{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:11:34Z","timestamp":1790075494343,"version":"4.0.1"},"reference-count":94,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360563"],"award-info":[{"award-number":["82360563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2023GXNSFBA026206"],"award-info":[{"award-number":["2023GXNSFBA026206"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Early and accurate diagnosis is critical for disease surveillance, therapeutic guidance, and relapse monitoring. Sensor arrays have emerged as a multi-analyte detection tool via non-specific interactions to generate unique fingerprint patterns with high levels of selectivity and discrimination. Conjugated polymers (CPs), with their tunable \u03c0-conjugated backbones, exceptional light-harvesting capability, and efficient \u201cmolecular wire effect,\u201d provide an ideal and versatile material platform for such arrays, enabling significant optical signal amplification and high sensitivity. This review systematically outlines the rational design and functionalization strategies of CPs for constructing high-performance sensor arrays. It delves into the structure\u2013property relationships that govern their sensing performance, covering main-chain engineering, side-chain functionalization, and microenvironmental regulation. Representative applications are discussed, including non-small cell lung cancer, breast cancer, bacterial and viral infections, Alzheimer\u2019s disease, and diabetic nephropathy, highlighting the remarkable diagnostic capabilities achieved through tailored CP materials. Finally, future perspectives are focused on novel material designs and device integration to advance this vibrant field.<\/jats:p>","DOI":"10.3390\/polym18030310","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:58:40Z","timestamp":1769180320000},"page":"310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research Advances in Conjugated Polymer-Based Optical Sensor Arrays for Early Diagnosis of Clinical Diseases"],"prefix":"10.3390","volume":"18","author":[{"given":"Qiuting","family":"Ye","sequence":"first","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University, Nanning 530021, China"},{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University, Nanning 530021, China"},{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieling","family":"Lao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guangxi Medical University, Nanning 530021, China"},{"name":"State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1021\/acs.chemrev.8b00226","article-title":"The Optoelectronic Nose: Colorimetric and Fluorometric Sensor Arrays","volume":"119","author":"Li","year":"2019","journal-title":"Chem. 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