":"5","author":"Gao","year":"2001","journal-title":"Eur. Phys. J. E"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1039\/B810363A","article-title":"Polyelectrolyte multilayer hollow capsules studied by small-angle neutron scattering (SANS)","volume":"5","author":"Leporatti","year":"2009","journal-title":"Soft Matter"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0927-7757(01)00537-4","article-title":"Polyelectrolyte multilayer capsules templated on biological cells: Core oxidation influences layer chemistry","volume":"183\u2013185","author":"Moya","year":"2001","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/1616-5195(20010701)1:5<209::AID-MABI209>3.0.CO;2-Y","article-title":"Entrapment of\u03b1-Chymotrypsin into Hollow Polyelectrolyte Microcapsules","volume":"1","author":"Tiourina","year":"2001","journal-title":"Macromol. Biosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1021\/ci050192n","article-title":"Entrapment of a Weak Polyanion and H+\/Na+ Exchange in Confined Polyelectrolyte Microcapsules","volume":"45","author":"Brumen","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1039\/C5SM01430A","article-title":"Nanomechanics of layer-by-layer polyelectrolyte complexes: A manifestation of ionic cross-links and fixed charges","volume":"12","author":"Han","year":"2016","journal-title":"Soft Matter"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/1521-4095(200109)13:17<1324::AID-ADMA1324>3.0.CO;2-L","article-title":"Smart Micro- and Nanocontainers for Storage, Transport, and Release","volume":"13","author":"Ibarz","year":"2001","journal-title":"Adv. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/bm010164n","article-title":"Permeation of Macromolecules into Polyelectrolyte Microcapsules","volume":"3","author":"Georgieva","year":"2002","journal-title":"Biomacromolecules"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1021\/cm011300y","article-title":"Controlled Permeability of Polyelectrolyte Capsules via Defined Annealing","volume":"14","author":"Ibarz","year":"2002","journal-title":"Chem. Mater."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1021\/ma050493y","article-title":"Effect of Organic Solvent on the Permeability and Stiffness of Polyelectrolyte Multilayer Microcapsules","volume":"38","author":"Kim","year":"2005","journal-title":"Macromolecules"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1021\/la0258603","article-title":"SANS Studies of Polyelectrolyte Multilayers on Colloidal Templates","volume":"18","author":"Leporatti","year":"2002","journal-title":"Langmuir"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1021\/jp049465s","article-title":"pH-Controlled Swelling of Polyelectrolyte Multilayer Microcapsules","volume":"108","author":"Kim","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1039\/c0sm00781a","article-title":"Thermal softening of superswollen polyelectrolyte microcapsules","volume":"7","author":"Kim","year":"2011","journal-title":"Soft Matter"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/macp.200350033","article-title":"Thermosensitive Hollow Capsules Based on Thermoresponsive Polyelectrolytes","volume":"204","author":"Glinel","year":"2003","journal-title":"Macromol. Chem. Phys."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Dubrovskii, A.V., Berezhnov, A.V., Kim, A.L., and Tikhonenko, S.A. (2023). Behaviour of FITC-Labeled Polyallylamine in Polyelectrolyte Microcapsules. Polymers, 15.","DOI":"10.3390\/polym15163330"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/00914037.2018.1429436","article-title":"Destruction of shells and release of a protein from microcapsules consisting of non-biodegradable polyelectrolytes","volume":"68","author":"Dubrovskii","year":"2019","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Musin, E.V., Kim, A.L., and Tikhonenko, S.A. (2020). Destruction of polyelectrolyte microcapsules formed on CaCO3 microparticles and the release of a protein included by the adsorption method. Polymers, 12.","DOI":"10.3390\/polym12030520"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"113832","DOI":"10.1016\/j.sna.2022.113832","article-title":"Environmental noise reduction for tunable resistive pulse sensing of extracellular vesicles","volume":"346","author":"Ejjigu","year":"2022","journal-title":"Sens. Actuators A Phys."},{"key":"ref_84","unstructured":"Kirk, K.A., Luitel, T., Narouei, F.H., and Andreescu, S. (2020). Nanoparticles in Biology and Medicine. Methods in Molecular Biology, Humana."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1039\/D0JA00020E","article-title":"Porosity determination of nano- and sub-micron particles by single particle inductively coupled plasma mass spectrometry","volume":"35","author":"Ungor","year":"2020","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1021\/acsanm.8b02051","article-title":"Advanced Characterization Techniques for Evaluating Porosity, Nanopore Tortuosity, and Electrical Connectivity at the Single-Nanoparticle Level","volume":"2","author":"Glasscott","year":"2019","journal-title":"ACS Appl. Nano Mater."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/11\/1521\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:49:31Z","timestamp":1760107771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/11\/1521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":86,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["polym16111521"],"URL":"https:\/\/doi.org\/10.3390\/polym16111521","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]}}}