{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:54:13Z","timestamp":1782896053604,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT) M\u00e9xico","award":["1360"],"award-info":[{"award-number":["1360"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT) M\u00e9xico","award":["248378"],"award-info":[{"award-number":["248378"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT) M\u00e9xico","award":["PID2023-147542OB-I00"],"award-info":[{"award-number":["PID2023-147542OB-I00"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT) M\u00e9xico","award":["PID2019-106099RB-C41"],"award-info":[{"award-number":["PID2019-106099RB-C41"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["1360"],"award-info":[{"award-number":["1360"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["248378"],"award-info":[{"award-number":["248378"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["PID2023-147542OB-I00"],"award-info":[{"award-number":["PID2023-147542OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["PID2019-106099RB-C41"],"award-info":[{"award-number":["PID2019-106099RB-C41"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>This study investigated the chemical, thermal, and mechanical properties of segmented polyurethanes (SPUs) synthesized using less common biodegradable polyester polyols, specifically poly(adipate) (PAD) and poly(sebacate) (PSC), to evaluate their potential as nerve guidance conduits (NGCs) in peripheral nerve regeneration. The synthesis of novel 4,4\u2032 methylene-bis-cyclohexyl diisocyanate (HMDI) SPUs was conducted in a two-step process: prepolymer formation and chain extension with 1,4-butanediol (BO) or 1,4-butanediamine (BA). SPUs were synthesized with two molar ratios\u2014polyol:HMDI:BA\/BO at 1:2:1 and 1:3:2 for the PAD:HMDI:BA system\u2014to optimize mechanical properties. 1HRMN analysis verified the expected chemical structure of SPUs, whereas Raman and IR spectroscopy confirmed successful polyurethane synthesis. X-ray diffractograms showed that PAD-based SPUs (SPUPAD) were amorphous while PSC-based SPUs (SPUPSC) exhibited semi-crystalline behavior. SPUPAD showed only one degradation stage by TGA, while DSC showed one thermal event. In contrast, SPUPSC exhibited two degradation stages and three thermal events that confirmed phase separation. The longitudinal tensile properties of an NGC fabricated from SPUA-PAD-2 (PAD:HMDI:BA (1:3:2)) after 30 days of immersion in water (25 \u00b0C) showed a lower modulus (4.46 \u00b1 0.5 MPa) than native intact nerves (15.87 \u00b1 2.21 MPa) but a similar modulus to extracted nerves (8.19 \u00b1 7.27 MPa). This system exhibited a longitudinal tensile force of 11.1 \u00b1 1.6 N, which is lower than that of peripheral nerves (19.85 \u00b1 7.21 N) but higher than that of commercial collagen-based nerve guide conduits (6.89 \u00b1 2.6 N). The observed properties suggest that PUA-PAD-2 has potential as a biomaterial for nerve regeneration applications.<\/jats:p>","DOI":"10.3390\/polym17121692","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T07:38:15Z","timestamp":1750232295000},"page":"1692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Segmented Polyurethanes Based on Adipate and Sebacate Biodegradable Polyesters for Use as Nerve Guide Conduits in Peripheral Nerve Regeneration"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9935-3735","authenticated-orcid":false,"given":"Alexis B.","family":"Sabido-Barahona","sequence":"first","affiliation":[{"name":"Materials Department, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, A. C., Calle 43 No. 130 x 32 y 34, Col. Chuburn\u00e1 de Hidalgo, Merida 97205, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-0559","authenticated-orcid":false,"given":"Rossana F.","family":"Vargas-Coronado","sequence":"additional","affiliation":[{"name":"Materials Department, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, A. C., Calle 43 No. 130 x 32 y 34, Col. Chuburn\u00e1 de Hidalgo, Merida 97205, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Hern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Materials Department, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, A. C., Calle 43 No. 130 x 32 y 34, Col. Chuburn\u00e1 de Hidalgo, Merida 97205, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6982-9165","authenticated-orcid":false,"given":"Antonio","family":"Mart\u00ednez-Richa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad de Guanajuato, Noria Alta s\/n, Guanajuato 36050, Guanajuato, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-0885","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"G\u00f3mez Ribelles","sequence":"additional","affiliation":[{"name":"Centre for Biomaterials and Tissue Engineering, CBIT, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabell\u00f3n 11. Planta 0, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-7794","authenticated-orcid":false,"given":"Juan V.","family":"Cauich-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Materials Department, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, A. C., Calle 43 No. 130 x 32 y 34, Col. 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Neurotmesis, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1098\/rsif.2011.0438","article-title":"A Biomaterials Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery","volume":"9","author":"Daly","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/term.2039","article-title":"In Vitro Characterization of a Nanostructured Fibrin Agarose Bio-Artificial Nerve Substitute","volume":"11","author":"Carriel","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.nano.2010.07.004","article-title":"Emerging Nanotechnology Approaches in Tissue Engineering for Peripheral Nerve Regeneration","volume":"7","author":"Cunha","year":"2011","journal-title":"Nanomedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jhsg.2024.01.024","article-title":"The Role of Tissue Engineering and Three-Dimensional\u2013Filled Conduits in Bridging Nerve Gaps: A Review of Recent Advancements","volume":"6","author":"Crook","year":"2024","journal-title":"J. Hand Surg. Glob. Online"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1586\/14737175.2014.887444","article-title":"Tissue Engineering of the Peripheral Nervous System","volume":"14","author":"Carriel","year":"2014","journal-title":"Expert Rev. Neurother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11552-014-9601-6","article-title":"Overcoming Short Gaps in Peripheral Nerve Repair: Conduits and Human Acellular Nerve Allograft","volume":"9","author":"Isaacs","year":"2014","journal-title":"HAND"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sanchez Rezza, A., Kulahci, Y., Gorantla, V.S., Zor, F., and Drzeniek, N.M. (2022). Implantable Biomaterials for Peripheral Nerve Regeneration\u2013Technology Trends and Translational Tribulations. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.863969"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Boni, R., Ali, A., Shavandi, A., and Clarkson, A.N. (2018). Current and Novel Polymeric Biomaterials for Neural Tissue Engineering. J. Biomed. Sci., 25.","DOI":"10.1186\/s12929-018-0491-8"},{"key":"ref_11","first-page":"57","article-title":"Implantable Nerve Guidance Conduits: Material Combinations, Multi-Functional Strategies and Advanced Engineering Innovations","volume":"11","author":"Yan","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"van Uden, S., Vanerio, N., Catto, V., Bonandrini, B., Tironi, M., Figliuzzi, M., Remuzzi, A., Kock, L., Redaelli, A.C.L., and Greco, F.G. (2019). A Novel Hybrid Silk-Fibroin\/Polyurethane Three-Layered Vascular Graft: Towards in Situ Tissue-Engineered Vascular Accesses for Haemodialysis. Biomed. Mater., 14.","DOI":"10.1088\/1748-605X\/aafc96"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103014","DOI":"10.1016\/j.jddst.2021.103014","article-title":"Biodegradable Polymeric Conduits: Platform Materials for Guided Nerve Regeneration and Vascular Tissue Engineering","volume":"67","author":"Hayat","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Szczepa\u0144czyk, P., Szlachta, M., Z\u0142ocista-Szewczyk, N., Ch\u0142opek, J., and Pielichowska, K. (2021). Recent Developments in Polyurethane-Based Materials for Bone Tissue Engineering. Polymers, 13.","DOI":"10.3390\/polym13060946"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110717","DOI":"10.1016\/j.msec.2020.110717","article-title":"Design and Comprehensive Assessment of a Biomimetic Tri-Layer Tubular Scaffold via Biodegradable Polymers for Vascular Tissue Engineering Applications","volume":"110","author":"Jia","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jbm.a.37394","article-title":"Biodegradable Polyurethane Scaffolds in Regenerative Medicine: Clinical Translation Review","volume":"110","author":"Pedersen","year":"2022","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1016\/j.biomaterials.2005.05.079","article-title":"Understanding the Biodegradation of Polyurethanes: From Classical Implants to Tissue Engineering Materials","volume":"26","author":"Santerre","year":"2005","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jbm.a.34732","article-title":"Alternating Block Polyurethanes Based on PCL and PEG as Potential Nerve Regeneration Materials","volume":"102","author":"Li","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0883911506076063","article-title":"Preliminary Studies on Peripheral Nerve Regeneration Using a New Polyurethane Conduit","volume":"22","author":"Yin","year":"2007","journal-title":"J. Bioact. Compat. Polym."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.msec.2018.05.063","article-title":"Biodegradable Shape-Memory Polymers Using Polycaprolactone and Isosorbide Based Polyurethane Blends","volume":"91","author":"Joo","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.msec.2017.07.047","article-title":"Development of Polyurethanes for Bone Repair","volume":"80","author":"Marzec","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_22","unstructured":"(2018). Standard Test Method for Tensile Properties of Thin Plastic Sheeting (Standard No. ASTM ASTM D882)."},{"key":"ref_23","unstructured":"Integra LifeSciences Corporation (2021). Integra LifeSciences NeuraGen\u00ae 3D: Pre-Clinical Evidence Summary, Integra LifeSciences Corporation."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Griffith, J.F., and Guggenberger, R. (2021). Peripheral Nerve Imaging. Musculoskeletal Diseases 2021\u20132024: Diagnostic Imaging, Springer.","DOI":"10.1007\/978-3-030-71281-5_18"},{"key":"ref_25","unstructured":"(1988). Cardiovascular Implants\u2014Tubular Vascular Prostheses (Standard No. ISO7198)."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110449","DOI":"10.1016\/j.eurpolymj.2021.110449","article-title":"Amphiphilic and Segmented Polyurethanes Based on Poly(\u03b5-Caprolactone)Diol and Poly(2-Ethyl-2-Oxazoline)Diol: Synthesis, Properties, and a Preliminary Performance Study of the 3D Printing","volume":"151","author":"Bronzeri","year":"2021","journal-title":"Eur. Polym. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.eurpolymj.2016.05.024","article-title":"Synthesis and Characterization of Castor Oil-Segmented Thermoplastic Polyurethane with Controlled Mechanical Properties","volume":"81","author":"Malin","year":"2016","journal-title":"Eur. Polym. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00396-011-2585-7","article-title":"Interrelationship between Ultimate Mechanical Properties of Variously Structured Polyurethanes and Poly(Urethane Urea)s and Stretching Rate Thereof","volume":"290","author":"Tereshatov","year":"2012","journal-title":"Colloid. Polym. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1021\/ma9804186","article-title":"Hydrogen-Bond Interactions between Urethane\u2212Urethane and Urethane\u2212Ester Linkages in a Liquid Crystalline Poly(Ester\u2212urethane)","volume":"32","author":"Yen","year":"1999","journal-title":"Macromolecules"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1039\/C3TB21500H","article-title":"Physicochemical Characterization of Segmented Polyurethanes Prepared with Glutamine or Ascorbic Acid as Chain Extenders and Their Hydroxyapatite Composites","volume":"2","author":"Paakinaho","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.compositesb.2011.04.050","article-title":"Thermogravimetric Study for Polyurethane Materials for Biomedical Applications","volume":"42","author":"Filip","year":"2011","journal-title":"Compos. B Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.eurpolymj.2011.07.020","article-title":"Molecular Mobility and Crystallinity in Polytetramethylene Ether Glycol in the Bulk and as Soft Component in Polyurethanes","volume":"47","author":"Raftopoulos","year":"2011","journal-title":"Eur. Polym. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1021\/ma00157a038","article-title":"DSC Annealing Study of Microphase Separation and Multiple Endothermic Behavior in Polyether-Based Polyurethane Block Copolymers","volume":"19","author":"Leung","year":"1986","journal-title":"Macromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Raftopoulos, K.N., Klonos, P.A., Tworzyd\u0142o, P., Ozimek, J., Hebda, E., Kyritsis, A., and Pielichowski, K. (2023). Effects of Segment Length and Crosslinking via POSS on the Calorimetric and Dynamic Glass Transition of Polyurethanes with Aliphatic Hard Segments. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216540"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/pol.1983.170210211","article-title":"Quantitative DSC Evaluation of Phase Segregation Rate in Linear Segmented Polyurethanes and Polyurethaneureas","volume":"21","author":"Camberlin","year":"1983","journal-title":"J. Polym. Sci. Polym. Chem. Ed."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1021\/ma0214456","article-title":"In-Situ Studies of Structure Development during Deformation of a Segmented Poly(Urethane\u2212urea) Elastomer","volume":"36","author":"Yeh","year":"2003","journal-title":"Macromolecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.polymer.2014.12.014","article-title":"Critical Parameters in Designing Segmented Polyurethanes and Their Effect on Morphology and Properties: A Comprehensive Review","volume":"58","author":"Wilkes","year":"2015","journal-title":"Polymer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1021\/ma0102114","article-title":"Microdomain Morphology of Poly(Urethane Urea) Multiblock Copolymers","volume":"34","author":"Garrett","year":"2001","journal-title":"Macromolecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1021\/ma000600i","article-title":"Microphase Separation of Segmented Poly(Urethane Urea) Block Copolymers","volume":"33","author":"Garrett","year":"2000","journal-title":"Macromolecules"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/009524430003200205","article-title":"DSC Study of Morphological Changes in Segmented Polyurethane Elastomers","volume":"32","author":"Bajsic","year":"2000","journal-title":"J. Elastomers Plast."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0032-3861(84)90078-8","article-title":"Properties of Polyurethane Oligomeric Blends versus High Molecular Weight Block Copolymers","volume":"25","author":"Hwang","year":"1984","journal-title":"Polymer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jbm.820270308","article-title":"Degradation of Medical\u2014Grade Polyurethane Elastomers: The Effect of Hydrogen Peroxide in Vitro","volume":"27","author":"Meijs","year":"1993","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Riehle, N., Athanasopulu, K., Kutuzova, L., G\u00f6tz, T., Kandelbauer, A., Tovar, G.E.M., and Lorenz, G. (2021). Influence of Hard Segment Content and Diisocyanate Structure on the Transparency and Mechanical Properties of Poly(Dimethylsiloxane)-Based Urea Elastomers for Biomedical Applications. Polymers, 13.","DOI":"10.3390\/polym13020212"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/bm061058u","article-title":"Synthesis of Highly Elastic Biodegradable Poly(Urethane Urea)","volume":"8","author":"Asplund","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Santamaria-Echart, A., Fernandes, I., Barreiro, F., Corcuera, M.A., and Eceiza, A. (2021). Advances in Waterborne Polyurethane and Polyurethane-Urea Dispersions and Their Eco-Friendly Derivatives: A Review. Polymers, 13.","DOI":"10.3390\/polym13030409"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1021\/acs.biomac.8b00264","article-title":"Design and Applications of Cell-Selective Surfaces and Interfaces","volume":"19","author":"Zhang","year":"2018","journal-title":"Biomacromolecules"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/JEP.S148944","article-title":"Polyethylene Glycol in Spinal Cord Injury Repair: A Critical Review","volume":"10","author":"Lu","year":"2018","journal-title":"J Exp Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jbm.a.35955","article-title":"Neurite Extension and Neuronal Differentiation of Human Induced Pluripotent Stem Cell Derived Neural Stem Cells on Polyethylene Glycol Hydrogels Containing a Continuous Young\u2019s Modulus Gradient","volume":"105","author":"Mosley","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jbm.b.30202","article-title":"Stimulation of Neurite Outgrowth in a Human Nerve Scaffold Designed for Peripheral Nerve Reconstruction","volume":"73B","author":"Dumont","year":"2005","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1089\/ten.tec.2010.0152","article-title":"Multichanneled Collagen Conduits for Peripheral Nerve Regeneration: Design, Fabrication, and Characterization","volume":"16","author":"Yao","year":"2010","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/jbm.a.36022","article-title":"Novel Flexible Nerve Conduits Made of Water\u2014Based Biodegradable Polyurethane for Peripheral Nerve Regeneration","volume":"105","author":"Hsu","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Fregnan, F., Muratori, L., Bassani, G.A., Crosio, A., Biagiotti, M., Vincoli, V., Carta, G., Pierimarchi, P., Geuna, S., and Alessandrino, A. (2020). Preclinical Validation of SilkBridgeTM for Peripheral Nerve Regeneration. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00835"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1016\/j.biomaterials.2014.02.013","article-title":"Scaffolds from Block Polyurethanes Based on Poly(\u03b5-Caprolactone) (PCL) and Poly(Ethylene Glycol) (PEG) for Peripheral Nerve Regeneration","volume":"35","author":"Niu","year":"2014","journal-title":"Biomaterials"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mankavi, F., Ibrahim, R., and Wang, H. (2023). Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration. 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