{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:43:23Z","timestamp":1783561403917,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Human bone is composed of organic and inorganic composite materials, contributing to its unique strength and flexibility. Hydroxyapatite (HAP) has been extensively studied for bone regeneration, due to its excellent bioactivity and osteoconductivity, which makes it a highly valuable biomaterial for tissue engineering applications. For better therapeutic effects, composite nanofibers containing polyvinyl alcohol (PVA) and polyvinyl Pyrrolidone (PVP) were developed using an electrospinning technique in this study. Herein, hydroxyapatite (a major inorganic constituent of native bone) concentrations varying from 5 to 25% were reinforced in the composite, which could alter the properties of nanofibers. The as-prepared composite nanofibers were characterized by SEM, TEM, XRD, and FT-IR spectroscopy, and a bioactivity assessment was performed in simulated body fluid (SBF). The ICP-OES analysis was used to determine the concentration of Ca2+ and PO42\u2013 ions before and after SBF immersion. To optimize the material selection, the nanofibrous scaffolds were subjected to cell proliferation and differentiation in MG-63 osteoblast cell lines, but no significant toxicity was observed. In conclusion, HAP-PVA-PVP scaffolds exhibit unique physical and chemical properties and ideal biocompatibility, with great promise to serve as effective candidates for bone tissue applications.<\/jats:p>","DOI":"10.3390\/polym16142023","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:12:49Z","timestamp":1721128369000},"page":"2023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optimization of Biologically Inspired Electrospun Scaffold for Effective Use in Bone Regenerative Applications"],"prefix":"10.3390","volume":"16","author":[{"given":"Susai Mani Mary","family":"Stella","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugapandian","family":"Rama","sequence":"additional","affiliation":[{"name":"Centre for Nonlinear Systems, Chennai Institute of Technology, Chennai 600069, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-8322","authenticated-orcid":false,"given":"T. M.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Guindy Campus, University of Madras, Chennai 600025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-4277","authenticated-orcid":false,"given":"Uthirapathy","family":"Vijayalakshmi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.colsurfb.2011.03.038","article-title":"Preparation and characterization of composite nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiation of mesenchymal stem cells","volume":"86","author":"Chen","year":"2011","journal-title":"Colloids Surf. 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