{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:51:13Z","timestamp":1792792273629,"version":"4.5.0"},"reference-count":67,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>The design of innovative biomaterials increasingly aims to reproduce the structure, properties, and behavior of natural tissues. Biomimetic materials are generally considered to promote biointegration. In bone tissue regeneration materials, biomimicry and mechanical competence represent complementary design objectives whose relative importance depends on the clinical requirements and the expected timeline of bone regeneration. In the present investigation, two types of 3D-printed PLA scaffolds for bone tissue regeneration, featuring conventional cubic and biomimetic gyroid-based triply periodic minimal surface (TPMS) architectures, respectively, were evaluated. Their degradation behavior was investigated during immersion in a protein-rich cell culture medium under dynamic conditions at 37 \u00b0C, followed by mechanical characterization and analytical modeling of the property evolution. The cubic scaffolds exhibited approximately 210% higher apparent compressive modulus and more than fourfold higher apparent compressive strength compared with the gyroid scaffolds in the initial state. During 21 days of immersion, gyroid scaffolds showed progressive mass loss reaching approximately 13%, whereas cubic scaffolds exhibited a slight mass increase associated with fluid uptake. Both architectures experienced a reduction in mechanical properties; however, the gyroid structures showed faster structural deterioration due to their higher porosity, increased fluid accessibility, and greater fluid uptake and degradation-induced structural deterioration. The Residual Property Model accurately predicted the mechanical degradation of cubic scaffolds but was unable to predict the gyroid response due to the dominant contribution of mass loss and structural degradation. The overall results indicate a trade-off between the two architectural approaches, whereby enhanced biomimetic features are associated with reduced mechanical performance.<\/jats:p>","DOI":"10.3390\/polym18161984","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:57:46Z","timestamp":1786708666000},"page":"1984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Structure\u2013Property Evolution of Cubic and Gyroid PLA Scaffolds During In Vitro Degradation Under Physiologically Relevant Conditions"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-3434","authenticated-orcid":false,"given":"Diana V.","family":"Portan","sequence":"first","affiliation":[{"name":"Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece"},{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-6944","authenticated-orcid":false,"given":"Lykourgos C.","family":"Kontaxis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Tselepidi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomechanics and Biomedical Engineering, Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-7457","authenticated-orcid":false,"given":"George C.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-2267","authenticated-orcid":false,"given":"Leonard","family":"Azamfirei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kozaniti, F.K., Deligianni, D.D., Georgiou, M.D., and Portan, D.V. (2022). The role of substrate topography and stiffness on MSC cells functions: Key material properties for biomimetic bone tissue engineering. Biomimetics, 7.","DOI":"10.3390\/biomimetics7010007"},{"key":"ref_2","unstructured":"Portan, D.V. (2023, January 10\u201314). Biomimetic biomaterials: Functioning principles, key properties and perspectives. Proceedings of the Book of Abstracts of the 10th International Conference on Structural Analysis and Advanced Materials (ICSAAM 2023), Zakynthos, Greece."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, H., Liu, J., Sun, C., Wang, Y., Sun, Y., and Shi, X. (2026). Design and fabrication of biomimetic gradient bone tissue engineering scaffolds: Evolution from single-gradient to multi-gradient. Gels, 12.","DOI":"10.3390\/gels12020131"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110035","DOI":"10.1016\/j.porgcoat.2026.110035","article-title":"Dual-biomimetic hydrogel coatings inspired by cell membrane and extracellular matrix: Boosting corrosion resistance and biocompatibility of magnesium alloys","volume":"214","author":"Pan","year":"2026","journal-title":"Prog. Org. Coat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e03325","DOI":"10.1002\/adhm.202503325","article-title":"Bioengineered lymphatic vessels in synthetic matrices to study breast cancer cell functions","volume":"15","author":"Odabasi","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e13484","DOI":"10.1002\/adma.202513484","article-title":"3D printing of gradient biomimetic scaffold via electrochemical molecular lock for tissue regeneration","volume":"38","author":"Yao","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_7","first-page":"641","article-title":"Lymphatic incorporated biomimetic scaffold enhances osteoangio-lymphogenic coupling via HIF-1\u03b1-mediated mitochondrial reprogramming for osteoporotic bone repair","volume":"56","author":"Sun","year":"2026","journal-title":"Bioact. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1039\/D5RA08241B","article-title":"Biomimetic multi-layer scaffolds with aligned polyurethane nanofibers and tailored hyaluronic acid\/gelatin hydrogels for sustained methylprednisolone release in potential cardiovascular applications","volume":"16","author":"Solouk","year":"2026","journal-title":"RSC Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e17195","DOI":"10.1002\/adfm.202517195","article-title":"Biomimetic microgrooved methacrylated silk fibroin cartilage scaffold for tracheal injury repair","volume":"36","author":"Wang","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e05734","DOI":"10.1002\/adhm.202505734","article-title":"Engineering next-generation vascular grafts with improved endothelialization and long-term patency","volume":"15","author":"Das","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e10329","DOI":"10.1002\/smll.202510329","article-title":"Structural design of tough porous materials: From natural to biomimetic","volume":"22","author":"Zhang","year":"2026","journal-title":"Small"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"173769","DOI":"10.1016\/j.cej.2026.173769","article-title":"Bamboo-based biomass materials with biomimetic structure and osteoconductive capability for bone regeneration","volume":"531","author":"Xia","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e07071","DOI":"10.1002\/adma.202507071","article-title":"Endogenous metal ion-enriched immunostimulating biomimetic scaffold improves in situ bone regeneration","volume":"38","author":"Yu","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2401919","DOI":"10.1002\/adhm.202401919","article-title":"3D bioprinted tissue-engineered bone with enhanced mechanical strength and bioactivities: Accelerating bone defect repair through sequential immunomodulatory properties","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Men, Y., Wang, T., Tang, S., and Zhang, C. (2026). Research on parametric construction and compressive mechanical properties of biomimetic bone trabecular porous scaffold based on Voronoi tessellation. Comput. Methods Biomech. Biomed. Eng., 1\u201311.","DOI":"10.1080\/10255842.2026.2659966"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100699","DOI":"10.1016\/j.mtadv.2026.100699","article-title":"Recent advances in 3D printing biomimetic gradient scaffolds for tendon-bone interface repair","volume":"29","author":"Zhang","year":"2026","journal-title":"Mater. Today Adv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1016\/S0142-9612(03)00339-9","article-title":"Biomimetic materials for tissue engineering","volume":"24","author":"Shin","year":"2003","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jbm.a.36265","article-title":"Modeling of the interaction between osteoblasts and biocompatible substrates as a function of adhesion strength","volume":"106","author":"Portan","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s11012-013-9871-z","article-title":"Investigation of nanomechanical properties of multilayered hybrid nanocomposites","volume":"49","author":"Papanicolaou","year":"2014","journal-title":"Meccanica"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10800-012-0468-3","article-title":"A novel experimental method for obtaining multi-layered TiO2 nanotubes through electrochemical anodizing","volume":"42","author":"Portan","year":"2012","journal-title":"J. Appl. Electrochem."},{"key":"ref_21","first-page":"181","article-title":"Manufacturing and characterization of TiO2 nanotubes on pure titanium surfaces for advanced biomedical applications","volume":"73","author":"Portan","year":"2012","journal-title":"UPB Sci. Bull. Ser. B Chem. Mater. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e12392","DOI":"10.1002\/smll.202512392","article-title":"Biomimetic multifunctional scaffolds for osteochondral regeneration: Bridging material design and functional integration","volume":"22","author":"Zhong","year":"2026","journal-title":"Small"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nmat1421","article-title":"Porous scaffold design for tissue engineering","volume":"4","author":"Hollister","year":"2005","journal-title":"Nat. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nmat2441","article-title":"Complexity in biomaterials for tissue engineering","volume":"8","author":"Place","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102833","DOI":"10.1016\/j.nxmate.2026.102833","article-title":"Biogenic hydroxyapatite derived from Polymesoda erosa shells tunes structure\u2013property\u2013performance in 3D-printed PLA\/PCL scaffolds for bone tissue engineering","volume":"13","author":"Haryati","year":"2026","journal-title":"Next Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1039\/D6BM00733C","article-title":"Advanced 3D-printed PLA scaffolds functionalized with dual small molecules for enhanced bone regeneration: In vitro and in vivo studies","volume":"14","year":"2026","journal-title":"Biomater. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107376","DOI":"10.1016\/j.jmbbm.2026.107376","article-title":"PLA-based composite implants for mandibular fracture: Towards bioresorbable solutions","volume":"177","author":"Bose","year":"2026","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Xu, Y., Peng, W., Poli, V., Lavagnolo, M.C., Kalambura, S., He, P.-J., L\u00fc, F., and Zhang, H. (2026). A review of the degradation mechanisms of biodegradable PLA\/PBAT films: Biological, chemical, and biochemical perspectives. Energy Environ. Sustain., 100071.","DOI":"10.1016\/j.eesus.2026.100071"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12938-026-01550-5","article-title":"Biodegradable synthetic polymers for biomedical and tissue engineering applications: Tailoring degradation kinetics with tissue regeneration timeline","volume":"25","author":"Saidin","year":"2026","journal-title":"BioMed. Eng. OnLine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100804","DOI":"10.1016\/j.mtadv.2026.100804","article-title":"Influence of scaffold porosity on the degradation of 3D-printed biodegradable polymers: Coupled bioreactor, modeling, and in vivo validation","volume":"30","author":"Aydin","year":"2026","journal-title":"Mater. Today Adv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1901065","DOI":"10.1002\/adem.201901065","article-title":"Recent progress on 3D-printed polylactic acid and its applications in bone repair","volume":"22","author":"Chen","year":"2020","journal-title":"Adv. Eng. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e00096","DOI":"10.1016\/j.bprint.2020.e00096","article-title":"On the effect of design and fabrication parameters on mechanical performance of 3D printed PLA scaffolds","volume":"20","author":"Baptista","year":"2020","journal-title":"Bioprinting"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107039","DOI":"10.1016\/j.jmbbm.2025.107039","article-title":"Impact of biodegradation on the mechanical and fatigue properties of 3D-printed PLA bone scaffolds","volume":"168","author":"Bakhtiari","year":"2025","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1177\/08927057251364174","article-title":"Structure-property relationships in 3D printed bone scaffolds: Role of TPMS architecture and porosity in PLA and nanohydroxyapatite reinforced composites","volume":"39","author":"Pazhamannil","year":"2026","journal-title":"J. Thermoplast. Compos. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10965-026-04785-x","article-title":"The effect of the biodegradation process on the structure and mechanical properties of 3D-printed composite materials based on PLA","volume":"33","author":"Kachalina","year":"2026","journal-title":"J. Polym. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/jctb.7893","article-title":"Biodegradation, mechanical and biocompatibility evaluation of compact and porous polylactic acid after long-term dynamic fluid immersion","volume":"100","author":"Portan","year":"2025","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Portan, D.V., Koliadima, A., Kapolos, J., and Azamfirei, L. (2025). Biomimetic design and assessment via microenvironmental testing: From food packaging biomaterials to implantable medical devices. Biomimetics, 10.","DOI":"10.3390\/biomimetics10060370"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"035001","DOI":"10.1088\/1748-605X\/ae55ed","article-title":"Biomimetic 3D-printed gyroid scaffolds with versatile bioactive coatings for complex craniomaxillofacial bone regeneration","volume":"21","author":"Tourbier","year":"2026","journal-title":"Biomed. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1152\/ajplegacy.1967.212.6.1405","article-title":"Regulation of blood flow in single capillaries","volume":"212","author":"Johnson","year":"1967","journal-title":"Am. J. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e51697","DOI":"10.1002\/app.51697","article-title":"Manufacturing technology and dynamic mechanical investigation of moisture-resistant Luffa cylindrica-reinforced epoxy composites","volume":"139","author":"Papanicolaou","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41697","DOI":"10.1002\/app.41697","article-title":"Stress relaxation behavior of starch powder\u2013epoxy resin composites","volume":"132","author":"Papanicolaou","year":"2015","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"48529","DOI":"10.1002\/app.48529","article-title":"Effect of thermal shock cycling on the quasi-static and dynamic flexural properties of flax fabric\u2013epoxy matrix laminates","volume":"137","author":"Kollia","year":"2020","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wong, K.J., Johar, M., Koloor, S.S.R., Petr\u016f, M., and Tamin, M.N. (2020). Moisture absorption effects on mode II delamination of carbon\/epoxy composites. Polymers, 12.","DOI":"10.3390\/polym12092162"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100243","DOI":"10.1016\/j.jcomc.2022.100243","article-title":"Moisture-induced changes in the mechanical behavior of 3D printed polymers","volume":"7","author":"Banjo","year":"2022","journal-title":"Compos. Part C Open Access"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5755\/j02.mech.31339","article-title":"The modified residual property model for fracture mechanics","volume":"29","author":"Saracoglu","year":"2023","journal-title":"Mechanika"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11668-026-02403-y","article-title":"Effect of water absorption on mode II delamination of adhesively bonded carbon\/epoxy composites","volume":"26","author":"Wong","year":"2026","journal-title":"J. Fail. Anal. Prev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"104064","DOI":"10.1016\/j.jmbbm.2020.104064","article-title":"Effects of design, porosity and biodegradation on mechanical and morphological properties of additive-manufactured triply periodic minimal surface scaffolds","volume":"112","author":"Behravesh","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"042002","DOI":"10.1088\/2053-1591\/ae45f3","article-title":"Mechanical properties of whole-body human bones: A review","volume":"13","author":"Verma","year":"2026","journal-title":"Mater. Res. Express"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0021-9290(88)90008-5","article-title":"On the dependence of the elasticity and strength of cancellous bone on apparent density","volume":"21","author":"Rice","year":"1988","journal-title":"J. Biomech."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113366","DOI":"10.1016\/j.ijsolstr.2025.113366","article-title":"TPMS-based scaffolds: Adaptation of morphological properties and mechanical response to reference tissue","volume":"315","author":"Elenskaya","year":"2025","journal-title":"Int. J. Solids Struct."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/8756-3282(94)90900-8","article-title":"Failure mechanisms in human vertebral cancellous bone","volume":"15","author":"Fyhrie","year":"1994","journal-title":"Bone"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1016\/j.actbio.2012.10.041","article-title":"High-resolution PLA-based composite scaffolds via 3-D printing technology","volume":"9","author":"Serra","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1021\/acsapm.5c00342","article-title":"3D-printed thermally activated shape memory PLA\/TBC composite scaffold with body-compatible temperature for minimally invasive bone repair","volume":"7","author":"Huang","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kwon, S., and Hwang, D. (2025). Understanding and resolving 3D printing challenges: A systematic literature review. Processes, 13.","DOI":"10.3390\/pr13061772"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"106156","DOI":"10.1016\/j.rineng.2025.106156","article-title":"Design and analysis of 3D-printed PLA scaffolds: Enhancing mechanical properties","volume":"27","author":"Rahman","year":"2025","journal-title":"Results Eng."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.matpr.2023.02.278","article-title":"Mechanical analysis and additive manufacturing of 3D-printed lattice materials for bone scaffolds","volume":"101","author":"Hulme","year":"2024","journal-title":"Mater. Today Proc."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Verisqa, F., Park, J.-H., Mandakhbayar, N., Cha, J.-R., Nguyen, L., Kim, H.-W., and Knowles, J.C. (2024). In vivo osteogenic and angiogenic properties of a 3D-printed isosorbide-based gyroid scaffold manufactured via digital light processing. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030609"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s13726-023-01191-8","article-title":"Accelerated degradation mechanism and mechanical behavior of 3D-printed PLA scaffolds for bone regeneration","volume":"32","author":"Zohoor","year":"2023","journal-title":"Iran. Polym. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0927-7757(01)01100-1","article-title":"Study on kinetics of early stage protein adsorption on poly(2-methoxyethylacrylate) (PMEA) surface","volume":"203","author":"Tanaka","year":"2002","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"126823","DOI":"10.1016\/j.polymer.2024.126823","article-title":"Critical role of the composition of the cell culture medium on cell attachment and viability on PLA biocomposite scaffolds under in vitro assay conditions","volume":"297","author":"Atay","year":"2024","journal-title":"Polymer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.actbio.2017.02.006","article-title":"A comparative study of simulated body fluids in the presence of proteins","volume":"53","author":"Zhao","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1002\/app.1983.070281013","article-title":"Interrelation between moisture absorption, mechanical behavior, and extent of the boundary interphase in particulate composites","volume":"28","author":"Theocaris","year":"1983","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Picado-Tejero, D., Mendoza-Cerezo, L., Rodr\u00edguez-Rego, J.M., Carrasco-Amador, J.P., and Marcos-Romero, A.C. (2025). Recent Advances in 3D Bioprinting of Porous Scaffolds for Tissue Engineering: A Narrative and Critical Review. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16090328"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/acsbiomaterials.3c01368","article-title":"Artificial Intelligence-Based 3D Printing Strategies for Bone Scaffold Fabrication and Its Application in Preclinical and Clinical Investigations","volume":"10","author":"Logeshwaran","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Vijaya Kumari, P.K., Carpenter, J., Cleon, B., Panebianco, C.J., Boerckel, J.D., Dean, D., and Vijayan, V.M. (2026). Plasma-enabled multiscale coupling of architecture and biointerfaces drives osteogenesis in 3D-printed gyroid scaffolds. bioRxiv.","DOI":"10.64898\/2026.04.16.718992"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.actbio.2023.08.041","article-title":"Hydroxyapatite 3D-Printed Scaffolds with Gyroid-Triply Periodic Minimal Surface (TPMS) Porous Structure: Fabrication and an In Vivo Pilot Study in Sheep","volume":"170","author":"Bouakaz","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1021\/acsbiomaterials.5c01845","article-title":"An experimental study on 3D-printed gyroid-shaped TC4 porous scaffolds guiding angiogenesis and osteogenesis in bone defect areas","volume":"12","author":"Wang","year":"2026","journal-title":"ACS Biomater. Sci. Eng."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/16\/1984\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:01:42Z","timestamp":1786708902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/18\/16\/1984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":67,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["polym18161984"],"URL":"https:\/\/doi.org\/10.3390\/polym18161984","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]}}}