{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:16Z","timestamp":1791644116759,"version":"4.3.4"},"reference-count":52,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIN\/AEI","award":["PID2020\u2013114694RB-I00"],"award-info":[{"award-number":["PID2020\u2013114694RB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Collagen-based membrane is the most commonly used biomaterial for guided bone and tissue regeneration; however, its barrier function can be threatened by its rapid degradation pattern, affecting the success of the regeneration process. Differences in the origin and functionalization of the membrane to obtain better properties can alter the degradation rate. The objective of this study was to examine the biodegradation pattern of two commercially available collagen membranes (Jason\u00ae and Collprotect\u00ae) manufactured using porcine pericardium or dermis, doped or not with zinc-ions or doxycycline, in a period up to 21 days. The membrane specimens were subjected to hydrolytic and bacterial degradation tests. The different immersion times were carried out from 12 h up to 21 days. At each time point, quantitative measurements of thickness and weight were made using a digital caliper and an analytic microbalance, respectively. ANOVA and Student\u2013Newman\u2013Keuls tests were carried out for comparison purposes (p &lt; 0.05). The differences between time-points within the same membranes and solutions were assessed by pairwise comparisons (p &lt; 0.001). Unfunctionalized Jason membrane made of porcine pericardium attained the highest resistance to both degradation tests. The functionalization of the membranes did not alter the biodegradation patterns. All the membranes completely degraded before 48 h in the bacterial collagenase solution, which was the most aggressive test.<\/jats:p>","DOI":"10.3390\/polym16223109","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:36:39Z","timestamp":1730806599000},"page":"3109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["In Vitro Degradation of Collagen-Based Membranes for Guided Bone Regeneration After Zn-Ions or Doxycycline Functionalization"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-2811","authenticated-orcid":false,"given":"Cristina","family":"Vallecillo","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Infante","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"\u00c1valos","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vallecillo-Rivas","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Restorative Dentistry, University Dental School & Hospital, University College Cork, Wilton, T12 E8YV Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledano","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Colegio M\u00e1ximo de Cartuja s\/n, University of Granada, 18071 Granada, Spain"},{"name":"Biosanitary Research Institute, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(01)00691-3","article-title":"Biomedical Applications of Collagen","volume":"221","author":"Lee","year":"2001","journal-title":"Int. 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