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The aim of our research was to formulate a low-cost hybrid nanoparticulate biomaterial using poly(lactic-co-glycolic acid) (PLGA), in which we incorporated the therapeutic agent (ciprofloxacin), and to deposit this material on titanium plates using the matrix-assisted pulsed laser evaporation (MAPLE) technique. The deposited material demonstrated antibacterial properties, with all analyzed samples inhibiting the growth of tested bacterial strains, confirming the release of active substances from the investigated biocomposite. The poly(lactic-co-glycolic acid)-ciprofloxacin (PLGA-CIP) nanoparticle scaffolds displayed a prolonged local sustained release profile over a period of 45 days, which shows great promise in bone infections. Furthermore, the burst release ensures a highly efficient concentration, followed by a constant sustained release which allows the drug to remain in the implant-adjacent area for an extended time period.<\/jats:p>","DOI":"10.3390\/polym16213064","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T08:44:04Z","timestamp":1730364244000},"page":"3064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of Hybrid Implantable Local Release Systems Based on PLGA Nanoparticles with Applications in Bone Diseases"],"prefix":"10.3390","volume":"16","author":[{"given":"Maria Viorica","family":"Cioc\u00eelteu","sequence":"first","affiliation":[{"name":"Department of Instrumental and Analytical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-6593","authenticated-orcid":false,"given":"Andreea Gabriela","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-1423","authenticated-orcid":false,"given":"Andrei","family":"Bi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-1497","authenticated-orcid":false,"given":"Costel Valentin","family":"Manda","sequence":"additional","affiliation":[{"name":"Department of Instrumental and Analytical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-202X","authenticated-orcid":false,"given":"Claudiu","family":"Nicolicescu","sequence":"additional","affiliation":[{"name":"Department of Engineering and Management of Technological Systems, Faculty of Mechanics, University of Craiova, 1 C\u0103lug\u0103reni Street, 220037 Drobeta Turnu-Severin, Mehedin\u0163i County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"R\u0103u","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela","family":"Belu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Silvia","family":"P\u00eervu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Balasoiu","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Virology and Parasitology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"N\u0103nescu","sequence":"additional","affiliation":[{"name":"Pharmacy Assistants Specialization, Department of Health and Motricity, Faculty of Medical and Behavioral Sciences, \u201cConstantin Br\u00e2ncu\u0219i\u201d University of Tg-Jiu, Romania No. 4, Tineretului St., 210185 Tg-Jiu, Gorj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Elena","family":"Nicolaescu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rare\u015f Street, 200349 Craiova, Dolj County, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5312\/wjo.v14.i2.42","article-title":"Diagnosis and treatment of chronic osteomyelitis based on nanomaterials","volume":"14","author":"Zeng","year":"2023","journal-title":"World J. 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