{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:39:16Z","timestamp":1785425956920,"version":"3.56.0"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["HRZZ IP-2024-05-4339"],"award-info":[{"award-number":["HRZZ IP-2024-05-4339"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"award":["HRZZ IP-2024-05-4339"],"award-info":[{"award-number":["HRZZ IP-2024-05-4339"]}],"id":[{"id":"https:\/\/ror.org\/03n51vw80","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"crossref","award":["NPOO.C3.2. R3-I1.04.0126"],"award-info":[{"award-number":["NPOO.C3.2. R3-I1.04.0126"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Electrospinning is a highly versatile technique for fabricating nanofibrous membranes with high surface-area-to-volume ratios and tunable porosity. Although polycaprolactone (PCL) is widely utilized in biomedical engineering due to its biocompatibility, its electrospinning traditionally relies on hazardous organic solvents like dichloromethane (DCM) and N,N-dimethylformamide (DMF). This paper details the development of a fully sustainable, green electrospinning process for PCL using a bio-derived binary mixture of acetic acid and formic acid. Processing parameters (applied voltage, tip-to-collector distance, and flow rate) were systematically optimized using a Design of Experiments (DoE) response surface methodology. Scanning electron microscopy (SEM) confirmed the successful fabrication of uniform, bead-free nanofibers with a mean diameter of 247 nm, representing a 37.3% reduction compared to conventional DCM:DMF-spun matrices. Fourier-transform infrared spectroscopy (FTIR) verified complete solvent evaporates.<\/jats:p>","DOI":"10.3390\/polym18121547","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:49:55Z","timestamp":1782121795000},"page":"1547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrospinning of Polycaprolactone Membranes Using Green Solvents for Organ-on-a-Chip Applications"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6092-9430","authenticated-orcid":false,"given":"Donna Danijela","family":"Dragun","sequence":"first","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Kuzman","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bla\u017eek","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floren","family":"Radovanovi\u0107-Peri\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-776X","authenticated-orcid":false,"given":"Iva Rezi\u0107","family":"Me\u0161trovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Textile Technology, University of Zagreb, Prilaz Baruna Filipovi\u0107a 28a, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-1038","authenticated-orcid":false,"given":"Fabio","family":"Faraguna","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-0856","authenticated-orcid":false,"given":"Ernest","family":"Me\u0161trovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Maruli\u0107a 19, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","article-title":"Reconstituting Organ-Level Lung Functions on a Chip","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41378-025-01142-8","article-title":"Toward continuous monitoring systems: Emerging trends of on-chip sensors in organ-on-a-chip","volume":"12","author":"Ling","year":"2026","journal-title":"Microsyst. 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