{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:29:55Z","timestamp":1792546195587,"version":"4.5.0"},"reference-count":151,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82071367"],"award-info":[{"award-number":["82071367"]}]},{"name":"National Natural Science Foundation of China","award":["2021A1515220047"],"award-info":[{"award-number":["2021A1515220047"]}]},{"name":"National Natural Science Foundation of China","award":["2023A1515011135"],"award-info":[{"award-number":["2023A1515011135"]}]},{"name":"Natural Science Foundation of Guangdong Province of China","award":["82071367"],"award-info":[{"award-number":["82071367"]}]},{"name":"Natural Science Foundation of Guangdong Province of China","award":["2021A1515220047"],"award-info":[{"award-number":["2021A1515220047"]}]},{"name":"Natural Science Foundation of Guangdong Province of China","award":["2023A1515011135"],"award-info":[{"award-number":["2023A1515011135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.<\/jats:p>","DOI":"10.3390\/polym16182606","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:36:00Z","timestamp":1726472160000},"page":"2606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":262,"title":["Recent Applications of PLGA in Drug Delivery Systems"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1708-5177","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Luo","sequence":"additional","affiliation":[{"name":"International School, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Institute for Drug Control, NMPA Key Laboratory for Quality Control and Evaluation of Pharmaceutical Excipients, Guangzhou 510660, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Institute for Drug Control, NMPA Key Laboratory for Quality Control and Evaluation of Pharmaceutical Excipients, Guangzhou 510660, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-5552","authenticated-orcid":false,"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1080\/10717544.2021.1938756","article-title":"PLGA-based biodegradable microspheres in drug delivery: Recent advances in research and application","volume":"28","author":"Su","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2022.05.039","article-title":"Novel drug delivery systems and disease models for pulmonary fibrosis","volume":"348","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jconrel.2020.08.012","article-title":"Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies","volume":"327","author":"Kashkooli","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2021.11.025","article-title":"Recent advances in polymeric transdermal drug delivery systems","volume":"341","author":"Sabbagh","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jconrel.2020.09.020","article-title":"Zero-order drug delivery: State of the art and future prospects","volume":"327","author":"Laracuente","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shen, X., Li, T., Xie, X., Feng, Y., Chen, Z., Yang, H., Wu, C., Deng, S., and Liu, Y. (2020). PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00381"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rigon, L., Salvalaio, M., Pederzoli, F., Legnini, E., Duskey, J.T., D\u2019Avanzo, F., De Filippis, C., Ruozi, B., Marin, O., and Vandelli, M.A. (2019). Targeting brain disease in MPSII: Preclinical evaluation of IDS-loaded PLGA nanoparticles. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082014"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133356","DOI":"10.1016\/j.cej.2021.133356","article-title":"Thiolate poly (lactic-co-glycolic acid) nanofibers loaded with dexamethasone and ropivacaine show enhanced sustained release in the treatment of neuropathic pain through a local therapy technique","volume":"431","author":"Lee","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2000353","DOI":"10.1002\/adhm.202000353","article-title":"Modification of PLGA scaffold by MSC-derived extracellular matrix combats macrophage inflammation to initiate bone regeneration via TGF-\u03b2-induced protein","volume":"9","author":"Deng","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/acs.chemmater.2c03003","article-title":"The future of drug delivery","volume":"35","author":"Gao","year":"2023","journal-title":"Chem. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jconrel.2023.09.015","article-title":"Aqueous remote loading of setmelanotide in poly (lactic-co-glycolic acid) microspheres for long-term obesity treatment","volume":"364","author":"Wang","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1016\/j.vaccine.2017.05.094","article-title":"Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination","volume":"36","author":"Guarecuco","year":"2018","journal-title":"Vaccine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41578-021-00405-w","article-title":"Clinical translation of long-acting drug delivery formulations","volume":"7","author":"Li","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108805","DOI":"10.1016\/j.matdes.2020.108805","article-title":"Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine","volume":"193","author":"Ghitman","year":"2020","journal-title":"Mater. Des."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1295\/polymj.34.786","article-title":"Direct synthesis with melt polycondensation and microstructure analysis of poly (L-lactic acid-co-glycolic acid)","volume":"34","author":"Gao","year":"2002","journal-title":"Polym. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1039\/D0BM01421D","article-title":"Green synthesis of methoxy-poly (ethylene glycol)-block-poly (L-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo","volume":"9","author":"Giram","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_17","first-page":"3807","article-title":"Poly (d, l-lactide-co-glycolide) Surface-Anchored Biotin-Loaded Irinotecan Nanoparticles for Active Targeting of Colon Cancer","volume":"9","author":"Giram","year":"2024","journal-title":"ACS Omega"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jconrel.2020.09.042","article-title":"Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability","volume":"328","author":"Rabanel","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.3390\/ijms15033640","article-title":"An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering","volume":"15","author":"Gentile","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41529-022-00277-7","article-title":"Recent advances in biodegradable polymers for sustainable applications","volume":"6","author":"Samir","year":"2022","journal-title":"NPJ Mater. Degrad."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jconrel.2013.05.034","article-title":"The effect of lauryl capping group on protein release and degradation of poly (d, l-lactic-co-glycolic acid) particles","volume":"172","author":"Samadi","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1701035","DOI":"10.1002\/adhm.201701035","article-title":"Functionalizing PLGA and PLGA derivatives for drug delivery and tissue regeneration applications","volume":"7","author":"Martins","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_23","first-page":"346","article-title":"Poly (lactic-co-glycolic acid)-based composite bone-substitute materials","volume":"6","author":"Zhao","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_24","first-page":"485","article-title":"Functional microspheres for tissue regeneration","volume":"25","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Behera, A. (2022). Nanomaterials. Advanced Materials: An Introduction to Modern Materials Science, Springer International Publishing.","DOI":"10.1007\/978-3-030-80359-9_3"},{"key":"ref_26","first-page":"220","article-title":"Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification","volume":"8","author":"Mei","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114950","DOI":"10.1016\/j.addr.2023.114950","article-title":"Solid implantable devices for sustained drug delivery","volume":"199","author":"Magill","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102147","DOI":"10.1016\/j.nantod.2024.102147","article-title":"Rational design of polymeric micelles for targeted therapeutic delivery","volume":"55","author":"Zheng","year":"2024","journal-title":"Nano Today"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Loureiro, J.A., and Pereira, M.C. (2020). PLGA based drug carrier and pharmaceutical applications: The most recent advances. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090903"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.msec.2017.12.036","article-title":"Recent advances of PLGA micro\/nanoparticles for the delivery of biomacromolecular therapeutics","volume":"92","author":"Ding","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_31","unstructured":"Wang, Y., Qu, W., and Choi, S. (2016). FDA\u2019s regulatory science program for generic PLA\/PLGA-based drug products. Am. Pharm. Rev., 20."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"114857","DOI":"10.1016\/j.addr.2023.114857","article-title":"Long-acting PLGA microspheres: Advances in excipient and product analysis toward improved product understanding","volume":"198","author":"Wan","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108250","DOI":"10.1016\/j.cclet.2023.108250","article-title":"PLGA-based implants for sustained delivery of peptides\/proteins: Current status, challenge and perspectives","volume":"34","author":"Hu","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Alsaab, H.O., Alharbi, F.D., Alhibs, A.S., Alanazi, N.B., Alshehri, B.Y., Saleh, M.A., Alshehri, F.S., Algarni, M.A., Almugaiteeb, T., and Uddin, M.N. (2022). PLGA-based nanomedicine: History of advancement and development in clinical applications of multiple diseases. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122728"},{"key":"ref_35","unstructured":"U.S. National Library of Medicine (2024, June 08). Available online: https:\/\/www.clinicaltrials.gov\/."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hua, Y., Wang, Z., Wang, D., Lin, X., Liu, B., Zhang, H., Gao, J., and Zheng, A. (2021). Key factor study for generic long-acting PLGA microspheres based on a reverse engineering of Vivitrol\u00ae. Molecules, 26.","DOI":"10.3390\/molecules26051247"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jconrel.2023.06.016","article-title":"Mechanistic evaluation of the initial burst release of leuprolide from spray-dried PLGA microspheres","volume":"361","author":"Schutzman","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2023.05.043","article-title":"Yeast cell membrane-camouflaged PLGA nanoparticle platform for enhanced cancer therapy","volume":"359","author":"He","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kshirsagar, S.M., Shrestha, N., Kipping, T., and Banga, A.K. (2024). Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases. Eur. J. Pharm. Biopharm., 200.","DOI":"10.1016\/j.ejpb.2024.114346"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Palanikumar, L., Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N., and Magzoub, M. (2020). pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol., 3.","DOI":"10.1038\/s42003-020-0817-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100831","DOI":"10.1016\/j.ajps.2023.100831","article-title":"Dual pH and microbial-sensitive galactosylated polymeric nanocargoes for multi-level targeting to combat ulcerative colitis","volume":"18","author":"Zeeshan","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1021\/acsnano.3c06019","article-title":"Stimuli-responsive polymer-based nanosystems for cancer theranostics","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2023.08.042","article-title":"Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions","volume":"362","author":"Braet","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lee, H.Y., Kim, D.S., Hwang, G.Y., Lee, J.K., Lee, H.L., Jung, J.W., Hwang, S.Y., Baek, S.W., lip Yoon, S., and Ha, Y. (2023). Multi-modulation of immune-inflammatory response using bioactive molecule-integrated PLGA composite for spinal fusion. Mater. Today Bio, 19.","DOI":"10.1016\/j.mtbio.2023.100611"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Watcharadulyarat, N., Rattanatayarom, M., Ruangsawasdi, N., and Patikarnmonthon, N. (2023). PEG\u2013PLGA nanoparticles for encapsulating ciprofloxacin. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-27500-y"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Giacon, N., Lo Cascio, E., Pennacchietti, V., De Maio, F., Santarelli, G., Sibilia, D., Tiberio, F., Sanguinetti, M., Lattanzi, W., and Toto, A. (2024). PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-63239-w"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chauhan, M., Shekhar, S., Yadav, B., Garg, V., Dutt, R., Mehata, A.K., Goswami, P., Koch, B., Muthu, M.S., and Singh, R.P. (2024). AS1411 aptamer\/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging. Biomater. Adv., 160.","DOI":"10.1016\/j.bioadv.2024.213833"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/10717544.2021.1943056","article-title":"Poly (lactic-co-glycolic acid) microsphere production based on quality by design: A review","volume":"28","author":"Hua","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00914037.2021.1985495","article-title":"Recent advances in PLGA based nanocarriers for drug delivery system: A state of the art review","volume":"72","author":"Pardeshi","year":"2023","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2022.05.014","article-title":"In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and temperature","volume":"347","author":"Wan","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2013.12.020","article-title":"Solvent induced phase inversion-based in situ forming controlled release drug delivery implants","volume":"176","author":"Thakur","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jconrel.2013.08.024","article-title":"PLGA in situ implants formed by phase inversion: Critical physicochemical parameters to modulate drug release","volume":"172","author":"Parent","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121265","DOI":"10.1016\/j.ijpharm.2021.121265","article-title":"Effect of polymer source variation on the properties and performance of risperidone microspheres","volume":"610","author":"Wan","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113912","DOI":"10.1016\/j.addr.2021.113912","article-title":"Drug release from in situ forming implants and advances in release testing","volume":"178","author":"Wang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"122948","DOI":"10.1016\/j.ijpharm.2023.122948","article-title":"Reverse engineering of Perseris and development of compositionally equivalent formulations","volume":"639","author":"Wang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Sun, X., Xu, C., Wu, G., Ye, Q., and Wang, C. (2017). Poly (lactic-co-glycolic acid): Applications and future prospects for periodontal tissue regeneration. Polymers, 9.","DOI":"10.3390\/polym9060189"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2019.05.003","article-title":"Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation","volume":"304","author":"Park","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_58","unstructured":"Hadar, J., Garner, J., Skidmore, S., Park, H., Park, K., Jhon, Y., and Wang, Y. (2018, January 22\u201324). Correlation analysis of refractive index (dn\/dc) for PLGAs with different ratios of lactide to glycolide. Proceedings of the 2018 Controlled Release Society (CRS) Annual Meeting, New York, NY, USA."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/jbm.b.33648","article-title":"Polymer degradation and drug delivery in PLGA-based drug\u2013polymer applications: A review of experiments and theories","volume":"105","author":"Xu","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Smith, A.N., Ulsh, J.B., Gupta, R., Tang, M.M., Peredo, A.P., Teinturier, T.D., Mauck, R.L., Gullbrand, S., and Hast, M.W. (2024). Characterization of degradation kinetics of additively manufactured PLGA under variable mechanical loading paradigms. J. Mech. Behav. Biomed. Mater., 153.","DOI":"10.1016\/j.jmbbm.2024.106457"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jconrel.2020.01.028","article-title":"Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on formulation approaches","volume":"320","author":"Molavi","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Butreddy, A., Gaddam, R.P., Kommineni, N., Dudhipala, N., and Voshavar, C. (2021). PLGA\/PLA-based long-acting injectable depot microspheres in clinical use: Production and characterization overview for protein\/peptide delivery. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168884"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1021\/acsbiomaterials.3c00041","article-title":"Injectable, in situ self-cross-linking, self-healing poly (l-glutamic acid)\/polyethylene glycol hydrogels for cartilage tissue engineering","volume":"9","author":"Li","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"120627","DOI":"10.1016\/j.ijpharm.2021.120627","article-title":"Analysis of semi-solvent effects for PLGA polymers","volume":"602","author":"Garner","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1163\/156856206775997322","article-title":"Synthesis and characterization of PLGA nanoparticles","volume":"17","author":"Astete","year":"2006","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"121777","DOI":"10.1016\/j.ijpharm.2022.121777","article-title":"Novel adapter method for in vitro release testing of in situ forming implants","volume":"621","author":"Wang","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wang, Q., Atluri, K., Tiwari, A.K., and Babu, R.J. (2023). Exploring the application of micellar drug delivery systems in cancer nanomedicine. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030433"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kim, G., Gavande, V., Shaikh, V., and Lee, W.K. (2023). Degradation behavior of poly (lactide-co-glycolide) monolayers investigated by Langmuir technique: Accelerating Effect. Molecules, 28.","DOI":"10.3390\/molecules28124810"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1021\/acsapm.0c00315","article-title":"PLGA barrier materials from CO2. The influence of lactide co-monomer on glycolic acid polyesters","volume":"2","author":"Gruter","year":"2020","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_70","first-page":"60","article-title":"The development and challenges of poly (lactic acid) and poly (glycolic acid)","volume":"3","author":"Jem","year":"2020","journal-title":"Adv. Ind. Eng. Polym. Res."},{"key":"ref_71","first-page":"1","article-title":"Polylactic-co-glycolic acid (PLGA)","volume":"1","author":"Avgoustakis","year":"2005","journal-title":"Encycl. Biomater. Biomed. Eng."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1021\/acs.macromol.4c00106","article-title":"Effect of Monomer Sequence Distribution on the Glass Transition Temperature of Poly (d, l-lactic-co-glycolic acid) (PLGA)","volume":"57","author":"Patil","year":"2024","journal-title":"Macromolecules"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2105373","DOI":"10.1002\/advs.202105373","article-title":"Structure-based varieties of polymeric nanocarriers and influences of their physicochemical properties on drug delivery profiles","volume":"9","author":"De","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijpharm.2015.08.063","article-title":"A protocol for assay of poly (lactide-co-glycolide) in clinical products","volume":"495","author":"Garner","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"122292","DOI":"10.1016\/j.ijpharm.2022.122292","article-title":"Characterization and in vitro release of minocycline hydrochloride microspheres prepared via coacervation","volume":"628","author":"Wang","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.polymdegradstab.2012.11.012","article-title":"Modulating drug release from poly (lactic-co-glycolic acid) thin films through terminal end-groups and molecular weight","volume":"98","author":"Huang","year":"2013","journal-title":"Polym. Degrad. Stab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/ten.teb.2012.0443","article-title":"Physicochemical properties and applications of poly (lactic-co-glycolic acid) for use in bone regeneration","volume":"19","author":"Lanao","year":"2013","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1021\/acsami.9b19435","article-title":"Metal-based nanostructures\/PLGA nanocomposites: Antimicrobial activity, cytotoxicity, and their biomedical applications","volume":"12","author":"Zare","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s11051-012-1316-4","article-title":"Biodegradable PLGA-b-PEG polymeric nanoparticles: Synthesis, properties, and nanomedical applications as drug delivery system","volume":"14","author":"Locatelli","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101739","DOI":"10.1016\/j.jddst.2020.101739","article-title":"Targeted delivery of emodin to adipocytes by aptamer-functionalized PEG-PLGA nanoparticles in vitro","volume":"57","author":"Yu","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2101536","DOI":"10.1002\/adhm.202101536","article-title":"PLGA\u2019s plight and the role of stealth surface modification strategies in its use for intravenous particulate drug delivery","volume":"11","author":"Sheffey","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ramalho, M.J., Serra, \u00c9., Lima, J., Loureiro, J.A., and Pereira, M.C. (2024). Chitosan-PLGA mucoadhesive nanoparticles for gemcitabine repurposing for glioblastoma therapy. Eur. J. Pharm. Biopharm., 200.","DOI":"10.1016\/j.ejpb.2024.114326"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s42114-023-00766-6","article-title":"Electrospun Janus core (ethyl cellulose\/\/polyethylene oxide)@ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance","volume":"6","author":"Zhou","year":"2023","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Soares, D.C.F., Domingues, S.C., Viana, D.B., and Tebaldi, M.L. (2020). Polymer-hybrid nanoparticles: Current advances in biomedical applications. Biomed. Pharmacother., 131.","DOI":"10.1016\/j.biopha.2020.110695"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.06.003","article-title":"Biomaterial functionalization with triple-helical peptides for tissue engineering","volume":"148","author":"Malcor","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1038\/s41467-023-39485-3","article-title":"Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Barros, C.H., Hiebner, D.W., Fulaz, S., Vitale, S., Quinn, L., and Casey, E. (2021). Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-00851-2"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wei, Y., Liu, Z., Zhu, X., Jiang, L., Shi, W., Wang, Y., Xu, N., Gang, F., Wang, X., and Zhao, L. (2020). Dual directions to address the problem of aseptic loosening via electrospun PLGA@ aspirin nanofiber coatings on titanium. Biomaterials, 257.","DOI":"10.1016\/j.biomaterials.2020.120237"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.schres.2022.08.015","article-title":"Evolution of antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia in the real-life: A 4-year follow-up naturalistic study","volume":"248","author":"Monteleone","year":"2022","journal-title":"Schizophr. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jconrel.2023.08.029","article-title":"In situ forming risperidone implants: Effect of PLGA attributes on product performance","volume":"361","author":"Wang","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2015.09.051","article-title":"In vitro-in vivo correlation of parenteral risperidone polymeric microspheres","volume":"218","author":"Shen","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2017.03.396","article-title":"Development of in vitro-in vivo correlation of parenteral naltrexone loaded polymeric microspheres","volume":"255","author":"Andhariya","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/s41467-024-45574-8","article-title":"Reconstitution of early paclitaxel biosynthetic network","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"110038","DOI":"10.1016\/j.msec.2019.110038","article-title":"In vitro evaluation of folate-modified PLGA nanoparticles containing paclitaxel for ovarian cancer therapy","volume":"105","author":"Luiz","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"8739815","DOI":"10.1155\/2022\/8739815","article-title":"The preventive effects of naringin and naringenin against paclitaxel-induced nephrotoxicity and cardiotoxicity in male Wistar rats","volume":"2022","author":"Khaled","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jconrel.2024.01.053","article-title":"Advances and future perspectives of intranasal drug delivery: A scientometric review","volume":"367","author":"Xu","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Huang, M., Liu, J., Fan, Y., Sun, J., Cheng, J.X., Zhang, X.F., Zhai, B.T., and Guo, D.Y. (2023). Development of curcumin-loaded galactosylated chitosan-coated nanoparticles for targeted delivery of hepatocellular carcinoma. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.127219"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2019.03.015","article-title":"Threatening cancer with nanoparticle aided combination oncotherapy","volume":"301","author":"Rawal","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/acsomega.2c06359","article-title":"Fabrication, optimization, and evaluation of paclitaxel and curcumin coloaded PLGA nanoparticles for improved antitumor activity","volume":"8","author":"Hu","year":"2022","journal-title":"ACS Omega"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"114904","DOI":"10.1016\/j.addr.2023.114904","article-title":"Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems","volume":"199","author":"Shi","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1038\/s41596-023-00843-6","article-title":"Development of ionic liquid-coated PLGA nanoparticles for applications in intravenous drug delivery","volume":"18","author":"Hamadani","year":"2023","journal-title":"Nat. Protoc."},{"key":"ref_103","first-page":"55","article-title":"Surface modification of PLGA microspheres","volume":"66","author":"Csucs","year":"2003","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"120450","DOI":"10.1016\/j.ijpharm.2021.120450","article-title":"Influence of PLGA molecular weight distribution on leuprolide release from microspheres","volume":"599","author":"Ochi","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1208\/s12249-019-1526-5","article-title":"Mannose-modified PLGA nanoparticles for sustained and targeted delivery in hepatitis B virus immunoprophylaxis","volume":"21","author":"Zhu","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"14227","DOI":"10.1080\/21655979.2022.2084498","article-title":"Prodigiosin: A promising biomolecule with many potential biomedical applications","volume":"13","author":"Islan","year":"2022","journal-title":"Bioengineered"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.msec.2016.04.071","article-title":"PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: Effects of particle size on drug release kinetics and cell viability","volume":"66","author":"Obayemi","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpain.2020.03.009","article-title":"Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain","volume":"22","author":"Tian","year":"2021","journal-title":"J. Pain"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2100738","DOI":"10.1002\/adfm.202100738","article-title":"Nanoagent-promoted mild-temperature photothermal therapy for cancer treatment","volume":"31","author":"Gao","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"12967","DOI":"10.1038\/ncomms12967","article-title":"Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy","volume":"7","author":"Shao","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jcis.2023.05.031","article-title":"Autophagy-induced intracellular signaling fractional nano-drug system for synergistic anti-tumor therapy","volume":"645","author":"Yan","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wang, C., Shi, X., Song, H., Zhang, C., Wang, X., Huang, P., Dong, A., Zhang, Y., Kong, D., and Wang, W. (2021). Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. Biomaterials, 268.","DOI":"10.1016\/j.biomaterials.2020.120579"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.biomaterials.2013.10.034","article-title":"The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","article-title":"To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery","volume":"148","author":"Danhier","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1021\/bm101482r","article-title":"Surface charge affects cellular uptake and intracellular trafficking of chitosan-based nanoparticles","volume":"12","author":"Yue","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41467-021-23244-3","article-title":"PLGA-particle vaccine carrying TLR3\/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy","volume":"12","author":"Koerner","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood\u2013brain barrier: Structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood\u2013brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jbm.b.34161","article-title":"Itraconazole encapsulated PLGA-nanoparticles covered with mannose as potential candidates against leishmaniasis","volume":"107","author":"Biswaro","year":"2019","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Handa, M., Sanap, S.N., Bhatta, R.S., Patil, G.P., Ghose, S., Singh, D.P., and Shukla, R. (2023). Combining donepezil and memantine via mannosylated PLGA nanoparticles for intranasal delivery: Characterization and preclinical studies. Biomater. Adv., 154.","DOI":"10.1016\/j.bioadv.2023.213663"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40005-022-00589-5","article-title":"Drug delivery to the brain via the nasal route of administration: Exploration of key targets and major consideration factors","volume":"53","author":"Jeong","year":"2023","journal-title":"J. Pharm. Investig."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.2147\/IJN.S208332","article-title":"Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders","volume":"14","author":"Pirzadeh","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Maiti, P., and Dunbar, G.L. (2018). Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061637"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1021\/acsomega.2c07326","article-title":"Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?","volume":"8","author":"Hegde","year":"2023","journal-title":"ACS Omega"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1021\/acsbiomaterials.8b00454","article-title":"Oral delivery of curcumin using silk nano-and microparticles","volume":"4","author":"Wu","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"112735","DOI":"10.1016\/j.matdes.2024.112735","article-title":"Ginkgo biloba extract-loaded PLGA microcapsules generated from microfluidics for Alzheimer\u2019s disease treatment","volume":"238","author":"Zhang","year":"2024","journal-title":"Mater. Des."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajps.2017.12.007","article-title":"Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jconrel.2020.10.007","article-title":"Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model","volume":"329","author":"Lin","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Karami, Z., Mehrzad, J., Akrami, M., and Hosseinkhani, S. (2023). Anti-inflammation-based treatment of atherosclerosis using Gliclazide-loaded biomimetic nanoghosts. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-41136-y"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","article-title":"The evolution of commercial drug delivery technologies","volume":"5","author":"Vargason","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jconrel.2015.07.029","article-title":"Single-injection vaccines: Progress, challenges, and opportunities","volume":"219","author":"McHugh","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1016\/j.vaccine.2017.08.013","article-title":"A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles","volume":"35","author":"Watkins","year":"2017","journal-title":"Vaccine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10529-023-03383-x","article-title":"Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: A review","volume":"45","author":"Danaeifar","year":"2023","journal-title":"Biotechnol. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1016\/j.vaccine.2014.05.071","article-title":"Eliciting cytotoxic T-lymphocyte responses from synthetic vectors containing one or two epitopes in a C57BL\/6 mouse model using peptide-containing biodegradable microspheres and adjuvants","volume":"32","author":"Rubsamen","year":"2014","journal-title":"Vaccine"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2014.10.053","article-title":"CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses","volume":"40","author":"Rosalia","year":"2015","journal-title":"Biomaterials"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/21645515.2015.1117714","article-title":"PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity","volume":"12","author":"Silva","year":"2016","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41551-020-00650-4","article-title":"Transdermal microneedles for the programmable burst release of multiple vaccine payloads","volume":"5","author":"Tran","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actbio.2021.03.067","article-title":"Recent advances in PLGA-based biomaterials for bone tissue regeneration","volume":"127","author":"Jin","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2019.04.002","article-title":"Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair","volume":"302","author":"Kim","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3530620","DOI":"10.1155\/2022\/3530620","article-title":"Establishment of FK506-Enriched PLGA Nanomaterial Neural Conduit Produced by Electrospinning for the Repair of Long-Distance Peripheral Nerve Injury","volume":"2022","author":"Xu","year":"2022","journal-title":"J. Nanomater."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Wang, Y., Kankala, R.K., Cai, Y.Y., Tang, H.X., Zhu, K., Zhang, J.T., Yang, D.Y., Wang, S.B., Zhang, Y.S., and Chen, A.Z. (2021). Minimally invasive co-injection of modular micro-muscular and micro-vascular tissues improves in situ skeletal muscle regeneration. Biomaterials, 277.","DOI":"10.1016\/j.biomaterials.2021.121072"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1586\/erm.09.15","article-title":"Current advances in research and clinical applications of PLGA-based nanotechnology","volume":"9","author":"Wang","year":"2009","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"6165759","DOI":"10.1155\/2022\/6165759","article-title":"Potential wound healing of PLGA nanoparticles containing a novel L-Carnitine\u2013GHK peptide conjugate","volume":"2022","author":"Ramezanpour","year":"2022","journal-title":"J. Nanomater."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/wound.2019.1094","article-title":"Nanotechnology approaches in chronic wound healing","volume":"10","author":"Castano","year":"2021","journal-title":"Adv. Wound Care"},{"key":"ref_145","unstructured":"Kesharwani, P. (2023). Chapter 17 - Biological toxicity and environmental hazards associated with PLGA nanoparticles. Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery, Elsevier. Micro and Nano Technologies."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.1021\/acsbiomaterials.0c01228","article-title":"Phenomenology of the initial burst release of drugs from PLGA microparticles","volume":"6","author":"Yoo","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1039\/D4NA00087K","article-title":"Using a systematic and quantitative approach to generate new insights into drug loading of PLGA nanoparticles using nanoprecipitation","volume":"6","author":"Hamdallah","year":"2024","journal-title":"Nanoscale Adv."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"105528","DOI":"10.1016\/j.jddst.2024.105528","article-title":"Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch","volume":"95","author":"Yang","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Bausart, M., Rodella, G., Dumont, M., Ucakar, B., Vanvarenberg, K., Malfanti, A., and Pr\u00e9at, V. (2023). Combination of local immunogenic cell death-inducing chemotherapy and DNA vaccine increases the survival of glioblastoma-bearing mice. Nanomed. Nanotechnol. Biol. Med., 50.","DOI":"10.1016\/j.nano.2023.102681"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Casanova, E.A., Rodriguez-Palomo, A., St\u00e4hli, L., Arnke, K., Gr\u00f6ninger, O., Generali, M., Neldner, Y., Tiziani, S., Dominguez, A.P., and Guizar-Sicairos, M. (2023). SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA\/aCaP scaffolds in a critical size bone defect model. Biomaterials, 294.","DOI":"10.1016\/j.biomaterials.2022.121989"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actbio.2024.03.029","article-title":"Dual-layer conduit containing VEGF-A\u2013Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis","volume":"180","author":"Huang","year":"2024","journal-title":"Acta Biomater."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/18\/2606\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:56:32Z","timestamp":1760111792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/18\/2606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":151,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["polym16182606"],"URL":"https:\/\/doi.org\/10.3390\/polym16182606","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]}}}