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Scanning electron microscopy (SEM) revealed that fiber morphology varied with electrospinning parameters, influencing microbial adhesion. Antimicrobial tests demonstrated that rPET@CS significantly inhibited Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans biofilm formation compared to control and uncoated rPET surfaces. Subcutaneous implantation of rPET@CS scaffolds induced a transient inflammatory response, with macrophage recruitment and collagen deposition supporting tissue integration. These findings highlight the potential of rPET@CS scaffolds as sustainable antimicrobial biomaterials for applications in infection-resistant coatings and biomedical implants.<\/jats:p>","DOI":"10.3390\/polym17081077","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:02:57Z","timestamp":1744801377000},"page":"1077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation"],"prefix":"10.3390","volume":"17","author":[{"given":"Andreea Mihaela","family":"Gr\u0103mad\u0103 (Pintilie)","sequence":"first","affiliation":[{"name":"Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, 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