{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:05:57Z","timestamp":1788293157094,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Slovak Research and Development Agency","award":["APVV-19-0290"],"award-info":[{"award-number":["APVV-19-0290"]}]},{"name":"Slovak Research and Development Agency","award":["KEGA 018TUKE-4\/2023"],"award-info":[{"award-number":["KEGA 018TUKE-4\/2023"]}]},{"name":"Slovak Research and Development Agency","award":["VEGA 1\/0599\/22"],"award-info":[{"award-number":["VEGA 1\/0599\/22"]}]},{"name":"Cultural and Educational Grant Agency M\u0160VVa\u0160 SR","award":["APVV-19-0290"],"award-info":[{"award-number":["APVV-19-0290"]}]},{"name":"Cultural and Educational Grant Agency M\u0160VVa\u0160 SR","award":["KEGA 018TUKE-4\/2023"],"award-info":[{"award-number":["KEGA 018TUKE-4\/2023"]}]},{"name":"Cultural and Educational Grant Agency M\u0160VVa\u0160 SR","award":["VEGA 1\/0599\/22"],"award-info":[{"award-number":["VEGA 1\/0599\/22"]}]},{"name":"Scientific Grant Agency","award":["APVV-19-0290"],"award-info":[{"award-number":["APVV-19-0290"]}]},{"name":"Scientific Grant Agency","award":["KEGA 018TUKE-4\/2023"],"award-info":[{"award-number":["KEGA 018TUKE-4\/2023"]}]},{"name":"Scientific Grant Agency","award":["VEGA 1\/0599\/22"],"award-info":[{"award-number":["VEGA 1\/0599\/22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The advancing development in biomaterials and biology has enabled the extension of 3D printing technology to the bioadditive manufacturing of degradable hard tissue substitutes. One of the key advantages of bioadditive manufacturing is that it has much smaller design limitations than conventional manufacturing and is therefore capable of producing implants with complex geometries. In this study, three distinct blends of polylactic acid (PLA) and polyhydroxybutyrate (PHB) were produced using Fused Deposition Modeling (FDM) technology. Two of these blends were plasticized with oligomeric lactic acid (OLA) at concentrations of 5 wt% and 10 wt%, while the third blend remained unplasticized. Each blend was fabricated in two structural modifications: solid and porous. The biodegradation behavior of the produced specimens was examined through an in vitro experiment using three different immersion solutions: saline solution, Hank\u2019s balanced salt solution (HBSS), and phosphate-buffered saline (PBS). All examined samples were also subjected to chemical analysis: atomic absorption spectroscopy (AAS), scanning electron microscopy (SEM), and energy-dispersive spectrometry (EDS). The results of the degradation experiments indicated a predominantly better absorption capacity of the samples with a porous structure compared to the full structure. At the same time, the blend containing a higher concentration of OLA exhibited enhanced pH stability over the evaluation period, maintaining relatively constant pH values before experiencing a minor decline at the end of the study. This observation indicates that the increased presence of the plasticizer may provide a buffering effect, effectively mitigating the acidification associated with material degradation.<\/jats:p>","DOI":"10.3390\/polym16212969","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:07:04Z","timestamp":1729674424000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of Oligomeric Lactic Acid and Structural Design on Biodegradation and Absorption of PLA-PHB Blends for Tissue Engineering"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-6879","authenticated-orcid":false,"given":"Jana","family":"\u010cajkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-9692","authenticated-orcid":false,"given":"Marianna","family":"Trebu\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Modr\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"I\u017ear\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Informatics, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, Letn\u00e1 9, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-849X","authenticated-orcid":false,"given":"Darina","family":"Ba\u010denkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-2867","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Balint","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"\u017div\u010d\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Ko\u0161ice, 042 00 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., and Alexy, P. 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