{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:17:10Z","timestamp":1791083830869,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n y Agencia Estatal de la Investigaci\u00f3n, Spain","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"Uni\u00f3n Europea \u201cNextGenerationEU\u201d\/PRTR","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]},{"name":"JCCM","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"JCCM","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"JCCM","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"JCCM","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"JCCM","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"JCCM","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"JCCM","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"JCCM","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"EU through Fondo Europeo de Desarrollo Regional","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]},{"name":"Universidad de Castilla-La Mancha","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"Universidad de Castilla-La Mancha","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"Universidad de Castilla-La Mancha","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"Universidad de Castilla-La Mancha","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"Universidad de Castilla-La Mancha","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"Universidad de Castilla-La Mancha","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"Universidad de Castilla-La Mancha","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"Universidad de Castilla-La Mancha","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]},{"name":"Instituto de Salud Carlos III","award":["CPP2021-008597"],"award-info":[{"award-number":["CPP2021-008597"]}]},{"name":"Instituto de Salud Carlos III","award":["MCIN\/AEI\/10.13039\/501100011033y"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033y"]}]},{"name":"Instituto de Salud Carlos III","award":["PID2020-117788RB-I00"],"award-info":[{"award-number":["PID2020-117788RB-I00"]}]},{"name":"Instituto de Salud Carlos III","award":["RED2022-134287-T"],"award-info":[{"award-number":["RED2022-134287-T"]}]},{"name":"Instituto de Salud Carlos III","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"Instituto de Salud Carlos III","award":["SBPLY\/21\/180501\/000132"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000132"]}]},{"name":"Instituto de Salud Carlos III","award":["2021-GRIN-31240"],"award-info":[{"award-number":["2021-GRIN-31240"]}]},{"name":"Instituto de Salud Carlos III","award":["PI16\/01121"],"award-info":[{"award-number":["PI16\/01121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The compounds targeting the bromo and extra terminal domain proteins (BET), such as the JQ1, present potent anti-cancer activity in preclinical models, however, the application of JQ1 at the clinical level is limited by its short half-life, rapid clearance, and non-selective inhibition of BET family proteins, leading to off-target effects and resistance. To address these challenges, the optimization of JQ1 delivery has been accomplished through polylactide (PLA) nanoparticles. PLA derivatives with varying molecular weights were synthesized via ring-opening polymerization using a zinc-based initiator and characterized using thermogravimetric analysis, differential scanning calorimetry, and infrared spectroscopy. PLA nanoparticles (NPs) were subsequently formulated, and the effects of key parameters\u2014including PLA molecular weight, organic phase concentration, and surfactant concentration\u2014on particle size, polydispersity index (PDI), and encapsulation efficiency were systematically investigated. PLA molecular weight and organic phase concentration mainly influenced the NPs size whilst the thermodynamic state of the NPs was unaffected by these two parameters. The surfactant concentration is correlated to the encapsulation efficacy of JQ1 as well as the release profile, suggesting the potential tool that the variation of these parameters represent for customizing the release of JQ1 according to specific needs.<\/jats:p>","DOI":"10.3390\/polym17010123","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T10:40:52Z","timestamp":1736160052000},"page":"123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fine-Tuning the Physicochemical Properties of Poly(lactic Acid) Nanoparticles for the Controlled Release of the BET Inhibitor JQ1: Influence of PVA Concentration"],"prefix":"10.3390","volume":"17","author":[{"given":"Nedjla","family":"Kedjar","sequence":"first","affiliation":[{"name":"Laboratory of Applied Chemistry (LAC), Faculty of Sciences Technology, University of Ain Temouchent Belhadj Bouchaib, Ain Temouchent 46000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6538-4345","authenticated-orcid":false,"given":"Eleonora","family":"Iannuzzi","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica, Universidad de Castilla-La Mancha, 02071 Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-5016","authenticated-orcid":false,"given":"Martin","family":"Kreuzer","sequence":"additional","affiliation":[{"name":"ALBA Synchrotron, Carrer de la Llum 2-26, 08290 Cerdanyola del Vall\u00e8s, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-0781","authenticated-orcid":false,"given":"Carlos","family":"Alonso-Moreno","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica, Universidad de Castilla-La Mancha, 02071 Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-489X","authenticated-orcid":false,"given":"Carmen","family":"Moya-Lopez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica, Universidad de Castilla-La Mancha, 02071 Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71285","DOI":"10.18632\/oncotarget.19744","article-title":"BET Inhibitors as Novel Therapeutic Agents in Breast Cancer","volume":"8","author":"Pandiella","year":"2017","journal-title":"Oncotarget"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103284","DOI":"10.1016\/j.pdpdt.2023.103284","article-title":"Application of serum SERS technology based on thermally annealed silver nanoparticle composite substrate in breast cancer","volume":"41","author":"Cheng","year":"2023","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_3","first-page":"051701","article-title":"Detection of breast cancer based on novel porous silicon Bragg reflector surface-enhanced Raman spectroscopy-active structure","volume":"18","author":"Ma","year":"2020","journal-title":"COL"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Shu, S., Lin, C.Y., Hansen He, H., Witwicki, R.M., Tabassum, D.P., Roberts, J.M., Janiszewska, M., Jin Huh, S., Liang, Y., and Ryan, J. (2016). Response and Resistance to BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Nature, 529.","DOI":"10.1038\/nature16508"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.phrs.2017.11.015","article-title":"Targeting Bromodomain and Extraterminal Proteins in Breast Cancer","volume":"129","author":"Sahni","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/nm1111-1325","article-title":"First Drugs Found to Inhibit Elusive Cancer Target","volume":"17","author":"Moyer","year":"2011","journal-title":"Nat. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Niza, E., Oca\u00f1a, A., Castro-Osma, J.A., Bravo, I., and Alonso-Moreno, C. (2021). Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment. Cancers, 13.","DOI":"10.3390\/cancers13143387"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Moya-Lopez, C., Gonz\u00e1lez-Fuentes, J., Bravo, I., Chapron, D., Bourson, P., Alonso-Moreno, C., and Hermida-Merino, D. (2022). Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081673"},{"key":"ref_9","first-page":"20","article-title":"Controlled Ring-Opening Polymerization of Lactide and Glycolide","volume":"104","author":"Bourissou","year":"2004","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/pi.5707","article-title":"Influence of A\u2032-\/\u03b1-Crystal Polymorphism on Properties of Poly(l-Lactic Acid)","volume":"68","author":"Androsch","year":"2019","journal-title":"Polym. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s40005-019-00453-z","article-title":"Poly(Lactic Acid)\/Poly(Lactic-Co-Glycolic Acid)-Based Microparticles: An Overview","volume":"49","author":"Blasi","year":"2019","journal-title":"J. Pharm. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1097\/00002030-200311210-00009","article-title":"Polylactic Acid Implants (New-Fill)\u00ae to Correct Facial Lipoatrophy in HIV-Infected Patients: Results of the Open-Label Study VEGA","volume":"17","author":"Valantin","year":"2003","journal-title":"Aids"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1093\/asj\/sjy012","article-title":"Physiochemical Characteristics of Poly-L-Lactic Acid (PLLA)","volume":"38","author":"Fitzgerald","year":"2018","journal-title":"Aesthetic Surg. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Elmowafy, E.M., Tiboni, M., and Soliman, M.E. (2019). Biocompatibility, Biodegradation and Biomedical Applications of Poly(Lactic Acid)\/Poly(Lactic-Co-Glycolic Acid) Micro and Nanoparticles, Springer.","DOI":"10.1007\/s40005-019-00439-x"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejps.2016.01.012","article-title":"Polymeric Nanoparticles for Oral Delivery of 5- Fluorouracil: Formulation Optimization, Cytotoxicity Assay and Pre-Clinical Pharmacokinetics Study","volume":"84","author":"Altmeyer","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Estupi\u00f1\u00e1n, \u00d3., Niza, E., Bravo, I., Rey, V., Torn\u00edn, J., Gallego, B., Casares, P.C., Moris, F., Oca\u00f1a, A., and Lorenzo, V.B. (2021). Mithramycin Delivery Systems to Develop Effective Therapies in Sarcomas. J. Nanobiotechnology, 19.","DOI":"10.1186\/s12951-021-01008-x"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/02652040903515490","article-title":"Insulin-S.O (Sodium Oleate) Complex-Loaded PLGA Nanoparticles: Formulation, Characterization and in Vivo Evaluation","volume":"27","author":"Sun","year":"2010","journal-title":"J. Microencapsul."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijpharm.2017.09.054","article-title":"Technical Aspects of Preparing PEG-PLGA Nanoparticles as Carrier for Chemotherapeutic agents by Nanoprecipitation Method","volume":"533","author":"Almoustafa","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/acs.molpharmaceut.0c01089","article-title":"Potential Roles of the Glass Transition Temperature of PLGA Microparticles in Drug Release Kinetics","volume":"18","author":"Park","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jconrel.2020.10.044","article-title":"Formulation Composition, Manufacturing Process, and Characterization of Poly(Lactide-Co-Glycolide) Microparticles","volume":"329","author":"Park","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1021\/acs.iecr.9b06630","article-title":"Mesoscale Modeling and Experimental Study of Quercetin Organization as Nanoparticles in the Poly-Lactic- Co-Glycolic Acid\/Water System under Different Conditions","volume":"59","author":"Slimane","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejpb.2008.01.013","article-title":"Dual Agents Loaded PLGA Nanoparticles: Systematic Study of Particle Size and Drug Entrapment Efficiency","volume":"69","author":"Song","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-3659(97)00106-5","article-title":"Influence of Experimental Parameters on the Characteristics of Poly (Lactic Acid) Nanoparticles Prepared by a Double Emulsion Method","volume":"50","author":"Zambaux","year":"1998","journal-title":"J. Control. Release"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/19430876.2010.532462","article-title":"Preparation of Poly(Lactic Acid) Nanoparticles and Optimization of the Particle Size","volume":"2","author":"Maharana","year":"2010","journal-title":"Int. J. Green Nanotechnol. Phys. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maggisano, V., Celano, M., Malivindi, R., Barone, I., Cosco, D., Mio, C., Mignogna, C.H., Panza, S., Damante, G., and Fresta, M. (2019). Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer. Cancers, 12.","DOI":"10.3390\/cancers12010091"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Juan, A., Noblejas-l, M., Arenas-moreira, M., Blasco-navarro, C., Clemente-casares, P., and Pandiella, A. (2022). Enhanced Antitumoral Activity of Encapsulated BET Inhibitors When Combined with PARP Inhibitors for the Treatment Of. Cancers, 14.","DOI":"10.3390\/cancers14184474"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"133452","DOI":"10.1016\/j.cej.2021.133452","article-title":"Biomimetic and Responsive Nanoparticles Loading JQ1 for Dual-Targeting Treatment of Vascular Restenosis via Multiple Actions","volume":"431","author":"Hao","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Celano, M., Gagliardi, A., Maggisano, V., Ambrosio, N., Bulotta, S., Fresta, M., Russo, D., and Cosco, D. (2022). Co-Encapsulation of Paclitaxel and JQ1 in Zein Nanoparticles as Potential Innovative Nanomedicine. Micromachines, 13.","DOI":"10.3390\/mi13101580"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Moya-Lopez, C., Bravo, I., Castro-Osma, J.A., Chapron, D., Bourson, P., Vagner, C., Cochez, M., Leon, N., Alonso-Moreno, C., and Hermida-Merino, D. (2022). Synthesis of High Molecular Weight Stereo-Di-Block Copolymers Driven by a Co-Initiator Free Catalyst. Polymers, 14.","DOI":"10.3390\/polym14020232"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Juan, A., Segrelles, C., del Campo-Balguer\u00edas, A., Bravo, I., Silva, I., Peral, J., Oca\u00f1a, A., Clemente-Casares, P., Alonso-Moreno, C., and Lorz, C. (2023). Anti-EGFR Conjugated Nanoparticles to Deliver Alpelisib as Targeted Therapy for Head and Neck Cancer. Cancer Nanotechnol., 14.","DOI":"10.1186\/s12645-023-00180-z"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/08940886.2017.1338410","article-title":"MIRAS: The Infrared Synchrotron Radiation Beamline at ALBA Synchrotron","volume":"30","author":"Yousef","year":"2017","journal-title":"Synchrotron Radiat. News"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Toplak, M., Read, S.T., Sandt, C., and Borondics, F. (2021). Quasar: Easy Machine Learning for Biospectroscopy. Cells, 10.","DOI":"10.3390\/cells10092300"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0032-3861(96)00711-2","article-title":"Influence of Residual monomers and Metals on Poly (L-Lactid) thermal Stability","volume":"38","author":"Ambientali","year":"1997","journal-title":"Polymer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"179387","DOI":"10.1016\/j.tca.2022.179387","article-title":"Thermochimica Acta Glass Transition Temperature of Poly (D, L -Lactic Acid) of Different Molar Mass","volume":"718","author":"Zhang","year":"2022","journal-title":"Thermochim. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhao, G., and Wang, G. (2021). Investigation on the \u03b1\/\u03b4 Crystal Transition of Poly (L -Lactic Acid) with Different Molecular Weights. Polymers, 13.","DOI":"10.3390\/polym13193280"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1021\/ma071258d","article-title":"Polymorphous Crystallization and Multiple Melting Behavior of Poly(L-Lactide): Molecular Weight Dependence","volume":"40","author":"Pan","year":"2007","journal-title":"Macromolecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.polymer.2017.02.063","article-title":"Effect of Molar Mass on the a 0\/a -Transition in Poly (L -Lactic Acid)","volume":"114","author":"Laura","year":"2017","journal-title":"Polymer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.polymer.2018.01.004","article-title":"Fundamental Thermal Properties of Polyvinyl Alcohol by Fast Scanning Calorimetry","volume":"137","author":"Thomas","year":"2018","journal-title":"Polymer"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Browne, E., Worku, Z.A., and Healy, A.M. (2020). Physicochemical Properties of Poly-Vinyl Polymers and Their Influence on Ketoprofen Amorphous Solid Dispersion Performance: A Polymer Selection Case Study. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050433"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9650","DOI":"10.1021\/ma2017666","article-title":"Structural Regularization in the Crystallization Process from the Glass or Melt of Poly (L -Lactic Acid) Viewed from the Temperature-Dependent and Time-Resolved Measurements of FTIR and Wide-Angle\/Small-Angle X-Ray Scatterings","volume":"44","author":"Wasanasuk","year":"2011","journal-title":"Macromolecules"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.colsurfa.2017.06.009","article-title":"Influence of Polymer Concentration on the Properties of Nano-Emulsions and Nanoparticles Obtained by a Low-Energy Method","volume":"536","author":"Homs","year":"2018","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0927-7757(00)00825-6","article-title":"Preparation of PLGA Nanoparticles Containing Estrogen by Emulsification \u2013 Diffusion Method","volume":"182","author":"Kwon","year":"2001","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2021.748449","article-title":"Role of BET Proteins in Inflammation and CNS Diseases","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective Inhibition of BET Bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.7150\/thno.13178","article-title":"BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating Foxm1","volume":"6","author":"Zhang","year":"2016","journal-title":"Theranostics"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Xu, Y., and Vakoc, C.R. (2017). Targeting Cancer Cells with BET Bromodomain Inhibitors. Cold Spring Harb. Perspect. Med., 7.","DOI":"10.1101\/cshperspect.a026674"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yellapu, N.K., Ly, T., Sardiu, M.E., Pei, D., Welch, D.R., Thompson, J.A., and Koestler, D.C. (2022). Synergistic Anti-Proliferative Activity of JQ1 and GSK2801 in Triple-Negative Breast Cancer. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09690-2"},{"key":"ref_48","first-page":"2304","article-title":"Effect of the Molecular Weight on the Physicochemical Properties of Poly(Lactic Acid) Nanoparticles and on the Amount of Ovalbumin Adsorption","volume":"22","author":"Palacio","year":"2011","journal-title":"J. Braz. Chem. Soc."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/1\/123\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:23:52Z","timestamp":1759919032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/1\/123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["polym17010123"],"URL":"https:\/\/doi.org\/10.3390\/polym17010123","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]}}}