{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:30:09Z","timestamp":1791433809274,"version":"4.3.3"},"reference-count":279,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Skin, the largest organ of the human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, the repair of skin lesions is a complex and time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves the application of a dressing to protect the wound, mitigate the risk of infection, and decrease the likelihood of secondary injuries. Pursuing solutions for accelerating wound healing has resulted in groundbreaking advancements in materials science, from hydrogels and hydrocolloids to foams and micro-\/nanofibers. Noting the convenience and flexibility in design, nanofibers merit a high surface-area-to-volume ratio, controlled release of therapeutics, mimicking of the extracellular matrix, and excellent mechanical properties. Core-shell nanofibers bring even further prospects to the realm of wound dressings upon separate compartments with independent functionality, adapted release profiles of bioactive agents, and better moisture management. In this review, we highlight core-shell nanofibers for wound dressing applications featuring a survey on common materials and synthesis methods. Our discussion embodies the wound healing process, optimal wound dressing characteristics, the current organic and inorganic material repertoire for multifunctional core-shell nanofibers, and common techniques to fabricate proper coaxial structures. We also provide an overview of antibacterial nanomaterials with an emphasis on their crystalline structures, properties, and functions. We conclude with an outlook for the potential offered by core-shell nanofibers toward a more advanced design for effective wound healing.<\/jats:p>","DOI":"10.3390\/polym16172526","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:15:59Z","timestamp":1725534959000},"page":"2526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis"],"prefix":"10.3390","volume":"16","author":[{"given":"Nariman","family":"Rajabifar","sequence":"first","affiliation":[{"name":"Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), Tehran P.O. Box 15875-4413, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-9724","authenticated-orcid":false,"given":"Amir","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Persian Gulf University, Bushehr P.O. Box 75169-13817, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnoosh","family":"Afshar","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering, Islamic Azad University-Mahshahr Campus, Mahshahr P.O. Box 63511-41111, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pezhman","family":"Mosallanezhad","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), Tehran P.O. Box 15875-4413, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-7519","authenticated-orcid":false,"given":"Payam","family":"Zarrintaj","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Shahrousvand","sequence":"additional","affiliation":[{"name":"Caspian Faculty of Engineering, College of Engineering, University of Tehran, Rasht P.O. Box 43841-119, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Nazockdast","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), Tehran P.O. Box 15875-4413, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clindermatol.2006.09.003","article-title":"Advances in wound dressings","volume":"25","author":"Ovington","year":"2007","journal-title":"Clin. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dhivya, S., Padma, V.V., and Santhini, E. (2015). Wound dressings\u2014A review. BioMedicine, 5.","DOI":"10.7603\/s40681-015-0022-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/bmj.332.7544.777","article-title":"Wound dressings","volume":"332","author":"Jones","year":"2006","journal-title":"Br. Med. J."},{"key":"ref_4","unstructured":"Paul, W. (2015). 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