{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:49:28Z","timestamp":1775242168661,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitization, CNCS\/CCCDI\u2014UEFISCDI","award":["PN-IV-P8-8.1-PRE-HE-ORG-2023-0048"],"award-info":[{"award-number":["PN-IV-P8-8.1-PRE-HE-ORG-2023-0048"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The development and application of antimicrobial coatings has become increasingly important in both medical and industrial settings due to the rising threat of microbial contamination and antibiotic resistance. This paper focuses on the formulation, characterization, and investigation of coatings based on quaternized polysulfone, which are designed to encapsulate two broad-spectrum antimicrobial drugs with complementary activity, amphotericin B (AmB) and norfloxacin (NFX), with the primary aim of inhibiting pathogen colonization on surgical instruments. Structural characterization using FTIR, 1H-NMR, and UV-Vis spectroscopy, along with supramolecular analysis via X-ray diffraction and polarized optical microscopy (POM), revealed strong physical interactions between the drugs and the quaternized polysulfone matrix. Scanning electron microscopy (SEM) confirmed a uniform distribution of the antimicrobial agents within the polymeric matrix. Surface wettability, assessed through water contact angle measurements, indicated moderate hydrophilicity (70\u201390\u00b0). The coatings also exhibited notable antioxidant activity, showing a 12-fold increase in DPPH radical inhibition compared to the control. Furthermore, all formulations demonstrated strong antimicrobial efficacy against three reference strains frequently associated with hospital-acquired infections, S. aureus, E. coli, and C. albicans, with inhibition zones ranging from 32 to 39.67 mm for bacterial strains and 13.86 to 20.86 mm for C. albicans. These data points indicate that these materials may be useful as antimicrobial coatings.<\/jats:p>","DOI":"10.3390\/polym17131869","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:47:26Z","timestamp":1751600846000},"page":"1869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quaternized Polysulfones as Matrix for the Development of Broad-Spectrum Antimicrobial Coatings for Medical Devices"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-0832","authenticated-orcid":false,"given":"Oana","family":"Dumbrava","sequence":"first","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-1709","authenticated-orcid":false,"given":"Irina","family":"Rosca","sequence":"additional","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ailincai","sequence":"additional","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-4912","authenticated-orcid":false,"given":"Luminita","family":"Marin","sequence":"additional","affiliation":[{"name":"\u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jain, S., Nehra, M., Kumar, R., Dilbaghi, N., Hu, T.Y., Kumar, S., Kaushik, A., and Li, C.-Z. (2021). Internet of Medical Things (IoMT)-Integrated Biosensors for Point-of-Care Testing of Infectious Diseases. Biosens. Bioelectron., 179.","DOI":"10.1016\/j.bios.2021.113074"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/jbm.a.36931","article-title":"Design of Dental Implants at Materials Level: An Overview","volume":"108","author":"Jiang","year":"2020","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.healun.2020.07.015","article-title":"Characterization of Infected, Explanted Ventricular Assist Device Drivelines: The Role of Biofilms and Microgaps in the Driveline Tunnel","volume":"39","author":"Qu","year":"2020","journal-title":"J. Heart Lung Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tibtech.2013.09.008","article-title":"Emerging Rules for Effective Antimicrobial Coatings","volume":"32","author":"Salwiczek","year":"2014","journal-title":"Trends Biotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1021\/acsami.1c01330","article-title":"Development of Novel Amphotericin B-Immobilized Nitric Oxide-Releasing Platform for the Prevention of Broad-Spectrum Infections and Thrombosis","volume":"13","author":"Devine","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ajic.2008.12.010","article-title":"Surgical Site Infection: Incidence and Impact on Hospital Utilization and Treatment Costs","volume":"37","author":"Fraeman","year":"2009","journal-title":"Am. J. Infect. Control"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jtcvs.2012.09.062","article-title":"Risk Factors for Surgical Site Infection in Pediatric Cardiac Surgery Patients Undergoing Delayed Sternal Closure","volume":"146","author":"Harder","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ajic.2013.06.022","article-title":"Microbial Contamination of Surgical Instruments Used for Laparotomy","volume":"42","author":"Saito","year":"2014","journal-title":"Am. J. Infect. Control"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.msec.2016.07.004","article-title":"The Potential of Photo-Deposited Silver Coatings on Foley Catheters to Prevent Urinary Tract Infections","volume":"69","author":"Cooper","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2014.12.015","article-title":"Development of a Catheter Functionalized by a Polydopamine Peptide Coating with Antimicrobial and Antibiofilm Properties","volume":"15","author":"Lim","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.actbio.2016.11.070","article-title":"A Review of the Recent Advances in Antimicrobial Coatings for Urinary Catheters","volume":"50","author":"Singha","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112017","DOI":"10.1016\/j.msec.2021.112017","article-title":"Electrically-Responsive Antimicrobial Coatings Based on a Tetracycline-Loaded Poly(3,4-Ethylenedioxythiophene) Matrix","volume":"123","author":"Student","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pinho, A.C., and Piedade, A.P. (2020). Polymeric Coatings with Antimicrobial Activity: A Short Review. Polymers, 12.","DOI":"10.3390\/polym12112469"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115664","DOI":"10.1016\/j.molliq.2021.115664","article-title":"Processing of Quaternized Polysulfones Solutions as Tool in Design of Electrospun Nanofibers: Microstructural Characteristics and Antimicrobial Activity","volume":"330","author":"Filimon","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bargan, A., Onofrei, M.D., Stoica, I., Doroftei, F., Dunca, S., and Filimon, A. (2022). Materials Based on Quaternized Polysulfones with Potential Applications in Biomedical Field: Structure\u2013Properties Relationship. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094721"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"112316","DOI":"10.1016\/j.eurpolymj.2023.112316","article-title":"Tailoring Properties and Applications of Polysulfone Membranes by Chemical Modification: Structure-Properties-Applications Relationship","volume":"196","author":"Dumbrava","year":"2023","journal-title":"Eur. Polym. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/00914037.2021.2006653","article-title":"Modification of Polysulfone and the Biomedical Application of Modified Polysulfone","volume":"72","author":"Chen","year":"2023","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wasy\u0142eczko, M., Wojciechowski, C., and Chwojnowski, A. (2024). Polyethersulfone Polymer for Biomedical Applications and Biotechnology. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084233"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10544-012-9639-6","article-title":"Porous Polysulfone Coatings for Enhanced Drug Delivery","volume":"14","author":"Sivaraman","year":"2012","journal-title":"Biomed. Microdevices"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.biotechadv.2017.11.010","article-title":"The Importance of Fungal Pathogens and Antifungal Coatings in Medical Device Infections","volume":"36","author":"Giles","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1177\/1535370216688572","article-title":"Emerging Technologies for Long-Term Antimicrobial Device Coatings: Advantages and Limitations","volume":"242","author":"Cyphert","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106229","DOI":"10.1016\/j.jinf.2024.106229","article-title":"Attributable Mortality of Candidemia\u2014Results from the ECMM Candida III Multinational European Observational Cohort Study","volume":"89","author":"Cornely","year":"2024","journal-title":"J. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1469-0691.2005.01318.x","article-title":"Inflammatory Response and Clinical Course of Adult Patients with Nosocomial Bloodstream Infections Caused by Candida spp.","volume":"12","author":"Wisplinghoff","year":"2006","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00000658-198307000-00008","article-title":"Candida Infections in Surgical Patients","volume":"198","author":"Marsh","year":"1983","journal-title":"Ann. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: Side Effects and Toxicity","volume":"26","year":"2009","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/jac\/dkg218","article-title":"In Vitro Activity of Amphotericin B and Itraconazole in Combination with Flucytosine, Sulfadiazine and Quinolones against Exophiala Spinifera","volume":"51","author":"Vitale","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/app.12677","article-title":"Viscometric Behavior of Quaternized Polysulfones","volume":"90","author":"Ghimici","year":"2003","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"116754","DOI":"10.1016\/j.carbpol.2020.116754","article-title":"Stereocomplexed Electrospun Nanofibers Containing Poly (Lactic Acid) Modified Quaternized Chitosan for Wound Healing","volume":"247","author":"Ren","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"121135","DOI":"10.1016\/j.carbpol.2023.121135","article-title":"Mesoporous Chitosan Nanofibers Loaded with Norfloxacin and Coated with Phenylboronic Acid Perform as Bioabsorbable Active Dressings to Accelerate the Healing of Burn Wounds","volume":"318","author":"Ailincai","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_30","unstructured":"(2010). Antibacterial Products\u2014Test for Antibacterial Activity and Efficacy (Standard No. JIS Z 2801)."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1001\/archinte.1959.00270080034004","article-title":"Single-Disk Antibiotic-Sensitivity Testing of Staphylococci; an Analysis of Technique and Results","volume":"104","author":"Bauer","year":"1959","journal-title":"AMA Arch. Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-291X(03)00504-7","article-title":"1H NMR Studies of Selective Interactions of Norfloxacin with Double-Stranded DNA","volume":"304","author":"Leijon","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0005-2736(93)90139-Q","article-title":"CD and NMR Studies on the Aggregation of Amphotericin-B in Solution","volume":"1148","author":"Easwaran","year":"1993","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Biomembr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"118900","DOI":"10.1016\/j.memsci.2020.118900","article-title":"Novel Polysulfone Ultrafiltration Membranes Incorporating Polydopamine Functionalized Graphene Oxide with Enhanced Flux and Fouling Resistance","volume":"620","author":"Alkhouzaam","year":"2021","journal-title":"J. Membr. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0975-1483.100017","article-title":"FTIR and Raman Spectroscopic Investigations of a Norfloxacin\/Carbopol934 Polymeric Suspension","volume":"4","author":"Sahoo","year":"2012","journal-title":"J. Young Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1021\/jp110543g","article-title":"Influence of K+ and Na+ Ions on the Aggregation Processes of Antibiotic Amphotericin B: Electronic Absorption and FTIR Spectroscopic Studies","volume":"115","author":"Arczewska","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijpharm.2005.11.031","article-title":"Encapsulation of Amphotericin B in Poly(Ethylene Glycol)-Block-Poly(\u03b5-Caprolactone-Co-Trimethylenecarbonate) Polymeric Micelles","volume":"309","author":"Vandermeulen","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ja.2011.83","article-title":"Simultaneous Determination of Purity and Potency of Amphotericin B by HPLC","volume":"64","author":"Chang","year":"2011","journal-title":"J. Antibiot."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1021\/acsomega.7b00703","article-title":"Counterpointing Scenarios on the Fate of Different Prototropic Forms of Norfloxacin Housed in the Pocket of Lysozyme: The Nonelectrostatic Interactions in the Protein Interior Are in the Controlling Role on the Prototropic Equilibria of the Guest","volume":"2","author":"Das","year":"2017","journal-title":"ACS Omega"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110316","DOI":"10.1016\/j.msec.2019.110316","article-title":"Polyvinyl Alcohol Boric Acid\u2014A Promising Tool for the Development of Sustained Release Drug Delivery Systems","volume":"107","author":"Ailincai","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1016\/j.ijhydene.2011.03.056","article-title":"Novel Quaternized Polysulfone\/ZrO2 Composite Membranes for Solid Alkaline Fuel Cell Applications","volume":"36","author":"Vinodh","year":"2011","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"120276","DOI":"10.1016\/j.molliq.2022.120276","article-title":"Solubility, Aggregation and Stability of Amphotericin B Drug in Pure Organic Solvents: Thermodynamic Analysis and Solid Form Characterization","volume":"366","author":"Soto","year":"2022","journal-title":"J. Mol. Liq."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1155\/2011\/462913","article-title":"New Solid Form of Norfloxacin: Structural Studies","volume":"25","author":"Bratu","year":"2011","journal-title":"J. Spectrosc."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lekoane, T., and Msomi, P.F. (2023). Quarternized Polysulfone\/ZSM-5 Zeolite Composite Anion Exchange Membrane Separators for Aluminum-Air Battery. J. Appl. Polym. Sci., 140.","DOI":"10.1002\/app.54006"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38397","DOI":"10.1039\/C4RA06426G","article-title":"Monodisperse PDLC Composites Generated by Use of Polyvinyl Alcohol Boric Acid as Matrix","volume":"4","author":"Marin","year":"2014","journal-title":"RSC Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3124304","DOI":"10.1155\/2020\/3124304","article-title":"Poly(Vinyl Alcohol Boric Acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies","volume":"2020","author":"Ailincai","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/OPX.0b013e3181da863e","article-title":"The Impact of Contact Angle on the Biocompatibility of Biomaterials","volume":"87","author":"Menzies","year":"2010","journal-title":"Optom. Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kumar, S., Bhushan, P., and Bhattacharya, S. (2017). Coatings on Surgical Tools and How to Promote Adhesion of Bio-Friendly Coatings on Their Surfaces. Adhesion in Pharmaceutical, Biomedical and Dental Fields, John Wiley & Sons.","DOI":"10.1002\/9781119323716.ch10"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijadhadh.2019.04.010","article-title":"Development and Characterization of a Multilayer Silver\/Silver-Tantalum Oxide Thin Film Coating on Stainless Steel for Biomedical Applications","volume":"92","author":"Alias","year":"2019","journal-title":"Int. J. Adhes. Adhes."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0142-9612(94)90025-6","article-title":"Surface Modification of Polymers for Medical Applications","volume":"15","author":"Ikada","year":"1994","journal-title":"Biomaterials"},{"key":"ref_51","first-page":"65","article-title":"III. An Essay on the Cohesion of Fluids","volume":"95","author":"Young","year":"1805","journal-title":"Philos. Trans. R. Soc. Lond."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/app.1969.070130815","article-title":"Estimation of the Surface Free Energy of Polymers","volume":"13","author":"Owens","year":"1969","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"i","DOI":"10.1021\/ba-1964-0043.fw001","article-title":"Contact Angle, Wettability, and Adhesion","volume":"43","author":"Fowkes","year":"1964","journal-title":"Adv. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"129392","DOI":"10.1016\/j.surfcoat.2023.129392","article-title":"Biocompatibility Evaluation, Wettability, and Scratch Behavior of Ta-Coated 316L Stainless Steel by DC Magnetron Sputtering for the Orthopedic Applications","volume":"459","author":"Pathote","year":"2023","journal-title":"Surf. Coat. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100945","DOI":"10.1016\/j.apmt.2021.100945","article-title":"Drug Powders with Tunable Wettability by Atomic and Molecular Layer Deposition: From Highly Hydrophilic to Superhydrophobic","volume":"22","author":"Zhang","year":"2021","journal-title":"Appl. Mater. Today"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Singh, D., and Dilip Saoji, S. (2024). The Role of Surface Energy and Wettability in Polymer-Based Drug Delivery Systems: Enhancing Bioadhesion and Drug Release Efficiency. J. Macromol. Sci. Part B Phys., 1\u20138.","DOI":"10.1080\/00222348.2024.2397910"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15467","DOI":"10.1039\/D1RA02402G","article-title":"Effect of Surface Energy and Roughness on Cell Adhesion and Growth\u2014Facile Surface Modification for Enhanced Cell Culture","volume":"11","author":"Majhy","year":"2021","journal-title":"RSC Adv."},{"key":"ref_58","first-page":"12","article-title":"Release Kinetics\u2014Concepts and Applications","volume":"8","author":"Paarakh","year":"2018","journal-title":"Int. J. Pharm. Res. Technol. (IJPRT)"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ailincai, D., Morariu, S., Rosca, I., Sandu, A.I., and Marin, L. (2023). Drug Delivery Based on a Supramolecular Chemistry Approach by Using Chitosan Hydrogels. Int. J. Biol. Macromol., 248.","DOI":"10.1016\/j.ijbiomac.2023.125800"},{"key":"ref_60","unstructured":"(2015). Mathematical Models of Drug Release. Strategies to Modify the Drug Release from Pharmaceutical Systems, Woodhead Publishing."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0006-2952(97)00267-0","article-title":"Amphotericin B as an Intracellular Antioxidant: Protection against 2,2\u2032-Azobis(2,4-Dimethylvaleronitrile)-Induced Peroxidation of Membrane Phospholipids in Rat Aortic Smooth Muscle Cells","volume":"54","author":"Osaka","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kancheva, V.D., Dettori, M.A., Fabbri, D., Alov, P., Angelova, S.E., Slavova-Kazakova, A.K., Carta, P., Menshov, V.A., Yablonskaya, O.I., and Trofimov, A.V. (2021). Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress. Antioxidants, 10.","DOI":"10.3390\/antiox10040624"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1780956","DOI":"10.1155\/2018\/1780956","article-title":"Anti-Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella Multocida Infection in Male New Zealand Rabbits","volume":"2018","author":"Alam","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"109431","DOI":"10.1016\/j.carres.2025.109431","article-title":"Quaternary Ammonium Salts of Chitosan Containing Aromatic Ring: Synthesis, Characterization, Antimicrobial, Antioxidant and Cytotoxicity","volume":"552","author":"Cui","year":"2025","journal-title":"Carbohydr. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jpowsour.2012.01.038","article-title":"Phosphoric Acid Doped Imidazolium Polysulfone Membranes for High Temperature Proton Exchange Membrane Fuel Cells","volume":"205","author":"Yang","year":"2012","journal-title":"J Power Sources"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.memsci.2015.06.010","article-title":"Influences of the Structure of Imidazolium Pendants on the Properties of Polysulfone-Based High Temperature Proton Conducting Membranes","volume":"493","author":"Yang","year":"2015","journal-title":"J. Membr. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"117591","DOI":"10.1016\/j.memsci.2019.117591","article-title":"Preparation of Anion Exchange Membrane by Efficient Functionalization of Polysulfone for Electrodialysis","volume":"596","author":"Liu","year":"2020","journal-title":"J. Membr. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1081\/PPT-100000248","article-title":"Polymers with Pendent Functional Groups. VI. A Comparative Study on the Chloromethylation of Linear Polystyrene and Polysulfone with Paraformaldehyde\/Me3SiCl","volume":"40","author":"Avram","year":"2001","journal-title":"Polym. Plast. Technol. 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