{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:59:19Z","timestamp":1785495559006,"version":"3.56.0"},"reference-count":46,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Technology Development Program of MSS","doi-asserted-by":"publisher","award":["RS-2023-00302877"],"award-info":[{"award-number":["RS-2023-00302877"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea\/Israel Industrial Research and Development Foundation","award":["2022-42-196"],"award-info":[{"award-number":["2022-42-196"]}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade Industry & Energy","doi-asserted-by":"publisher","award":["RS-2024-00433253"],"award-info":[{"award-number":["RS-2024-00433253"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00433253"],"award-info":[{"award-number":["RS-2024-00433253"]}],"id":[{"id":"https:\/\/ror.org\/008nkqk13","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Autologous skin grafting is considered the standard treatment for full-thickness skin defects and provides essential dermal reconstruction to support both functional and aesthetic skin outcomes. However, it has limitations, such as increased donor-site morbidity, suboptimal aesthetic outcomes, thickness mismatches, texture irregularities, and scar contractions. Several dermal substitutes have been developed to overcome these limitations. In the present study, we introduce TissueDerm Graft\u00ae, a novel collagen-based dermal substitute designed to improve both functional and aesthetic outcomes in skin grafting by providing a regular structure that supports dermal tissue regeneration. We compared the properties and efficacy of TissueDerm Graft\u00ae with those of bovine acellular dermal matrix (Matriderm\u00ae). A full-thickness skin defect was induced in minipigs and TissueDerm Graft\u00ae or Matriderm\u00ae were simultaneously transplanted with a split-thickness skin graft (STSG). In the present study, TissueDerm Graft\u00ae exhibited tightly packed and uniform collagen fibers, a consistent pore distribution, and elastin. The full-thickness skin defect model demonstrated favorable wound healing without inducing excessive inflammatory responses or excessive scar formation. Compared with the single implantation of STSG and co-implantation of STSG and Matriderm\u00ae, the co-implantation of STSG and TissueDerm Graft\u00ae improved the visual outcomes. These findings suggest that TissueDerm Graft\u00ae could serve as a promising dermal substitute for skin grafting and skin tissue regeneration.<\/jats:p>","DOI":"10.3390\/polym18151885","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:11:38Z","timestamp":1785492698000},"page":"1885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wound Healing Efficacy of Novel Dermal Substitute TissueDerm Graft\u00ae in Full-Thickness Skin Defects"],"prefix":"10.3390","volume":"18","author":[{"given":"Kyu-Sik","family":"Shim","sequence":"first","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5530-2161","authenticated-orcid":false,"given":"Dohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongwoo","family":"Park","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Saem","family":"Jo","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeon","family":"Koo","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Jai","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-159X","authenticated-orcid":false,"given":"Tai Suk","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-4110","authenticated-orcid":false,"given":"Wooyeol","family":"Baek","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd., Seoul 03721, Republic of Korea"},{"name":"Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Martin","year":"2024","journal-title":"Nat. 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