{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:45:31Z","timestamp":1793285131264,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Incheon National University","award":["2023 (2023-0133)"],"award-info":[{"award-number":["2023 (2023-0133)"]}]},{"name":"Incheon National University","award":["RS-2024-00399300"],"award-info":[{"award-number":["RS-2024-00399300"]}]},{"name":"Ministry of Science and ICT through the National Research Foundation of Korea","award":["2023 (2023-0133)"],"award-info":[{"award-number":["2023 (2023-0133)"]}]},{"name":"Ministry of Science and ICT through the National Research Foundation of Korea","award":["RS-2024-00399300"],"award-info":[{"award-number":["RS-2024-00399300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Organic electrochemical transistors (OECTs) have attracted considerable interest in the context of wearable and implantable biosensors due to their remarkable signal amplification combined with seamless integration into biological systems. These properties underlie OECTs\u2019 potential utility across a range of bioelectronic applications. One of the main challenges to their practical applications is the mechanical limitation of PEDOT:PSS, the most typical conductive polymer used as a channel layer, when the OECTs are applied to implantable and stretchable bioelectronics. In this work, we address this critical issue by employing natural rubber latex (NRL) as an additive in PEDOT:PSS to improve flexibility and stretchability of the OECT channels. Although the inclusion of NRL leads to a decrease in transconductance, mainly due to a reduced carrier mobility from 0.3 to 0.1 cm2\/V\u00b7s, the OECTs maintain satisfactory transconductance, exceeding 5 mS. Furthermore, it is demonstrated that the OECTs exhibit excellent mechanical stability while maintaining their performance even after 100 repetitive bending cycles. This work, therefore, suggests that the NRL\/PEDOT:PSS composite film can be deployed for wearable\/implantable applications, where high mechanical stability is needed. This finding opens up new avenues for practical use of OECTs in more robust and versatile wearable and implantable biosensors.<\/jats:p>","DOI":"10.3390\/polym16162287","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T10:54:54Z","timestamp":1723546494000},"page":"2287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Highly Stable Flexible Organic Electrochemical Transistors with Natural Rubber Latex Additives"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-0751","authenticated-orcid":false,"given":"Miguel Henrique","family":"Boratto","sequence":"first","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-8273","authenticated-orcid":false,"given":"Carlos F. O.","family":"Graeff","sequence":"additional","affiliation":[{"name":"Physics and Meteorology Department, S\u00e3o Paulo State University (UNESP), Bauru 17033-360, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-5466","authenticated-orcid":false,"given":"Sanggil","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea"},{"name":"Center for Brain-Machine Interface, Incheon National University, Incheon 22012, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1600247","DOI":"10.1002\/advs.201600247","article-title":"Voltage amplifier based on organic electrochemical transistor","volume":"4","author":"Braendlein","year":"2017","journal-title":"Adv. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"053301","DOI":"10.1063\/5.0039345","article-title":"Expanding the understanding of organic electrochemical transistor function","volume":"118","author":"Nissa","year":"2021","journal-title":"Appl. Phys. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s12274-021-3856-3","article-title":"Flexible organic electrochemical transistors for chemical and biological sensing","volume":"15","author":"Wang","year":"2022","journal-title":"Nano Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"012005","DOI":"10.1088\/2631-7990\/acfd69","article-title":"Device design principles and bioelectronic applications for flexible organic electrochemical transistors","volume":"6","author":"Gao","year":"2024","journal-title":"Int. J. Extrem. Manuf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/ncomms2573","article-title":"In vivo recordings of brain activity using organic transistors","volume":"4","author":"Khodagholy","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1002\/adma.201400263","article-title":"Electrocardiographic recording with conformable organic electrochemical transistor fabricated on resorbable bioscaffold","volume":"26","author":"Campana","year":"2014","journal-title":"Adv. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/adhm.201400356","article-title":"Organic electrochemical transistors for clinical applications","volume":"4","author":"Leleux","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2301782","DOI":"10.1002\/adma.202301782","article-title":"Tunable organic active neural probe enabling near-sensor signal processing","volume":"35","author":"Lee","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/adma.201404378","article-title":"Flexible organic electrochemical transistors for highly selective enzyme biosensors and used for saliva testing","volume":"27","author":"Liao","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/adhm.201600494","article-title":"Organic transistors arrays integrated with finger-powered microfluidics for multianalyte saliva testing","volume":"5","author":"Pappa","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2004790","DOI":"10.1002\/adma.202004790","article-title":"Microfabricated ion-selective transistors with fast and super-Nernstian response","volume":"32","author":"Han","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Guo, K., Wustoni, S., Koklu, A., D\u00edas-Galicia, E., Moser, M., Hama, A., Alqahtani, A.A., Ahmad, A.N., Alhamlan, F.S., and Shuaib, M. (2021). Rapid single-molecule detection of COVID-19 and MERs antigens via nanobody-functionalized organic electrochemical transistors. Nat. Biomed. Eng., 5.","DOI":"10.1038\/s41551-021-00734-9"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eadd4111","DOI":"10.1126\/sciadv.add4111","article-title":"Pulsed transistor operation enables miniaturization of electrochemical aptamer-based sensors","volume":"8","author":"Bidinger","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2100853","DOI":"10.1002\/aelm.202100853","article-title":"Printed organic electrochemical transistors for detecting nutrients in whole plant sap","volume":"8","author":"Strand","year":"2022","journal-title":"Adv. Electron. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1002\/adma.201503674","article-title":"Neuromorphic functions in PEDOT:PSS organic electrochemical transistors","volume":"27","author":"Gkoupidenis","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nmat4856","article-title":"A non-volatile organic electrochemical device as a low-voltage artificial synapse for neuromorphic computing","volume":"16","author":"Burgt","year":"2017","journal-title":"Nat. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41928-018-0103-3","article-title":"Organic electronics for neuromorphic computing","volume":"1","author":"Burgt","year":"2018","journal-title":"Nat. Electron."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2101186","DOI":"10.1002\/aelm.202101186","article-title":"Correlation between transient response and neuromorphic behavior in organic electrochemical transistors","volume":"8","author":"Yamamoto","year":"2022","journal-title":"Adv. Electron. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1002\/adma.201303080","article-title":"Organic electrochemical transistors with maximum transconductance at zero gate bias","volume":"25","author":"Rivnay","year":"2013","journal-title":"Adv. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/ncomms3133","article-title":"High transconductance organic electrochemical transistors","volume":"4","author":"Khodagholy","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1400251","DOI":"10.1126\/sciadv.1400251","article-title":"High-performance transistors for bioelectronics through tuning of channel thickness","volume":"1","author":"Rivnay","year":"2015","journal-title":"Sci. Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101673","DOI":"10.1016\/j.xcrp.2023.101673","article-title":"Flexible organic electrochemical transistors for bioelectronics","volume":"4","author":"Zhao","year":"2023","journal-title":"Cell Rep. Phys. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1806133","DOI":"10.1002\/adma.201806133","article-title":"Stretchable conductive polymers and composites based on PEDOT and PEDOT:PSS","volume":"31","author":"Kayser","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41528-023-00245-4","article-title":"Fully 3D-printed organic electrochemical transistors","volume":"7","author":"Masseti","year":"2023","journal-title":"npj Flex. Electron."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1021\/acsami.3c14961","article-title":"Additive blending effects on PEDOT:PSS composite films for wearable organic electrochemical transistors","volume":"16","author":"Tseng","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121107","DOI":"10.1063\/5.0017936","article-title":"Flexible conductive blend of natural rubber latex with PEDOT:PSS","volume":"8","author":"Boratto","year":"2020","journal-title":"APL Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105451","DOI":"10.1016\/j.orgel.2019.105451","article-title":"A simple strategy for high stretchable, flexible and conductive polymer films based on PEDOT:PSS-PDMS blends","volume":"76","author":"Luo","year":"2020","journal-title":"Org. Electron."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"112126","DOI":"10.1016\/j.msec.2021.112126","article-title":"Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis","volume":"126","author":"Guerra","year":"2022","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s10854-023-10911-y","article-title":"Effects of organic additives on film characteristics of flexible PEDOT:PSS\/latex","volume":"34","author":"Silva","year":"2022","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1021\/acsami.1c00879","article-title":"Stretchable and healable conductive elastomer based on PEDOT:PSS\/Natural rubber for self-powered temperature and strain sensing","volume":"13","author":"Yang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2301018","DOI":"10.1002\/adem.202301018","article-title":"PEDOT:PSS\/Natural rubber latex inks for screen-printing multifunctional wearable strain-humidity sensors","volume":"25","author":"Ren","year":"2023","journal-title":"Adv. Eng. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"073302","DOI":"10.1063\/5.0079011","article-title":"Highly stable PEDOT:PSS electrochemical transistors","volume":"120","author":"Bidinger","year":"2021","journal-title":"Appl. Phys. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"043301","DOI":"10.1063\/1.4906872","article-title":"Organic electrochemical transistors for cell-based impedance sensing","volume":"106","author":"Rivnay","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1038\/s41467-017-01812-w","article-title":"Benchmarking organic mixed conductors for transistors","volume":"8","author":"Inal","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.matt.2023.12.021","article-title":"Electrostatic self-assembly yields a structurally stabilized PEDOT:PSS with efficient mixed transport and high-performance OECTs","volume":"7","author":"Taussig","year":"2024","journal-title":"Matter"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1039\/c3tb20451k","article-title":"Highly selective and sensitive glucose sensors based on organic electrochemical transistors with graphene modified gate electrodes","volume":"1","author":"Liao","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1038\/natrevmats.2017.86","article-title":"Organic electrochemical transistors","volume":"3","author":"Rivnay","year":"2018","journal-title":"Nat. Rev. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1002\/adma.201500218","article-title":"Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes","volume":"27","author":"Williamson","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101966","DOI":"10.1016\/j.isci.2020.101966","article-title":"Diurnal in vivo xylem sap glucose and sucrose monitoring using implantable organic electrochemical transistor sensors","volume":"24","author":"Diacci","year":"2021","journal-title":"iScience"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yogev, D., Goldberg, T., Arami, A., Tejman-Yarden, S., Winkler, T.E., and Maoz, B.M. (2023). Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges. APL Bioeng., 7.","DOI":"10.1063\/5.0152290"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ferreira, P.A.B., Araujo, M.C.M., Prado, C.M., Lima, R.A., Rodr\u00edguez, B.A.G., and Dutra, R.F. (2020). An ultrasensitive Cystatin C renal failure immunosensor based on a PPy\/CNT electrochemical capacitor grafted on interdigitated electrode. Colloids Surf. B Biointerfaces, 189.","DOI":"10.1016\/j.colsurfb.2020.110834"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100164","DOI":"10.1016\/j.snr.2023.100164","article-title":"Development of interdigitated electrode based enzyme sensor for triglyceride monitoring using engineered oxygen insensitive glycerol 3-phosphate oxidase","volume":"5","author":"Lee","year":"2023","journal-title":"Sens. Actuators Rep."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/16\/2287\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:36:02Z","timestamp":1760110562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/16\/2287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":42,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["polym16162287"],"URL":"https:\/\/doi.org\/10.3390\/polym16162287","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}