{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:58:18Z","timestamp":1790827098023,"version":"4.1.0"},"reference-count":115,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Training Centre for Cell & Tissue Engineering Technologies","award":["IC190100026"],"award-info":[{"award-number":["IC190100026"]}]},{"name":"Max Planck Queensland Centre for the Materials Science of Extracellular Matrices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>This study investigates the effects of hydration, temperature, and \u03b3-irradiation on the structural, thermal, and mechanical properties of Lactoprene\u00ae 7415, a linear block copolymer consisting of 74% lactide, 15% trimethylene carbonate, 11% \u03b5-caprolactone repeating units, and 40 wt% \u03b2-TCP\/Lactoprene\u00ae 7415 composite. Techniques including static and dynamic mechanical testing or differential scanning calorimetry have evidenced structural changes resulting from irradiation- or water-induced crystallinity, crosslinking, chain scission or plasticization. Notably, hydration and physiological temperatures reduced the mechanical properties but conferred hyperelastic characteristics to the polymeric and composite samples. \u03b3-irradiation was detrimental for the mechanical properties, except for those of the pure polymer in dry conditions. Our results evidence a complex interplay between the polymer, particles, temperature, hydration and water. Such observations could have implications in future designs and investigations of composite materials for scaffold-guided bone regeneration (SGBR), such as sterilization processes or minimally invasive surgery.<\/jats:p>","DOI":"10.3390\/polym18070817","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:45:42Z","timestamp":1774626342000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Gamma Irradiation and Simulated Physiological Conditions on the Physicochemical Properties of a 3D-Printed \u03b2TCP Composite"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9528-5518","authenticated-orcid":false,"given":"Elham","family":"Seifi","sequence":"first","affiliation":[{"name":"ARC Training Centre for Cell and Tissue Engineering Technologies, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-6266","authenticated-orcid":false,"given":"Sacha","family":"Cavelier","sequence":"additional","affiliation":[{"name":"ARC Training Centre for Cell and Tissue Engineering Technologies, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"Max Planck Queensland Centre for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-7401","authenticated-orcid":false,"given":"Kerr D. G.","family":"Samson","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, Faculty of Science, Queensland University of Technology, Brisbane 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-2134","authenticated-orcid":false,"given":"Dietmar W.","family":"Hutmacher","sequence":"additional","affiliation":[{"name":"ARC Training Centre for Cell and Tissue Engineering Technologies, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"Centre for Biomedical Technologies, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"Max Planck Queensland Centre for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane 4059, Australia"},{"name":"Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jbm.a.33161","article-title":"Triblock copolymers of \u03b5-caprolactone, L-lactide, and trimethylene carbonate: Biodegradability and elastomeric behavior","volume":"99","author":"Widjaja","year":"2011","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jmbbm.2011.11.001","article-title":"Triblock copolymers of \u03b5-caprolactone, trimethylene carbonate, and L-lactide: Effects of using random copolymer as hard-block","volume":"6","author":"Widjaja","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/macp.200300184","article-title":"Triblock copolymers based on 1,3-trimethylene carbonate and lactide as biodegradable thermoplastic elastomers","volume":"205","author":"Zhang","year":"2004","journal-title":"Macromol. Chem. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.jconrel.2006.09.033","article-title":"Thermoplastic elastomers based on poly(lactide)\u2013poly(trimethylene carbonate-co-caprolactone)\u2013poly(lactide) triblock copolymers and their stereocomplexes","volume":"116","author":"Zhang","year":"2006","journal-title":"J. Control. Release"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e70069","DOI":"10.1111\/jace.70069","article-title":"Comprehensive physicochemical evaluation of 3D-printed medical-grade poly (lactic acid)-based composite: Mechanical, thermal, and morphological properties","volume":"108","author":"Seifi","year":"2025","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zafar, M.J., Zhu, D., and Zhang, Z. (2019). 3D printing of bioceramics for bone tissue engineering. Materials, 12.","DOI":"10.3390\/ma12203361"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/C2BM00071G","article-title":"A tissue engineering approach based on the use of bioceramics for bone repair","volume":"1","author":"Salinas","year":"2013","journal-title":"Biomater. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e11614","DOI":"10.1002\/adma.202511614","article-title":"Water interactions in hydrated aliphatic polyester composite scaffolds","volume":"38","author":"Cavelier","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_9","unstructured":"Hill, D. (1998). Design Engineering of Biomaterials for Medical Devices, Wiley-VCH."},{"key":"ref_10","unstructured":"Tekade, R.K. (2020). Chapter 21\u2014Achieving sterility in biomedical and pharmaceutical products (part-II): Radiation sterilization. The Future of Pharmaceutical Product Development and Research, Academic Press."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"122671","DOI":"10.1016\/j.ijpharm.2023.122671","article-title":"A review of conventional and emerging technologies for hydrogels sterilization","volume":"634","author":"Bento","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/S0142-9612(01)00412-4","article-title":"Impact of sterilization on the porous design and cell behavior in collagen sponges prepared for tissue engineering","volume":"23","author":"Noah","year":"2002","journal-title":"Biomaterials"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2041731416648810","DOI":"10.1177\/2041731416648810","article-title":"Sterilization techniques for biodegradable scaffolds in tissue engineering applications","volume":"7","author":"Dai","year":"2016","journal-title":"J. Tissue Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165297","DOI":"10.1016\/j.nimb.2024.165297","article-title":"Exploring the impact of gamma rays and electron beam irradiation on physico-mechanical properties of polymers & polymer composites: A comprehensive review","volume":"549","author":"Bansal","year":"2024","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0141-3910(95)00150-6","article-title":"An electron spin resonance study on \u03b3-irradiated poly (l-lactic acid) and poly (d, l-lactic acid)","volume":"50","author":"Babanalbandi","year":"1995","journal-title":"Polym. Degrad. Stab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.radphyschem.2004.03.050","article-title":"Radiation cross-linked plastics: A versatile material solution for packaging, automotive, Electrotechnic and Electronics","volume":"71","author":"Rouif","year":"2004","journal-title":"Radiat. Phys. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nimb.2005.03.252","article-title":"Radiation cross-linked polymers: Recent developments and new applications","volume":"236","author":"Rouif","year":"2005","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0969-806X(01)00478-9","article-title":"New material synthesis by radiation processing at high temperature\u2014Polymer modification with improved irradiation technology","volume":"63","author":"Seguchi","year":"2002","journal-title":"Radiat. Phys. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1016\/j.biomaterials.2006.06.024","article-title":"Finalizing the properties of porous scaffolds of aliphatic polyesters through radiation sterilization","volume":"27","author":"Plikk","year":"2006","journal-title":"Biomaterials"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0032-3861(83)90198-2","article-title":"Radiation effects on poly (lactic acid)","volume":"24","author":"Gupta","year":"1983","journal-title":"Polymer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.medengphy.2008.07.005","article-title":"Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material","volume":"31","author":"Cottam","year":"2009","journal-title":"Med. Eng. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1111\/j.1551-2916.2006.01151.x","article-title":"Influence of \u03b3 irradiation on the mechanical strength and in vitro biodegradation of porous hydroxyapatite\/collagen composite","volume":"89","author":"Yunoki","year":"2006","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s10856-010-4046-0","article-title":"Effects of sterilisation by high-energy radiation on biomedical poly-(\u03b5-caprolactone)\/hydroxyapatite composites","volume":"21","author":"Corda","year":"2010","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1464-410X.2010.09310.x","article-title":"Developing biodegradable scaffolds for tissue engineering of the urethra","volume":"107","author":"Selim","year":"2011","journal-title":"BJU Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/(SICI)1097-4628(19970314)63:11<1499::AID-APP12>3.0.CO;2-Y","article-title":"Comparison of the effect of ethylene oxide and \u03b3-irradiation on selected tyrosine-derived polycarbonates and poly (L-lactic acid)","volume":"63","author":"Hooper","year":"1997","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0032-3861(85)90056-4","article-title":"Irradiation effects on polycaprolactone","volume":"26","author":"Narkis","year":"1985","journal-title":"Polymer"},{"key":"ref_27","first-page":"1","article-title":"A study of the effects of gamma irradiation on the structural and mechanical properties of polyvinyl butyral film","volume":"152","author":"Nasrabadi","year":"2018","journal-title":"Radiat. Phys. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0168-583X(02)01473-8","article-title":"Radiation induced crystallinity damage in poly (L-lactic acid)","volume":"197","year":"2002","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radphyschem.2013.12.001","article-title":"Gamma irradiation of melt processed biomedical PDLLA\/HAP nanocomposites","volume":"97","author":"Dadbin","year":"2014","journal-title":"Radiat. Phys. Chem."},{"key":"ref_30","unstructured":"(2023). Materials, Standard Test Method for Compressive Properties of Rigid Plastics (Standard No. ASTM D695)."},{"key":"ref_31","unstructured":"(2025). Sterilization of Health Care Products\u2014Radiation\u2014Part 1: Requirements for the Development, Validation and Routine Control of a Sterilization Process for Medical Devices (Standard No. ISO 11137-1:2025)."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/BF01498927","article-title":"Investigation of the structure of solution grown crystals of lactide copolymers by means of chemical reactions","volume":"251","author":"Fischer","year":"1973","journal-title":"Kolloid-Z. Und Z. Polym."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/mabi.201500078","article-title":"The relationship between water Structure and blood compatibility in poly (2-methoxyethyl acrylate)(PMEA) analogues","volume":"15","author":"Sato","year":"2015","journal-title":"Macromol. Biosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.polymdegradstab.2012.09.014","article-title":"The effects of gamma irradiation on the morphology and properties of polylactide\/Cloisite 30B nanocomposites","volume":"98","author":"Zaidi","year":"2013","journal-title":"Polym. Degrad. Stab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0141-3910(01)00030-1","article-title":"Degradation of poly (L-lactic acid) by \u03b3-irradiation","volume":"72","author":"Nugroho","year":"2001","journal-title":"Polym. Degrad. Stab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.polymdegradstab.2018.11.014","article-title":"The effect of gamma-irradiation on morphology and properties of melt-spun poly (lactic acid)\/cellulose fibers","volume":"160","author":"Aouat","year":"2019","journal-title":"Polym. Degrad. Stab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.radphyschem.2007.02.035","article-title":"Thermal and crystallization behaviour of gamma irradiated PLLA","volume":"76","author":"Milicevic","year":"2007","journal-title":"Radiat. Phys. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Khattari, Z., and Mahdy, E.A. (2024). Probabilistic approach to assessing the radiation shielding capabilities of carbonated hydroxyapatite modified by carbonate-to-phosphate ratio and temperature. Research Square.","DOI":"10.21203\/rs.3.rs-4421590\/v1"},{"key":"ref_39","first-page":"463","article-title":"Preparation and characterization of nanocomposites based on poly (\u03b5-caprolactone) and the surface grafted nanohydroxyapatite with the comb-shaped poly (\u03b5-caprolactone) brushes","volume":"20","author":"Fu","year":"2012","journal-title":"Polym. Polym. Compos."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.polymer.2011.04.028","article-title":"The influence of hydroxyapatite (HA) microparticles (m) and nanoparticles (n) on the thermal and dynamic mechanical properties of poly-l-lactide","volume":"52","author":"Wilberforce","year":"2011","journal-title":"Polymer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/0032-3861(96)81134-7","article-title":"Water absorption and states of water in semicrystalline poly (vinyl alcohol) films","volume":"37","author":"Hodge","year":"1996","journal-title":"Polymer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/polb.21823","article-title":"Dielectric relaxations of chitosan: The effect of water on the \u03b1-relaxation and the glass transition temperature","volume":"47","author":"Prokhorov","year":"2009","journal-title":"J. Polym. Sci. Part B Polym. Phys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.polymer.2016.11.031","article-title":"Water-induced structural changes in poly (lactic acid) and PLLA-clay nanocomposites","volume":"107","author":"Lorenzo","year":"2016","journal-title":"Polymer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/app.27102","article-title":"Effect of crystallization temperature on crystal modifications and crystallization kinetics of poly (L-lactide)","volume":"107","author":"Pan","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.polymdegradstab.2012.06.001","article-title":"Hygrothermal ageing of reprocessed polylactide","volume":"97","author":"Badia","year":"2012","journal-title":"Polym. Degrad. Stab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1021\/jp500219j","article-title":"Analysis of structural rearrangements of poly (lactic acid) in the presence of water","volume":"118","author":"Vyavahare","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.carbpol.2018.11.045","article-title":"Effect of hydration on water state, glass transition dynamics and crystalline structure in chitosan films","volume":"206","author":"Qiao","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijbiomac.2017.05.008","article-title":"Hydration-induced crystalline transformation of starch polymer under ambient conditions","volume":"103","author":"Qiao","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/vnl.21775","article-title":"Changes in crystallization behaviors of poly (vinyl alcohol) induced by water content","volume":"26","author":"Xiang","year":"2020","journal-title":"J. Vinyl Addit. Technol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.polymdegradstab.2008.10.027","article-title":"Effect of \u03b3-dose rate on crystallinity and morphological changes of \u03b3-sterilized biomedical polypropylene","volume":"94","author":"Alariqi","year":"2009","journal-title":"Polym. Degrad. Stab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0969-806X(02)00194-9","article-title":"Study on increase in crystallinity in \u03b3-irradiated poly(vinylidene fluoride)","volume":"65","author":"Zhao","year":"2002","journal-title":"Radiat. Phys. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"170563","DOI":"10.1016\/j.ijleo.2023.170563","article-title":"\u03b3-irradiation induced effects on structural, morphological and photoluminescence properties of PEO-PVA blended polymer films","volume":"274","author":"Kaouach","year":"2023","journal-title":"Optik"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/pi.4611","article-title":"Gamma radiation induced property modification of poly (lactic acid)\/hydroxyapatite bio-nanocomposites","volume":"63","author":"Dadbin","year":"2014","journal-title":"Polym. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/app.30815","article-title":"Heat and humidity performance of injection molded PLA for durable applications","volume":"115","author":"Harris","year":"2010","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"110473","DOI":"10.1016\/j.polymdegradstab.2023.110473","article-title":"The effect of water sorption on the calorimetric signature of aging in DGEBA epoxies","volume":"216","author":"Comeau","year":"2023","journal-title":"Polym. Degrad. Stab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107519","DOI":"10.1016\/j.polymertesting.2022.107519","article-title":"1-Year pullout strength and degradation of ultrasound welded vs tapped craniomaxillofacial fixation screws","volume":"109","author":"Ayyachi","year":"2022","journal-title":"Polym. Test."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0167-7322(99)80007-5","article-title":"Understanding hydrated polymers: The perspective of NMR","volume":"80","author":"McBrierty","year":"1999","journal-title":"J. Mol. Liq."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/089270579600900402","article-title":"Effects of water on a graphite\/epoxy composite","volume":"9","author":"Zhou","year":"1996","journal-title":"J. Thermoplast. Compos. Mater."},{"key":"ref_59","first-page":"22","article-title":"A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications","volume":"4","author":"Li","year":"2019","journal-title":"Bioact. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2005.07.009","article-title":"Plasticizing effect of water on poly (lactide-co-glycolide)","volume":"108","author":"Blasi","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_61","first-page":"115","article-title":"Influence of humidity on glass transition of PLA films","volume":"3","year":"2014","journal-title":"Res. Rev. Mater. Sci. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mastalygina, E.E., and Aleksanyan, K.V. (2024). Recent approaches to the plasticization of poly(lactic acid) (PLA) (a review). Polymers, 16.","DOI":"10.3390\/polym16010087"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1039\/c3ta15204a","article-title":"Sodium dodecyl sulfate\/epoxy composite: Water-induced shape memory effect and its mechanism","volume":"2","author":"Wang","year":"2014","journal-title":"J. Mater. Chem. A"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.carbpol.2014.01.031","article-title":"Water-induced shape-memory poly (d, l-lactide)\/microcrystalline cellulose composites","volume":"104","author":"Liu","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"12525","DOI":"10.1016\/j.ijhydene.2018.08.131","article-title":"Effect of gamma radiation on crosslinking, water uptake and ion exchange on polystyrene-co-acrylic acid copolymers useful for fuel cells","volume":"44","author":"Benavides","year":"2019","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"138703","DOI":"10.1016\/j.conbuildmat.2024.138703","article-title":"Effect of gamma-ray irradiation on the mechanical, thermal, and morphological behavior of sisal fiber\/bio-PBS composites","volume":"450","author":"Kumar","year":"2024","journal-title":"Constr. Build. Mater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1475-925X-12-95","article-title":"Effect of gamma radiation and accelerated aging on the mechanical and thermal behavior of HDPE\/HA nano-composites for bone tissue regeneration","volume":"12","author":"Alothman","year":"2013","journal-title":"Biomed. Eng. Online"},{"key":"ref_68","unstructured":"Carraher, C.E. (2003). Seymour\/Carraher\u2019s Polymer Chemistry, CRC Press."},{"key":"ref_69","unstructured":"Courtney, T.H. (2005). Mechanical Behavior of Materials, Waveland Press."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nimb.2012.07.007","article-title":"Effect of gamma irradiation on the properties of plastic bottle sheet","volume":"287","author":"Kumar","year":"2012","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. At."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.radphyschem.2017.02.058","article-title":"The alterations in high density polyethylene properties with gamma irradiation","volume":"139","author":"Zaki","year":"2017","journal-title":"Radiat. Phys. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"100243","DOI":"10.1016\/j.jcomc.2022.100243","article-title":"Moisture-induced changes in the mechanical behavior of 3D printed polymers","volume":"7","author":"Banjo","year":"2022","journal-title":"Compos. Part C Open Access"},{"key":"ref_73","first-page":"261","article-title":"Crosslinked poly (\u03f5-caprolactone\/D, L-lactide)\/bioactive glass composite scaffolds for bone tissue engineering","volume":"77","author":"Meretoja","year":"2006","journal-title":"J. Biomed. Mater. Res. Part A Off. J. Soc. Biomater. Jpn. Soc. Biomater. Aust. Soc. Biomater. Korean Soc. Biomater."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0142-9612(97)00069-0","article-title":"Nano-apatite\/polymer composites: Mechanical and physicochemical characteristics","volume":"18","author":"Liu","year":"1997","journal-title":"Biomaterials"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.polymdegradstab.2005.04.006","article-title":"Water absorption and enzymatic degradation of poly (lactic acid)\/rice starch composites","volume":"90","author":"Yew","year":"2005","journal-title":"Polym. Degrad. Stab."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.rser.2017.05.143","article-title":"Hydrolytic degradation of polylactic acid (PLA) and its composites","volume":"79","author":"Elsawy","year":"2017","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_77","first-page":"163","article-title":"Normal bone physiology, remodelling and its hormonal regulation","volume":"40","author":"Mallorie","year":"2022","journal-title":"Surgery"},{"key":"ref_78","unstructured":"Treloar, L.G. (1975). The Physics of Rubber Elasticity, Clarendon Press."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1063\/1.1723785","article-title":"Theory of the elastic properties of rubber","volume":"11","author":"James","year":"1943","journal-title":"J. Chem. Phys."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1021553504549","article-title":"Impact behavior of hydroxyapatite reinforced polyethylene composites","volume":"14","author":"Zhang","year":"2003","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.compositesb.2008.01.002","article-title":"Effects of particle size, particle\/matrix interface adhesion and particle loading on mechanical properties of particulate\u2013polymer composites","volume":"39","author":"Fu","year":"2008","journal-title":"Compos. Part B Eng."},{"key":"ref_82","first-page":"196","article-title":"3D printing of HA\/PCL composite tissue engineering scaffolds","volume":"2","author":"Jiao","year":"2019","journal-title":"Adv. Ind. Eng. Polym. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1177\/0021998316636205","article-title":"The effect of beta-tricalcium phosphate on mechanical and thermal performances of poly (lactic acid)","volume":"50","author":"Ferri","year":"2016","journal-title":"J. Compos. Mater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.mechmat.2006.12.001","article-title":"Micromechanics model for particulate composites","volume":"39","author":"Kontou","year":"2007","journal-title":"Mech. Mater."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1016\/j.actbio.2009.03.024","article-title":"The nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair","volume":"5","author":"Cui","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.materresbull.2003.10.013","article-title":"Chemical synthesis of hydroxyapatite\/poly (\u03b5-caprolactone) composites","volume":"39","author":"Choi","year":"2004","journal-title":"Mater. Res. Bull."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.compscitech.2010.06.008","article-title":"Strain rate dependency of mechanical properties of TCP\/PLLA composites after immersion in simulated body environments","volume":"70","author":"Kobayashi","year":"2010","journal-title":"Compos. Sci. Technol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/app.10955","article-title":"Biodegradable and biocompatible nanocomposites of poly (\u03f5-caprolactone) with hydroxyapatite nanocrystals: Thermal and mechanical properties","volume":"86","author":"Hao","year":"2002","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.msec.2015.06.020","article-title":"New generation poly (\u03b5-caprolactone)\/gel-derived bioactive glass composites for bone tissue engineering: Part I. Material properties","volume":"56","author":"Dziadek","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1016\/j.biomaterials.2005.04.018","article-title":"Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility","volume":"26","author":"Hong","year":"2005","journal-title":"Biomaterials"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/S0032-3861(02)00048-4","article-title":"Effects of coupling agent and morphology on the impact strength of high density polyethylene\/CaCO3 composites","volume":"43","author":"Liu","year":"2002","journal-title":"Polymer"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1111\/j.1151-2916.2000.tb01560.x","article-title":"Colloidal processing of ceramics","volume":"83","author":"Lewis","year":"2000","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"358ra127","DOI":"10.1126\/scitranslmed.aaf7704","article-title":"Hyperelastic \u201cbone\u201d: A highly versatile, growth factor\u2013free, osteoregenerative, scalable, and surgically friendly biomaterial","volume":"8","author":"Jakus","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jbm.a.35684","article-title":"Multi and mixed 3 D-printing of graphene-hydroxyapatite hybrid materials for complex tissue engineering","volume":"105","author":"Jakus","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"200","DOI":"10.61298\/rans.2025.3.1.200","article-title":"Impacts of high-dose gamma irradiation on the mechanical, structural and thermal properties of doum fiber reinforced High-Density Polyethylene (HDPe)","volume":"3","author":"Iorshase","year":"2025","journal-title":"Recent Adv. Nat. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"035035","DOI":"10.1088\/2053-1591\/aa6651","article-title":"Effect of particle size on gamma radiation shielding property of gadolinium oxide dispersed epoxy resin matrix composite","volume":"4","author":"Li","year":"2017","journal-title":"Mater. Res. Express"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"101416","DOI":"10.1016\/j.nxmate.2025.101416","article-title":"Gamma irradiation effects on mechanical and environmental performance of Al2O3-TiO2 reinforced jute-glass hybrid composites","volume":"10","author":"Ali","year":"2026","journal-title":"Next Mater."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0969-806X(03)00070-7","article-title":"Gamma irradiation processing of hydroxyapatite\/poly-L-lactide composite biomaterial","volume":"67","year":"2003","journal-title":"Radiat. Phys. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.radphyschem.2006.02.013","article-title":"Radiation-induced degradation of hydroxyapatite\/poly L-lactide composite biomaterial","volume":"76","year":"2007","journal-title":"Radiat. Phys. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0927-0256(01)00154-9","article-title":"The stress\u2013strain response and ultimate strength of filled elastomers","volume":"21","author":"Drozdov","year":"2001","journal-title":"Comput. Mater. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1021\/cm0619398","article-title":"Hydrogen bonding interaction of poly (D, L-lactide)\/hydroxyapatite nanocomposites","volume":"19","author":"Zhou","year":"2007","journal-title":"Chem. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0142-9612(00)00283-0","article-title":"Chemically coupled hydroxyapatite\u2013polyethylene composites: Structure and properties","volume":"22","author":"Wang","year":"2001","journal-title":"Biomaterials"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Dhakal, H.N., and Zhang, Z. (2012). Polymer Matrix Composites: Moisture Effects and Dimensional Stability. Wiley Encyclopedia of Composites, John Wiley & Sons.","DOI":"10.1002\/9781118097298.weoc178"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chavarri-Prado, D., Brizuela-Velasco, A., \u00c1lvarez-Arenal, \u00c1., Dieguez-Pereira, M., P\u00e9rez-Pevida, E., Viteri-Agust\u00edn, I., and Estrada-Mart\u00ednez, A. (2020). The bone buttress theory: The effect of the mechanical loading of bone on the osseointegration of dental implants. Biology, 10.","DOI":"10.3390\/biology10010012"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i4.50","article-title":"Mechanical signaling for bone modeling and remodeling","volume":"19","author":"Robling","year":"2009","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"108998","DOI":"10.1016\/j.matdes.2020.108998","article-title":"Coupling effects of gamma irradiation and absorbed moisture on silicone foam","volume":"195","author":"Wang","year":"2020","journal-title":"Mater. Des."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.eurpolymj.2017.06.011","article-title":"Shape memory effect in 3D-printed scaffolds for self-fitting implants","volume":"93","author":"Senatov","year":"2017","journal-title":"Eur. Polym. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1002\/jbm.a.35500","article-title":"Scaffolds with shape memory behavior for the treatment of large bone defects","volume":"103","author":"Rychter","year":"2015","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1021\/am405101k","article-title":"Electrospun biomimetic fibrous scaffold from shape memory polymer of PDLLA-co-TMC for bone tissue engineering","volume":"6","author":"Bao","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_110","first-page":"100097","article-title":"Features and futures of X-ray free-electron lasers","volume":"2","author":"Huang","year":"2021","journal-title":"Innovation"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"223902","DOI":"10.1103\/PhysRevLett.120.223902","article-title":"Element selectivity in second-harmonic generation of GaFeO3 by a soft-X-ray free-electron laser","volume":"120","author":"Yamamoto","year":"2018","journal-title":"Phys. Rev. Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1021\/jp409805p","article-title":"Water dynamics in protein hydration shells: The molecular origins of the dynamical perturbation","volume":"118","author":"Fogarty","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11517","DOI":"10.1038\/s41467-025-66717-5","article-title":"Experimental determination of structural motifs of interference-free water undecamer cluster (H2O) 11","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41578-022-00530-0","article-title":"Emerging ultrafast techniques for studying quantum materials","volume":"8","author":"Zong","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/acs.jpclett.4c00210","article-title":"Spectroscopic and Theoretical Identifications of Two Structural Motifs of (H2O) 10 Cluster","volume":"15","author":"Zhang","year":"2024","journal-title":"J. Phys. Chem. Lett."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/7\/817\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:53:16Z","timestamp":1774626796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/7\/817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":115,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["polym18070817"],"URL":"https:\/\/doi.org\/10.3390\/polym18070817","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}