{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:59:56Z","timestamp":1782989996896,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010792","name":"Tungs\u2019 Taichung Metroharbor Hospital","doi-asserted-by":"publisher","award":["TTMHH-R1100039"],"award-info":[{"award-number":["TTMHH-R1100039"]}],"id":[{"id":"10.13039\/100010792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Mesoporous bioactive glass (MBG) is an advanced biomaterial widely recognized for its application in bone regenerative engineering. This study synthesized an MBG powder (80 mol% SiO2, 5 mol% P2O5, and 15 mol% CaO) using a facile sol-gel method with the non-ionic surfactant Pluronic\u00ae P123, which acted as a pore-forming agent. MBGs form bioactive surfaces that facilitate HA formation, and the presence of Pluronic\u00ae P123 increases the surface area and promotes HA nucleation. Various percentages of strontium (Sr) doping were examined to improve bioreactivity, biological response, and bone formation, with 3SMBG (3 mol% Sr) showing the highest specific surface area. In vitro biocompatibility tests revealed HA formation on all glass surfaces after immersion in simulated body fluid (SBF), indicated by sheet-like HA morphologies, the presence of PO43\u2212 and CO32\u2212 functional groups, and the amorphous structure along with SrCO3 crystalline phases corresponding to HA and Sr-HA structures. Sr doping resulted in delayed initial degradation and sustained release of Sr2+, achieving over 95% cell viability. Surfactant-induced mesoporous structure and Sr incorporation synergistically enhance osteocyte induction and formation in vitro. These findings suggest that Sr-doped MBG, particularly with P123-assisted Sr\/Ca substitution, optimizes the material\u2019s properties for advanced bone regenerative applications.<\/jats:p>","DOI":"10.3390\/polym17020187","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:13:07Z","timestamp":1736835187000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synergistic Effect of Strontium Doping and Surfactant Addition in Mesoporous Bioactive Glass for Enhanced Osteogenic Bioactivity and Advanced Bone Regeneration"],"prefix":"10.3390","volume":"17","author":[{"given":"Ya-Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology, Tung\u2019s Taichung Metro Harbor Hospital, Taichung 435, Taiwan"},{"name":"Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-9961","authenticated-orcid":false,"given":"Tien-Li","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Jung","family":"Chang","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Graduate Institute of Manufacturing Technology, National Taipei University of Technology, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-5667","authenticated-orcid":false,"given":"Yuh-Jing","family":"Chiou","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Chemical Engineering and Biotechnology, Tatung University, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-4043","authenticated-orcid":false,"given":"Wei-Min","family":"Chang","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci-Fen","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-1005","authenticated-orcid":false,"given":"Chin-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kang","family":"Chang","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Medical Research, Tung\u2019s Taichung Metro Harbor Hospital, Taichung 435, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Nursing, Jenteh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-8687","authenticated-orcid":false,"given":"Chung-Kwei","family":"Lin","sequence":"additional","affiliation":[{"name":"Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","first-page":"53","article-title":"MBG\/ PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features","volume":"15","author":"Li","year":"2021","journal-title":"Bioact. 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