{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:40:36Z","timestamp":1792003236862,"version":"4.4.0"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007120","name":"KMITL","doi-asserted-by":"crossref","award":["RE-KRIS\/FF67\/025"],"award-info":[{"award-number":["RE-KRIS\/FF67\/025"]}],"id":[{"id":"10.13039\/501100007120","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Type II collagen is a primary fibrillar component of articular cartilage, and its early degradation is a key biomarker of joint-degenerative disorders such as osteoarthritis, rheumatoid arthritis, gout, etc. Reliable detection at low concentrations remains challenging due to limited assay accessibility, complex analytical procedures, and nonspecific responses in multicomponent biological matrices. This research reports the development of a Molecularly Imprinted Polymer (MIP)\u2013based electrochemical sensor engineered for the selective recognition of type II collagen. A series of monomer formulations were evaluated, and the 1AAM:2VP composition produced a well-defined imprinted layer on screen-printed carbon electrodes, yielding the highest electrochemical sensitivity and linearity. The optimized sensor exhibited strong anodic and cathodic responses proportional to increasing collagen concentrations, with a calibration slope corresponding to an R2 value of 0.9394. Minimal signal interference was observed, confirming high molecular selectivity. The limit of detection (LOD) was calculated to be approximately 0.065 \u00b5g\/mL. These characteristics demonstrate that the proposed MIP sensor provides a low-cost, accessible, and highly selective analytical platform suitable for early-stage cartilage degeneration monitoring.<\/jats:p>","DOI":"10.3390\/polym18030321","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:14:07Z","timestamp":1769426047000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrochemical Characterization of a Molecularly Imprinted Polymer Sensor for the Selective Recognition of Type II Collagen in Joint Degeneration Monitoring"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5669-0823","authenticated-orcid":false,"given":"Jindapa","family":"Nampeng","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, School of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-226X","authenticated-orcid":false,"given":"Naphatsawan","family":"Vongmanee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuchart","family":"Pintavirooj","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5890-6427","authenticated-orcid":false,"given":"Sarinporn","family":"Visitsattapongse","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118180","DOI":"10.1016\/j.bios.2025.118180","article-title":"Synovial exosomal type II collagen as a biomarker for osteoarthritis Progression: From molecular evaluation to AI-powered SERS-based diagnosis","volume":"293","author":"Shin","year":"2026","journal-title":"Biosens. Bioelectron."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100432","DOI":"10.1016\/j.talo.2025.100432","article-title":"MIP-based sensing strategies for the diagnosis of prostate and lung cancers","volume":"11","year":"2025","journal-title":"Talanta Open"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100444","DOI":"10.1016\/j.talo.2025.100444","article-title":"Sensitive and selective detection of cancer biomarkers with molecularly imprinted biosensors","volume":"11","year":"2025","journal-title":"Talanta Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/s41598-024-83750-4","article-title":"Artificial intelligence-enhanced diagnosis of degenerative joint disease using temporomandibular joint panoramic radiography and joint noise data","volume":"15","author":"Choi","year":"2025","journal-title":"Sci. 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