{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:03:07Z","timestamp":1787029387513,"version":"build-2736575974"},"reference-count":108,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Today, polymeric drug delivery systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with sodium taurinate (PKT) or potassium sulfanilate (PKSK) and employed as carriers for Vancomycin against bacterial infections. Modified PKs were easily prepared by the Paal\u2013Knorr reaction and loaded with Vancomycin at a variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM, and elemental analysis. Antimicrobial activity was tested against Gram-positive Staphylococcus aureus ATCC 25923 and correlated to the different pHs used for its loading (between 2.3 and 8.8). In particular, the minimum inhibitory concentrations achieved with PKT and PKSK loaded with Vancomycin were similar, at 0.23 \u03bcg\/mL and 0.24 \u03bcg\/mL, respectively, i.e., six times lower than that with Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS.<\/jats:p>","DOI":"10.3390\/polym16131890","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T05:08:34Z","timestamp":1719896914000},"page":"1890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones"],"prefix":"10.3390","volume":"16","author":[{"given":"Rachele","family":"Rampazzo","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"},{"name":"Department of Architecture and Industrial Design, University of Campania \u201cLuigi Vanvitelli\u201d, 81031 Aversa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-9952","authenticated-orcid":false,"given":"Andrea","family":"Vavasori","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Ronchin","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Riello","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-692X","authenticated-orcid":false,"given":"Gloria","family":"Saorin","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-210X","authenticated-orcid":false,"given":"Valentina","family":"Beghetto","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, University Ca\u2019 Foscari of Venice, Via Torino5 155, 30172 Venice, Italy"},{"name":"Crossing S.r.l., Viale della Repubblica 193\/b, 31100 Treviso, Italy"},{"name":"Consorzio Interuniversitario per le Reattivit\u00e0 Chimiche e la Catalisi (CIRCC), Via C. 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