{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:05Z","timestamp":1791378125498,"version":"4.3.2"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda (CONAHCyT)","award":["931068"],"award-info":[{"award-number":["931068"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda (CONAHCyT)","award":["CF-2023-I-2901"],"award-info":[{"award-number":["CF-2023-I-2901"]}]},{"name":"Ciencia de Frontera Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda","award":["931068"],"award-info":[{"award-number":["931068"]}]},{"name":"Ciencia de Frontera Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda","award":["CF-2023-I-2901"],"award-info":[{"award-number":["CF-2023-I-2901"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Magnesium-based coronary stents have gained significant interest due to their excellent biocompatibility, biodegradability, and mechanical properties. However, a key limitation of magnesium in biomedical applications is its low corrosion resistance, which compromises its structural integrity and mechanical strength over time. Polymeric coatings can overcome this challenge, enhancing magnesium-based implants\u2019 corrosion resistance and overall performance. This study applied a polylactic acid (PLA) nanofiber coating to WE43 magnesium (Mg) stents via electrospinning to reduce their corrosion rate. Both uncoated and coated stents underwent in vitro immersion tests in Hank\u2019s solution for 1, 3, 7, and 14 days. The effectiveness of the PLA coating was evaluated through morphological analysis, chemical composition assessment, corrosion behavior (weight change), magnesium ion release, and in vitro biocompatibility. The corrosion observed in the uncoated WE43 stents indicates that protective coatings are necessary to regulate degradation rates over extended implantation periods. The results demonstrated that coated stents exhibited improved performance, maintaining the integrity of the PLA coating for up to 14 days. The coated stents demonstrated reduced surface damage and lower weight loss resulting from lower magnesium release. In our study, the coated stents demonstrated a reduced corrosion rate (0.216 \u00b1 0.013 mm\/year) compared with the uncoated stents (0.312 \u00b1 0.010 mm\/year), both after 14 days. Additionally, in vitro biocompatibility results confirmed the non-toxic nature of PLA-coated stents, which enhances cellular proliferation and contributes to a more favorable environment for vascular healing. These findings suggest that PLA coatings can effectively prolong the functional durability of WE43 Mg stents, offering a promising solution for enhancing the performance of biodegradable stents in cardiovascular applications.<\/jats:p>","DOI":"10.3390\/polym17111510","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:28:42Z","timestamp":1748435322000},"page":"1510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulated Degradation of Polylactic Acid Electrospun Coating on WE43 Stents"],"prefix":"10.3390","volume":"17","author":[{"given":"Mariana","family":"Mac\u00edas-Naranjo","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-6832","authenticated-orcid":false,"given":"Marilena","family":"Antunes-Ricardo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, The Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Moreno Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Noelia","family":"De la Pe\u00f1a Aguirre","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-4239","authenticated-orcid":false,"given":"Ciro A.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-9636","authenticated-orcid":false,"given":"Elisa","family":"Vazquez-Lepe","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, N.L, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huang, W., Huo, M., Cheng, N., and Wang, R. 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