{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:00:13Z","timestamp":1780887613166,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Government","award":["125012200641-2"],"award-info":[{"award-number":["125012200641-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The synthesis of reactive sucrose derivatives is of significant interest for the development of novel biocompatible polymers. In this study, an octa-substituted sucrose derivative containing isocyanate groups was synthesized via a urethane-forming reaction carried out in an aprotic solvent at the phase interface. This approach exhibits high selectivity and provides a target product yield of up to 60%. Subsequently, using the same reaction mechanism, the isocyanate derivative was converted into an octa-functional methacrylate derivative capable of forming three-dimensional cross-linked networks. The structures of both the intermediate and final products were confirmed by IR, 1H NMR, and mass spectrometry. The sucrose-based prepolymer was further evaluated in the formation of cross-linked structures for potential application as bone-substituting implants. Using various photocuring techniques, including two-photon 3D printing, both plates and microstructured scaffolds were fabricated. These structures exhibited high thermal stability, elastic properties comparable to those of bone tissue, and no toxic effects on cells.<\/jats:p>","DOI":"10.3390\/polym18121417","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:32:46Z","timestamp":1780885966000},"page":"1417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-6437","authenticated-orcid":false,"given":"Vladislav","family":"Kaplin","sequence":"first","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Glagolev","sequence":"additional","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-0118","authenticated-orcid":false,"given":"Nikita","family":"Minaev","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, Moscow 123182, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenii","family":"Epifanov","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, Moscow 123182, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-8899","authenticated-orcid":false,"given":"Nadezhda","family":"Aksenova","sequence":"additional","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"},{"name":"Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia","family":"Akovantseva","sequence":"additional","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Zarkhina","sequence":"additional","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vasileva","sequence":"additional","affiliation":[{"name":"Translational Medicine Research Center, Sirius University of Science and Technology, Sochi 354340, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kiseleva","sequence":"additional","affiliation":[{"name":"Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zimens","sequence":"additional","affiliation":[{"name":"A.V. 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