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Functionalized poly(l-lactide-co-d,l-lactide) copolymer filled with hydroxyapatite was used to produce two personalized implants for upper and lower jaw reconstruction via 3D printing. Morphology analysis (SEM, \u00b5CT), gel permeation chromatography, and thermal analysis quantified the effects of melt processing and sterilization on chain structure. Physical properties of sterilized parts, such as hardness and density, proved suitable for bone implants. Removal of the upper jaw implant after 4 months and of the lower jaw substitute after 18 months enabled monitoring of bioresorption and tissue regrowth over time. Gradual overgrowth of the implants with human tissue, initiated by the osteoconductive filler, was observed, along with time-dependent polylactide degradation, showing up to 92% molar mass reduction. The medical procedures confirmed safety, nontoxicity, non-allergenicity, and, most importantly, the tissue-forming properties of the polylactide-based formulation.<\/jats:p>","DOI":"10.3390\/polym18091034","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:29:11Z","timestamp":1777033751000},"page":"1034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D-Printed Polylactide-Based Implants: Influence of Processing, Radiation Sterilization and In Vivo Bioresorption on Structural and Physicochemical Material Characteristics"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-1284","authenticated-orcid":false,"given":"Monika","family":"Dobrzy\u0144ska-Mizera","sequence":"first","affiliation":[{"name":"Institute of Materials Technology, Division of Plastic Processing, Poznan University of Technology, Piotrowo 3, 61-138 Poznan, 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Fundamentals of Machinery Design, Faculty of Mechanical Engineering, Silesian University of Technology, Konarskiego 18A, 44-100 Gliwice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-0128","authenticated-orcid":false,"given":"Jacek","family":"Andrzejewski","sequence":"additional","affiliation":[{"name":"Institute of Materials Technology, Division of Plastic Processing, Poznan University of Technology, Piotrowo 3, 61-138 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2300-0834","authenticated-orcid":false,"given":"Patryk","family":"Mietli\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Mechanical Technology, Division of Metrology and Measurement Systems, Poznan University of Technology, Piotrowo 3, 61-138 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-1942","authenticated-orcid":false,"given":"Bartosz","family":"Gapi\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Mechanical Technology, Division of Metrology and Measurement Systems, Poznan University of Technology, Piotrowo 3, 61-138 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Stagraczy\u0144ski","sequence":"additional","affiliation":[{"name":"4th Military Clinical Hospital with Polyclinic, Rudolfa Weigla 5, 53-114 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Mikulski","sequence":"additional","affiliation":[{"name":"Artdent Dental Office, Piekarska 11-13, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Longo","sequence":"additional","affiliation":[{"name":"National Research 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