{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:11:36Z","timestamp":1792789896578,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Acera Surgical Inc."},{"name":"LSU Health Foundation New Orleans"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates the use of a synthetic electrospun fiber matrix (SEFM) as a post-resection regeneration template to accelerate re-granulation and improve subsequent skin graft incorporation. This prospective pilot study enrolled Hurley Stage II or III patients undergoing surgical resection of HS lesions. SEFM was applied to the resulting wounds in conjunction with negative pressure wound therapy (NPWT). Patients were monitored post-operatively for granulation tissue formation and underwent skin grafting once granulation was sufficient. Skin graft incorporation was assessed at follow-up visits. Complications, including graft loss (partial or complete) and infection, were assessed at each encounter. A total of 21 wounds in eight patients met the inclusion criteria and were enrolled. The average time to skin grafting was 14 \u00b1 3.2 days. After grafting, the average graft incorporation was 71 \u00b1 28%. No complications occurred during the study. These initial results indicate that by supporting granulation tissue formation, combined use of SEFM and NPWT may aid in successful engraftment of topographically challenging areas post-HS excision.<\/jats:p>","DOI":"10.3390\/polym17192563","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:27:53Z","timestamp":1758623273000},"page":"2563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds Following Excision of Hidradenitis Suppurativa Lesions: A Prospective Pilot Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Michael","family":"Madueke","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lau","sequence":"additional","affiliation":[{"name":"Keliomics, Inc., 4640 S. Macadam Ave, Portland, OR 97239, USA"},{"name":"Louisiana State University Health Sciences Center, Department of Surgery, Section of Plastic & Reconstructive Surgery, 1542 Tulane Ave, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/01.ASW.0000363559.53350.84","article-title":"Hidradenitis suppurativa: A clinician\u2019s tool for early diagnosis and treatment","volume":"23","author":"Beshara","year":"2010","journal-title":"Adv. Skin Wound Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20406223211055920","DOI":"10.1177\/20406223211055920","article-title":"New perspectives on the treatment of hidradenitis suppurativa","volume":"12","author":"Vilarrasa","year":"2021","journal-title":"Thera. Adv. Chronic Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e1582","DOI":"10.1002\/hsr2.1582","article-title":"Advanced wound management approaches in Hidradenitis Suppurativa postsurgical lesions","volume":"6","author":"Michelucci","year":"2023","journal-title":"Health Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/bjd.17588","article-title":"Inter- and intrarater reliability of Hurley staging for hidradenitis suppurativa","volume":"181","author":"Ovadja","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Shukla, R., Karagaiah, P., Patil, A., Farnbach, K., Ortega-Loayza, A.G., Tzellos, T., Szepietowski, J.C., Giulini, M., Schepler, H., and Grabbe, S. (2022). Surgical treatment in hidradenitis suppurativa. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092311"},{"key":"ref_6","first-page":"13","article-title":"Surgical procedures for hidradenitis suppurativa","volume":"102","author":"Vellaichamy","year":"2018","journal-title":"Cutis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s00268-017-4091-7","article-title":"35-year experience with surgical treatment of hidradenitis suppurativa","volume":"41","author":"Burney","year":"2017","journal-title":"World J. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/iwj.13241","article-title":"Factors influencing the local cure rate of hidradenitis suppurativa following wide local excision","volume":"17","author":"Ngaage","year":"2019","journal-title":"Int. Wound J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0970-0358.26898","article-title":"Reconstruction in extensive axillary Hidradenitis suppurativa with local fasciocutaneous V-Y advancement flaps","volume":"39","author":"Sharma","year":"2020","journal-title":"Indian J. Plast. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e255037","DOI":"10.1136\/bcr-2023-255037","article-title":"Use of multiple fasciocutaneous flaps for the management of extensive hidradenitis suppurativa","volume":"16","author":"Alshammary","year":"2023","journal-title":"BMJ Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000507297","article-title":"Hidradenitis suppurativa: Surgical and postsurgical managment","volume":"6","author":"Manfredini","year":"2021","journal-title":"Skin Appendage Disord."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gore, M. (2022). Preparation for a successful skin grafting. Skin Grafts for Successful Wound Closure, IntechOpen.","DOI":"10.5772\/intechopen.95174"},{"key":"ref_13","first-page":"18","article-title":"The basics of Integra dermal regeneration template and its expanding clinical applications","volume":"33","author":"Chang","year":"2019","journal-title":"Semin. Plast. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/jbcr\/irac135","article-title":"Use of dermal regenerative templates for burns","volume":"44","author":"Mason","year":"2023","journal-title":"J. Burn. Care Res."},{"key":"ref_15","first-page":"e38608","article-title":"Integra dermal regeneration template: From design to clinical use","volume":"15","author":"Taupin","year":"2023","journal-title":"Cureus"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rajaram, R., Zhang, M., Premaratne, G., and Ng, S. (2024). Novosorb BTM\u2014History, production and application in challenging wounds. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1450973"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2869","DOI":"10.1097\/GOX.0000000000002869","article-title":"Infectious complications associated with the use of Integra: A systematic review of the literature","volume":"8","author":"Gonzalez","year":"2020","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_18","first-page":"100112","article-title":"Treatment of traumatic crush injury using a synthetic hybrid-scale fiber matrix in conjunction with split-thickness skin graft","volume":"2","author":"Martini","year":"2022","journal-title":"Foot Ankle Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.25270\/wnds\/23117","article-title":"Synergistic clinical application of synthetic electrospun fiber wound matrix in the management of a complex traumatic wound: Degloving left groin and thigh auger injury","volume":"36","author":"Fernandez","year":"2024","journal-title":"Wounds"},{"key":"ref_20","first-page":"e14515","article-title":"Treatment of a complex pressure ulcer using a synthetic hybrid-scale fiber matrix","volume":"13","author":"Herron","year":"2021","journal-title":"Cureus"},{"key":"ref_21","first-page":"e1736","article-title":"What makes the optimal wound healing material? A review of current science and introduction of a synthetic nanofabricated wound care scaffold","volume":"9","author":"MacEwan","year":"2017","journal-title":"Cureus"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"MacEwan, M., Jeng, L., Kov\u00e1cs, T., and Sallade, E. (2023). Clinical application of bioresorbable, synthetic, electrospun matrix in wound healing. Bioengineering, 10.","DOI":"10.3390\/bioengineering10010009"},{"key":"ref_23","first-page":"E77","article-title":"Implantable nanomedical scaffold facilitates healing of chronic lower extremity wounds","volume":"30","author":"Regulski","year":"2018","journal-title":"Wounds"},{"key":"ref_24","first-page":"100362","article-title":"A prospective, blinded, randomized controlled clinical trial evaluating the effect of the synthetic electrospun fiber matrix in the treatment of chronic diabetic foot ulcers","volume":"4","author":"Husain","year":"2024","journal-title":"Foot Ankle Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5114\/reum.2018.80709","article-title":"Hidradenitis suppurativa\u2014Known and unknown disease","volume":"56","author":"Wieczorek","year":"2018","journal-title":"Reumatologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1097\/DSS.0000000000000806","article-title":"Surgical management of hidradenitis suppurativa: Outcomes of 590 consecutive patients","volume":"42","author":"Kohorst","year":"2016","journal-title":"Dermatol. Surg."},{"key":"ref_27","first-page":"35","article-title":"Surgical management of hidradenitis suppurativa: A narrative review","volume":"15","author":"Chawla","year":"2022","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/j.jamcollsurg.2018.08.393","article-title":"Tumescent-based radical excision of hidradenitis suppurativa: Safe, fast, and efficacious","volume":"227","author":"Torabi","year":"2018","journal-title":"J. Am. Coll. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/srt.12759","article-title":"Hidradenitis suppurativa: Current understanding, diagnostic and surgical challenges, and developments in ultrasound application","volume":"26","author":"Alkin","year":"2020","journal-title":"Skin Res. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bjps.2020.08.026","article-title":"Hidradenitis suppurativa: A review of post-operative outcomes","volume":"74","author":"Elliott","year":"2021","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_31","first-page":"e50055","article-title":"Antimicrobial effectiveness testing of resorbable electrospun fiber matrix per United States Pharmacopeia (USP) <51>","volume":"15","author":"Sallade","year":"2023","journal-title":"Cureus"},{"key":"ref_32","first-page":"31","article-title":"Basic science of wound healing","volume":"26","author":"Enoch","year":"2008","journal-title":"Surgery"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40814-019-0543-1","article-title":"Cost-effectiveness and value of information analysis of a low-friction environment following skin graft in patients with burn injury","volume":"6","author":"Kandiyali","year":"2020","journal-title":"Pilot Feasibility Stud."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e5301","DOI":"10.1097\/GOX.0000000000005301","article-title":"Axillary hidradenitis suppurativa: A comparison between two perforator flap reconstructive approaches after radical surgical management","volume":"11","author":"Alabdulkareem","year":"2023","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.25270\/wnds\/2021.237244","article-title":"Synthetic hybrid-scale fiber matrix in the trauma and acute care surgical practice","volume":"33","author":"Fernandez","year":"2021","journal-title":"Wounds"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/sur.2017.089","article-title":"Prolonged operative duration increases risk of surgical site infections: A systematic review","volume":"18","author":"Cheng","year":"2017","journal-title":"Surg. Infect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.surg.2023.02.001","article-title":"The association between obesity and postoperative outcomes in a broad surgical population: A 7-year American College of Surgeons National Surgical Quality Improvement analysis","volume":"173","author":"Madsen","year":"2023","journal-title":"Surgery"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.burns.2016.10.023","article-title":"The antimicrobial spectrum of Xeroform\u00ae","volume":"43","author":"Barillo","year":"2017","journal-title":"Burns"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/ans.16936","article-title":"Experience with Novosorb\u00ae Biodegradable Temporizing Matrix in reconstruction of complex wounds","volume":"91","author":"Li","year":"2021","journal-title":"ANZ J. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.25270\/wnds\/2022.106115","article-title":"Performance of biodegradable temporizing matrix vs collage-chondroitin silicone bilayer dermal regeneration substitutes in soft tissue wound healing: A retrospective analysis","volume":"34","author":"Wu","year":"2022","journal-title":"Wounds"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E160","DOI":"10.25270\/wnds\/22067","article-title":"A synthetic hybrid-scale fiber matrix for complex surgical wounds: Consensus guidelines","volume":"35","author":"Fernandez","year":"2023","journal-title":"Wounds"}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/19\/2563\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:32Z","timestamp":1760035652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/17\/19\/2563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":41,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["polym17192563"],"URL":"https:\/\/doi.org\/10.3390\/polym17192563","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}