{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:47:13Z","timestamp":1788184033722,"version":"build-2803163510"},"reference-count":75,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Melanoma excision procedures frequently result in complex wounds that require simultaneous tumor suppression and tissue regeneration. However, current post-surgical care heavily relies on synthetic drugs, facing challenges like antibiotic resistance and delayed healing. To address this notable gap, this study introduces a novel \u201cmineral-botanical\u201d hybrid nanofibrous dressing to reduce reliance on conventional synthetic agents. The nanofiber surfaces were subsequently functionalized with a supercritical CO2 extract of Inula helenium, thereby introducing a highly bioactive botanical agent not previously explored in this hybrid wound-care context. Comprehensive physical and structural characterizations demonstrated that the bioactive coating serves as a resilient physical barrier, significantly enhancing the dressing\u2019s structural integrity in fluidic environments. In vitro biological evaluations revealed a dual-action mechanism: the biomaterial exhibited excellent biocompatibility and accelerated migration in human dermal fibroblasts (HDFs), achieving nearly 100% in vitro wound closure at 24 h. Conversely, the Inula helenium-coated nanofibers demonstrated distinct, selective cytotoxicity against A375 melanoma cells, effectively restricting their proliferation and reducing their viability. Furthermore, the hybrid platform exhibited significant antioxidant potential and achieved 94% antibacterial inhibition against Staphylococcus aureus. In conclusion, this study presents a sustainable, dual-function wound dressing that suppresses residual cancer cells while promoting healthy tissue regeneration, offering a promising alternative to conventional synthetic oncological dressings.<\/jats:p>","DOI":"10.3390\/polym18151857","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:13:47Z","timestamp":1785320027000},"page":"1857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mineral\u2013Botanical Hybrid Nanofibrous Dressing for Post-Surgical Melanoma Wound Healing"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-1020","authenticated-orcid":false,"given":"Tubanur","family":"Avci","sequence":"first","affiliation":[{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eray","family":"Altan","sequence":"additional","affiliation":[{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6351-8874","authenticated-orcid":false,"given":"Ceren","family":"Aytar","sequence":"additional","affiliation":[{"name":"T\u00dcB\u0130TAK Science High School, Kocaeli 41400, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5169-9999","authenticated-orcid":false,"given":"Zehra","family":"Kanli","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine, Istanbul Arel University, Istanbul 34010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap Ayaz","family":"Seyhan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-5997","authenticated-orcid":false,"given":"Savas","family":"Evran","sequence":"additional","affiliation":[{"name":"Department of Jewelry and Jewelry Design, Faculty of Applied Sciences, Marmara University, Istanbul 34865, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-4419","authenticated-orcid":false,"given":"Gulgun Bosgelmez","family":"Tinaz","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-6489","authenticated-orcid":false,"given":"Oguzhan","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-3392","authenticated-orcid":false,"given":"Canan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-259X","authenticated-orcid":false,"given":"Ahmet Akif","family":"K\u0131z\u0131lkurtlu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istanbul Atlas University, Istanbul 34403, Turkey"},{"name":"Atlas University Research Center (ARC), Atlas University, Istanbul 34408, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/iwj.13786","article-title":"Emerging treatment strategies in wound care","volume":"19","author":"Mirhaj","year":"2022","journal-title":"Int. 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