{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:46Z","timestamp":1760060746613,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency, ANR","doi-asserted-by":"publisher","award":["ANR-20-CE18-0037"],"award-info":[{"award-number":["ANR-20-CE18-0037"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Higher Education and Research","award":["ANR-20-CE18-0037"],"award-info":[{"award-number":["ANR-20-CE18-0037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>With aging, harsh working conditions or sports injuries, the meniscus can degrade, causing pains to the patient. Nowadays, the treatment consists of the surgical replacement of this cartilage. Since this procedure can lead to complications due to open wounds and potential infections, synthesizing a polyurethane-based injectable joint filler represents an interesting alternative. In this study, poly(\u03b4-decalactone)triol oligomers and Lysine diisocyanate were chosen as starting monomers to create an isocyanate-based prepolymer, because of their biocompatibility and liquid state at room temperature. Nevertheless, to fully replace the meniscus, the joint filler must crosslink in vivo, and this should occur in a short time window. Accordingly, in this work, we studied the catalytic activity of a range of relatively safe compounds for the alcohol\/isocyanate addition reaction. A preliminary 1H NMR kinetic study of the catalyzed addition of 1-butanol or 3-pentanol on lysine diisocyanate ethyl ester at body temperature has been performed to reach this objective. Among catalysts, stannous octoate was the most effective with either primary or secondary alcohol, allowing them to reach 92 and 80% alcohol conversion, respectively. In addition, the conversion of the primary and secondary isocyanates of lysine diisocyanate ethyl ester was monitored for all the catalysts and revealed different behaviors depending on the catalyst employed. Stannous octoate, unlike the others, showed a similar reactivity for primary and secondary isocyanates with conversions of 49 and 47%, respectively. Finally, when employing the most effective catalyst, curing of the poly(\u03b4-decalactone) triisocyanate with glycerol at 35 \u00b0C provided a polyurethane elastomer that exhibits an elastic modulus of 519 kPa and a swelling index lower than 3% in PBS, making it suitable for injectable polyurethane joint filler application.<\/jats:p>","DOI":"10.3390\/polym17182548","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:05:17Z","timestamp":1758535517000},"page":"2548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalyst Selection for Body-Temperature Curable Polyurethane Networks from Poly(\u03b4-Decalactone) and Lysine Diisocyanate"],"prefix":"10.3390","volume":"17","author":[{"given":"Marine","family":"Boursier","sequence":"first","affiliation":[{"name":"ICGM, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-9684","authenticated-orcid":false,"given":"Aurelien","family":"Lebrun","sequence":"additional","affiliation":[{"name":"PAC Chimie Balard Montpellier\u2014UAR2041, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Parra","sequence":"additional","affiliation":[{"name":"PAC Chimie Balard Montpellier\u2014UAR2041, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-5547","authenticated-orcid":false,"given":"Sylvain","family":"Caillol","sequence":"additional","affiliation":[{"name":"ICGM, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-4547","authenticated-orcid":false,"given":"Claire","family":"Negrell","sequence":"additional","affiliation":[{"name":"ICGM, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Pinaud","sequence":"additional","affiliation":[{"name":"ICGM, CNRS, ENSCM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"ref_1","unstructured":"(2024, May 31). Polyurethane Market Size, Trends, Share, Growth, Report 2032. Available online: https:\/\/www.precedenceresearch.com\/polyurethane-market."},{"key":"ref_2","unstructured":"(2025, June 01). Polyurethane Market Size, Share & Trends Analysis Report By Product (Rigid Foam, Flexible Foam), By Application (Construction, Furniture & Interiors), By Region, And Segment Forecasts, 2022\u20132030. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/polyurethane-pu-market#."},{"key":"ref_3","unstructured":"Fortune Business Insights (2021). Polyurethane Market Size, Share & COVID-19 Impact Analysis and Regional Forecast 2021\u20132028, Fortune Business Insights."},{"key":"ref_4","first-page":"93","article-title":"A Brief Discussion on Advances in Polyurethane Applications","volume":"3","author":"Das","year":"2020","journal-title":"Adv. Ind. Eng. Polym. Res."},{"key":"ref_5","first-page":"1083","article-title":"Biobased Polyurethanes for Biomedical Applications","volume":"6","author":"Wendels","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.msec.2014.10.027","article-title":"Fabrication of Polyurethane and Polyurethane Based Composite Fibres by the Electrospinning Technique for Soft Tissue Engineering of Cardiovascular System","volume":"46","author":"Gubanska","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpharm.2013.04.063","article-title":"Polyurethane-Based Drug Delivery Systems","volume":"450","author":"Cherng","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0142-9612(94)90198-8","article-title":"Hydrolytic Stability of Polyurethane Medical Adhesive Dressings","volume":"15","author":"Pavlova","year":"1994","journal-title":"Biomaterials"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Magnin, A., Pollet, E., Phalip, V., and Av\u00e9rous, L. (2020). Evaluation of Biological Degradation of Polyurethanes. Biotechnol. Adv., 39.","DOI":"10.1016\/j.biotechadv.2019.107457"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yeoh, F.H., Lee, C.S., Kang, Y.B., Wong, S.F., Cheng, S.F., and Ng, W.S. (2020). Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications. Polymers, 12.","DOI":"10.3390\/polym12081842"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1177\/0363546520913528","article-title":"Polyurethane Meniscal Scaffold for the Treatment of Partial Meniscal Deficiency: 5-Year Follow-up Outcomes: A European Multicentric Study","volume":"48","author":"Toanen","year":"2020","journal-title":"Am. J. Sports Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12178-024-09902-1","article-title":"The Current State of Meniscus Replacements","volume":"17","year":"2024","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_13","first-page":"e8590","article-title":"Meniscal Tears: Current Understanding, Diagnosis, and Management","volume":"12","author":"Bhan","year":"2020","journal-title":"Cureus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/jars.2000.4819","article-title":"Meniscal Repair Devices","volume":"16","author":"Barber","year":"2000","journal-title":"Arthroscopy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41467-024-47029-6","article-title":"Silk Fibroin Hydrogel Adhesive Enables Sealed-Tight Reconstruction of Meniscus Tears","volume":"15","author":"Pan","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10856-016-5694-5","article-title":"Tissue Adhesives for Meniscus Tear Repair: An Overview of Current Advances and Prospects for Future Clinical Solutions","volume":"27","author":"Hannink","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijbiomac.2023.125674","article-title":"Injectable Hydrogels for Cartilage and Bone Tissue Regeneration: A Review","volume":"246","author":"Ghandforoushan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40204-022-00185-8","article-title":"Injectable Hydrogels for Bone and Cartilage Tissue Engineering: A Review","volume":"11","author":"Olov","year":"2022","journal-title":"Prog. Biomater."},{"key":"ref_19","first-page":"1","article-title":"Injectable and in Situ Foaming Shape-Adaptive Porous Bio-Based Polyurethane Scaffold Used for Cartilage Regeneration","volume":"39","author":"Bahatibieke","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110705","DOI":"10.1016\/j.msec.2020.110705","article-title":"Injectable Double-Crosslinked Hydrogels with Kartogenin-Conjugated Polyurethane Nano-Particles and Transforming Growth Factor \u03923 for in-Situ Cartilage Regeneration","volume":"110","author":"Fan","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxlet.2022.01.011","article-title":"Toxicity of High-Molecular-Weight Polyethylene Glycols in Sprague Dawley Rats","volume":"359","author":"Fang","year":"2022","journal-title":"Toxicol. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/0192623317714068","article-title":"Magnetic Resonance and Ultrastructural Characterization of PEGylation-Associated Vacuolation in Nonclinical Models","volume":"45","author":"Forest","year":"2017","journal-title":"Toxicol. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7196","DOI":"10.1039\/C5PY01203A","article-title":"New biomaterials from renewable resources\u2014Amphiphilic block copolymers from \u03b4-decalactone","volume":"6","author":"Bansal","year":"2015","journal-title":"Polym. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1039\/D4NA00176A","article-title":"A poly-\u03b4-decalactone (PDL) based nanoemugel for topical delivery of ketoconazole and eugenol against Candida albicans","volume":"6","author":"Dubey","year":"2024","journal-title":"Nanoscale Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2201378","DOI":"10.1002\/adhm.202201378","article-title":"Tailored Biocompatible Polyurethane-Poly(Ethylene Glycol) Hydrogels as a Versatile Nonfouling Biomaterial","volume":"11","author":"Speidel","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.eurpolymj.2016.08.008","article-title":"Biocompatibility and Hemocompatibility Evaluation of Polyether Urethanes Synthesized Using DBU Organocatalyst","volume":"84","author":"Basterretxea","year":"2016","journal-title":"Eur. Polym. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"46861","DOI":"10.1002\/app.46861","article-title":"One-Pot Synthesis of Palm Oil-Based Polyester Polyol for Production of Biodegradable and Biocompatible Polyurethane","volume":"135","author":"Yeoh","year":"2018","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101805","DOI":"10.1016\/j.progpolymsci.2024.101805","article-title":"Sustainable Polyurethanes: Toward New Cutting-Edge Opportunities","volume":"151","author":"Delavarde","year":"2024","journal-title":"Prog. Polym. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2000114","DOI":"10.1002\/macp.202000114","article-title":"Current and Future Trends in Polyurethanes: An Industrial Perspective","volume":"221","author":"Eling","year":"2020","journal-title":"Macromol. Chem. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0926-860X(01)00910-3","article-title":"Trends in Industrial Catalysis in the Polyurethane Industry","volume":"221","author":"Wegener","year":"2001","journal-title":"Appl. Catal. A Gen."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijbiomac.2006.06.023","article-title":"Modification of the Biopolymer Castor Oil with Free Isocyanate Groups to Be Applied as Bioadhesive","volume":"40","author":"Ferreira","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1557\/jmr.2018.286","article-title":"Effect of an Organotin Catalyst on the Physicochemical Properties and Biocompatibility of Castor Oil-Based Polyurethane\/Cellulose Composites","volume":"33","author":"Valero","year":"2018","journal-title":"J. Mater. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/0021955X05055113","article-title":"Polyurethane Catalysis by Tertiary Amines","volume":"41","author":"Tamano","year":"2005","journal-title":"J. Cell. Plast."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16235","DOI":"10.1021\/ja408641g","article-title":"Organic Acid-Catalyzed Polyurethane Formation via a Dual-Activated Mechanism: Unexpected Preference of n-Activation over o-Activation of Isocyanates","volume":"135","author":"Sardon","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1021\/ma2026258","article-title":"Cyclic Guanidines as Efficient Organocatalysts for the Synthesis of Polyurethanes","volume":"45","author":"Alsarraf","year":"2012","journal-title":"Macromolecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/acs.macromol.1c02491","article-title":"Harnessing Catalysis Selectivity and Isophorone Diisocyanate Asymmetry for Tailored Polyurethane Prepolymers and Networks","volume":"55","author":"Arnould","year":"2022","journal-title":"Macromolecules"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1039\/D0PY00864H","article-title":"Identifying Competitive Tin-or Metal-Free Catalyst Combinations to Tailor Polyurethane Prepolymer and Network Properties","volume":"11","author":"Arnould","year":"2020","journal-title":"Polym. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.biomaterials.2007.12.046","article-title":"Synthesis, Mechanical Properties, Biocompatibility, and Biodegradation of Polyurethane Networks from Lysine Polyisocyanates","volume":"29","author":"Guelcher","year":"2008","journal-title":"Biomaterials"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1021\/acsapm.4c01187","article-title":"Development of a Catalyst System for Enhanced Properties of Coconut Diethanolamide-Based Rigid Poly(Urethane-Urea) Foam","volume":"6","author":"Bondaug","year":"2024","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/pola.1994.080321216","article-title":"Hydrolyzable Poly (Ester-Urethane) Networks from L-Lysine Diisocyanate and D,L-Lactide\/e-Caprolactone Homo- and Copolyester","volume":"32","author":"Storey","year":"1994","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1021\/acs.macromol.5b00384","article-title":"Synthesis of Polyurethanes Using Organocatalysis: A Perspective","volume":"48","author":"Sardon","year":"2015","journal-title":"Macromolecules"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/15685551.2016.1152545","article-title":"Novel Nucleophilic\/Basic and Acidic Organocatalysts for Reaction between Poorly Reactive Diisocyanate and Diols","volume":"19","author":"Belmokaddem","year":"2016","journal-title":"Des. Monomers Polym."},{"key":"ref_43","unstructured":"Lhomme, J. (2025, June 01). Nouveaux Catalyseurs et Syst\u00e8mes Catalytiques Appliqu\u00e9s \u00e0 La Synth\u00e8se Du Polyur\u00e9thane via La R\u00e9action Isocyanate Alcool, Universit\u00e9 Claude Bernard Lyon 1\u2014Institut National des Sciences Appliqu\u00e9es. Available online: https:\/\/tel.archives-ouvertes.fr\/tel-01077954."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Havlickova, K., Kostakova, E.K., Lisnenko, M., Hauzerova, S., Stuchlik, M., Vrchovecka, S., Vistejnova, L., Molacek, J., Lukas, D., and Prochazkova, R. (2024). The Impacts of the Sterilization Method and the Electrospinning Conditions of Nanofibrous Biodegradable Layers on Their Degradation and Hemocompatibility Behavior. Polymers, 16.","DOI":"10.3390\/polym16081029"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111820","DOI":"10.1016\/j.msec.2020.111820","article-title":"Tough and Biodegradable Polyurethane-Curcumin Composited Hydrogel with Antioxidant, Antibacterial and Antitumor Properties","volume":"121","author":"Feng","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, W., and Wang, C. (2012). Polyurethane for Biomedical Applications: A Review of Recent Developments, Elsevier Masson SAS.","DOI":"10.1533\/9781908818188.115"},{"key":"ref_47","unstructured":"Gangolli, S. (2005). Dictionary of Substances and Their Effects (DOSE, 3rd Electronic Edition), Royal Society of Chemistry."},{"key":"ref_48","unstructured":"(2025, September 08). Available online: https:\/\/www.chemicalbook.com\/article\/trifluoroacetic-acid-physicochemical-property-uses-and-nmr-challenge.htm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1063\/1.1740728","article-title":"Ionization of Strong Electrolytes. IV. Nuclear Magnetic Resonance and Dissociation of Trifluoroacetic Acid","volume":"23","author":"Hood","year":"1955","journal-title":"J. Chem. Phys."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Shertzer, H.G. (2000). Patty\u2019s Toxicology CD-ROM, John Wiley sons. Org. Sulfur Compd. Online Post. Date April 16, 2001.","DOI":"10.1002\/9780471125471.tox094"},{"key":"ref_51","unstructured":"Serjeant, E.P., and Dempsey, B. (1979). Ionisation Constants of Organic Acids in Aqueous Solution, Elsevier."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/sojmse.2016.00140","article-title":"The Effect of Inhibitor on the Corrosion of Aluminium in Acidic Solutions","volume":"4","author":"Uma","year":"2016","journal-title":"SOJ Mater. Sci. Eng."},{"key":"ref_53","unstructured":"(2025, September 08). 2-ethylhexanoic Acid Tin(II) Salt|C16H30O4Sn|CID 9318\u2014PubChem, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/9318#section=Hazards-Summary."},{"key":"ref_54","unstructured":"(2025, September 08). N,N-Dimethylcyclohexylamine|C8H17N|CID 7415\u2014PubChem, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/7415#section=Physical-Description."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16096","DOI":"10.1039\/D3NJ02747C","article-title":"The Kinetics of Uncatalyzed and Catalyzed Urethane Forming Reactions of Aliphatic Diisocyanates with Butan-1-Ol","volume":"47","author":"Serra","year":"2023","journal-title":"New J. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.fluid.2011.09.022","article-title":"Estimation of PKa Values for Carboxylic Acids, Alcohols, Phenols and Amines Using Changes in the Relative Gibbs Free Energy","volume":"313","author":"Zeng","year":"2012","journal-title":"Fluid Phase Equilib."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Waleed, H.Q., Viskolcz, B., and Fiser, B. (2024). Urethane Synthesis in the Presence of Organic Acid Catalysts\u2014A Computational Study. Molecules, 29.","DOI":"10.3390\/molecules29102375"},{"key":"ref_58","first-page":"14","article-title":"Infrared Spectroscopy of Polymers XIII: Polyurethanes","volume":"38","author":"Smith","year":"2023","journal-title":"Spectroscopy"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/pola.22577","article-title":"Quantitative IR Characterization of Urea Groups in Waterborne Polyurethanes","volume":"46","author":"Shi","year":"2007","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/B:JMSM.0000021114.39595.1e","article-title":"Design, Synthesis and Properties of a Degradable Polyurethane Scaffold for Meniscus Regeneration","volume":"15","author":"Heijkants","year":"2004","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/acsomega.8b02593","article-title":"Fabrication and in Vitro Evaluation of Nanocomposite Hydrogel Scaffolds Based on Gelatin\/PCL-PEG-PCL for Cartilage Tissue Engineering","volume":"4","author":"Asadi","year":"2019","journal-title":"ACS Omega"}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/18\/2548\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:46:34Z","timestamp":1760035594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/18\/2548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,20]]},"references-count":61,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["polym17182548"],"URL":"https:\/\/doi.org\/10.3390\/polym17182548","relation":{},"ISSN":["2073-4360"],"issn-type":[{"type":"electronic","value":"2073-4360"}],"subject":[],"published":{"date-parts":[[2025,9,20]]}}}