{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:14:03Z","timestamp":1792790043166,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010824","name":"Sinopec","doi-asserted-by":"crossref","award":["224130"],"award-info":[{"award-number":["224130"]}],"id":[{"id":"10.13039\/501100010824","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/0161q6d74","id-type":"ROR","asserted-by":"crossref"}]},{"award":["224130"],"award-info":[{"award-number":["224130"]}],"id":[{"id":"https:\/\/ror.org\/0161q6d74","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>A continuous-flow microfluidic strategy was developed for the synthesis of nitrogen-containing bio-based polyols via cyclohexylamine aminolysis of epoxidized soybean oil (ESO). The effects of temperature, residence time, catalyst loading, flow rate, and channel diameter on epoxy and hydroxyl values were systematically investigated. Under optimal conditions (100 \u00b0C, 60 min, 5 wt% catalyst), a hydroxyl value of 259 mgKOH\/g and a residual epoxy value of 0.11% were achieved. Compared to a conventional batch process requiring 12 h, the microfluidic method shortened the reaction time to minutes while delivering significantly higher hydroxyl values and narrower molecular weight distribution. FTIR, GPC, DSC, and TGA analyses confirmed more complete conversion, suppressed etherification side reactions, and superior structural uniformity in the microreactor-derived products. Based on the experimental results, microfluidic processing showed the potential for efficient and sustainable production of nitrogen-containing bio-based polyols.<\/jats:p>","DOI":"10.3390\/polym18182217","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:24:33Z","timestamp":1789129473000},"page":"2217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microfluidic Process Intensification for the Synthesis of Nitrogen-Containing Bio-Based Polyols via Aminolysis of Epoxidized Soybean Oil"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-3789","authenticated-orcid":false,"given":"Ke","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Safety, Sinopec Research Institute of Safety Engineering Co., Ltd., Qingdao 266000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Technical Testing Center of Shengli Oilfield Branch of China Petrochemical Corporation, Dongying 257000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Technical Testing Center of Shengli Oilfield Branch of China Petrochemical Corporation, Dongying 257000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, Sinopec Research Institute of Safety Engineering Co., Ltd., Qingdao 266000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangkai","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Safety, Sinopec Research Institute of Safety Engineering Co., Ltd., Qingdao 266000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"nwaf450","DOI":"10.1093\/nsr\/nwaf450","article-title":"Synthesis of Bio-Based N-Containing Compounds from Biomass","volume":"12","author":"Ji","year":"2025","journal-title":"Natl. 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