{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:29:37Z","timestamp":1789658977549,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00247626"],"award-info":[{"award-number":["RS-2023-00247626"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2023-00247626"],"award-info":[{"award-number":["RS-2023-00247626"]}],"id":[{"id":"https:\/\/ror.org\/01p262204","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Korean government","doi-asserted-by":"publisher","award":["RS-2026-25471006"],"award-info":[{"award-number":["RS-2026-25471006"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Shape memory polymers (SMPs) have emerged as a distinctive class of functional polymers for tissue engineering and regenerative medical devices because they couple programmable shape transformation with the biological, mechanical, and degradation requirements of regenerating tissue. Unlike conventional static scaffolds, SMP-based constructs can be delivered in compact temporary configurations, deployed under clinically relevant stimuli, and recovered into porous, anatomically conformal architectures that mechanically and biologically engage with host tissue. This review provides an engineering-oriented perspective on SMPs as functional polymers, emphasizing how shape recovery alone is insufficient and how regenerative performance emerges from coupled control of polymer chemistry, transition behavior, recovery force, fixity, degradation kinetics, and cytocompatibility. Material platforms ranging from biodegradable polyesters and polyurethanes to hydrogels, natural-polymer composites, and dynamic covalent networks are compared in terms of their ability to support tissue-specific functions including minimally invasive deployment, self-fitting, mechanical conditioning, and staged remodeling. The review further discusses 4D-printed patient-specific architectures and translational barriers, including sterilization, packaging, fatigue, manufacturing reproducibility, and regulatory validation. Together, these perspectives reframe SMPs from shape-recovery materials into integrated regenerative engineering platforms guiding the next generation of dynamic polymeric biomaterials.<\/jats:p>","DOI":"10.3390\/polym18182250","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:23:53Z","timestamp":1789496633000},"page":"2250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shape Memory Polymers as Functional Platforms for Dynamic Tissue Engineering and Regenerative Medical Devices"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-8554","authenticated-orcid":false,"given":"Kyubae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Gachon University, Seongnam 13120, Republic of Korea"},{"name":"Department of Biomedical Materials, Konyang University, Daejeon 35365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue Engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","article-title":"Scaffolds in Tissue Engineering Bone and Cartilage","volume":"21","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1369-7021(11)70058-X","article-title":"Biomaterials & Scaffolds for Tissue Engineering","volume":"14","year":"2011","journal-title":"Mater. 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