{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:16:55Z","timestamp":1791908215701,"version":"4.3.4"},"reference-count":266,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Provincial Medical Health Science and Technology Project","award":["202404071374"],"award-info":[{"award-number":["202404071374"]}]},{"name":"Fundamental Research Funds for Central Universities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The regeneration of complex tissues demands advanced scaffolds that offer biomimetic support and tissue-specific bioactive guidance. However, the materials in clinic face big challenges with immune rejection, limited donors, and unsatisfactory inductive activity. Fortunately, cellulose-based scaffolds have risen as a leading sustainable platform, considering their natural abundance, inherent biocompatibility, and highly tunable properties. This review comprehensively presented their evolution from rational design to potential clinical application. The primary cellulose sources and key detailed engineering strategies, including chemical modification, composite formulation, and bioactive functionalization, were arranged logically. The modification of cellulose can tune the physical, chemical, and biological behavior of scaffolds, along with advanced three-dimensional printing fabrication techniques. These material advances have enabled targeted functional outcomes in preclinical models, demonstrating promise for specific applications such as wound healing and bone repair. However, their broad clinical translation is contingent upon resolving persistent challenges, including controlled biodegradation and immune compatibility, which we critically assess alongside emerging frontiers such as smart responsive systems. By bridging material innovation with clinical needs, this review may provide an integrated perspective to guide future cellulose-based scaffold design for tissue regeneration.<\/jats:p>","DOI":"10.3390\/polym18050614","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:22:21Z","timestamp":1772551341000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["From Design to Application: Advanced Cellulose Scaffolds for Engineered Tissue Regeneration"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4212-8211","authenticated-orcid":false,"given":"Yao","family":"Tong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the 960th Hospital of the People\u2019s Liberation Army Joint Logistic Support Force, Jinan 250031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkun","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the 960th Hospital of the People\u2019s Liberation Army Joint Logistic Support Force, Jinan 250031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4030","authenticated-orcid":false,"given":"Jinfeng","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ghilan, A., Nicu, R., Ciolacu, D.E., and Ciolacu, F. (2023). Insight into the latest medical applications of nanocellulose. Materials, 16.","DOI":"10.3390\/ma16124447"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dar, M.A., Xie, R.R., Liu, J., Ali, S., Pawar, K.D., Sudiana, I.M., and Sun, J.Z. (2025). Current paradigms and future challenges in harnessing nanocellulose for advanced applications in tissue engineering: A critical state-of-the-art review for biomedicine. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041449"},{"key":"ref_3","first-page":"466","article-title":"Bifunctional adECM bioscaffold with STIM1-ASCs and IGF-2 promotes functional masseter VML repair via myogenesis and fibrosis suppression","volume":"54","author":"Liang","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"123192","DOI":"10.1016\/j.biomaterials.2025.123192","article-title":"Micropore structure engineering of injectable granular hydrogels via controlled liquid-liquid phase separation facilitates regenerative wound healing in mice and pigs","volume":"318","author":"Guan","year":"2025","journal-title":"Biomaterials"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1007\/s10570-024-05874-0","article-title":"Nanocellulose\/Polypyrrole hydrogel scaffolds with mechanical strength and electrical activity matching native cardiac tissue for myocardial tissue engineering","volume":"31","author":"Hou","year":"2024","journal-title":"Cellulose"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109197","DOI":"10.1016\/j.cclet.2023.109197","article-title":"Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges","volume":"35","author":"Xu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijbiomac.2016.12.091","article-title":"Fabrication and characterization of electrospun cellulose\/nano-hydroxyapatite nanofibers for bone tissue engineering","volume":"97","author":"Ao","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dsouza, M.V., Dodamani, S., Kurangi, B., Kumbar, V., and Hussain, M. (2025). Functionalized nanoscaffolds for drug delivery using biomaterials: A glimmer of hope in diabetic wound management. Regen. Eng. Transl. Med.","DOI":"10.1007\/s40883-025-00415-y"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"123593","DOI":"10.1016\/j.carbpol.2025.123593","article-title":"Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds","volume":"359","author":"Iwasaki","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Won, T., Goh, M., Lim, C., Moon, J., Lee, K., Park, J., Chung, K., Kim, Y., Lee, S., and Hong, H. (2025). Recent progress in cellulose nanofibril hydrogels for biomedical applications. Polymers, 17.","DOI":"10.20944\/preprints202507.1771.v1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139285","DOI":"10.1016\/j.jcis.2025.139285","article-title":"Development of 3D printable conductive cellulose-based hydrogel with incorporation of rGO for neural tissue engineering","volume":"703","author":"Usala","year":"2026","journal-title":"J. Colloid Interface Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1515\/ntrev-2021-0098","article-title":"Physical, thermal, and mechanical properties of highly porous polylactic acid\/cellulose nanofibre scaffolds prepared by salt leaching technique","volume":"10","author":"Radakisnin","year":"2021","journal-title":"Nanotechnol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110860","DOI":"10.1016\/j.cclet.2025.110860","article-title":"Porous carbon derived from biomass-based polymers: Innovative applications in supercapacitors","volume":"37","author":"Lv","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijbiomac.2022.07.037","article-title":"Bacterial cellulose-based composites for nerve tissue engineering","volume":"217","author":"Jabbari","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"112168","DOI":"10.1016\/j.eurpolymj.2023.112168","article-title":"Bio-scaffold for bone tissue engineering with focus on bacterial cellulose, biological materials for hydroxyapatite synthesis and growth factors","volume":"194","author":"Boyetey","year":"2023","journal-title":"Eur. Polym. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/acsbiomaterials.9b01549","article-title":"Cell-infiltrative nanocellulose hydrogel that promotes in vivo tissue remodeling","volume":"6","author":"Nishiguchi","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102536","DOI":"10.1016\/j.tice.2024.102536","article-title":"Investigate the in vitro biocompatibility, biodegradation, cytotoxicity, and differentiation potential of 3-D gelatin-nanocellulose composite scaffolds loaded with nanohydroxyapatite and simvastatin","volume":"91","author":"Mohammadi","year":"2024","journal-title":"Tissue Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"131478","DOI":"10.1016\/j.matchemphys.2025.131478","article-title":"Cellulose nanocrystal-reinforced bioactive glass-tragacanth gum nanocomposite scaffold for bone tissue regeneration: A multi-objective optimization","volume":"347","author":"Karmati","year":"2026","journal-title":"Mater. Chem. Phys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10570-023-05611-z","article-title":"Polydopamine-based surface functionalization of watermelon rind as a 3D nanofibrous cellulose scaffold for osteogenesis","volume":"31","author":"Banaeyan","year":"2023","journal-title":"Cellulose"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"122873","DOI":"10.1016\/j.biomaterials.2024.122873","article-title":"LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA\/Rock\/Myosin II pathway","volume":"314","author":"Pang","year":"2025","journal-title":"Biomaterials"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1557\/s43578-022-00560-y","article-title":"Preparation and properties study of polylactic acid\/bacterial cellulose composite scaffolds by solvent removal","volume":"37","author":"Wu","year":"2022","journal-title":"J. Mater. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119044","DOI":"10.1016\/j.carbpol.2021.119044","article-title":"In-situ self-assembly of bacterial cellulose\/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair","volume":"281","author":"Liu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1021\/acsbiomaterials.8b00178","article-title":"Customizing the shape and microenvironment biochemistry of biocompatible macroscopic plant-derived cellulose scaffolds","volume":"4","author":"Hickey","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1039\/D4TB00397G","article-title":"Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications","volume":"12","author":"Tamo","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2400002","DOI":"10.1002\/advs.202400002","article-title":"Biomimetic versatile anisotropic, electroactive cellulose hydrogel scaffolds tailored from fern stem serving as nerve conduit and cardiac patch","volume":"12","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_26","first-page":"1","article-title":"Engineering cellulose for regenerative medicine: Bacterial cellulose and beyond","volume":"1","author":"Nagpal","year":"2025","journal-title":"Regen. Eng. Transl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s10570-020-03674-w","article-title":"Cellulose and its derivatives: Towards biomedical applications","volume":"28","author":"Seddiqi","year":"2021","journal-title":"Cellulose"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.15376\/biores.20.2.2464-2467","article-title":"Nanocellulose targets regenerative medicine","volume":"20","author":"Kitaoka","year":"2025","journal-title":"Bioresources"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"121311","DOI":"10.1016\/j.carbpol.2023.121311","article-title":"Quantitative evaluation of fiber network structure-property relationships in bacterial cellulose hydrogels","volume":"321","author":"Takayama","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijbiomac.2019.06.232","article-title":"Comparative study of plant and bacterial cellulose pellicles regenerated from dissolved states","volume":"137","author":"Khan","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/fpf2.12001","article-title":"Cellulose nanofibers, nanocrystals, and bacterial nanocellulose: Fabrication, characterization, and their most recent applications","volume":"1","author":"Rostamabadi","year":"2024","journal-title":"Future Postharvest Food"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"138719","DOI":"10.1016\/j.ijbiomac.2024.138719","article-title":"Microbial consortia-derived cellulose biomaterial: Synthesis, characterization, and utility in neural tissue regeneration","volume":"288","author":"Rebello","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kamal, T., Ul-Islam, M., Khan, S.B., Bakhsh, E.M., and Chani, M.T.S. (2022). Preparation, Characterization, and biological features of cactus coated bacterial cellulose hydrogels. Gels, 8.","DOI":"10.3390\/gels8020088"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"B\u0142a\u017cy\u0144ska-Spychalska, A., Kur, M., Brzeski, T., Zaj\u0105c, W., Pankiewicz, T., Bielecki, S., Woli\u0144ski, J., and Jankau, J. (2023). Potential of bacterial cellulose in reconstructive surgery of body integumentary system: Preliminary studies in animals. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14080397"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1021\/acs.biomac.3c00380","article-title":"Assessment of the alga cladophora glomerata as a source for cellulose nanocrystals","volume":"24","author":"Mihhels","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"56025","DOI":"10.1021\/acsomega.5c07631","article-title":"Ketal-modified cellulose as a biodegradable bioplastic","volume":"10","author":"Broaders","year":"2025","journal-title":"ACS Omega"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xu, J., Liu, X., and Zhang, Q. (2024). The biosynthesis of bacterial cellulose composites accompanied by spray feeding of biomasses. Polymers, 16.","DOI":"10.3390\/polym16172541"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"123480","DOI":"10.1016\/j.carbpol.2025.123480","article-title":"Mineralized cellulose nanofibers reinforced bioactive hydrogel remodels the osteogenic and angiogenic microenvironment for enhancing bone regeneration","volume":"357","author":"Liu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.15376\/biores.19.1.1590-1601","article-title":"Modification methods\u2019 effects on the characteristics of carboxylated cellulose fibers: Carboxyl group introduction method versus physical properties","volume":"19","author":"Wang","year":"2024","journal-title":"Bioresources"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"122654","DOI":"10.1016\/j.carbpol.2024.122654","article-title":"Amidation of carboxy groups in TEMPO-oxidized cellulose for improving surface hydrophobization and thermal stability of TEMPO-CNCs","volume":"347","author":"Yoshikawa","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.1021\/acs.biomac.4c00735","article-title":"Effects of ring opening and chemical modification on the properties of dry and moist cellulose-predictions with molecular dynamics simulations","volume":"25","author":"Elf","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1021\/acsabm.2c00794","article-title":"Responses of rat mesenchymal stromal cells to nanocellulose with different functional groups","volume":"6","author":"Rashad","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"025029","DOI":"10.1088\/1758-5090\/ab736e","article-title":"3D printable carboxylated cellulose nanocrystal-reinforced hydrogel inks for tissue engineering","volume":"12","author":"Kumar","year":"2020","journal-title":"Biofabrication"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jiec.2015.01.006","article-title":"Electrospun non-leaching biocombatible antimicrobial cellulose acetate nanofibrous mats","volume":"27","author":"Li","year":"2015","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijbiomac.2021.01.050","article-title":"Lignin-mediated in-situ synthesis of CuO nanoparticles on cellulose nanofibers: A potential wound dressing material","volume":"173","author":"Haider","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1021\/acsami.4c18632","article-title":"Interfacial nanoengineering of hydrogel surfaces via block copolymer self-assembly","volume":"17","author":"Cosimi","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.biomaterials.2006.09.036","article-title":"The role of independently variable grafting density and layer thickness of polymer nanolayers on peptide adsorption and cell adhesion","volume":"28","author":"Singh","year":"2007","journal-title":"Biomaterials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.snb.2010.06.034","article-title":"Influence of the grafted chain length on responsive behaviors of the grafted poly(DEA-co-DMAEMA) hydrogel","volume":"149","author":"Chen","year":"2010","journal-title":"Sens. Actuators B Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20220145","DOI":"10.1002\/EXP.20220145","article-title":"Recent advances in enzymatic biofuel cells enabled by innovative materials and techniques","volume":"3","author":"Huang","year":"2023","journal-title":"Exploration"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Leisz, S., Trutschel, M.-L., M\u00e4der, K., Scheller, C., Strauss, C., and Simmermacher, S. (2020). Tabotamp\u00ae, respectively, surgicel\u00ae, increases the cell death of neuronal and glial cells in vitro. Materials, 13.","DOI":"10.3390\/ma13112453"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"32852","DOI":"10.1039\/D4RA04948A","article-title":"Effect of catalyst and oxidant concentrations in a tempo oxidation system on the production of cellulose nanofibers","volume":"14","author":"Park","year":"2024","journal-title":"RSC Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112166","DOI":"10.1016\/j.compositesb.2025.112166","article-title":"Revolutionizing thermal energy harvesting: Bio-flex gel empowered by deep eutectic solvent with exceptional thermopower and electromagnetic wave shielding","volume":"295","author":"Chen","year":"2025","journal-title":"Compos. Part B-Eng."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, J., He, K.Y., and Xu, Q. (2023). Tissue regeneration with gelatine\/polysaccharide derived hydrogel scaffolds: From formulation to in vivo efficacy. Gels, 9.","DOI":"10.3390\/gels9090744"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4252\/wjsc.v16.i4.334","article-title":"Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing","volume":"16","author":"Xiang","year":"2024","journal-title":"World J. Stem Cells"},{"key":"ref_55","first-page":"1548","article-title":"Enhanced wound healing through hydrogel: Arthrospira platensis and chlorella vulgaris in carboxymethyl cellulose\/ carboxymethyl chitosan\/gelatin matrix with decellularized amniotic membrane in male wistar rats","volume":"28","author":"Kheradmandi","year":"2025","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"ref_56","first-page":"297","article-title":"Three-dimensional bioprinted silk fibroin-hydroxypropyl cellulose scaffold loaded with tendon stem\/progenitor cells for the prevention of heterotopic ossification following Achilles tendon injury","volume":"11","author":"Ning","year":"2025","journal-title":"Int. J. Bioprint."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42614","DOI":"10.1039\/D5RA05954B","article-title":"The lysine degradation pathway analyzed with 1H-NMR-targeted metabolomics of MG63 cells on poly(l-lactide)-based scaffolds","volume":"15","author":"Ziblim","year":"2025","journal-title":"RSC Adv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"146041","DOI":"10.1016\/j.ijbiomac.2025.146041","article-title":"Evaluation of PHB-chitosan\/CNC scaffolds\u2019 applicability for bone tissue engineering via MG-63 osteoblastic cell cultivation and osteogenic markers gene expression","volume":"320","author":"Mohammadalipour","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_59","first-page":"7357","article-title":"Preparation of scaffolds of amorphous calcium phosphate and bacterial cellulose for use in tissue regeneration by freeze-drying process","volume":"11","author":"Tiomnova","year":"2021","journal-title":"Biointerface Res. Appl. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20210083","DOI":"10.1002\/EXP.20210083","article-title":"Bioactive inorganic particles-based biomaterials for skin tissue engineering","volume":"2","author":"Ma","year":"2022","journal-title":"Exploration"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.colsurfb.2015.04.014","article-title":"Effect of negatively charged cellulose nanofibers on the dispersion of hydroxyapatite nanoparticles for scaffolds in bone tissue engineering","volume":"130","author":"Park","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e2400129","DOI":"10.1002\/marc.202400129","article-title":"Implantable patch of oxidized nanofibrillated cellulose and lysozyme amyloid nanofibrils for the regeneration of infarcted myocardium tissue and local delivery of rna-loaded nanoparticles","volume":"45","author":"Carvalho","year":"2024","journal-title":"Macromol. Rapid Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e20240044","DOI":"10.1002\/EXP.20240044","article-title":"Exploring the potential and advancements of circular RNA therapeutics","volume":"5","author":"Wang","year":"2025","journal-title":"Exploration"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"20220173","DOI":"10.1002\/EXP.20220173","article-title":"Gel\/hydrogel-based in situ biomaterial platforms for cancer postoperative treatment and recovery","volume":"3","author":"Feng","year":"2023","journal-title":"Exploration"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1039\/D3TB00661A","article-title":"Natural polyphenol tannin-immobilized composites: Rational design and versatile applications","volume":"11","author":"Guan","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1007\/s10570-019-02739-9","article-title":"Fabrication and bioevaluation of a medicated electrospun mat based on azido-cellulose acetate via click chemistry","volume":"26","author":"Nada","year":"2019","journal-title":"Cellulose"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.compscitech.2003.09.011","article-title":"Grafting of rgd peptides to cellulose to enhance human osteoprogenitor cells adhesion and proliferation","volume":"64","author":"Bareille","year":"2004","journal-title":"Compos. Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hao, L., Zhang, Y., Sun, Y., Han, Y., Ye, J., Wang, H., Gao, L., Wang, D., Gao, Y., and Yang, Y. (2025). Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care. Chin. Chem. Lett., 111597.","DOI":"10.1016\/j.cclet.2025.111597"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ijbiomac.2015.12.076","article-title":"Antibiotic loaded carboxymethylcellulose\/MCM-41 nanocomposite hydrogel films as potential wound dressing","volume":"85","author":"Namazi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_70","first-page":"306","article-title":"Bacterial cellulose-based scaffold with in-situ cationic micelle modification for urethral stricture disease: Sustained drug components release, cytokines recruitment, and bacterial microenvironment regulation","volume":"51","author":"Zhu","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"121232","DOI":"10.1016\/j.carbpol.2023.121232","article-title":"Trackable and highly fluorescent nanocellulose-based printable bio-resins for image-guided tissue regeneration","volume":"320","author":"Dutta","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"111591","DOI":"10.1016\/j.eurpolymj.2022.111591","article-title":"Stimuli-responsive nanocellulose hydrogels: An overview","volume":"180","author":"Deng","year":"2022","journal-title":"Eur. Polym. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"120542","DOI":"10.1016\/j.carbpol.2023.120542","article-title":"Tailoring and application of a multi-responsive cellulose nanofibre-based 3D nanonetwork wound dressing","volume":"305","author":"Dong","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"123455","DOI":"10.1016\/j.carbpol.2025.123455","article-title":"Recent progress in nanocellulose-based biocomposites for bone tissue engineering and wound healing applications","volume":"357","author":"Parthasarathy","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"118494","DOI":"10.1016\/j.carbpol.2021.118494","article-title":"Decellularized natural 3D cellulose scaffold derived from Borassus flabellifer (Linn.) as extracellular matrix for tissue engineering applications","volume":"272","author":"Mahendiran","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"112736","DOI":"10.1016\/j.eurpolymj.2023.112736","article-title":"Designing advanced hydrogel inks with direct ink writing based 3D printability for engineered biostructures","volume":"205","author":"Bhardwaj","year":"2024","journal-title":"Eur. Polym. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1021\/acsbiomaterials.0c01158","article-title":"Composite inks for extrusion printing of biological and biomedical constructs","volume":"7","author":"Ravanbakhsh","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"115144","DOI":"10.1016\/j.carbpol.2019.115144","article-title":"Advances in tissue engineering of nanocellulose-based scaffolds: A review","volume":"224","author":"Luo","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_79","first-page":"1016","article-title":"Mechanically reinforced injectable hydrogels","volume":"2","author":"Cranston","year":"2019","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Read, S.A., Go, C.S., Ferreira, M.J.S., Ligorio, C., Kimber, S.J., Dumanli, A.G., and Domingos, M.A.N. (2023). Nanocrystalline cellulose as a versatile engineering material for extrusion-based bioprinting. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102432"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wang, Q., Backman, O., Nuopponen, M., Xu, C., and Wang, X. (2021). Rheological and printability assessments on biomaterial inks of nanocellulose\/photo-crosslinkable biopolymer in light-aided 3D printing. Front. Chem. Eng., 3.","DOI":"10.3389\/fceng.2021.723429"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Elango, J., and Zamora-Ledezma, C. (2025). Rheological, structural, and biological trade-offs in bioink design for 3D bioprinting. Gels, 11.","DOI":"10.3390\/gels11080659"},{"key":"ref_83","first-page":"8525930","article-title":"Bilateral crosslinking with glutaraldehyde and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide: An optimization strategy for the application of decellularized human amniotic membrane in tissue engineering","volume":"2024","author":"Zabihi","year":"2024","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jbm.a.37267","article-title":"Incorporating nanocrystalline cellulose into a multifunctional hydrogel for heart valve tissue engineering applications","volume":"110","author":"Ma","year":"2021","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jmbbm.2015.08.043","article-title":"The surface grafting of graphene oxide with poly (ethylene glycol) as a reinforcement for poly(lactic acid) nanocomposite scaffolds for potential tissue engineering applications","volume":"53","author":"Zhang","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"20210029","DOI":"10.1002\/EXP.20210029","article-title":"Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering","volume":"2","author":"Wan","year":"2022","journal-title":"Exploration"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/ten.teb.2020.0252","article-title":"The use of fibers in bone tissue engineering","volume":"28","author":"Petre","year":"2022","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.eurpolymj.2019.02.008","article-title":"Bioinspired scaffold induced regeneration of neural tissue","volume":"114","author":"Altun","year":"2019","journal-title":"Eur. Polym. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"214485","DOI":"10.1016\/j.bioadv.2025.214485","article-title":"Influence of electrospinning parameters on polycaprolactone fiber alignment for the differentiation of embryonic stem cells into neuronal lineage\u2014A systematic study","volume":"179","author":"Tabassum","year":"2026","journal-title":"Biomater. Adv."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e56463","DOI":"10.1002\/app.56463","article-title":"Design of cellulose nanocrystal-integrated poly(vinyl alcohol)\/polyethylene glycol electrospun nanofiber scaffolds for biomedical applications","volume":"142","author":"Nasalapure","year":"2025","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/adhm.201501018","article-title":"Upregulating hif-1\u03b1 by hydrogel nanofibrous scaffolds for rapidly recruiting angiogenesis relative cells in diabetic wound","volume":"5","author":"Chen","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"130779","DOI":"10.1016\/j.ijbiomac.2024.130779","article-title":"A triple-crosslinking strategy for high-performance regenerated cellulose fibers derived from waste cotton textiles","volume":"264","author":"Huang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/09276440.2024.2448883","article-title":"Towards coupling agent-free composites made from regenerated cellulose\/HDPE by UV radiation-induced cross-linking","volume":"32","author":"Bade","year":"2025","journal-title":"Compos. Interfaces"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1007\/s10570-025-06537-4","article-title":"Chitosan\/microfibrillated cellulose\/bioceramic scaffolds for bone tissue engineering","volume":"32","author":"Sivasankar","year":"2025","journal-title":"Cellulose"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.actbio.2019.11.026","article-title":"Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model","volume":"102","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biomaterials.2005.06.039","article-title":"Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury","volume":"27","author":"Stokols","year":"2006","journal-title":"Biomaterials"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2410452","DOI":"10.1002\/adma.202410452","article-title":"Tunable Bicontinuous macroporous cell culture scaffolds via kinetically controlled phase separation","volume":"37","author":"Dudaryeva","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"055030","DOI":"10.1088\/1748-605X\/ad6ac5","article-title":"Fabrication of 3D PCL\/PVP scaffolds using monosodium glutamate as porogen by solvent casting\/particulate leaching method for oral and maxillofacial bone tissue engineering","volume":"19","author":"Thai","year":"2024","journal-title":"Biomed. Mater."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ijbiomac.2022.03.193","article-title":"Effect of glutaraldehyde and calcium chloride as different crosslinking agents on the characteristics of chitosan\/cellulose nanocrystals scaffold","volume":"208","author":"Doustdar","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"155409","DOI":"10.1016\/j.cej.2024.155409","article-title":"Highly functionalized all-cellulose nanocomposites via bacteria-enabled in-situ modifications","volume":"498","author":"Ojagh","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pogorelova, N., Parshin, D., Lipovka, A., Besov, A., Digel, I., and Larionov, P. (2024). Structural and viscoelastic properties of bacterial cellulose composites: Implications for prosthetics. Polymers, 16.","DOI":"10.3390\/polym16223200"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"eaao6804","DOI":"10.1126\/sciadv.aao6804","article-title":"3D printing of bacteria into functional complex materials","volume":"3","author":"Schaffner","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Mahdavi, M., Mahmoudi, N., Anaran, F.R., and Simchi, A. (2016). Electrospinning of nanodiamond-modified polysaccharide nanofibers with physico-mechanical properties close to natural skins. Mar. Drugs, 14.","DOI":"10.3390\/md14070128"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1039\/C9BM00939F","article-title":"TThe topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues","volume":"7","author":"Huang","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/jbm.b.33776","article-title":"Characterization and biocompatibility evaluation of bacterial cellulose-based wound dressing hydrogel: Effect of electron beam irradiation doses and concentration of acrylic acid","volume":"105","author":"Mohamad","year":"2016","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"135213","DOI":"10.1016\/j.ijbiomac.2024.135213","article-title":"3D printing of bacterial cellulose for potential wound healing applications: Current trends and prospects","volume":"279","author":"Adhikari","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13036-019-0177-0","article-title":"Functional cellulose-based hydrogels as extracellular matrices for tissue engineering","volume":"13","author":"Dutta","year":"2019","journal-title":"J. Biol. Eng."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"170132","DOI":"10.1016\/j.cej.2025.170132","article-title":"Schiff base-grafted bacterial cellulose-PCL composites: Humidity\/temperature-driven hydrogen bond reconfiguration for mechanically adaptive nanofiber","volume":"525","author":"Qin","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"115671","DOI":"10.1016\/j.carbpol.2019.115671","article-title":"A novel and green cellulose-based Schiff base-Cu (II) complex and its excellent antibacterial activity","volume":"230","author":"Xu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"101604","DOI":"10.1016\/j.mtbio.2025.101604","article-title":"3D bioprinted piezoelectric hydrogel synergized with LIPUS to promote bone regeneration","volume":"31","author":"Li","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9964384","DOI":"10.1155\/term\/9964384","article-title":"3D-printed triply periodic minimal surface ceramic scaffold loaded with bone morphogenetic protein-2 and zoledronic for cranium defect repairment","volume":"2025","author":"Yan","year":"2025","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Ruccolo, L., Evangelista, A., Benazzo, M., Conti, B., and Pisani, S. (2025). Electrospun bio-scaffolds for mesenchymal stem cell-mediated neural differentiation: Systematic review of advances and future directions. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199528"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.actbio.2025.01.025","article-title":"E-jet 3D printed aligned nerve guidance conduits incorporated with decellularized extracellular matrix hydrogel encapsulating extracellular vesicles for peripheral nerve repair","volume":"194","author":"Fan","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s44316-025-00046-x","article-title":"From waste to wealth and regeneration: A prisma review of sustainable biomaterials for scalable tissue engineering","volume":"2","author":"Moazzam","year":"2025","journal-title":"Biotechnol. Sustain. Mater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.actbio.2008.07.009","article-title":"Synthesis and characterization of elastic and macroporous chitosan-gelatin cryogels for tissue engineering","volume":"5","author":"Kathuria","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1021\/acs.biomac.1c01268","article-title":"Double-modified bacterial cellulose\/soy protein isolate composites by laser hole forming and selective oxidation used for urethral repair","volume":"23","author":"Yang","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref_117","first-page":"101070","article-title":"Multifaceted mechanical responsive metamaterials: Mechanisms, fabrications, and applications","volume":"7","author":"Yang","year":"2026","journal-title":"Innovation"},{"key":"ref_118","first-page":"100928","article-title":"3D Bioprintable hydrogels via enzymatic crosslinking of hyaluronic acid and phenol-functionalized gelatin to mimic extracellular (ECM) network","volume":"11","author":"Bracchi","year":"2025","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"146233","DOI":"10.1016\/j.foodchem.2025.146233","article-title":"Soybean protein isolate\/sodium alginate double-network hydrogels with high mechanical strength via synergistic cross-linking of imine and ionic bonds","volume":"494","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"143461","DOI":"10.1016\/j.ijbiomac.2025.143461","article-title":"Advanced supramolecular hydrogels and their applications in the formulation of next-generation bioinks for tissue engineering: A review","volume":"311","author":"Jing","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.aej.2024.01.003","article-title":"Research progress on nanocellulose and its composite materials as orthopedic implant biomaterials","volume":"87","author":"Shen","year":"2024","journal-title":"Alex. Eng. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1021\/acs.biomac.3c00975","article-title":"Nanocellulose-based hybrid scaffolds for skin and bone tissue engineering: A 10-year overview","volume":"25","author":"Sreedharan","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"141344","DOI":"10.1016\/j.ijbiomac.2025.141344","article-title":"Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration","volume":"306","author":"Yu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e02380","DOI":"10.1002\/adhm.202502380","article-title":"Uniting 4D printing and melt electrowriting for the enhancement of regenerative small diameter vascular grafts","volume":"14","author":"Ihle","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_125","first-page":"295","article-title":"Bioaerogels produced from tempo oxidized nano cellulose with chitosan, gelatin, and alginate: General performances for wound dressing application","volume":"32","author":"Ondaral","year":"2024","journal-title":"Cellulose"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"129661","DOI":"10.1016\/j.ijbiomac.2024.129661","article-title":"Bilayer regenerated cellulose\/quaternized chitosan-hyaluronic acid\/collagen electrospun scaffold for potential wound healing applications","volume":"261","author":"Adhikari","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e2100167","DOI":"10.1002\/mabi.202100167","article-title":"Fabrication of robust, shape recoverable, macroporous bacterial cellulose scaffolds for cartilage tissue engineering","volume":"21","author":"Xun","year":"2021","journal-title":"Macromol. Biosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1038\/s41467-025-61619-y","article-title":"Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109660","DOI":"10.1016\/j.compositesb.2022.109660","article-title":"A facile strategy toward hierarchically porous composite scaffold for osteosarcoma ablation and massive bone defect repair","volume":"234","author":"Ling","year":"2022","journal-title":"Compos. Part B-Eng."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/rb\/rbv015","article-title":"Biomimetic biphasic scaffolds for osteochondral defect repair","volume":"2","author":"Li","year":"2015","journal-title":"Regen. Biomater."},{"key":"ref_131","first-page":"100099","article-title":"A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration","volume":"15","author":"Younus","year":"2024","journal-title":"Biomater. Biosyst."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"100671","DOI":"10.1016\/j.mtadv.2025.100671","article-title":"In situ grown bacterial cellulose-based integrated biphasic biomimetic scaffold for synchronous repair of critical-sized osteochondral defects","volume":"28","author":"Huang","year":"2025","journal-title":"Mater. Today Adv."},{"key":"ref_133","first-page":"100542","article-title":"3d-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage-bone interface","volume":"5","author":"Zhang","year":"2024","journal-title":"Innovation"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"127990","DOI":"10.1016\/j.ijbiomac.2023.127990","article-title":"Oriented bacterial cellulose microfibers with tunable mechanical performance fabricated via green reassembly avenue","volume":"254","author":"Tan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Utoiu, E., Manoiu, V.S., Oprita, E.I., and Craciunescu, O. (2024). Bacterial cellulose: A sustainable source for hydrogels and 3D-printed scaffolds for tissue engineering. Gels, 10.","DOI":"10.3390\/gels10060387"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Cetin, F.S., Avci, T., Uygur, E., Ilhan, E., Kaya, E., Tinaz, G.B., Duta, L., Dogan, C., and Gunduz, O. (2025). Development and characterization of antimicrobial chitosan\/polyethylene oxide\/bacterial cellulose nanofibers. Polymers, 17.","DOI":"10.3390\/polym17050693"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/0883911519877432","article-title":"A facile green approach for fabricating bacterial cellulose scaffold with macroporous structure and cell affinity","volume":"34","author":"Zhong","year":"2019","journal-title":"J. Bioact. Compat. Polym."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"103634","DOI":"10.1016\/j.cis.2025.103634","article-title":"Advanced biomaterials in tissue engineering: A critical review of nanocomposites based on bacterial cellulose, mxenes, hydroxyapatite, and metal particles for regenerative medicine","volume":"345","author":"Davlet","year":"2025","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"110221","DOI":"10.1016\/j.compositesb.2022.110221","article-title":"Advanced applications of cellulose-based composites in fighting bone diseases","volume":"245","author":"Deng","year":"2022","journal-title":"Compos. Part B Eng."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"113091","DOI":"10.1016\/j.matdes.2024.113091","article-title":"Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair","volume":"243","author":"Liu","year":"2024","journal-title":"Mater. Des."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.colsurfb.2013.11.042","article-title":"Biomimetic nanocomposites of carboxymethyl cellulose-hydroxyapatite: Novel three dimensional load bearing bone grafts","volume":"115","author":"Garai","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.matlet.2016.01.010","article-title":"Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration","volume":"168","author":"Yamaguchi","year":"2016","journal-title":"Mater. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1039\/D2TB02611B","article-title":"Organized mineralized cellulose nanostructures for biomedical applications","volume":"11","author":"Feng","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1007\/s10570-022-04542-5","article-title":"Electrospinning of liquefied banana stem residue in conjugation with hydroxyapatite nanocrystals: Towards new scaffolds for bone tissue engineering","volume":"29","author":"Sadathojai","year":"2022","journal-title":"Cellulose"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Li, L., Lu, P., Liu, Y., Yang, J., and Li, S. (2023). Three-dimensional-bioprinted bioactive glass\/cellulose composite scaffolds with porous structure towards bone tissue engineering. Polymers, 15.","DOI":"10.3390\/polym15092226"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"121769","DOI":"10.1016\/j.jnoncrysol.2022.121769","article-title":"Preparation and characterization of 3D nanocomposite scaffold from bioactive glass\/\u03b2-tricalcium phosphate via Robocasting method for bone tissue engineering","volume":"593","author":"Monfared","year":"2022","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_147","first-page":"100936","article-title":"Harnessing stereomicrostructural engineering for next-generation biodegradable adhesives","volume":"6","author":"Zhao","year":"2025","journal-title":"Innovation"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"230152","DOI":"10.1155\/2014\/230152","article-title":"Bone formation in a rat tibial defect model using carboxymethyl cellulose\/BioC\/bone morphogenic protein-2 hybrid materials","volume":"2014","author":"Song","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Simpson, C.R., Kelly, H.M., and Murphy, C.M. (2025). The design and development of an injectable thermoresponsive hydrogel for controlled simvastatin release in bone repair applications. Gels, 11.","DOI":"10.3390\/gels11120995"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"108418","DOI":"10.1016\/j.compositesb.2020.108418","article-title":"Bio-inspired cellulose reinforced anisotropic composite hydrogel with zone-dependent complex mechanical adaptability and cell recruitment characteristics","volume":"202","author":"Wang","year":"2020","journal-title":"Compos. Part B-Eng."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Xu, B., Luo, Z.Y., Wang, D., Huang, Z.Y., Zhou, Z.K., and Wang, H.Y. (2022). In vitro and in vivo repair effects of the ncf-col-nha aerogel scaffold loaded with sost monoclonal antibody and sdf-1 in steroid-induced osteonecrosis. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.825231"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"110893","DOI":"10.1016\/j.msec.2020.110893","article-title":"Evaluation of BMP-2 and VEGF loaded 3D printed hydroxyapatite composite scaffolds with enhanced osteogenic capacity in vitro and in vivo","volume":"112","author":"Chen","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"142578","DOI":"10.1016\/j.ijbiomac.2025.142578","article-title":"Alginate\/bacterial cellulose\/GelMA scaffolds with aligned nanopatterns and hollow channel networks for vascularized bone repair","volume":"308","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"132124","DOI":"10.1016\/j.ijbiomac.2024.132124","article-title":"Biomimetic design of platelet-rich plasma controlled release bacterial cellulose\/hydroxyapatite composite hydrogel for bone tissue engineering","volume":"269","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_155","first-page":"267","article-title":"Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration","volume":"21","author":"Cai","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"110686","DOI":"10.1016\/j.cclet.2024.110686","article-title":"Remedying infectious bone defects via 3D printing technology","volume":"36","author":"Wang","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"ref_157","first-page":"515","article-title":"Cellulose-in-cellulose 3D-printed bioaerogels for bone tissue engineering","volume":"31","author":"Malandain","year":"2023","journal-title":"Cellulose"},{"key":"ref_158","first-page":"100447","article-title":"Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers","volume":"7","author":"Diaz","year":"2024","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"113613","DOI":"10.1016\/j.matdes.2025.113613","article-title":"Anisotropic robust poly(vinyl alcohol) hydrogels inspired by bio-tissue","volume":"250","author":"Jin","year":"2025","journal-title":"Mater. Des."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1007\/s12274-023-5414-7","article-title":"Critical impact of nanocellulose on the synthesis of porous cellulose monolith with oriented microchannels: Structure control, mechanics, and mass transport","volume":"16","author":"Tang","year":"2023","journal-title":"Nano Res."},{"key":"ref_161","first-page":"336","article-title":"Constructing osteo-inductive bio-ink for 3D printing through hybridization of gelatin with maleic acid modified bacterial cellulose by regulating addition volumes of maleic acid solution","volume":"9","author":"Wang","year":"2024","journal-title":"J. Bioresour. Bioprod."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Salihu, R., Razak, S.I.A., Sani, M.H., Wsoo, M.A., Zawawi, N.A., and Shahir, S. (2024). Citrate-modified bacterial cellulose as a potential scaffolding material for bone tissue regeneration. PLoS ONE, 19.","DOI":"10.2139\/ssrn.4677846"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"054102","DOI":"10.1088\/1748-605X\/ac14cb","article-title":"3D-printed biphasic scaffolds for the simultaneous regeneration of osteochondral tissues","volume":"16","author":"Natarajan","year":"2021","journal-title":"Biomed. Mater."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.2147\/IJN.S137361","article-title":"In vitro and in vivo studies of a novel bacterial cellulose-based acellular bilayer nanocomposite scaffold for the repair of osteochondral defects","volume":"12","author":"Kumbhar","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"20210170","DOI":"10.1002\/EXP.20210170","article-title":"Microneedle system for tissue engineering and regenerative medicine","volume":"3","author":"Zhang","year":"2023","journal-title":"Exploration"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"527","DOI":"10.5114\/aoms.2013.33433","article-title":"Modified bacterial cellulose tubes for regeneration of damaged peripheral nerves","volume":"3","author":"Cala","year":"2013","journal-title":"Arch. Med. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"35667","DOI":"10.1038\/s41598-025-19632-0","article-title":"Biocompatibility and structural insights of seaweed-derived cellulose scaffolds in a subcutaneous implantation model","volume":"15","author":"Mann","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Cherng, J.H., Chou, S.C., Chen, C.L., Wang, Y.W., Chang, S.J., Fan, G.Y., Leung, F.S., and Meng, E. (2021). Bacterial cellulose as a potential bio-scaffold for effective re-epithelialization therapy. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13101592"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"107058","DOI":"10.1016\/j.jddst.2025.107058","article-title":"Wound healing in the modern era: Emerging research, biomedical advances, and transformative clinical approaches","volume":"110","author":"Bogadi","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1007\/s10570-025-06768-5","article-title":"Production of bacterial cellulose from diverse food wastes: Effects on physical properties, structure, and performance","volume":"32","author":"Ye","year":"2025","journal-title":"Cellulose"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/adhm.201200368","article-title":"Bacterial cellulose nanofibrillar patch as a wound healing platform of tympanic membrane perforation","volume":"2","author":"Kim","year":"2013","journal-title":"Adv. Healthc. Mater."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.carbpol.2018.12.014","article-title":"Production of bacterial cellulose hydrogels with tailored crystallinity from Enterobacter sp. FY-07 by the controlled expression of colanic acid synthetic genes","volume":"207","author":"Liu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.carbpol.2010.12.017","article-title":"Preparation and evaluation of a kind of bacterial cellulose dry films with antibacterial properties","volume":"84","author":"Wei","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1039\/C8TB01109E","article-title":"Cellulose\/keratin-catechin nanocomposite hydrogel for wound hemostasis","volume":"6","author":"Sun","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1186\/s12951-025-03803-2","article-title":"A simple and effective hydrogel dressing for advanced management of full-thickness skin wound by multi-functional strategies","volume":"23","author":"Dong","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"20230066","DOI":"10.1002\/EXP.20230066","article-title":"Recent advances in reactive oxygen species scavenging nanomaterials for wound healing","volume":"4","author":"Joorabloo","year":"2024","journal-title":"Exploration"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102631","DOI":"10.1016\/j.surfin.2023.102631","article-title":"Improved biological activities of dual nanofibrous chitosan\/bacterial cellulose wound dressing by a novel silver-based metal-organic framework","volume":"36","author":"Barjasteh","year":"2023","journal-title":"Surf. Interfaces"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e2201286","DOI":"10.1002\/adhm.202201286","article-title":"Sprayable antibacterial hydrogels by simply mixing of aminoglycoside antibiotics and cellulose nanocrystals for the treatment of infected wounds","volume":"11","author":"Li","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/rb\/rbx025","article-title":"Progress in development of bioderived materials for dermal wound healing","volume":"4","author":"Da","year":"2017","journal-title":"Regen. Biomater."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"70005","DOI":"10.1002\/EXP.70005","article-title":"Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies","volume":"5","author":"Du","year":"2025","journal-title":"Exploration"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1007\/s10570-021-03853-3","article-title":"Growth factor functionalized biodegradable nanocellulose scaffolds for potential wound healing application","volume":"28","author":"Liu","year":"2021","journal-title":"Cellulose"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1021\/acsnano.4c17291","article-title":"Starfish-inspired synergistic reinforced hydrogel wound dressing: Dual responsiveness and enhanced bioactive compound delivery for advanced skin regeneration and management","volume":"19","author":"Hong","year":"2025","journal-title":"ACS Nano"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"123424","DOI":"10.1016\/j.carbpol.2025.123424","article-title":"A sustained H2S-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing","volume":"355","author":"Zhao","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"109466","DOI":"10.1016\/j.jbiomech.2019.109466","article-title":"Fabrication and evaluation of a bilayer hydrogel-electrospinning scaffold prepared by the freeze-gelation method","volume":"98","author":"Kamali","year":"2020","journal-title":"J. Biomech."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.burns.2021.07.002","article-title":"Application of bacterial nanocellulose-based wound dressings in the management of thermal injuries: Experience in 92 children","volume":"48","author":"Maurer","year":"2022","journal-title":"Burns"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2174\/1389450120666181129092144","article-title":"Opportunities of bacterial cellulose to treat epithelial tissues","volume":"20","author":"Beekmann","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1039\/D2BM02092K","article-title":"3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes","volume":"11","author":"Li","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/1673-5374.264441","article-title":"Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration","volume":"15","author":"Dun","year":"2020","journal-title":"Neural Regener. Res."},{"key":"ref_189","first-page":"112","article-title":"Advances in nerve guidance conduits for peripheral nerve repair and regeneration","volume":"12","author":"Zheng","year":"2023","journal-title":"Am. J. Stem Cells"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1039\/D3BM01163A","article-title":"Beyond the limiting gap length: Peripheral nerve regeneration through implantable nerve guidance conduits","volume":"12","author":"Riva","year":"2024","journal-title":"Biomater. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Zhong, C. (2020). Industrial-scale production and applications of bacterial cellulose. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.605374"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/jbm.a.36330","article-title":"Development and biocompatibility evaluation of biodegradable bacterial cellulose as a novel peripheral nerve scaffold","volume":"106","author":"Hou","year":"2018","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4103\/1673-5374.235023","article-title":"Optimization of nanofiber scaffold properties towards nerve guidance channel design","volume":"13","author":"Shea","year":"2018","journal-title":"Neural Regener. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.msec.2017.03.142","article-title":"Ice-templating of anisotropic structures with high permeability","volume":"76","author":"Pawelec","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Tseng, Y.-H., Ma, T.-L., Tan, D.-H., Su, A.-J.A., Washington, K.M., Wang, C.-C., Huang, Y.-C., Wu, M.-C., and Su, W.-F. (2023). Injectable hydrogel guides neurons growth with specific directionality. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097952"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"109181","DOI":"10.1016\/j.nanoen.2023.109181","article-title":"Piezotronic effect for in situ electrostimulation of neural stem cell therapy for nerve injury","volume":"120","author":"Wang","year":"2024","journal-title":"Nano Energy"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s42765-025-00590-1","article-title":"An electromechanical converted bacterial cellulose based composite film for repairing peripheral nerve injury through mimicking physiological electrical signal","volume":"7","author":"Zhao","year":"2025","journal-title":"Adv. Fiber Mater."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ijbiomac.2022.01.130","article-title":"Reduced graphene oxide\/cellulose nanocrystal composite films with high specific capacitance and tensile strength","volume":"200","author":"Ding","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"22031","DOI":"10.1039\/D2RA04320C","article-title":"In situpolymerization and electrical conductivity of polypyrrole\/cellulose nanocomposites using schweizer\u2019s reagent","volume":"12","author":"Fraser","year":"2022","journal-title":"RSC Adv."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Carrascosa, A., S\u00e1nchez, J.S., Mor\u00e1n-Aguilar, M.G., Gabriel, G., and Vilaseca, F. (2024). Advanced flexible wearable electronics from hybrid nanocomposites based on cellulose nanofibers, pedot: Pss and reduced graphene oxide. Polymers, 16.","DOI":"10.3390\/polym16213035"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.actbio.2020.03.007","article-title":"An engineered three-dimensional stem cell niche in the inner ear by applying a nanofibrillar cellulose hydrogel with a sustained-release neurotrophic factor delivery system","volume":"108","author":"Chang","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10856-020-06479-2","article-title":"Nanofibrous bicomponent scaffolds for the dual delivery of NGF and GDNF: Controlled release of growth factors and their biological effects","volume":"32","author":"Liu","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1021\/acs.biomac.5c00984","article-title":"Interface modifiable bacterial cellulose hydrogel based nerve guidance conduit effectively rehabilitate sciatic nerve injured rat","volume":"26","author":"Qiao","year":"2025","journal-title":"Biomacromolecules"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"130454","DOI":"10.1016\/j.ijbiomac.2024.130454","article-title":"Functionalization of bacterial cellulose: Exploring diverse applications and biomedical innovations: A review","volume":"264","author":"Saleh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Asakura, A., Iwai, T., Ikeguchi, R., Aoyama, T., Noguchi, T., Yoshimoto, K., Sakamoto, D., Fujita, K., Miyazaki, Y., and Akieda, S. (2024). Nerve regeneration using a Bio 3D conduit derived from umbilical cord-Derived mesenchymal stem cells in a rat sciatic nerve defect model. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0310711"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/ten.tea.2009.0480","article-title":"Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering","volume":"16","author":"Moutos","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"101457","DOI":"10.1016\/j.mtla.2022.101457","article-title":"3D Bioprinting of human Mesenchymal Stem Cells in a novel tunic decellularized ECM bioink for Cartilage Tissue Engineering","volume":"23","author":"Govindharaj","year":"2022","journal-title":"Materialia"},{"key":"ref_208","first-page":"501","article-title":"Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product","volume":"20","author":"Guo","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"108476","DOI":"10.1016\/j.bej.2022.108476","article-title":"3D bacterial cellulose-chitosan-alginate-gelatin hydrogel scaffold for cartilage tissue engineering","volume":"184","author":"Phatchayawat","year":"2022","journal-title":"Biochem. Eng. J."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/jbm.a.32784","article-title":"Behavior of human chondrocytes in engineered porous bacterial cellulose scaffolds","volume":"94","author":"Andersson","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"118790","DOI":"10.1016\/j.carbpol.2021.118790","article-title":"Hierarchical porous bacterial cellulose scaffolds with natural biomimetic nanofibrous structure and a cartilage tissue-specific microenvironment for cartilage regeneration and repair","volume":"276","author":"Li","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/14658011.2018.1447340","article-title":"Bacterial cellulose\/hyaluronic acid composite hydrogels with improved viscoelastic properties and good thermodynamic stability","volume":"47","author":"Jia","year":"2018","journal-title":"Plast. Rubber Compos."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13036-025-00502-2","article-title":"Decellularized apple hypanthium as a plant-based biomaterial for cartilage regeneration in vitro: A comparative study of progenitor cell types and environmental conditions","volume":"19","author":"Hammad","year":"2025","journal-title":"J. Biol. Eng."},{"key":"ref_214","first-page":"365","article-title":"3D bio-printed proteinaceous bioactive scaffold loaded with dual growth factor enhanced chondrogenesis and in situ cartilage regeneration","volume":"46","author":"Shanto","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s44164-022-00019-8","article-title":"Bamos project: Osteochondral scaffold innovation applied to osteoarthritis","volume":"1","author":"Donate","year":"2022","journal-title":"Vitr. Models"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/jbm.a.37440","article-title":"Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine achilles tendon and its potential application for anterior cruciate ligament repair","volume":"111","author":"Cheng","year":"2023","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/adhm.201501048","article-title":"Enhancing the biomechanical performance of anisotropic nanofibrous scaffolds in tendon tissue engineering: Reinforcement with cellulose nanocrystals","volume":"5","author":"Domingues","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ijbiomac.2020.09.249","article-title":"Multifunctional nanofibrous patches composed of nanocellulose and lysozyme nanofibers for cutaneous wound healing","volume":"165","author":"Silva","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1007\/s10570-022-04492-y","article-title":"Electric field-assisted wet spinning to fabricate strong, tough, and continuous nanocellulose long fibers","volume":"29","author":"Panicker","year":"2022","journal-title":"Cellulose"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"105956","DOI":"10.1016\/j.archoralbio.2024.105956","article-title":"Effect of simultaneous and sequential use of TGF-\u03b21 and TGF-\u03b23 with FGF-2 on teno\/ligamentogenic differentiation of periodontal ligament stem cells","volume":"162","author":"Azadi","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"102510","DOI":"10.1016\/j.mtbio.2025.102510","article-title":"Multidimensional biomimetic strategy integrating structural, functional and biological cues for enhanced tendon-to-bone interface regeneration","volume":"35","author":"Liang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1016\/j.actbio.2010.04.023","article-title":"Improving bacterial cellulose for blood vessel replacement: Functionalization with a chimeric protein containing a cellulose-binding module and an adhesion peptide","volume":"6","author":"Andrade","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Liu, D.C., Meng, Q.S., and Hu, J.G. (2023). Bacterial nanocellulose hydrogel: A promising alternative material for the fabrication of engineered vascular grafts. Polymers, 15.","DOI":"10.3390\/polym15183812"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0079-6700(01)00021-1","article-title":"Bacterial synthesized cellulose-artificial blood vessels for microsurgery","volume":"26","author":"Klemm","year":"2001","journal-title":"Prog. Polym. Sci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jbm.b.31791","article-title":"Bacterial cellulose as a potential vascular graft: Mechanical characterization and constitutive model development","volume":"97B","author":"Zahedmanesh","year":"2011","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.actbio.2009.09.019","article-title":"Real-time measurements of coagulation on bacterial cellulose and conventional vascular graft materials","volume":"6","author":"Fink","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"135749","DOI":"10.1016\/j.ijbiomac.2024.135749","article-title":"Conductive, injectable, and self-healing collagen-hyaluronic acid hydrogels loaded with bacterial cellulose and gold nanoparticles for heart tissue engineering","volume":"280","author":"Tohidi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"102321","DOI":"10.1016\/j.jormas.2025.102321","article-title":"Dispersed bacterial cellulose (DBC) alone graft material and adding DBC or the boric acid-absorbed DBC to xenograft increases the new bone formation during rabbit maxillary sinus augmentation- a pilot study","volume":"126","author":"Ceylan","year":"2025","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1039\/D1TB02044G","article-title":"Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces","volume":"10","author":"Singh","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"102302","DOI":"10.1016\/j.jvsv.2025.102302","article-title":"Application of bacterial cellulose film as a wound dressing in varicose vein surgery: A randomized clinical trial","volume":"13","author":"Maia","year":"2025","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e20192260","DOI":"10.1590\/0100-6991e-20192260","article-title":"Bacterial cellulose biopolymer film and gel dressing for the treatment of ischemic wounds after lower limb revascularization","volume":"46","author":"Maia","year":"2019","journal-title":"Rev. Col. Bras. Cir."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1080\/10717544.2021.1977423","article-title":"Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development","volume":"28","author":"Stanescu","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"117123","DOI":"10.1016\/j.carbpol.2020.117123","article-title":"A covalently cross-linked hyaluronic acid\/bacterial cellulose composite hydrogel for potential biological applications","volume":"252","author":"Tang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"120252","DOI":"10.1016\/j.carbpol.2022.120252","article-title":"The state-of-the-art application of functional bacterial cellulose-based materials in biomedical fields","volume":"300","author":"Qian","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1557\/mrs2010.653","article-title":"Bacterial nanocellulose as a renewable material for biomedical applications","volume":"35","author":"Gatenholm","year":"2010","journal-title":"MRS Bull."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Jankau, J., B\u0142a\u017cy\u0144ska-Spychalska, A., Kubiak, K., J\u0119drzejczak-Krzepkowska, M., Pankiewicz, T., Ludwicka, K., Dettlaff, A., and P\u0119ksa, R. (2022). Bacterial cellulose properties fulfilling requirements for a biomaterial of choice in reconstructive surgery and wound healing. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.805053"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"120906","DOI":"10.1016\/j.carbpol.2023.120906","article-title":"The controlled degradation of bacterial cellulose in simulated physiological environment by immobilization and release of cellulase","volume":"314","author":"Liu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2023.03.007","article-title":"Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition","volume":"161","author":"Avery","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1039\/D4NR04622F","article-title":"Ti3C2TX mxene augments osmo-adaptive repression of the inflammatory stress response for improved wound repair","volume":"17","author":"Kiziloz","year":"2025","journal-title":"Nanoscale"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2014.10.016","article-title":"Dynamic reciprocity in cell-scaffold interactions","volume":"82\u201383","author":"Mauney","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s10570-024-05771-6","article-title":"Fabrication of porous bone scaffolds using degradable and mouldable bacterial cellulose","volume":"31","year":"2024","journal-title":"Cellulose"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1515\/HF.2007.099","article-title":"Studies on oxidative modifications of cellulose in the periodate system: Molecular weight distribution and carbonyl group profiles","volume":"61","author":"Potthast","year":"2007","journal-title":"Holzforschung"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Busuioc, C., Isopencu, G., Banciu, A., Banciu, D.D., Oprea, O., Mocanu, A., Deleanu, I., Zaulet, M., Popescu, L., and Tanasuica, R. (2022). Bacterial cellulose hybrid composites with calcium phosphate for bone tissue regeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232416180"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.eurpolymj.2012.10.002","article-title":"Biodegradable blends of cellulose with synthetic polymers and some other polysaccharides","volume":"49","author":"Rogovina","year":"2013","journal-title":"Eur. Polym. J."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41529-024-00487-1","article-title":"A review of biomaterial degradation assessment approaches employed in the biomedical field","volume":"8","author":"Mndlovu","year":"2024","journal-title":"npj Mater. Degrad."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"128369","DOI":"10.1016\/j.ijbiomac.2023.128369","article-title":"Composite of bacterial cellulose and gelatin: A versatile biocompatible scaffold for tissue engineering","volume":"256","author":"Rzhepakovsky","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"124526","DOI":"10.1016\/j.carbpol.2025.124526","article-title":"Membrane emulsification-derived cellulose microbeads encapsulating vitamin C with pH-sensitive release via chitosan nanowhisker coating","volume":"372","author":"Lee","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jmapro.2024.09.057","article-title":"Parameter optimization for accurate and repeatable strut width in the 3D printing of composite bone scaffolds","volume":"131","author":"Bappy","year":"2024","journal-title":"J. Manuf. Process."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"20210086","DOI":"10.1002\/EXP.20210086","article-title":"Exploration of nanozymes in viral diagnosis and therapy","volume":"2","author":"Lee","year":"2022","journal-title":"Exploration"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"120464","DOI":"10.1016\/j.carbpol.2022.120464","article-title":"Cellulose nanocrystals vs. cellulose nanospheres: A comparative study of cytotoxicity and macrophage polarization potential","volume":"303","author":"Patel","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"eadx4556","DOI":"10.1126\/sciadv.adx4556","article-title":"Sustainable synthesis of amino-cellulose nanofibers for biomaterial platforms","volume":"11","author":"Shi","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/adhm.201500845","article-title":"The role of surface nanotopography and chemistry on primary neutrophil and macrophage cellular responses","volume":"5","author":"Christo","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00170-025-15978-x","article-title":"Optimization of main process control parameters of PHA bio-polymer in material extrusion additive manufacturing: Experimental design and predictive models","volume":"139","author":"Vidakis","year":"2025","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Yong, X., Liu, Y.-X., Chaparro, F.J., Tian, Z., Jia, Y., Gosser, J., Gaumer, J., Ross, L., Tafreshi, H., and Lannutti, J.J. (2023). Visualization of porosity and pore size gradients in electrospun scaffolds using laser metrology. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282903"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"101025","DOI":"10.1016\/j.mtchem.2022.101025","article-title":"AC electrospinning: Impact of high voltage and solvent on the electrospinnability and productivity of polycaprolactone electrospun nanofibrous scaffolds","volume":"26","author":"Sivan","year":"2022","journal-title":"Mater. Today Chem."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"eabo7047","DOI":"10.1126\/scitranslmed.abo7047","article-title":"3D-bioprinted human tissue and the path toward clinical translation","volume":"14","author":"Bliley","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Furlan, L., Zamuner, A., Riccioni, A., Sabbadin, G., Russo, T., Gallicchio, V., D\u2019auria, G., Falcigno, L., Manni, L., and Ballarin, L. (2025). Comparative analysis of tunicate vs. plant-based cellulose in chitosan hydrogels for bone regeneration. Gels, 11.","DOI":"10.3390\/gels11020102"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/15685551.2023.2284482","article-title":"3D bioprinted scaffolds of polysaccharide hydrogels in osteochondral and cartilage tissue engineering","volume":"26","author":"Huang","year":"2023","journal-title":"Des. Monomers Polym."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1016\/j.cclet.2021.04.023","article-title":"A bibliometric analysis: Research progress and prospects on transition metal dichalcogenides in the biomedical field","volume":"32","author":"Liu","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"20210033","DOI":"10.1002\/EXP.20210033","article-title":"Advances in 4d-printed physiological monitoring sensors","volume":"1","author":"Mahmud","year":"2021","journal-title":"Exploration"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"214245","DOI":"10.1016\/j.bioadv.2025.214245","article-title":"Enhancing calcium phosphate cements: A review of bacterial cellulose (bc) and other biopolymer reinforcements for biomedical applications","volume":"172","author":"Dusim","year":"2025","journal-title":"Biomater. Adv."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"20417314211027677","DOI":"10.1177\/20417314211027677","article-title":"Current standards and ethical landscape of engineered tissues-3D bioprinting perspective","volume":"12","author":"Sekar","year":"2021","journal-title":"J. Tissue Eng."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"106761","DOI":"10.1016\/j.ejps.2024.106761","article-title":"Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering","volume":"196","author":"Armengol","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"123","DOI":"10.18063\/ijb.v4i1.123","article-title":"Pre-clinical evaluation of advanced nerve guide conduits using a novel 3D in vitro testing model","volume":"4","author":"Behbehani","year":"2024","journal-title":"Int. J. Bioprint."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pneurobio.2010.10.002","article-title":"Repairing injured peripheral nerves: Bridging the gap","volume":"92","author":"Deumens","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/1947603519852402","article-title":"Preoperative grades of osteoarthritis and meniscus volume correlate with clinical outcomes of osteochondral graft treatment for cartilage defects in the knee","volume":"12","author":"Wang","year":"2019","journal-title":"Cartilage"}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/5\/614\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:23:39Z","timestamp":1772717019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/5\/614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":266,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["polym18050614"],"URL":"https:\/\/doi.org\/10.3390\/polym18050614","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}